Metabolic profiles of regulatory T cells and their adaptations to the tumor microenvironment: implications for antitumor immunity

Lactic acid promotes PD-1 expression in regulatory T cells in highly glycolytic tumor microenvironments

(2022) Shogo Kumagai et al.   CANCER CELL

Combination strategies with PD-1/PD-L1 blockade: current advances and future directions

(2022) Ming Yi et al.   Molecular Cancer

Regulation of PD-L1 expression in the tumor microenvironment

(2021) Ming Yi et al.   Journal of Hematology & Oncology

Targeting hypoxic tumor microenvironment in pancreatic cancer

(2021) Jinxin Tao et al.   Journal of Hematology & Oncology

Glucose metabolism characteristics and TLR8-mediated metabolic control of CD4+ Treg cells in ovarian cancer cells microenvironment

(2021) Rui Xu et al.   Cell Death & Disease

Immunosuppressive Amino-Acid Catabolizing Enzymes in Multiple Sclerosis

(2021) Jorge Correale   Frontiers in Immunology

Metabolic profiles of regulatory T cells in the tumour microenvironment

(2021) Disha Rao et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

The construction, expression, and enhanced anti-tumor activity of YM101: a bispecific antibody simultaneously targeting TGF-β and PD-L1

(2021) Ming Yi et al.   Journal of Hematology & Oncology

CTLA-4 blockade drives loss of Treg stability in glycolysis-low tumours

(2021) Roberta Zappasodi et al.   NATURE

Metabolic support of tumour-infiltrating regulatory T cells by lactic acid

(2021) McLane J. Watson et al.   NATURE

Lipid signalling enforces functional specialization of Treg cells in tumours

(2021) Seon Ah Lim et al.   NATURE

Investigating the Role of Indoleamine 2,3-Dioxygenase in Acute Myeloid Leukemia: A Systematic Review

(2021) Georgia Wells et al.   Frontiers in Immunology

MondoA-TXNIP axis maintains regulatory T cell identity and function in colorectal cancer microenvironment

(2021) Ying Lu et al.   GASTROENTEROLOGY

Signals of pseudo-starvation unveil the amino acid transporter SLC7A11 as key determinant in the control of Treg cell proliferative potential

(2021) Claudio Procaccini et al.   IMMUNITY

Indoleamine 2,3-dioxygenase 1 (IDO1) inhibitors in clinical trials for cancer immunotherapy

(2021) Kai Tang et al.   Journal of Hematology & Oncology

Next generation of immune checkpoint inhibitors and beyond

(2021) Julian A. Marin-Acevedo et al.   Journal of Hematology & Oncology

PPARγ marks splenic precursors of multiple nonlymphoid-tissue Treg compartments

(2021) Chaoran Li et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Reprogramming lipid metabolism prevents effector T cell senescence and enhances tumor immunotherapy

(2021) Xia Liu et al.   Science Translational Medicine

Tumor resident regulatory T cells

(2021) Ariella Glasner et al.   SEMINARS IN IMMUNOLOGY

Recruitment and Expansion of Tregs Cells in the Tumor Environment—How to Target Them?

(2021) Justine Cinier et al.   Cancers

Pan-cancer analysis reveals tumor-associated macrophage communication in the tumor microenvironment

(2021) Linbang Wang et al.   Experimental Hematology & Oncology

Curcumin Analog GO‐Y030 Boosts the Efficacy of Anti‐PD‐1 Cancer Immunotherapy

(2021) Takashi MaruYama et al.   CANCER SCIENCE

Blockade of checkpoint receptor PVRIG unleashes anti-tumor immunity of NK cells in murine and human solid tumors

(2021) Yangyang Li et al.   Journal of Hematology & Oncology

Combine and conquer: manganese synergizing anti-TGF-β/PD-L1 bispecific antibody YM101 to overcome immunotherapy resistance in non-inflamed cancers

(2021) Ming Yi et al.   Journal of Hematology & Oncology

Spatial architecture of the immune microenvironment orchestrates tumor immunity and therapeutic response

