Combine and conquer: manganese synergizing anti-TGF-β/PD-L1 bispecific antibody YM101 to overcome immunotherapy resistance in non-inflamed cancers

The construction, expression, and enhanced anti-tumor activity of YM101: a bispecific antibody simultaneously targeting TGF-β and PD-L1

(2021) Ming Yi et al.   Journal of Hematology & Oncology

Predictive biomarkers of anti-PD-1/PD-L1 therapy in NSCLC

(2021) Mengke Niu et al.   Experimental Hematology & Oncology

Manganese salts function as potent adjuvants

(2021) Rui Zhang et al.   Cellular & Molecular Immunology

Development of Immunotherapy Combination Strategies in Cancer

(2021) Timothy A. Yap et al.   Cancer Discovery

The biology of combination immunotherapy in recurrent metastatic head and neck cancer

(2021) Xun Yuan et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Manganese-Based Nanoactivator Optimizes Cancer Immunotherapy via Enhancing Innate Immunity

(2020) Lin Hou et al.   ACS Nano

The role of cancer-derived microRNAs in cancer immune escape

(2020) Ming Yi et al.   Journal of Hematology & Oncology

Emerging therapeutic agents for advanced non-small cell lung cancer

(2020) Ruqin Chen et al.   Journal of Hematology & Oncology

Small molecules targeting the innate immune cGAS‒STING‒TBK1 signaling pathway

(2020) Chunyong Ding et al.   Acta Pharmaceutica Sinica B

cGAS-STING, an important pathway in cancer immunotherapy

(2020) Minlin Jiang et al.   Journal of Hematology & Oncology

Targeting immune checkpoints in hematological malignancies

(2020) Basit Salik et al.   Journal of Hematology & Oncology

VISTA: an immune regulatory protein checking tumor and immune cells in cancer immunotherapy

(2020) Xing Huang et al.   Journal of Hematology & Oncology

Role of CD47 in Hematological Malignancies

(2020) Entsar Eladl et al.   Journal of Hematology & Oncology

Microenvironment characterization and multi-omics signatures related to prognosis and immunotherapy response of hepatocellular carcinoma

(2020) Furong Liu et al.   Experimental Hematology & Oncology

The frequency and inter-relationship of PD-L1 expression and tumour mutational burden across multiple types of advanced solid tumours in China

(2020) Yanhui Chen et al.   Experimental Hematology & Oncology

Manganese is critical for antitumor immune responses via cGAS-STING and improves the efficacy of clinical immunotherapy

(2020) Mengze Lv et al.   CELL RESEARCH

Atezolizumab for First-Line Treatment of PD-L1–Selected Patients with NSCLC

(2020) Roy S. Herbst et al.   NEW ENGLAND JOURNAL OF MEDICINE

Safety and clinical activity with an anti-PD-1 antibody JS001 in advanced melanoma or urologic cancer patients

(2019) Bixia Tang et al.   Journal of Hematology & Oncology

Avelumab plus Axitinib versus Sunitinib for Advanced Renal-Cell Carcinoma

(2019) Robert J. Motzer et al.   NEW ENGLAND JOURNAL OF MEDICINE

Recent advances on anti-angiogenesis receptor tyrosine kinase inhibitors in cancer therapy

(2019) Shuang Qin et al.   Journal of Hematology & Oncology

Transforming Growth Factor-β Signaling in Immunity and Cancer

(2019) Eduard Batlle et al.   IMMUNITY

Activating cGAS-STING pathway for the optimal effect of cancer immunotherapy

(2019) Anping Li et al.   Journal of Hematology & Oncology

Synergistic effect of immune checkpoint blockade and anti-angiogenesis in cancer treatment

(2019) Ming Yi et al.   Molecular Cancer

Complementing the Cancer-Immunity Cycle

(2019) Ruben Pio et al.   Frontiers in Immunology

A novel asymmetrical anti-HER2/CD3 bispecific antibody exhibits potent cytotoxicity for HER2-positive tumor cells

(2019) Shengnan Yu et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Prospects for combining immune checkpoint blockade with PARP inhibition

