Targeting hypoxic tumor microenvironment in pancreatic cancer

Cancer statistics, 2020

(2020) Rebecca L. Siegel et al.   CA-A CANCER JOURNAL FOR CLINICIANS

PTBP3 promotes malignancy and hypoxia‐induced chemoresistance in pancreatic cancer cells by ATG12 up‐regulation

(2020) Jun Ma et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Nonrecurring Circuit Nanozymatic Enhancement of Hypoxic Pancreatic Cancer Phototherapy Using Speckled Ru–Te Hollow Nanorods

(2020) Seounghun Kang et al.   ACS Nano

Curcumin inhibits pancreatic cancer cell invasion and EMT by interfering with tumor‑stromal crosstalk under hypoxic conditions via the IL‑6/ERK/NF‑κB axis

(2020) Wei Li et al.   ONCOLOGY REPORTS

MiR-301a transcriptionally activated by HIF-2α promotes hypoxia-induced epithelial-mesenchymal transition by targeting TP63 in pancreatic cancer

(2020) Kun-Dong Zhang et al.   WORLD JOURNAL OF GASTROENTEROLOGY

Loss of heterozygosity for KrasG12D promotes REDD1-dependent, non-canonical glutamine metabolism in pancreatic ductal adenocarcinoma

(2020) Yu Ma et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

NDRG1 suppresses basal and hypoxia-induced autophagy at both the initiation and degradation stages and sensitizes pancreatic cancer cells to lysosomal membrane permeabilization

(2020) Sumit Sahni et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Pancreatic stellate cells exhibit adaptation to oxidative stress evoked by hypoxia

(2020) Matias Estaras et al.   BIOLOGY OF THE CELL

Loss of HIF1A From Pancreatic Cancer Cells Increases Expression of PPP1R1B and Degradation of p53 to Promote Invasion and Metastasis

(2020) Ashutosh Tiwari et al.   GASTROENTEROLOGY

YEATS2 is a target of HIF1α and promotes pancreatic cancer cell proliferation and migration

(2020) Zhirui Zeng et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Pancreatic cancer

(2020) Jonathan D Mizrahi et al.   LANCET

A Novel E2F1-EP300-VMP1 Pathway Mediates Gemcitabine-Induced Autophagy in Pancreatic Cancer Cells Carrying Oncogenic KRAS

(2020) Alejandro Ropolo et al.   Frontiers in Endocrinology

RER1 enhances carcinogenesis and stemness of pancreatic cancer under hypoxic environment

(2019) Shi Chen et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Enhancing responsiveness of pancreatic cancer cells to gemcitabine treatment under hypoxia by heme oxygenase-1 inhibition

(2019) Maher Y. Abdalla et al.   Translational Research

The Activity of Kv 11.1 Potassium Channel Modulates F-Actin Organization During Cell Migration of Pancreatic Ductal Adenocarcinoma Cells

(2019) Sagar Manoli et al.   Cancers

Long noncoding RNA FEZF1-AS1 predicts poor prognosis and modulates pancreatic cancer cell proliferation and invasion through miR-142/HIF-1α and miR-133a/EGFR upon hypoxia/normoxia

(2019) Zheng-Lin Ou et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Inhibition of HSP90 overcomes resistance to chemotherapy and radiotherapy in pancreatic cancer

(2019) Ganji Purnachandra Nagaraju et al.   INTERNATIONAL JOURNAL OF CANCER

UHRF1 promotes aerobic glycolysis and proliferation via suppression of SIRT4 in pancreatic cancer

(2019) Qiangsheng Hu et al.   CANCER LETTERS

Regulation of pH by Carbonic Anhydrase 9 Mediates Survival of Pancreatic Cancer Cells With Activated KRAS in Response to Hypoxia

(2019) Paul C. McDonald et al.   GASTROENTEROLOGY

Propofol inhibits pancreatic cancer progress under hypoxia via ADAM 8

(2019) Yutong Gao et al.   Journal of Hepato-Biliary-Pancreatic Sciences

Knockdown of hypoxia-inducible factor-1 alpha by tumor targeted delivery of CRISPR/Cas9 system suppressed the metastasis of pancreatic cancer