(2021) Tong Fu et al.   Journal of Hematology & Oncology

Mechanisms of regulatory T cell infiltration in tumors: implications for innovative immune precision therapies

(2021) Shohei Koyama et al.   Journal for ImmunoTherapy of Cancer

PLA2G4A promotes right-sided colorectal cancer progression by inducing CD39+γδ Treg polarization

(2021) Yang Zhan et al.   JCI Insight

Antiangiogenic therapy reverses the immunosuppressive breast cancer microenvironment

(2021) Wuzhen Chen et al.   Biomarker Research

Noncoding RNAs link metabolic reprogramming to immune microenvironment in cancers

(2021) Yiyin Zhang et al.   Journal of Hematology & Oncology

Targeting CD47 for cancer immunotherapy

(2021) Zhongxing Jiang et al.   Journal of Hematology & Oncology

Contradictory roles of lipid metabolism in immune response within the tumor microenvironment

(2021) Weina Yu et al.   Journal of Hematology & Oncology

Combination strategies to maximize the benefits of cancer immunotherapy

(2021) Shaoming Zhu et al.   Journal of Hematology & Oncology

Dysregulated tumor-associated macrophages in carcinogenesis, progression and targeted therapy of gynecological and breast cancers

(2021) Tianhan Xu et al.   Journal of Hematology & Oncology

Intratumor heterogeneity: the hidden barrier to immunotherapy against MSI tumors from the perspective of IFN-γ signaling and tumor-infiltrating lymphocytes

(2021) Wantao Wu et al.   Journal of Hematology & Oncology

Mechanistic Insight into PPARγ and Tregs in Atherosclerotic Immune Inflammation

(2021) Zhao Gao et al.   Frontiers in Pharmacology

Synergistic antitumor activity of pan-PI3K inhibition and immune checkpoint blockade in bladder cancer

(2021) Shaoming Zhu et al.   Journal for ImmunoTherapy of Cancer

Landscape of Myeloid-derived Suppressor Cell in Tumor Immunotherapy

(2021) Zhaonian Hao et al.   Biomarker Research

Next frontier in tumor immunotherapy: macrophage-mediated immune evasion

(2021) Yingqi Qiu et al.   Biomarker Research

Roles of tumor-associated macrophages in tumor progression: implications on therapeutic strategies

(2021) Shuangli Zhu et al.   Experimental Hematology & Oncology

Regulatory T Cells and Human Disease

(2020) Shimon Sakaguchi et al.   Annual Review of Immunology

Myeloid-derived suppressor cells—new and exciting players in lung cancer

(2020) Zhenzhen Yang et al.   Journal of Hematology & Oncology

CD36-mediated metabolic adaptation supports regulatory T cell survival and function in tumors

(2020) Haiping Wang et al.   NATURE IMMUNOLOGY

Glutathione Restricts Serine Metabolism to Preserve Regulatory T Cell Function

(2020) Henry Kurniawan et al.   Cell Metabolism

Diet-induced dyslipidemia induces metabolic and migratory adaptations in regulatory T cells

(2020) J Amersfoort et al.   CARDIOVASCULAR RESEARCH

An Oncogenic Alteration Creates a Microenvironment that Promotes Tumor Progression by Conferring a Metabolic Advantage to Regulatory T Cells

(2020) Shogo Kumagai et al.   IMMUNITY

Microenvironment characterization and multi-omics signatures related to prognosis and immunotherapy response of hepatocellular carcinoma

(2020) Furong Liu et al.   Experimental Hematology & Oncology

Regulatory T Cell Stability and Migration Are Dependent on mTOR

(2020) Romain Vallion et al.   JOURNAL OF IMMUNOLOGY

Tolerance in the Age of Immunotherapy

(2020) Jeffrey A. Bluestone et al.   NEW ENGLAND JOURNAL OF MEDICINE

HIF-2α is indispensable for regulatory T cell function

(2020) Tzu-Sheng Hsu et al.   Nature Communications

Regulation of metabolic reprogramming by tumor suppressor genes in pancreatic cancer

