Metformin: Do we finally have an anti-aging drug?

Answering the ultimate question “What is the Proximal Cause of Aging?”

(2016) Mikhail V. Blagosklonny   Aging-US

Cell cycle arrest is not yet senescence, which is not just cell cycle arrest: terminology for TOR-driven aging

(2016) Mikhail V. Blagosklonny   Aging-US

Metformin inhibits the senescence-associated secretory phenotype by interfering with IKK/NF-κB activation

(2013) Olga Moiseeva et al.   AGING CELL

The Hallmarks of Aging

(2013) Carlos López-Otín et al.   CELL

Metformin Retards Aging in C. elegans by Altering Microbial Folate and Methionine Metabolism

(2013) Filipe Cabreiro et al.   CELL

The key role of growth hormone–insulin–IGF-1 signaling in aging and cancer

(2013) Vladimir N. Anisimov et al.   CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY

Mechanism of metformin: Inhibition of DNA damage and proliferative activity in Drosophila midgut stem cell

(2013) Hyun-Jin Na et al.   MECHANISMS OF AGEING AND DEVELOPMENT

mTOR is a key modulator of ageing and age-related disease

(2013) Simon C. Johnson et al.   NATURE

Hypothalamic programming of systemic ageing involving IKK-β, NF-κB and GnRH

(2013) Guo Zhang et al.   NATURE

Metformin improves healthspan and lifespan in mice

(2013) Alejandro Martin-Montalvo et al.   Nature Communications

Prospective Treatment of Age-Related Diseases by Slowing Down Aging

(2012) Mikhail V. Blagosklonny   AMERICAN JOURNAL OF PATHOLOGY

Impact of caloric restriction on health and survival in rhesus monkeys from the NIA study

(2012) Julie A. Mattison et al.   NATURE

Activation of AMPK by the Putative Dietary Restriction Mimetic Metformin Is Insufficient to Extend Lifespan in Drosophila

(2012) Cathy Slack et al.   PLoS One

Cancer Prevention With a Diabetes Pill?

(2012) G. Taubes   SCIENCE

Metformin slows down aging and extends life span of female SHR mice

(2011) Vladimir N. Anisimov et al.   CELL CYCLE

Metformin extends life span of HER-2/neu transgenic mice and in combination with melatonin inhibits growth of transplantable tumors in vivo

(2011) Vladimir N. Anisimov et al.   CELL CYCLE

Growth stimulation leads to cellular senescence when the cell cycle is blocked

(2010) Zoya N. Demidenko et al.   CELL CYCLE

Metformin and cancer: Doses, mechanisms and the dandelion and hormetic phenomena

(2010) Begoña Martin-Castillo et al.   CELL CYCLE

Metformin and Energy Metabolism in Breast Cancer: From Insulin Physiology to Tumour-initiating Stem Cells

(2010) A. Vazquez-Martin et al.   CURRENT MOLECULAR MEDICINE

Modern approach to metabolic rehabilitation of cancer patients: biguanides (phenformin and metformin) and beyond

(2010) Lev M Berstein   Future Oncology

Metformin Supplementation and Life Span in Fischer-344 Rats

(2010) D. L. Smith et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Metformin Induces a Dietary Restriction–Like State and the Oxidative Stress Response to Extend C. elegans Healthspan via AMPK, LKB1, and SKN-1

(2010) Brian Onken et al.   PLoS One

Paradoxical suppression of cellular senescence by p53

(2010) Z. N. Demidenko et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Caloric restriction: From soup to nuts

(2009) Stephen R. Spindler   AGEING RESEARCH REVIEWS

mTOR Regulation and Therapeutic Rejuvenation of Aging Hematopoietic Stem Cells

(2009) C. Chen et al.   Science Signaling

Toxicity and toxicokinetics of metformin in rats

(2009) Michael P. Quaile et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Carcinogenesis and aging 20 years after: Escaping horizon

(2008) Vladimir N. Anisimov   MECHANISMS OF AGEING AND DEVELOPMENT