(2019) Man Li et al.   JOURNAL OF CONTROLLED RELEASE

P4HA1/HIF1α feedback loop drives the glycolytic and malignant phenotypes of pancreatic cancer

(2019) X.P. Cao et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Hypoxia-induced shedding of MICA and HIF1A-mediated immune escape of pancreatic cancer cells from NK cells: role of circ_0000977/miR-153 axis

(2019) Zheng-Lin Ou et al.   RNA Biology

Downregulation of miR-21 inhibits the malignant phenotype of pancreatic cancer cells by targeting VHL

(2019) Jinjin Sun et al.   OncoTargets and Therapy

Absence of HIF1A Leads to Glycogen Accumulation and an Inflammatory Response That Enables Pancreatic Tumor Growth

(2019) Marco Maruggi et al.   CANCER RESEARCH

Extravascular gelation shrinkage-derived internal stress enables tumor starvation therapy with suppressed metastasis and recurrence

(2019) Kun Zhang et al.   Nature Communications

LW6 enhances chemosensitivity to gemcitabine and inhibits autophagic flux in pancreatic cancer

(2019) Xianbin Zhang et al.   Journal of Advanced Research

RAD51 is a potential marker for prognosis and regulates cell proliferation in pancreatic cancer

(2019) Xiaomeng Zhang et al.   Cancer Cell International

A Variant of SLC1A5 Is a Mitochondrial Glutamine Transporter for Metabolic Reprogramming in Cancer Cells

(2019) Hee Chan Yoo et al.   Cell Metabolism

Mechanism of miR-210 involved in epithelial–mesenchymal transition of pancreatic cancer cells under hypoxia

(2019) Jun Ni et al.   JOURNAL OF RECEPTORS AND SIGNAL TRANSDUCTION

Transcription factor NFAT5 contributes to the glycolytic phenotype rewiring and pancreatic cancer progression via transcription of PGK1

(2019) Yongsheng Jiang et al.   Cell Death & Disease

Hypoxic tumor-derived exosomal miR-301a mediates M2 macrophage polarization via PTEN/PI3Kγ to promote pancreatic cancer metastasis

(2018) Xiaofeng Wang et al.   CANCER RESEARCH

Pharmacologic ascorbate (P-AscH−) suppresses hypoxia-inducible Factor-1α (HIF-1α) in pancreatic adenocarcinoma

(2018) Justin G. Wilkes et al.   CLINICAL & EXPERIMENTAL METASTASIS

Parallel Accumulation of Tumor Hyaluronan, Collagen and Other Drivers of Tumor Progression

(2018) Xiaoming Li et al.   CLINICAL CANCER RESEARCH

miR-301a plays a pivotal role in hypoxia-induced gemcitabine resistance in pancreatic cancer

(2018) Guangtao Luo et al.   EXPERIMENTAL CELL RESEARCH

Hypoxia-induced LncRNA-BX111 promotes metastasis and progression of pancreatic cancer through regulating ZEB1 transcription

(2018) Shi-jiang Deng et al.   ONCOGENE

MiRNA-646-mediated reciprocal repression between HIF-1α and MIIP contributes to tumorigenesis of pancreatic cancer

(2018) Yi Niu et al.   ONCOGENE

A rationally designed NRP1-independent superagonist SEMA3A mutant is an effective anticancer agent

(2018) Noemi Gioelli et al.   Science Translational Medicine

Weak HIF-1alpha expression indicates poor prognosis in resectable pancreatic ductal adenocarcinoma

(2018) Joni Leppänen et al.   World Journal of Surgical Oncology

TCF7L2 positively regulates aerobic glycolysis via the EGLN2/HIF-1α axis and indicates prognosis in pancreatic cancer

(2018) Jinfeng Xiang et al.   Cell Death & Disease

MicroRNA-224 Promotes Pancreatic Cancer Cell Proliferation and Migration by Targeting the TXNIP-Mediated HIF1α Pathway

(2018) Guanghui Zhu et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

A catalase-loaded hierarchical zeolite as an implantable nanocapsule for ultrasound-guided oxygen self-sufficient photodynamic therapy against pancreatic cancer

(2018) Dehong Hu et al.   Nanoscale

Blocking HIF signaling via novel inhibitors of CA9 and APE1/Ref-1 dramatically affects pancreatic cancer cell survival

(2018) Derek P. Logsdon et al.   Scientific Reports

High expression of WNT7A predicts poor prognosis and promote tumor metastasis in pancreatic ductal adenocarcinoma

(2018) Dong-jin Wu et al.   Scientific Reports

Hypoxia-induced autophagy of stellate cells inhibits expression and secretion of lumican into microenvironment of pancreatic ductal adenocarcinoma

(2018) Xinqun Li et al.   CELL DEATH AND DIFFERENTIATION

Hypoxia potentiates gemcitabine-induced stemness in pancreatic cancer cells through AKT/Notch1 signaling

(2018) Zhengle Zhang et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Fucoidan-Manganese Dioxide Nanoparticles Potentiate Radiation Therapy by Co-Targeting Tumor Hypoxia and Angiogenesis

(2018) Sung-Won Shin et al.   Marine Drugs

Cyclooxygenase-2 inhibition potentiates the efficacy of vascular endothelial growth factor blockade and promotes an immune stimulatory microenvironment in preclinical models of pancreatic cancer

(2018) Yuqing Zhang et al.   MOLECULAR CANCER RESEARCH

Hypoxia-driven paracrine osteopontin/integrin αvβ3 signaling promotes pancreatic cancer cell epithelial-mesenchymal transition and cancer stem cell-like properties by modulating forkhead box protein M1

(2018) Junyu Cao et al.   Molecular Oncology

Prolyl hydroxylase domain 3 influences the radiotherapy efficacy of pancreatic cancer cells by targeting hypoxia-inducible factor-1α

(2018) Li-rui Tang et al.   OncoTargets and Therapy

Design, synthesis, and evaluation of benzofuran derivatives as novel anti-pancreatic carcinoma agents via interfering the hypoxia environment by targeting HIF-1α pathway

(2017) Xiao-li Xu et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Oxygen generating nanoparticles for improved photodynamic therapy of hypoxic tumours

(2017) Yingjie Sheng et al.   JOURNAL OF CONTROLLED RELEASE

Long noncoding RNA NORAD, a novel competing endogenous RNA, enhances the hypoxia-induced epithelial-mesenchymal transition to promote metastasis in pancreatic cancer

(2017) Hongzhe Li et al.   Molecular Cancer

Hypoxia-inducible factor-2α promotes tumor progression and has crosstalk with Wnt/β-catenin signaling in pancreatic cancer

(2017) Qi Zhang et al.   Molecular Cancer

HIF-3α Promotes Metastatic Phenotypes in Pancreatic Cancer by Transcriptional Regulation of the RhoC–ROCK1 Signaling Pathway

(2017) Xianfei Zhou et al.   MOLECULAR CANCER RESEARCH

BLIMP1 Induces Transient Metastatic Heterogeneity in Pancreatic Cancer

(2017) Shin-Heng Chiou et al.   Cancer Discovery

HIF1/2α mediates hypoxia-induced LDHA expression in human pancreatic cancer cells

(2017) Xin-gang Cui et al.   Oncotarget

Acetate Recapturing by Nuclear Acetyl-CoA Synthetase 2 Prevents Loss of Histone Acetylation during Oxygen and Serum Limitation

(2017) Vinay Bulusu et al.   Cell Reports

MiR-142 modulates human pancreatic cancer proliferation and invasion by targeting hypoxia-inducible factor 1 (HIF-1α) in the tumor microenvironments

(2017) Yebin Lu et al.   Biology Open

Inhibition of hypoxic response decreases stemness and reduces tumorigenic signaling due to impaired assembly of HIF1 transcription complex in pancreatic cancer

(2017) Olivia McGinn et al.   Scientific Reports

Micro/Nanoparticle-Augmented Sonodynamic Therapy (SDT): Breaking the Depth Shallow of Photoactivation

(2016) Xiaoqin Qian et al.   ADVANCED MATERIALS

The differential effects of metronomic gemcitabine and antiangiogenic treatment in patient-derived xenografts of pancreatic cancer: treatment effects on metabolism, vascular function, cell proliferation, and tumor growth

(2016) Donald T. Yapp et al.   ANGIOGENESIS

Hypoxia Responsive, Tumor Penetrating Lipid Nanoparticles for Delivery of Chemotherapeutics to Pancreatic Cancer Cell Spheroids

(2016) Prajakta Kulkarni et al.   BIOCONJUGATE CHEMISTRY

Cancer statistics in China, 2015

(2016) Wanqing Chen et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Hypoxia regulates ABCG2activity through the activivation of ERK1/2/HIF-1α and contributes to chemoresistance in pancreatic cancer cells

(2016) Xiaodan He et al.   CANCER BIOLOGY & THERAPY

Long Noncoding RNAs in Cancer Pathways

(2016) Adam M. Schmitt et al.   CANCER CELL

Arsenic trioxide plus PX-478 achieves effective treatment in pancreatic ductal adenocarcinoma

(2016) Mingxiao Lang et al.   CANCER LETTERS

miR-1236 regulates hypoxia-induced epithelial–mesenchymal transition and cell migration/invasion through repressing SENP1 and HDAC3

(2016) Sung-Yuan Chen et al.   CANCER LETTERS

Hypoxia induces TWIST-activated epithelial–mesenchymal transition and proliferation of pancreatic cancer cells in vitro and in nude mice

(2016) Shi Chen et al.   CANCER LETTERS

Hypoxic stellate cells of pancreatic cancer stroma regulate extracellular matrix fiber organization and cancer cell motility

(2016) Masafumi Sada et al.   CANCER LETTERS

Nucleolin Targeting Impairs the Progression of Pancreatic Cancer and Promotes the Normalization of Tumor Vasculature

(2016) Maud-Emmanuelle Gilles et al.   CANCER RESEARCH

VEGF Promotes Glycolysis in Pancreatic Cancer via HIF1? Up-Regulation

(2016) S. Shi et al.   CURRENT MOLECULAR MEDICINE

α-Solanine inhibits vascular endothelial growth factor expression by down-regulating the ERK1/2-HIF-1α and STAT3 signaling pathways

(2016) Zhengde Wen et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Hypoxia and Transforming Growth Factor β Cooperate to Induce Fibulin-5 Expression in Pancreatic Cancer

(2016) Mary Topalovski et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

HIF-2α promotes epithelial-mesenchymal transition through regulating Twist2 binding to the promoter of E-cadherin in pancreatic cancer

(2016) Jian Yang et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

PKM2 promotes tumor angiogenesis by regulating HIF-1α through NF-κB activation

(2016) Ninel Azoitei et al.   Molecular Cancer

MiR-548an, Transcriptionally Downregulated by HIF1 /HDAC1, Suppresses Tumorigenesis of Pancreatic Cancer by Targeting Vimentin Expression

(2016) S. Zhu et al.   MOLECULAR CANCER THERAPEUTICS

Regulation of HIF1  under Hypoxia by APE1/Ref-1 Impacts CA9 Expression: Dual Targeting in Patient-Derived 3D Pancreatic Cancer Models

(2016) D. P. Logsdon et al.   MOLECULAR CANCER THERAPEUTICS

Hypoxia-induced oxidative stress promotes MUC4 degradation via autophagy to enhance pancreatic cancer cells survival

(2016) S Joshi et al.   ONCOGENE

Curcumin inhibits hypoxia-induced epithelial-mesenchymal transition in pancreatic cancer cells via suppression of the hedgehog signaling pathway

(2016) LEI CAO et al.   ONCOLOGY REPORTS

Selective GPR55 antagonism reduces chemoresistance in cancer cells

(2016) Nagendra S. Singh et al.   PHARMACOLOGICAL RESEARCH

Combination therapy with BPTES nanoparticles and metformin targets the metabolic heterogeneity of pancreatic cancer

(2016) Amira Elgogary et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Molecular targeted therapy for pancreatic adenocarcinoma: A review of completed and ongoing late phase clinical trials

(2016) Catalina Mosquera et al.   Cancer Genetics

Hypoxia-induced lncRNA-NUTF2P3-001 contributes to tumorigenesis of pancreatic cancer by derepressing the miR-3923/KRAS pathway

(2016) Xiang Li et al.   Oncotarget

Targeting hypoxic microenvironment of pancreatic xenografts with the hypoxia-activated prodrug TH-302

(2016) Ines Lohse et al.   Oncotarget

miR-138-5p suppresses autophagy in pancreatic cancer by targeting SIRT1

(2016) She Tian et al.   Oncotarget

Microenvironment mediated alterations to metabolic pathways confer increased chemo-resistance in CD133+ tumor initiating cells

(2016) Alice Nomura et al.   Oncotarget

Unique metabolic features of pancreatic cancer stroma: relevance to the tumor compartment, prognosis, and invasive potential

(2016) Erik S. Knudsen et al.   Oncotarget

Co-delivery of HIF1α siRNA and gemcitabine via biocompatible lipid-polymer hybrid nanoparticles for effective treatment of pancreatic cancer

(2015) Xiao Zhao et al.   BIOMATERIALS

Acetyl-CoA Synthetase 2 Promotes Acetate Utilization and Maintains Cancer Cell Growth under Metabolic Stress

(2015) Zachary T. Schug et al.   CANCER CELL

Antiangiogenic effects of a novel synthetic curcumin analogue in pancreatic cancer

(2015) Ganji Purnachandra Nagaraju et al.   CANCER LETTERS

Fibulin-5 Blocks Microenvironmental ROS in Pancreatic Cancer

(2015) M. Wang et al.   CANCER RESEARCH

Targeting the LOX/hypoxia axis reverses many of the features that make pancreatic cancer deadly: inhibition of LOX abrogates metastasis and enhances drug efficacy

(2015) Bryan W Miller et al.   EMBO Molecular Medicine

DKK3 blocked translocation of β-catenin/EMT induced by hypoxia and improved gemcitabine therapeutic effect in pancreatic cancer Bxpc-3 cell

(2015) Qingqu Guo et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

LB-1 Exerts Antitumor Activity in Pancreatic Cancer by Inhibiting HIF-1α and Stat3 Signaling

(2015) Fei Niu et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Oxygen carrying microbubbles for enhanced sonodynamic therapy of hypoxic tumours

(2015) Conor McEwan et al.   JOURNAL OF CONTROLLED RELEASE

Suppressed expression of LDHB promotes pancreatic cancer progression via inducing glycolytic phenotype

(2015) Jiujie Cui et al.   MEDICAL ONCOLOGY

The mRNA-binding protein HuR promotes hypoxia-induced chemoresistance through posttranscriptional regulation of the proto-oncogene PIM1 in pancreatic cancer cells

(2015) F F Blanco et al.   ONCOGENE

Resveratrol inhibits hypoxia-driven ROS-induced invasive and migratory ability of pancreatic cancer cells via suppression of the Hedgehog signaling pathway

(2015) WEI LI et al.   ONCOLOGY REPORTS

Hypoxia promotes C-X-C chemokine receptor type 4 expression through microRNA-150 in pancreatic cancer cells

(2015) JIN-SHAN SUN et al.   Oncology Letters

Hif1a Deletion Reveals Pro-Neoplastic Function of B Cells in Pancreatic Neoplasia

(2015) K. E. Lee et al.   Cancer Discovery

Inhibition of HIF-1α by PX-478 enhances the anti-tumor effect of gemcitabine by inducing immunogenic cell death in pancreatic ductal adenocarcinoma

(2015) Tiansuo Zhao et al.   Oncotarget

Transcriptional Regulation of Urokinase-type Plasminogen Activator Receptor by Hypoxia-Inducible Factor 1 Is Crucial for Invasion of Pancreatic and Liver Cancer

(2015) Peter Büchler et al.   NEOPLASIA

N-acetyl-l-cysteine sensitizes pancreatic cancers to gemcitabine by targeting the NFκB pathway

(2014) Suparna Qanungo et al.   BIOMEDICINE & PHARMACOTHERAPY

Antiangiogenesis Strategies Revisited: From Starving Tumors to Alleviating Hypoxia

(2014) Rakesh K. Jain   CANCER CELL

Depletion of Carcinoma-Associated Fibroblasts and Fibrosis Induces Immunosuppression and Accelerates Pancreas Cancer with Reduced Survival

(2014) Berna C. Özdemir et al.   CANCER CELL

Stromal Elements Act to Restrain, Rather Than Support, Pancreatic Ductal Adenocarcinoma

(2014) Andrew D. Rhim et al.   CANCER CELL

LSD1 sustains pancreatic cancer growth via maintaining HIF1α-dependent glycolytic process

(2014) Yi Qin et al.   CANCER LETTERS

α-Mangostin inhibits hypoxia-driven ROS-induced PSC activation and pancreatic cancer cell invasion

(2014) Jianjun Lei et al.   CANCER LETTERS

Inhibition of protein phosphatase 2A sensitizes pancreatic cancer to chemotherapy by increasing drug perfusion via HIF-1α-VEGF mediated angiogenesis

(2014) Xueli Bai et al.   CANCER LETTERS

LASP1 Is a HIF1  Target Gene Critical for Metastasis of Pancreatic Cancer

(2014) T. Zhao et al.   CANCER RESEARCH

Reoxygenation from chronic hypoxia promotes metastatic processes in pancreatic cancer through the Hedgehog signaling

(2014) Yoshihiro Morifuji et al.   CANCER SCIENCE

Hypoxic Regulation of Glutamine Metabolism through HIF1 and SIAH2 Supports Lipid Synthesis that Is Necessary for Tumor Growth

(2014) Ramon C. Sun et al.   Cell Metabolism

Extracellular Lumican Inhibits Pancreatic Cancer Cell Growth and Is Associated with Prolonged Survival after Surgery

(2014) X. Li et al.   CLINICAL CANCER RESEARCH

CD133 facilitates epithelial-mesenchymal transition through interaction with the ERK pathway in pancreatic cancer metastasis

(2014) Qiang Ding et al.   Molecular Cancer

Effects of the HIF-1α and NF-κB loop on epithelial-mesenchymal transition and chemoresistance induced by hypoxia in pancreatic cancer cells

(2014) ZHUO-XIN CHENG et al.   ONCOLOGY REPORTS

Upregulation of autophagy by hypoxia-inducible factor-1α promotes EMT and metastatic ability of CD133+ pancreatic cancer stem-like cells during intermittent hypoxia

(2014) HAITAO ZHU et al.   ONCOLOGY REPORTS

Evaluation of the “Steal” Phenomenon on the Efficacy of Hypoxia Activated Prodrug TH-302 in Pancreatic Cancer

(2014) Kate M. Bailey et al.   PLoS One

Gemcitabine Induces Poly (ADP-Ribose) Polymerase-1 (PARP-1) Degradation through Autophagy in Pancreatic Cancer

(2014) Yufeng Wang et al.   PLoS One

The clinical significance and regulation mechanism of hypoxia-inducible factor-1 and miR-191 expression in pancreatic cancer

(2014) Zhenguo Song et al.   TUMOR BIOLOGY

Severe hypoxia induces complete antifolate resistance in carcinoma cells due to cell cycle arrest

(2014) S Raz et al.   Cell Death & Disease

HIF-1-Mediated Suppression of Acyl-CoA Dehydrogenases and Fatty Acid Oxidation Is Critical for Cancer Progression

(2014) De Huang et al.   Cell Reports

Activated PAR-2 Regulates Pancreatic Cancer Progression through ILK/HIF-α–Induced TGF-α Expression and MEK/VEGF-A–Mediated Angiogenesis

(2013) Li-Hsun Chang et al.   AMERICAN JOURNAL OF PATHOLOGY

Increasing role of UHRF1 in the reading and inheritance of the epigenetic code as well as in tumorogenesis

(2013) Christian Bronner et al.   BIOCHEMICAL PHARMACOLOGY

Synergistic interaction of novel lactate dehydrogenase inhibitors with gemcitabine against pancreatic cancer cells in hypoxia

(2013) M Maftouh et al.   BRITISH JOURNAL OF CANCER

Role of the Hypoxia-inducible factor-1 alpha induced autophagy in the conversion of non-stem pancreatic cancer cells into CD133+ pancreatic cancer stem-like cells

(2013) Haitao Zhu et al.   Cancer Cell International

Protein-bound polysaccharide decreases invasiveness and proliferation in pancreatic cancer by inhibition of hedgehog signaling and HIF-1α pathways under hypoxia

(2013) Hideya Onishi et al.   CANCER LETTERS

Protein kinase Cα inhibitor protects against downregulation of claudin-1 during epithelial–mesenchymal transition of pancreatic cancer

(2013) Daisuke Kyuno et al.   CARCINOGENESIS

Pancreatic cancers rely on a novel glutamine metabolism pathway to maintain redox balance

(2013) Costas A. Lyssiotis et al.   CELL CYCLE

HIF1 Contributes to Hypoxia-Induced Pancreatic Cancer Cells Invasion via Promoting QSOX1 Expression

(2013) Chen-Ye Shi et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Myo-inositol trispyrophosphate-mediated hypoxia reversion controls pancreatic cancer in rodents and enhances gemcitabine efficacy

(2013) Zahary Raykov et al.   INTERNATIONAL JOURNAL OF CANCER

Triptolide reverses hypoxia-induced epithelial-mesenchymal transition and stem-like features in pancreatic cancer by NF-κB downregulation

(2013) Li Liu et al.   INTERNATIONAL JOURNAL OF CANCER

An Undesired Effect of Chemotherapy

(2013) Sumit Arora et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The CX3CL1/CX3CR1 reprograms glucose metabolism through HIF-1 pathway in pancreatic adenocarcinoma

(2013) He Ren et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Hypoxia promotes tumor cell survival in acidic conditions by preserving ATP levels

(2013) Scott K. Parks et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Hypoxia induces the overexpression of microRNA-21 in pancreatic cancer cells

(2013) Thomas A. Mace et al.   JOURNAL OF SURGICAL RESEARCH

Lumican affects tumor cell functions, tumor–ECM interactions, angiogenesis and inflammatory response

(2013) Dragana Nikitovic et al.   MATRIX BIOLOGY

Hedgehog signaling regulates hypoxia induced epithelial to mesenchymal transition and invasion in pancreatic cancer cells via a ligand-independent manner

(2013) Jianjun Lei et al.   Molecular Cancer

Stem Cell Marker Nestin Is Critical for TGF-β1-Mediated Tumor Progression in Pancreatic Cancer

(2013) Huei-Ting Su et al.   MOLECULAR CANCER RESEARCH

PG545, an Angiogenesis and Heparanase Inhibitor, Reduces Primary Tumor Growth and Metastasis in Experimental Pancreatic Cancer

(2013) K. T. Ostapoff et al.   MOLECULAR CANCER THERAPEUTICS

BIBF 1120 (Nintedanib), a Triple Angiokinase Inhibitor, Induces Hypoxia but not EMT and Blocks Progression of Preclinical Models of Lung and Pancreatic Cancer

(2013) B. Kutluk Cenik et al.   MOLECULAR CANCER THERAPEUTICS

Glutamine supports pancreatic cancer growth through a KRAS-regulated metabolic pathway

(2013) Jaekyoung Son et al.   NATURE

Arginase II Expressed in Cancer-Associated Fibroblasts Indicates Tissue Hypoxia and Predicts Poor Outcome in Patients with Pancreatic Cancer

(2013) Yoshinori Ino et al.   PLoS One

Hypoxic and Ras-transformed cells support growth by scavenging unsaturated fatty acids from lysophospholipids

(2013) J. J. Kamphorst et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Strengthened glycolysis under hypoxia supports tumor symbiosis and hexosamine biosynthesis in pancreatic adenocarcinoma

(2013) F. Guillaumond et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Angiotensin inhibition enhances drug delivery and potentiates chemotherapy by decompressing tumour blood vessels

(2013) Vikash P. Chauhan et al.   Nature Communications

Enzymatic Targeting of the Stroma Ablates Physical Barriers to Treatment of Pancreatic Ductal Adenocarcinoma

(2012) Paolo P. Provenzano et al.   CANCER CELL

CHC promotes tumor growth and angiogenesis through regulation of HIF-1α and VEGF signaling

(2012) Kuo-Hua Tung et al.   CANCER LETTERS

Hedgehog inhibitor decreases chemosensitivity to 5-fluorouracil and gemcitabine under hypoxic conditions in pancreatic cancer

(2012) Hideya Onishi et al.   CANCER SCIENCE

Oncogenic Kras Maintains Pancreatic Tumors through Regulation of Anabolic Glucose Metabolism