(2020) Mengqi Liu et al.   Experimental Hematology & Oncology

Obesity and the risk of Multiple Sclerosis. The role of Leptin

(2020) Mariano Marrodan et al.   Annals of Clinical and Translational Neurology

Lysosomal Acid Lipase Deficiency Controls T- and B-Regulatory Cell Homeostasis in the Lymph Nodes of Mice with Human Cancer Xenotransplants

(2020) Xinchun Ding et al.   AMERICAN JOURNAL OF PATHOLOGY

Immunometabolism of regulatory T cells in cancer

(2020) Mario Galgani et al.   MOLECULAR ASPECTS OF MEDICINE

Mitochondrial complex III is essential for suppressive function of regulatory T cells

(2019) Samuel E. Weinberg et al.   NATURE

Regulatory T cells in cancer immunosuppression — implications for anticancer therapy

(2019) Yosuke Togashi et al.   Nature Reviews Clinical Oncology

The PI3K p110δ Isoform Inhibitor Idelalisib Preferentially Inhibits Human Regulatory T Cell Function

(2019) Stalin Chellappa et al.   JOURNAL OF IMMUNOLOGY

HIF-1α Is a Metabolic Switch between Glycolytic-Driven Migration and Oxidative Phosphorylation-Driven Immunosuppression of Tregs in Glioblastoma

(2019) Jason Miska et al.   Cell Reports

Activation of Mevalonate Pathway via LKB1 Is Essential for Stability of Treg Cells

(2019) Maheshwor Timilshina et al.   Cell Reports

Requirement of Mitochondrial Transcription Factor A in Tissue-Resident Regulatory T Cell Maintenance and Function

(2019) Zheng Fu et al.   Cell Reports

Dysregulation of glutamate transport enhances Treg function that promotes VEGF blockade resistance in glioblastoma

(2019) Yu Long et al.   CANCER RESEARCH

Mitochondrial Integrity Regulated by Lipid Metabolism Is a Cell-Intrinsic Checkpoint for Treg Suppressive Function

(2019) Cameron S. Field et al.   Cell Metabolism

Amino Acids License Kinase mTORC1 Activity and Treg Cell Function via Small G Proteins Rag and Rheb

(2019) Hao Shi et al.   IMMUNITY

Metabolic Pathways Involved in Regulatory T Cell Functionality

(2019) Rosalie W. M. Kempkes et al.   Frontiers in Immunology

Etomoxir Inhibits Macrophage Polarization by Disrupting CoA Homeostasis

(2018) Ajit S. Divakaruni et al.   Cell Metabolism

Etomoxir Actions on Regulatory and Memory T Cells Are Independent of Cpt1a-Mediated Fatty Acid Oxidation

(2018) Brenda Raud et al.   Cell Metabolism

TLR-mediated metabolic reprogramming in the tumor microenvironment: potential novel strategies for cancer immunotherapy

(2018) Lan Huang et al.   Cellular & Molecular Immunology

Tryptophan Metabolism Contributes to Radiation-Induced Immune Checkpoint Reactivation in Glioblastoma

(2018) Pravin Kesarwani et al.   CLINICAL CANCER RESEARCH

Fatty acid metabolism complements glycolysis in the selective regulatory T cell expansion during tumor growth

(2018) Ilenia Pacella et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Metabolic Control of CD8 + T Cell Fate Decisions and Antitumor Immunity

(2018) Lianjun Zhang et al.   TRENDS IN MOLECULAR MEDICINE

Regulatory T cells trigger effector T cell DNA damage and senescence caused by metabolic competition

(2018) Xia Liu et al.   Nature Communications

The Role of Lipid Metabolism in T Lymphocyte Differentiation and Survival

(2018) Duncan Howie et al.   Frontiers in Immunology

D-2-hydroxyglutarate interferes with HIF-1α stability skewing T-cell metabolism towards oxidative phosphorylation and impairing Th17 polarization

(2018) Martin Böttcher et al.   OncoImmunology

TLR8-Mediated Metabolic Control of Human Treg Function: A Mechanistic Target for Cancer Immunotherapy

(2018) Lingyun Li et al.   Cell Metabolism

PI3K p110δ inactivation antagonizes chronic lymphocytic leukemia and reverses T cell immune suppression

(2018) Shuai Dong et al.   JOURNAL OF CLINICAL INVESTIGATION

PI3Kδ inhibition modulates regulatory and effector T-cell differentiation and function in chronic lymphocytic leukemia

(2018) Bola S. Hanna et al.   LEUKEMIA

Effects of tumor metabolic microenvironment on regulatory T cells

(2018) Yi-an Wang et al.   Molecular Cancer

Altered cancer metabolism in mechanisms of immunotherapy resistance

(2018) Rishab Ramapriyan et al.   PHARMACOLOGY & THERAPEUTICS

Roquin Suppresses the PI3K-mTOR Signaling Pathway to Inhibit T Helper Cell Differentiation and Conversion of Treg to Tfr Cells

(2017) Katharina Essig et al.   IMMUNITY

Regulatory T Cell Migration Is Dependent on Glucokinase-Mediated Glycolysis

(2017) Madhav Kishore et al.   IMMUNITY

Stabilizing human regulatory T cells for tolerance inducing immunotherapy

(2017) Xuehui He et al.   Immunotherapy

Homeostatic control of metabolic and functional fitness of Treg cells by LKB1 signalling

(2017) Kai Yang et al.   NATURE

Metabolic control of regulatory T cell (Treg) survival and function by Lkb1

(2017) Nanhai He et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Slc3a2 Mediates Branched-Chain Amino-Acid-Dependent Maintenance of Regulatory T Cells

(2017) Kayo Ikeda et al.   Cell Reports

l-Arginine-Dependent Epigenetic Regulation of Interleukin-10, but Not Transforming Growth Factor-β, Production by Neonatal Regulatory T Lymphocytes

(2017) Hong-Ren Yu et al.   Frontiers in Immunology

Attenuation of CD4 + CD25 + Regulatory T Cells in the Tumor Microenvironment by Metformin, a Type 2 Diabetes Drug

(2017) Yuki Kunisada et al.   EBioMedicine

Regulatory T cells in cancer immunotherapy

(2016) Atsushi Tanaka et al.   CELL RESEARCH

Regulatory T Cells Exhibit Distinct Features in Human Breast Cancer

(2016) George Plitas et al.   IMMUNITY

Role of Metabolism in the Immunobiology of Regulatory T Cells

(2016) Mario Galgani et al.   JOURNAL OF IMMUNOLOGY

Foxp3 and Toll-like receptor signaling balance Treg cell anabolic metabolism for suppression

(2016) Valerie A Gerriets et al.   NATURE IMMUNOLOGY

Lactate Contribution to the Tumor Microenvironment: Mechanisms, Effects on Immune Cells and Therapeutic Relevance

(2016) Susana Romero-Garcia et al.   Frontiers in Immunology

Increased proportion of FoxP3+ regulatory T cells in tumor infiltrating lymphocytes is associated with tumor recurrence and reduced survival in patients with glioblastoma

(2015) Elias J. Sayour et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

ER Stress Sensor XBP1 Controls Anti-tumor Immunity by Disrupting Dendritic Cell Homeostasis

(2015) Juan R. Cubillos-Ruiz et al.   CELL

Metabolic Competition in the Tumor Microenvironment Is a Driver of Cancer Progression

(2015) Chih-Hao Chang et al.   CELL

The role of all-trans retinoic acid in the biology of Foxp3+ regulatory T cells

(2015) Zhong-Min Liu et al.   Cellular & Molecular Immunology

Essential role of mitochondrial energy metabolism in Foxp3+ T-regulatory cell function and allograft survival

(2015) Ulf H. Beier et al.   FASEB JOURNAL

Treg cells require the phosphatase PTEN to restrain TH1 and TFH cell responses

(2015) Sharad Shrestha et al.   NATURE IMMUNOLOGY

Glutamine-dependent α-ketoglutarate production regulates the balance between T helper 1 cell and regulatory T cell generation

(2015) Dorota Klysz et al.   Science Signaling

Glutamine-dependent α-ketoglutarate production regulates the balance between T helper 1 cell and regulatory T cell generation

(2015) Dorota Klysz et al.   Science Signaling

The PTEN pathway in Tregs is a critical driver of the suppressive tumor microenvironment

(2015) M. D. Sharma et al.   Science Advances

Metformin Ameliorates Inflammatory Bowel Disease by Suppression of the STAT3 Signaling Pathway and Regulation of the between Th17/Treg Balance

(2015) Seon-Yeong Lee et al.   PLoS One

The Glucose Transporter Glut1 Is Selectively Essential for CD4 T Cell Activation and Effector Function

(2014) Andrew N. Macintyre et al.   Cell Metabolism

Metabolic programming and PDHK1 control CD4+ T cell subsets and inflammation

(2014) Valerie A. Gerriets et al.   JOURNAL OF CLINICAL INVESTIGATION

Inactivation of PI(3)K p110δ breaks regulatory T-cell-mediated immune tolerance to cancer

(2014) Khaled Ali et al.   NATURE

De novo fatty acid synthesis controls the fate between regulatory T and T helper 17 cells

(2014) Luciana Berod et al.   NATURE MEDICINE

An Increased Abundance of Tumor-Infiltrating Regulatory T Cells Is Correlated with the Progression and Prognosis of Pancreatic Ductal Adenocarcinoma

(2014) Yichen Tang et al.   PLoS One

Critical role of all-trans retinoic acid in stabilizing human natural regulatory T cells under inflammatory conditions

(2014) L. Lu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Selective Inhibition of Regulatory T Cells by Targeting the PI3K-Akt Pathway

(2014) R. Abu-Eid et al.   Cancer Immunology Research

Control of the Immune Response by Pro-Angiogenic Factors

(2014) Thibault Voron et al.   Frontiers in Oncology

Glutamine Sensitivity Analysis Identifies the xCT Antiporter as a Common Triple-Negative Breast Tumor Therapeutic Target

(2013) Luika A. Timmerman et al.   CANCER CELL

mTOR Complex 2 Controls Glycolytic Metabolism in Glioblastoma through FoxO Acetylation and Upregulation of c-Myc

(2013) Kenta Masui et al.   Cell Metabolism

Mitochondria Are Required for Antigen-Specific T Cell Activation through Reactive Oxygen Species Signaling

(2013) Laura A. Sena et al.   IMMUNITY

Development and Maintenance of Regulatory T cells

(2013) Naganari Ohkura et al.   IMMUNITY

IDO expressing fibroblasts promote the expansion of antigen specific regulatory T cells

(2013) Terry-Ann Curran et al.   IMMUNOBIOLOGY

Commensal microbe-derived butyrate induces the differentiation of colonic regulatory T cells

(2013) Yukihiro Furusawa et al.   NATURE

Metabolites produced by commensal bacteria promote peripheral regulatory T-cell generation

(2013) Nicholas Arpaia et al.   NATURE

mTORC1 couples immune signals and metabolic programming to establish Treg-cell function

(2013) Hu Zeng et al.   NATURE

Rapid effector function of memory CD8+ T cells requires an immediate-early glycolytic switch

(2013) Patrick M Gubser et al.   NATURE IMMUNOLOGY

Regulatory T cells: recommendations to simplify the nomenclature

(2013) Abul K Abbas et al.   NATURE IMMUNOLOGY

AMP-Activated Protein Kinase Regulation and Biological Actions in the Heart

(2012) Vlad G. Zaha et al.   CIRCULATION RESEARCH

The Prognostic Value of FoxP3+ Tumor-Infiltrating Lymphocytes in Cancer: A Critical Review of the Literature

(2012) R. J. deLeeuw et al.   CLINICAL CANCER RESEARCH

PPAR-γ is a major driver of the accumulation and phenotype of adipose tissue Treg cells

(2012) Daniela Cipolletta et al.   NATURE

Safety, Activity, and Immune Correlates of Anti–PD-1 Antibody in Cancer

(2012) Suzanne L. Topalian et al.   NEW ENGLAND JOURNAL OF MEDICINE

Hypoxia-inducible factor-1 alpha-dependent induction of FoxP3 drives regulatory T-cell abundance and function during inflammatory hypoxia of the mucosa

