Quantification of the pace of biological aging in humans through a blood test, the DunedinPoAm DNA methylation algorithm

Longitudinal trajectories, correlations and mortality associations of nine biological ages across 20-years follow-up

(2020) Xia Li et al.   eLife

A Peripheral Blood DNA Methylation Signature of Hepatic Fat Reveals a Potential Causal Pathway for Non-Alcoholic Fatty Liver Disease

(2019) Jiantao Ma et al.   DIABETES

Impacts of air pollution, temperature, and relative humidity on leukocyte distribution: An epigenetic perspective

(2019) Xu Gao et al.   ENVIRONMENT INTERNATIONAL

Comparative validation of an epigenetic mortality risk score with three aging biomarkers for predicting mortality risks among older adult males

(2019) Xu Gao et al.   INTERNATIONAL JOURNAL OF EPIDEMIOLOGY

From discoveries in ageing research to therapeutics for healthy ageing

(2019) Judith Campisi et al.   NATURE

Reversal of epigenetic aging and immunosenescent trends in humans

(2019) Gregory M. Fahy et al.   AGING CELL

Comparability of biological aging measures in the National Health and Nutrition Examination Study, 1999–2002

(2019) Waylon J. Hastings et al.   PSYCHONEUROENDOCRINOLOGY

Short-term ambient particle radioactivity level and renal function in older men: Insight from the Normative Aging Study

(2019) Xu Gao et al.   ENVIRONMENT INTERNATIONAL

Brain-age in midlife is associated with accelerated biological aging and cognitive decline in a longitudinal birth cohort

(2019) Maxwell L. Elliott et al.   MOLECULAR PSYCHIATRY

An epigenetic biomarker of aging for lifespan and healthspan

(2018) Morgan E. Levine et al.   Aging-US

Analysis of DNA Methylation in Young People: Limited Evidence for an Association Between Victimization Stress and Epigenetic Variation in Blood

(2018) Sarah J. Marzi et al.   AMERICAN JOURNAL OF PSYCHIATRY

Lung function association with outdoor temperature and relative humidity and its interaction with air pollution in the elderly

(2018) Johanna Lepeule et al.   ENVIRONMENTAL RESEARCH

DNA methylation-based biomarkers and the epigenetic clock theory of ageing

(2018) Steve Horvath et al.   NATURE REVIEWS GENETICS

The plateau of human mortality: Demography of longevity pioneers

(2018) Elisabetta Barbi et al.   SCIENCE

Associations Between Ambient Particle Radioactivity and Blood Pressure: The NAS (Normative Aging Study)

(2018) Marguerite M. Nyhan et al.   Journal of the American Heart Association

A framework for selection of blood-based biomarkers for geroscience-guided clinical trials: report from the TAME Biomarkers Workgroup

(2018) Jamie N. Justice et al.   GeroScience

Artificial intelligence for aging and longevity research: Recent advances and perspectives

(2018) Alex Zhavoronkov et al.   AGEING RESEARCH REVIEWS

Accelerated DNA methylation age and the use of antihypertensive medication among older adults

(2018) Xu Gao et al.   Aging-US

Leveraging DNA-Methylation Quantitative-Trait Loci to Characterize the Relationship between Methylomic Variation, Gene Expression, and Complex Traits

(2018) Eilis Hannon et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Epigenome-wide Association of DNA Methylation in Whole Blood With Bone Mineral Density

(2017) John A Morris et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Change in the Rate of Biological Aging in Response to Caloric Restriction: CALERIE Biobank Analysis

(2017) Daniel W Belsky et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Epigenome-wide association studies identify DNA methylation associated with kidney function

(2017) Audrey Y. Chu et al.   Nature Communications

Epigenetic Patterns in Blood Associated With Lipid Traits Predict Incident Coronary Heart Disease Events and Are Enriched for Results From Genome-Wide Association StudiesCLINICAL PERSPECTIVE

(2017) Åsa K. Hedman et al.   Circulation-Cardiovascular Genetics

Lung function discordance in monozygotic twins and associated differences in blood DNA methylation

(2017) Anneli C. S. Bolund et al.   Clinical Epigenetics

Developing criteria for evaluation of geroprotectors as a key stage toward translation to the clinic

(2016) Alexey Moskalev et al.   AGING CELL

Aging: progressive decline in fitness due to the rising deleteriome adjusted by genetic, environmental, and stochastic processes

(2016) Vadim N. Gladyshev   AGING CELL

Genome-Wide Analysis of DNA Methylation and Fine Particulate Matter Air Pollution in Three Study Populations: KORA F3, KORA F4, and the Normative Aging Study

(2016) Tommaso Panni et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

Differential DNA methylation and PM2.5 species in a 450K epigenome-wide association study