(2012) Haoqiang Ying et al.   CELL

Breathless cancer cells get fat on glutamine

(2012) Dimitrios Anastasiou et al.   CELL RESEARCH

Attenuation of reactive oxygen species by antioxidants suppresses hypoxia-induced epithelial-mesenchymal transition and metastasis of pancreatic cancer cells

(2012) Yoshihide Shimojo et al.   CLINICAL & EXPERIMENTAL METASTASIS

Nupr1-Aurora Kinase A Pathway Provides Protection against Metabolic Stress-Mediated Autophagic-Associated Cell Death

(2012) T. Hamidi et al.   CLINICAL CANCER RESEARCH

The novel hypoxic cytotoxin, TX-2098 has antitumor effect in pancreatic cancer; possible mechanism through inhibiting VEGF and hypoxia inducible factor-1α targeted gene expression

(2012) Kotaro Miyake et al.   EXPERIMENTAL CELL RESEARCH

Autophagy mediates survival of pancreatic tumour-initiating cells in a hypoxic microenvironment

(2012) Vanessa Rausch et al.   JOURNAL OF PATHOLOGY

Energy metabolism and proliferation in pancreatic carcinogenesis

(2012) Ivonne Regel et al.   LANGENBECKS ARCHIVES OF SURGERY

The role of stroma in pancreatic cancer: diagnostic and therapeutic implications

(2012) Mert Erkan et al.   Nature Reviews Gastroenterology & Hepatology

Epigenetics and the environment: emerging patterns and implications

(2012) Robert Feil et al.   NATURE REVIEWS GENETICS

MUC1 enhances hypoxia-driven angiogenesis through the regulation of multiple proangiogenic factors

(2012) S Kitamoto et al.   ONCOGENE

MUC1 regulates PDGFA expression during pancreatic cancer progression

(2012) M Sahraei et al.   ONCOGENE

Hypoxia Induces EMT in Low and Highly Aggressive Pancreatic Tumor Cells but Only Cells with Cancer Stem Cell Characteristics Acquire Pronounced Migratory Potential

(2012) Alexei V. Salnikov et al.   PLoS One

Hypoxia-Inducible Factor-1α Regulates Chemotactic Migration of Pancreatic Ductal Adenocarcinoma Cells through Directly Transactivating the CX3CR1 Gene

(2012) Tiansuo Zhao et al.   PLoS One

Time-Dependent Stabilization of Hypoxia Inducible Factor-1α by Different Intracellular Sources of Reactive Oxygen Species

(2012) Maura Calvani et al.   PLoS One

MUC1 mucin stabilizes and activates hypoxia-inducible factor 1 alpha to regulate metabolism in pancreatic cancer

(2012) N. V. Chaika et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mitochondrial localization and structure-based phosphate activation mechanism of Glutaminase C with implications for cancer metabolism

(2012) A. Cassago et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Comparative testing of various pancreatic cancer stem cells results in a novel class of pancreatic-cancer-initiating cells

(2012) Kshama R. Jaiswal et al.   Stem Cell Research

Prolyl hydroxylase-2 (PHD2) exerts tumor-suppressive activity in pancreatic cancer

(2011) Yun Su et al.   CANCER

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

Downregulation of tight junction-associated MARVEL protein marvelD3 during epithelial–mesenchymal transition in human pancreatic cancer cells

(2011) Takashi Kojima et al.   EXPERIMENTAL CELL RESEARCH

Reductive glutamine metabolism by IDH1 mediates lipogenesis under hypoxia

(2011) Christian M. Metallo et al.   NATURE

Antiangiogenic therapy, hypoxia and metastasis: risky liaisons, or not?

(2011) Katrien De Bock et al.   Nature Reviews Clinical Oncology

Hypoxia Induces Tumor Aggressiveness and the Expansion of CD133-Positive Cells in a Hypoxia-Inducible Factor-1α-Dependent Manner in Pancreatic Cancer Cells

(2011) Okito Hashimoto et al.   PATHOBIOLOGY

 -catenin/TCF4 complex induces the epithelial-to-mesenchymal transition (EMT)-activator ZEB1 to regulate tumor invasiveness

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