(2012) E. T. Clambey et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Control of TH17/Treg Balance by Hypoxia-Inducible Factor 1

(2011) Eric V. Dang et al.   CELL

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

Exhaustion of tumor-specific CD8+ T cells in metastases from melanoma patients

(2011) Lukas Baitsch et al.   JOURNAL OF CLINICAL INVESTIGATION

HIF1α–dependent glycolytic pathway orchestrates a metabolic checkpoint for the differentiation of TH17 and Tregcells

(2011) Lewis Z. Shi et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Cutting Edge: Distinct Glycolytic and Lipid Oxidative Metabolic Programs Are Essential for Effector and Regulatory CD4+ T Cell Subsets

(2011) R. D. Michalek et al.   JOURNAL OF IMMUNOLOGY

Prognostic potential of FOXP3 expression in non-small cell lung cancer cells combined with tumor-infiltrating regulatory T cells

(2011) Hiroyuki Tao et al.   LUNG CANCER

An endogenous tumour-promoting ligand of the human aryl hydrocarbon receptor

(2011) Christiane A. Opitz et al.   NATURE

T cell exhaustion

(2011) E John Wherry   NATURE IMMUNOLOGY

Phosphoinositide 3-kinase and the mammalian target of rapamycin pathways control T cell migration

(2010) David Finlay et al.   Annals of the New York Academy of Sciences

Increased thioredoxin-1 production in human naturally occurring regulatory T cells confers enhanced tolerance to oxidative stress

(2010) D. Mougiakakos et al.   BLOOD

An Oscillatory Switch in mTOR Kinase Activity Sets Regulatory T Cell Responsiveness

(2010) Claudio Procaccini et al.   IMMUNITY

IDO Upregulates Regulatory T Cells via Tryptophan Catabolite and Suppresses Encephalitogenic T Cell Responses in Experimental Autoimmune Encephalomyelitis

(2010) Y. Yan et al.   JOURNAL OF IMMUNOLOGY

Cutting Edge: All-Trans Retinoic Acid Sustains the Stability and Function of Natural Regulatory T Cells in an Inflammatory Milieu

(2010) X. Zhou et al.   JOURNAL OF IMMUNOLOGY

Improved Survival with Ipilimumab in Patients with Metastatic Melanoma

(2010) F. Stephen Hodi et al.   NEW ENGLAND JOURNAL OF MEDICINE

Stromal regulatory T-cells are associated with a favourable prognosis in gastric cancer of the cardia

(2009) Matthias Haas et al.   BMC GASTROENTEROLOGY

Functional Delineation and Differentiation Dynamics of Human CD4+ T Cells Expressing the FoxP3 Transcription Factor

(2009) Makoto Miyara et al.   IMMUNITY

Lean, but not obese, fat is enriched for a unique population of regulatory T cells that affect metabolic parameters

(2009) Markus Feuerer et al.   NATURE MEDICINE

Defining the role of hypoxia-inducible factor 1 in cancer biology and therapeutics

(2009) G L Semenza   ONCOGENE

Prognostic significance of tumor-infiltrating T-lymphocytes in primary and metastatic lesions of advanced stage ovarian cancer

(2008) Ninke Leffers et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Regulatory T Cells and Immune Tolerance

(2008) Shimon Sakaguchi et al.   CELL

Hypoxia controls CD4+CD25+ regulatory T-cell homeostasis via hypoxia-inducible factor-1α

(2008) Jeremy Ben-Shoshan et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Tumor-Infiltrating FOXP3+ T Regulatory Cells Show Strong Prognostic Significance in Colorectal Cancer

(2008) Paul Salama et al.   JOURNAL OF CLINICAL ONCOLOGY

The AKT–mTOR axis regulates de novo differentiation of CD4+Foxp3+cells

(2008) Sokol Haxhinasto et al.   JOURNAL OF EXPERIMENTAL MEDICINE

T cell receptor signaling controls Foxp3 expression via PI3K, Akt, and mTOR

(2008) S. Sauer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA