Role of Metabolism in the Immunobiology of Regulatory T Cells

The Proteomic Landscape of Human Ex Vivo Regulatory and Conventional T Cells Reveals Specific Metabolic Requirements

(2016) Claudio Procaccini et al.   IMMUNITY

Autophagy enforces functional integrity of regulatory T cells by coupling environmental cues and metabolic homeostasis

(2016) Jun Wei et al.   NATURE IMMUNOLOGY

Weight Gain Alters Adiponectin Receptor 1 Expression on Adipose Tissue-Resident Helios+ Regulatory T Cells

(2016) P. Ramos-Ramírez et al.   SCANDINAVIAN JOURNAL OF IMMUNOLOGY

Immunologic Effects of Metformin and Pioglitazone Treatment on Metabolic Syndrome and Multiple Sclerosis

(2016) Laura Negrotto et al.   JAMA Neurology

Oscillatory mTOR inhibition and Tregincrease in kidney transplantation

(2015) M. Sabbatini et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Essential role of mitochondrial energy metabolism in Foxp3+ T-regulatory cell function and allograft survival

(2015) Ulf H. Beier et al.   FASEB JOURNAL

Foxp3 lacking exons 2 and 7 is unable to confer suppressive ability to regulatory T cells in vivo

(2015) Anne-Laure Joly et al.   JOURNAL OF AUTOIMMUNITY

Treg cells require the phosphatase PTEN to restrain TH1 and TFH cell responses

(2015) Sharad Shrestha et al.   NATURE IMMUNOLOGY

Glycolysis controls the induction of human regulatory T cells by modulating the expression of FOXP3 exon 2 splicing variants

(2015) Veronica De Rosa et al.   NATURE IMMUNOLOGY

Control of PI(3) kinase in Treg cells maintains homeostasis and lineage stability

(2015) Alexandria Huynh et al.   NATURE IMMUNOLOGY

Glutamine-dependent α-ketoglutarate production regulates the balance between T helper 1 cell and regulatory T cell generation

(2015) Dorota Klysz et al.   Science Signaling

Glutamine-dependent α-ketoglutarate production regulates the balance between T helper 1 cell and regulatory T cell generation

(2015) Dorota Klysz et al.   Science Signaling

The PTEN pathway in Tregs is a critical driver of the suppressive tumor microenvironment

(2015) M. D. Sharma et al.   Science Advances

Metformin Ameliorates Inflammatory Bowel Disease by Suppression of the STAT3 Signaling Pathway and Regulation of the between Th17/Treg Balance

(2015) Seon-Yeong Lee et al.   PLoS One

IL-1β promotes Th17 differentiation by inducing alternative splicing of FOXP3

(2015) Reiner K. W. Mailer et al.   Scientific Reports

The Glucose Transporter Glut1 Is Selectively Essential for CD4 T Cell Activation and Effector Function

(2014) Andrew N. Macintyre et al.   Cell Metabolism

Treg functional stability and its responsiveness to the microenvironment

(2014) Joseph Barbi et al.   IMMUNOLOGICAL REVIEWS

1α,25-dihydroxyvitamin D3 in combination with transforming growth factor-βincreases the frequency of Foxp3+regulatory T cells through preferential expansion and usage of interleukin-2

(2014) Emma S. Chambers et al.   IMMUNOLOGY

Indoleamine 2,3-Dioxygenase 1 (IDO1) Is Up-Regulated in Thyroid Carcinoma and Drives the Development of an Immunosuppressant Tumor Microenvironment

(2014) Sonia Moretti et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Metabolic programming and PDHK1 control CD4+ T cell subsets and inflammation

(2014) Valerie A. Gerriets et al.   JOURNAL OF CLINICAL INVESTIGATION

Modulation of T Cell and Innate Immune Responses by Retinoic Acid

(2014) M. Raverdeau et al.   JOURNAL OF IMMUNOLOGY

De novo fatty acid synthesis controls the fate between regulatory T and T helper 17 cells

(2014) Luciana Berod et al.   NATURE MEDICINE

Beneficial Metabolic Effects of Rapamycin Are Associated with Enhanced Regulatory Cells in Diet-Induced Obese Mice

(2014) Kassem Makki et al.   PLoS One

Critical role of all-trans retinoic acid in stabilizing human natural regulatory T cells under inflammatory conditions

(2014) L. Lu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Glutamine protects mice from acute graft-versus-host disease (aGVHD)

(2013) Eun-Kee Song et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Indoles mitigate the development of experimental autoimmune encephalomyelitis by induction of reciprocal differentiation of regulatory T cells and Th17 cells

(2013) Michael Rouse et al.   BRITISH JOURNAL OF PHARMACOLOGY

Meta-Immunological Profiling of Children With Type 1 Diabetes Identifies New Biomarkers to Monitor Disease Progression

(2013) M. Galgani et al.   DIABETES

Lack of adiponectin leads to increased lymphocyte activation and increased disease severity in a mouse model of multiple sclerosis