(2016) Lingzhen Dai et al.   Epigenetics

The Longitudinal Study of Aging in Human Young Adults: Knowledge Gaps and Research Agenda

(2016) Terrie E. Moffitt et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Frameworks for Proof-of-Concept Clinical Trials of Interventions That Target Fundamental Aging Processes

(2016) Jamie Justice et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Dynamics of biomarkers in relation to aging and mortality

(2016) Konstantin G. Arbeev et al.   MECHANISMS OF AGEING AND DEVELOPMENT

Epigenome-wide association study of body mass index and the adverse outcomes of adiposity

(2016) Simone Wahl et al.   NATURE

Constant molecular aging rates vs. the exponential acceleration of mortality

(2016) Caleb E. Finch et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Epigenome-wide Association Studies and the Interpretation of Disease -Omics

(2016) Ewan Birney et al.   PLoS Genetics

A Genome-Wide mQTL Analysis in Human Adipose Tissue Identifies Genetic Variants Associated with DNA Methylation, Gene Expression and Metabolic Traits

(2016) Petr Volkov et al.   PLoS One

Integration of ‘omics’ data in aging research: from biomarkers to systems biology

(2015) Jonas Zierer et al.   AGING CELL

DNA Methylation of the Aryl Hydrocarbon Receptor Repressor Associations With Cigarette Smoking and Subclinical AtherosclerosisCLINICAL PERSPECTIVE

(2015) Lindsay M. Reynolds et al.   Circulation-Cardiovascular Genetics

A 2-Year Randomized Controlled Trial of Human Caloric Restriction: Feasibility and Effects on Predictors of Health Span and Longevity

(2015) Eric Ravussin et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Quantification of biological aging in young adults

(2015) Daniel W. Belsky et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Healthy aging: The ultimate preventative medicine

(2015) M. Kaeberlein et al.   SCIENCE

The Dunedin Multidisciplinary Health and Development Study: overview of the first 40 years, with an eye to the future

(2015) Richie Poulton et al.   SOCIAL PSYCHIATRY AND PSYCHIATRIC EPIDEMIOLOGY

Hypomethylation of smoking-related genes is associated with future lung cancer in four prospective cohorts

(2015) Francesca Fasanelli et al.   Nature Communications

DNA Methylation of the Aryl Hydrocarbon Receptor Repressor Associations With Cigarette Smoking and Subclinical AtherosclerosisCLINICAL PERSPECTIVE

(2015) Lindsay M. Reynolds et al.   Circulation-Cardiovascular Genetics

Epigenome-wide association of DNA methylation markers in peripheral blood from Indian Asians and Europeans with incident type 2 diabetes: a nested case-control study

(2015) John C Chambers et al.   Lancet Diabetes & Endocrinology

Geroscience: Linking Aging to Chronic Disease

(2014) Brian K. Kennedy et al.   CELL

The Doubly Labeled Water Method Produces Highly Reproducible Longitudinal Results in Nutrition Studies

(2014) William W. Wong et al.   JOURNAL OF NUTRITION

Economic and social implications of aging societies

(2014) S. Harper   SCIENCE

The risks and rewards of covariate adjustment in randomized trials: an assessment of 12 outcomes from 8 studies

(2014) Brennan C Kahan et al.   Trials

Energy requirements in nonobese men and women: results from CALERIE

(2013) et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

The Hallmarks of Aging

(2013) Carlos López-Otín et al.   CELL

Substantial Health And Economic Returns From Delayed Aging May Warrant A New Focus For Medical Research

(2013) Dana P. Goldman et al.   HEALTH AFFAIRS

From promises to practical strategies in epigenetic epidemiology

(2013) Jonathan Mill et al.   NATURE REVIEWS GENETICS

DNA methylation age of human tissues and cell types

(2013) Steve Horvath   GENOME BIOLOGY

DNA methylation arrays as surrogate measures of cell mixture distribution

(2012) Eugene Houseman et al.   BMC BIOINFORMATICS

Modeling the Rate of Senescence: Can Estimated Biological Age Predict Mortality More Accurately Than Chronological Age?

(2012) M. E. Levine   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Genome-wide Methylation Profiles Reveal Quantitative Views of Human Aging Rates

(2012) Gregory Hannum et al.   MOLECULAR CELL

Approaches for quantifying energy intake and %calorie restriction during calorie restriction interventions in humans: the multicenter CALERIE study

(2011) Susan B. Racette et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Adverse childhood experiences, allostasis, allostatic load, and age-related disease

(2011) Andrea Danese et al.   PHYSIOLOGY & BEHAVIOR

U.S. Disparities in Health: Descriptions, Causes, and Mechanisms

(2007) Nancy E. Adler et al.   Annual Review of Public Health