AMP-Activated Protein Kinase Regulation and Biological Actions in the Heart

Embryonic expression of AMPK γ subunits and the identification of a novel γ2 transcript variant in adult heart

(2012) Katalin Pinter et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

AMPK isoform expression in the normal and failing hearts

(2012) Maengjo Kim et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Functional dissection of lysine deacetylases reveals that HDAC1 and p300 regulate AMPK

(2012) Yu-yi Lin et al.   NATURE

The Ancient Drug Salicylate Directly Activates AMP-Activated Protein Kinase

(2012) S. A. Hawley et al.   SCIENCE

Enhancing AMPK activation during ischemia protects the diabetic heart against reperfusion injury

(2011) Marta A. Paiva et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Protective Effects of Erythropoietin on Myocardial Infarction in Rats: The Role of AMP-Activated Protein Kinase Signaling Pathway

(2011) Xiu-Jiang Li et al.   AMERICAN JOURNAL OF THE MEDICAL SCIENCES

AMP-activated protein kinase modulates cardiac autophagy in diabetic cardiomyopathy

(2011) Zhonglin Xie et al.   Autophagy

AMP-Activated Protein Kinase Regulates E3 Ligases in Rodent Heart

(2011) Kedryn K. Baskin et al.   CIRCULATION RESEARCH

AMP Activated Protein Kinase-α2 Regulates Expression of Estrogen-Related Receptor-α, a Metabolic Transcription Factor Related to Heart Failure Development

(2011) Xinli Hu et al.   HYPERTENSION

Suppression of 5′-Nucleotidase Enzymes Promotes AMP-activated Protein Kinase (AMPK) Phosphorylation and Metabolism in Human and Mouse Skeletal Muscle

(2011) Sameer S. Kulkarni et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Resistin Promotes Cardiac Hypertrophy via the AMP-activated Protein Kinase/Mammalian Target of Rapamycin (AMPK/mTOR) and c-Jun N-terminal Kinase/Insulin Receptor Substrate 1 (JNK/IRS1) Pathways

(2011) Soojeong Kang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Adrenergic Regulation of AMP-activated Protein Kinase in Brown Adipose Tissuein Vivo

(2011) Thomas Pulinilkunnil et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A small molecule AMPK activator protects the heart against ischemia–reperfusion injury

(2011) Agnes S. Kim et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Hypoxia Triggers AMPK Activation through Reactive Oxygen Species-Mediated Activation of Calcium Release-Activated Calcium Channels

(2011) P. T. Mungai et al.   MOLECULAR AND CELLULAR BIOLOGY

Structure of mammalian AMPK and its regulation by ADP

(2011) Bing Xiao et al.   NATURE

AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1

(2011) Joungmok Kim et al.   NATURE CELL BIOLOGY

Hydrogen peroxide differentially modulates cardiac myocyte nitric oxide synthesis

(2011) J. L. Sartoretto et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

AMP-activated protein kinase: also regulated by ADP?

(2011) D. Grahame Hardie et al.   TRENDS IN BIOCHEMICAL SCIENCES

Cardiac-specific leptin receptor deletion exacerbates ischaemic heart failure in mice

(2010) Kenneth R. McGaffin et al.   CARDIOVASCULAR RESEARCH

Use of Cells Expressing γ Subunit Variants to Identify Diverse Mechanisms of AMPK Activation

(2010) Simon A. Hawley et al.   Cell Metabolism

Interdependence of AMPK and SIRT1 for Metabolic Adaptation to Fasting and Exercise in Skeletal Muscle

(2010) Carles Cantó et al.   Cell Metabolism

Hypoxia induces PGC-1α expression and mitochondrial biogenesis in the myocardium of TOF patients

(2010) Lingyun Zhu et al.   CELL RESEARCH

Impaired Macrophage Migration Inhibitory Factor–AMP-Activated Protein Kinase Activation and Ischemic Recovery in the Senescent Heart

(2010) Heng Ma et al.   CIRCULATION

Metformin Use and Mortality in Ambulatory Patients With Diabetes and Heart Failure

(2010) David Aguilar et al.   Circulation-Heart Failure

Metformin Activates AMP Kinase through Inhibition of AMP Deaminase

(2010) Jiangyong Ouyang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

T-cadherin is critical for adiponectin-mediated cardioprotection in mice

(2010) Martin S. Denzel et al.   JOURNAL OF CLINICAL INVESTIGATION

Metformin inhibits hepatic gluconeogenesis in mice independently of the LKB1/AMPK pathway via a decrease in hepatic energy state

(2010) Marc Foretz et al.   JOURNAL OF CLINICAL INVESTIGATION

Deficiency in AMP-activated protein kinase exaggerates high fat diet-induced cardiac hypertrophy and contractile dysfunction

(2010) Subat Turdi et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Identification of a Nuclear Export Signal in the Catalytic Subunit of AMP-activated Protein Kinase

(2010) Nevzat Kazgan et al.   MOLECULAR BIOLOGY OF THE CELL

MicroRNA-451 Regulates LKB1/AMPK Signaling and Allows Adaptation to Metabolic Stress in Glioma Cells

(2010) Jakub Godlewski et al.   MOLECULAR CELL

Receptor-mediated activation of ceramidase activity initiates the pleiotropic actions of adiponectin

(2010) William L Holland et al.   NATURE MEDICINE

 -Subunit myristoylation is the gatekeeper for initiating metabolic stress sensing by AMP-activated protein kinase (AMPK)

(2010) J. S. Oakhill et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Signaling Kinase AMPK Activates Stress-Promoted Transcription via Histone H2B Phosphorylation

(2010) D. Bungard et al.   SCIENCE

Phosphorylation of ULK1 (hATG1) by AMP-Activated Protein Kinase Connects Energy Sensing to Mitophagy

(2010) D. F. Egan et al.   SCIENCE

Suppression of 5′-AMP-activated protein kinase activity does not impair recovery of contractile function during reperfusion of ischemic hearts

(2009) Clifford D. L. Folmes et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

The Glycogen-Binding Domain on the AMPK β Subunit Allows the Kinase to Act as a Glycogen Sensor

(2009) Andrew McBride et al.   Cell Metabolism

Metformin Prevents Progression of Heart Failure in Dogs

(2009) Hideyuki Sasaki et al.   CIRCULATION

Resveratrol Prevents the Prohypertrophic Effects of Oxidative Stress on LKB1

(2009) Vernon W. Dolinsky et al.   CIRCULATION

Nutrient Stress Activates Inflammation and Reduces Glucose Metabolism by Suppressing AMP-Activated Protein Kinase in the Heart

(2009) H. J. Ko et al.   DIABETES

PKA phosphorylates and inactivates AMPKα to promote efficient lipolysis

(2009) Nabil Djouder et al.   EMBO JOURNAL

Cardiac macrophage migration inhibitory factor inhibits JNK pathway activation and injury during ischemia/reperfusion

(2009) Dake Qi et al.   JOURNAL OF CLINICAL INVESTIGATION

Structural insight into the autoinhibition mechanism of AMP-activated protein kinase

(2009) Lei Chen et al.   NATURE

AMPK regulates energy expenditure by modulating NAD+ metabolism and SIRT1 activity

(2009) Carles Cantó et al.   NATURE

Myocardial ischemic postconditioning against ischemia-reperfusion is impaired in ob/ob mice

(2008) Omar Bouhidel et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Activation of AMP-Activated Protein Kinase by Metformin Improves Left Ventricular Function and Survival in Heart Failure

(2008) Susheel Gundewar et al.   CIRCULATION RESEARCH

Regulation of LKB1/STRAD Localization and Function by E-Cadherin

(2008) Michael Sebbagh et al.   CURRENT BIOLOGY

Glucose Restriction Inhibits Skeletal Myoblast Differentiation by Activating SIRT1 through AMPK-Mediated Regulation of Nampt

(2008) Marcella Fulco et al.   DEVELOPMENTAL CELL

AMP-Activated Protein Kinase Regulates GLUT4 Transcription by Phosphorylating Histone Deacetylase 5

(2008) S. L. McGee et al.   DIABETES

Downregulation of AMP-activated protein kinase by Cidea-mediated ubiquitination and degradation in brown adipose tissue

(2008) Jingzong Qi et al.   EMBO JOURNAL

AMP Activated Protein Kinase-α2 Deficiency Exacerbates Pressure-Overload–Induced Left Ventricular Hypertrophy and Dysfunction in Mice

(2008) Ping Zhang et al.   HYPERTENSION

Small Molecule Antagonizes Autoinhibition and Activates AMP-activated Protein Kinase in Cells

(2008) Tao Pang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

SIRT1 Modulation of the Acetylation Status, Cytosolic Localization, and Activity of LKB1

(2008) Fan Lan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Inhibition of GLUT4 Translocation by Tbc1d1, a Rab GTPase-activating Protein Abundant in Skeletal Muscle, Is Partially Relieved by AMP-activated Protein Kinase Activation

(2008) Jose A. Chavez et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Resveratrol Inhibits Cardiac Hypertrophy via AMP-activated Protein Kinase and Akt

(2008) Anita Y. M. Chan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Recycle or die: The role of autophagy in cardioprotection

(2008) Åsa B. Gustafsson et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

AMPK Phosphorylation of Raptor Mediates a Metabolic Checkpoint

(2008) Dana M. Gwinn et al.   MOLECULAR CELL

Macrophage migration inhibitory factor stimulates AMP-activated protein kinase in the ischaemic heart

(2008) Edward J. Miller et al.   NATURE

Reversibility of PRKAG2 Glycogen-Storage Cardiomyopathy and Electrophysiological Manifestations

(2007) Cordula M. Wolf et al.   CIRCULATION