(2013) Laura Piccio et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

IDO expressing fibroblasts promote the expansion of antigen specific regulatory T cells

(2013) Terry-Ann Curran et al.   IMMUNOBIOLOGY

TSC1 regulates the balance between effector and regulatory T cells

(2013) Yoon Park et al.   JOURNAL OF CLINICAL INVESTIGATION

Childhood body mass index and multiple sclerosis risk: a long-term cohort study

(2013) Kassandra L Munger et al.   Multiple Sclerosis Journal

Metabolites produced by commensal bacteria promote peripheral regulatory T-cell generation

(2013) Nicholas Arpaia et al.   NATURE

Treg induction by a rationally selected mixture of Clostridia strains from the human microbiota

(2013) Koji Atarashi et al.   NATURE

mTORC1 couples immune signals and metabolic programming to establish Treg-cell function

(2013) Hu Zeng et al.   NATURE

The Microbial Metabolites, Short-Chain Fatty Acids, Regulate Colonic Treg Cell Homeostasis

(2013) P. M. Smith et al.   SCIENCE

The Duration of T Cell Stimulation Is a Critical Determinant of Cell Fate and Plasticity

(2013) N. Miskov-Zivanov et al.   Science Signaling

Transcriptional control of regulatory T cell development and function

(2013) Chong T. Luo et al.   TRENDS IN IMMUNOLOGY

The role of 1α,25-dihydroxyvitamin D3 and cytokines in the promotion of distinct Foxp3+and IL-10+CD4+T cells

(2012) Zoë Urry et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Cutting Edge: Fasting-Induced Hypoleptinemia Expands Functional Regulatory T Cells in Systemic Lupus Erythematosus

(2012) Y. Liu et al.   JOURNAL OF IMMUNOLOGY

PPAR-γ is a major driver of the accumulation and phenotype of adipose tissue Treg cells

(2012) Daniela Cipolletta et al.   NATURE

Hypoxia-inducible factor-1 alpha-dependent induction of FoxP3 drives regulatory T-cell abundance and function during inflammatory hypoxia of the mucosa

(2012) E. T. Clambey et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The development and immunosuppressive functions of CD4+ CD25+ FoxP3+ regulatory T cells are under influence of the adenosine-A2A adenosine receptor pathway

(2012) Akio Ohta et al.   Frontiers in Immunology

Depleting regulatory T cells with arginine-rich, cell-penetrating, peptide-conjugated morpholino oligomer targeting FOXP3 inhibits regulatory T-cell function

(2011) M A Morse et al.   CANCER GENE THERAPY

Control of TH17/Treg Balance by Hypoxia-Inducible Factor 1

(2011) Eric V. Dang et al.   CELL

The Transcription Factor Myc Controls Metabolic Reprogramming upon T Lymphocyte Activation

(2011) Ruoning Wang et al.   IMMUNITY

HIF1α–dependent glycolytic pathway orchestrates a metabolic checkpoint for the differentiation of TH17 and Tregcells

(2011) Lewis Z. Shi et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Regulatory T Cells Require Mammalian Target of Rapamycin Signaling To Maintain Both Homeostasis and Alloantigen-Driven Proliferation in Lymphocyte-Replete Mice

(2011) Y. Wang et al.   JOURNAL OF IMMUNOLOGY

Transcriptomes of the B and T Lineages Compared by Multiplatform Microarray Profiling

(2011) M. W. Painter et al.   JOURNAL OF IMMUNOLOGY

Cutting Edge: Distinct Glycolytic and Lipid Oxidative Metabolic Programs Are Essential for Effector and Regulatory CD4+ T Cell Subsets

(2011) R. D. Michalek et al.   JOURNAL OF IMMUNOLOGY

An endogenous tumour-promoting ligand of the human aryl hydrocarbon receptor

(2011) Christiane A. Opitz et al.   NATURE

Estrogen-related receptor-  is a metabolic regulator of effector T-cell activation and differentiation

(2011) R. D. Michalek et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The mammalian target of rapamycin regulates cholesterol biosynthetic gene expression and exhibits a rapamycin-resistant transcriptional profile

(2011) B. T. Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mammalian target of rapamycin up-regulation of pyruvate kinase isoenzyme type M2 is critical for aerobic glycolysis and tumor growth

(2011) Q. Sun et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Toll-Like Receptor 2 Pathway Establishes Colonization by a Commensal of the Human Microbiota

(2011) J. L. Round et al.   SCIENCE

ATP Inhibits the Generation and Function of Regulatory T Cells Through the Activation of Purinergic P2X Receptors

(2011) U. Schenk et al.   Science Signaling

An Oscillatory Switch in mTOR Kinase Activity Sets Regulatory T Cell Responsiveness

(2010) Claudio Procaccini et al.   IMMUNITY

The Mammalian Target of Rapamycin: Linking T Cell Differentiation, Function, and Metabolism