(2019) Anping Li et al.   Journal of Hematology & Oncology

Emerging agents and regimens for hepatocellular carcinoma

(2019) Xiao-Dong Zhu et al.   Journal of Hematology & Oncology

Novel immune checkpoint targets: moving beyond PD-1 and CTLA-4

(2019) Shuang Qin et al.   Molecular Cancer

Blocking TGF-β Signaling To Enhance The Efficacy Of Immune Checkpoint Inhibitor

(2019) Xianguang Bai et al.   OncoTargets and Therapy

Manganese Increases the Sensitivity of the cGAS-STING Pathway for Double-Stranded DNA and Is Required for the Host Defense against DNA Viruses

(2018) Chenguang Wang et al.   IMMUNITY

DACH1 antagonizes CXCL8 to repress tumorigenesis of lung adenocarcinoma and improve prognosis

(2018) Qian Liu et al.   Journal of Hematology & Oncology

TGFβ drives immune evasion in genetically reconstituted colon cancer metastasis

(2018) Daniele V. F. Tauriello et al.   NATURE

Enhanced preclinical antitumor activity of M7824, a bifunctional fusion protein simultaneously targeting PD-L1 and TGF-β

(2018) Yan Lan et al.   Science Translational Medicine

TIGIT and PD-1 dual checkpoint blockade enhances antitumor immunity and survival in GBM

(2018) Alice L. Hung et al.   OncoImmunology

Targeting the TGFβ pathway with galunisertib, a TGFβRI small molecule inhibitor, promotes anti-tumor immunity leading to durable, complete responses, as monotherapy and in combination with checkpoint blockade

(2018) Rikke B. Holmgaard et al.   Journal for ImmunoTherapy of Cancer

STING agonist therapy in combination with PD-1 immune checkpoint blockade enhances response to carboplatin chemotherapy in high-grade serous ovarian cancer

(2018) Abdi Ghaffari et al.   BRITISH JOURNAL OF CANCER

Biomarkers for predicting efficacy of PD-1/PD-L1 inhibitors

(2018) Ming Yi et al.   Molecular Cancer

TGFβ attenuates tumour response to PD-L1 blockade by contributing to exclusion of T cells

(2018) Sanjeev Mariathasan et al.   NATURE

A Paradigm Shift in Cancer Immunotherapy: From Enhancement to Normalization

(2018) Miguel F. Sanmamed et al.   CELL

Design of amidobenzimidazole STING receptor agonists with systemic activity

(2018) Joshi M. Ramanjulu et al.   NATURE

Elements of cancer immunity and the cancer–immune set point

(2017) Daniel S. Chen et al.   NATURE

PD-L1 (B7-H1) and PD-1 pathway blockade for cancer therapy: Mechanisms, response biomarkers, and combinations

(2016) Weiping Zou et al.   Science Translational Medicine

Manganese Is Essential for Neuronal Health

(2015) Kyle J. Horning et al.   Annual Review of Nutrition

Anti–PD-1/PD-L1 therapy of human cancer: past, present, and future

(2015) Lieping Chen et al.   JOURNAL OF CLINICAL INVESTIGATION

Combination cancer immunotherapies tailored to the tumour microenvironment

(2015) Mark J. Smyth et al.   Nature Reviews Clinical Oncology

Pembrolizumab versus Ipilimumab in Advanced Melanoma

(2015) Caroline Robert et al.   NEW ENGLAND JOURNAL OF MEDICINE

Oncology Meets Immunology: The Cancer-Immunity Cycle

(2013) Daniel S. Chen et al.   IMMUNITY

Mouse, but not Human STING, Binds and Signals in Response to the Vascular Disrupting Agent 5,6-Dimethylxanthenone-4-Acetic Acid

(2013) J. Conlon et al.   JOURNAL OF IMMUNOLOGY

clusterProfiler: an R Package for Comparing Biological Themes Among Gene Clusters

(2012) Guangchuang Yu et al.   OMICS-A JOURNAL OF INTEGRATIVE BIOLOGY

ROAST: rotation gene set tests for complex microarray experiments

(2010) Di Wu et al.   BIOINFORMATICS

Effect of phosphodiesterase 7 inhibitor ASB16165 on development and function of cytotoxic T lymphocyte

(2008) Kumiko Kadoshima-Yamaoka et al.   INTERNATIONAL IMMUNOPHARMACOLOGY