(2010) Jonathan D. Powell et al.   IMMUNITY

Novel immunomodulatory effects of adiponectin on dendritic cell functions

(2010) Julia Yuen Shan Tsang et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

TCR ligand density and affinity determine peripheral induction of Foxp3 in vivo

(2010) Rachel A. Gottschalk et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Cutting Edge: Mechanisms of IL-2-Dependent Maintenance of Functional Regulatory T Cells

(2010) L. Barron et al.   JOURNAL OF IMMUNOLOGY

Leptin Modulates the Survival of Autoreactive CD4+ T Cells through the Nutrient/Energy-Sensing Mammalian Target of Rapamycin Signaling Pathway

(2010) M. Galgani et al.   JOURNAL OF IMMUNOLOGY

IDO Upregulates Regulatory T Cells via Tryptophan Catabolite and Suppresses Encephalitogenic T Cell Responses in Experimental Autoimmune Encephalomyelitis

(2010) Y. Yan et al.   JOURNAL OF IMMUNOLOGY

Rapamycin inhibits relapsing experimental autoimmune encephalomyelitis by both effector and regulatory T cells modulation

(2010) Marianna Esposito et al.   JOURNAL OF NEUROIMMUNOLOGY

Characterisation of Foxp3 splice variants in human CD4+ and CD8+ T cells—Identification of Foxp3Δ7 in human regulatory T cells

(2010) Gurman Kaur et al.   MOLECULAR IMMUNOLOGY

A polysaccharide from the human commensal Bacteroides fragilis protects against CNS demyelinating disease

(2010) J Ochoa-Repáraz et al.   Mucosal Immunology

Aryl hydrocarbon receptor negatively regulates dendritic cell immunogenicity via a kynurenine-dependent mechanism

(2010) N. T. Nguyen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Inducible Foxp3+ regulatory T-cell development by a commensal bacterium of the intestinal microbiota

(2010) J. L. Round et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Induction of Colonic Regulatory T Cells by Indigenous Clostridium Species

(2010) K. Atarashi et al.   SCIENCE

Glucose transporters in the 21st Century

(2009) Bernard Thorens et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Regulation of Treg functionality by acetylation-mediated Foxp3 protein stabilization

(2009) J. van Loosdregt et al.   BLOOD

The mTOR Kinase Differentially Regulates Effector and Regulatory T Cell Lineage Commitment

(2009) Greg M. Delgoffe et al.   IMMUNITY

Gut commensal Lactobacillus reuteri 100-23 stimulates an immunoregulatory response

(2009) Megan Livingston et al.   IMMUNOLOGY AND CELL BIOLOGY

Generation and Accumulation of Immunosuppressive Adenosine by Human CD4+CD25highFOXP3+Regulatory T Cells

(2009) Magis Mandapathil et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

IDO Activates Regulatory T Cells and Blocks Their Conversion into Th17-Like T Cells

(2009) B. Baban et al.   JOURNAL OF IMMUNOLOGY

Role of Gut Commensal Microflora in the Development of Experimental Autoimmune Encephalomyelitis

(2009) J. Ochoa-Reparaz et al.   JOURNAL OF IMMUNOLOGY

Regulatory T cells exert checks and balances on self tolerance and autoimmunity

(2009) Kajsa Wing et al.   NATURE IMMUNOLOGY

Lean, but not obese, fat is enriched for a unique population of regulatory T cells that affect metabolic parameters

(2009) Markus Feuerer et al.   NATURE MEDICINE

Infectious tolerance via the consumption of essential amino acids and mTOR signaling

(2009) S. P. Cobbold et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

SREBP Activity Is Regulated by mTORC1 and Contributes to Akt-Dependent Cell Growth

(2008) Thomas Porstmann et al.   Cell Metabolism

Rapamycin Monotherapy in Patients With Type 1 Diabetes Modifies CD4+CD25+FOXP3+ Regulatory T-Cells

(2008) P. Monti et al.   DIABETES

The kinetics of CD4+Foxp3+ T cell accumulation during a human cutaneous antigen-specific memory response in vivo

(2008) Milica Vukmanovic-Stejic et al.   JOURNAL OF CLINICAL INVESTIGATION

Small intestinal CD103+dendritic cells display unique functional properties that are conserved between mice and humans

(2008) Elin Jaensson et al.   JOURNAL OF EXPERIMENTAL MEDICINE

De novo induction of antigen-specific CD4+CD25+Foxp3+ regulatory T cells in vivo following systemic antigen administration accompanied by blockade of mTOR

(2008) Johnthomas Kang et al.   JOURNAL OF LEUKOCYTE BIOLOGY

A microbial symbiosis factor prevents intestinal inflammatory disease

(2008) Sarkis K. Mazmanian et al.   NATURE

Rapamycin differentially inhibits S6Ks and 4E-BP1 to mediate cell-type-specific repression of mRNA translation

(2008) A. Y. Choo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

T cell receptor signaling controls Foxp3 expression via PI3K, Akt, and mTOR

(2008) S. Sauer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA