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Title
SIRT6 Widely Regulates Aging, Immunity, and Cancer
Authors
Keywords
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Journal
Frontiers in Oncology
Volume 12, Issue -, Pages -
Publisher
Frontiers Media SA
Online
2022-04-06
DOI
10.3389/fonc.2022.861334
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Note: Only part of the references are listed.- SIRT6 enhances oxidative phosphorylation in breast cancer and promotes mammary tumorigenesis in mice
- (2021) Pamela Becherini et al. Cancer & Metabolism
- Cyclosporine modulates neutrophil functions via the SIRT6–HIF‐1α–glycolysis axis to alleviate severe ulcerative colitis
- (2021) Huiying Lu et al. Clinical and Translational Medicine
- The nuclear sirtuin SIRT6 protects the heart from developing aging-associated myocyte senescence and cardiac hypertrophy
- (2021) Vinodkumar B. Pillai et al. Aging-US
- Emerging Therapeutic Potential of SIRT6 Modulators
- (2021) Francesco Fiorentino et al. JOURNAL OF MEDICINAL CHEMISTRY
- Restoration of energy homeostasis by SIRT6 extends healthy lifespan
- (2021) A. Roichman et al. Nature Communications
- N-Acetylcysteine Improves Inflammatory Response in COPD Patients by Regulating Th17/Treg Balance through Hypoxia Inducible Factor-1α Pathway
- (2021) Xiaopeng Liu et al. Biomed Research International
- Sirtuins as Metabolic Regulators of Immune Cells Phenotype and Function
- (2021) Lídia Fortuny et al. Genes
- FOXO3a‑SIRT6 axis suppresses aerobic glycolysis in melanoma
- (2020) Zhen Dong et al. INTERNATIONAL JOURNAL OF ONCOLOGY
- Silencing Sirtuin 6 induces cell cycle arrest and apoptosis in non-small cell lung cancer cell lines
- (2020) Varunkumar Krishnamoorthy et al. GENOMICS
- Sirt6 promotes tumorigenesis and drug resistance of diffuse large B-cell lymphoma by mediating PI3K/Akt signaling
- (2020) Juan Yang et al. JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
- Sirt6 inhibition delays the onset of experimental autoimmune encephalomyelitis by reducing dendritic cell migration
- (2020) Giovanni Ferrara et al. Journal of Neuroinflammation
- The deacetylase SIRT6 promotes the repair of UV-induced DNA damage by targeting DDB2
- (2020) Anke Geng et al. NUCLEIC ACIDS RESEARCH
- CRISPR/Cas9‐mediated Knockout of SIRT6 Imparts Remarkable Antiproliferative Response in Human Melanoma Cells in vitro and in vivo
- (2020) Liz M. Garcia‐Peterson et al. PHOTOCHEMISTRY AND PHOTOBIOLOGY
- Is nuclear sirtuin SIRT6 a master regulator of immune function?
- (2020) Vinodkumar B Pillai et al. AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
- Inhibition of SIRT6 potentiates the anti-tumor effect of doxorubicin through suppression of the DNA damage repair pathway in osteosarcoma
- (2020) Zhongkai Zhang et al. JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
- Emerging roles of SIRT6 in human diseases and its modulators
- (2020) Gang Liu et al. MEDICINAL RESEARCH REVIEWS
- α-Hederin inhibits the growth of lung cancer A549 cells in vitro and in vivo by decreasing SIRT6 dependent glycolysis
- (2020) Cong Fang et al. PHARMACEUTICAL BIOLOGY
- A novel SIRT6 activator ameliorates neuroinflammation and ischemic brain injury via EZH2/FOXC1 axis
- (2020) Tailin He et al. Acta Pharmaceutica Sinica B
- SIRT6/HIF-1α axis promotes papillary thyroid cancer progression by inducing epithelial–mesenchymal transition
- (2019) Zhou Yang et al. Cancer Cell International
- HIF-1-Dependent Reprogramming of Glucose Metabolic Pathway of Cancer Cells and Its Therapeutic Significance
- (2019) Ayako Nagao et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Myeloid cell-specific sirtuin 6 deficiency delays wound healing in mice by modulating inflammation and macrophage phenotypes
- (2019) Jeung-Hyun Koo et al. EXPERIMENTAL AND MOLECULAR MEDICINE
- Adipose sirtuin 6 drives macrophage polarization toward M2 through IL-4 production and maintains systemic insulin sensitivity in mice and humans
- (2019) Mi-Young Song et al. EXPERIMENTAL AND MOLECULAR MEDICINE
- Overexpression of Sirt6 promotes M2�macrophage transformation, alleviating renal injury in diabetic nephropathy
- (2019) Liqiang Ji et al. INTERNATIONAL JOURNAL OF ONCOLOGY
- SIRT6 promotes the Warburg effect of papillary thyroid cancer cell BCPAP through reactive oxygen species
- (2019) Weiping Yu et al. OncoTargets and Therapy
- Inflammation and Cancer: Triggers, Mechanisms, and Consequences
- (2019) Florian R. Greten et al. IMMUNITY
- SIRT6 promotes transcription of a subset of NRF2 targets by mono-ADP-ribosylating BAF170
- (2019) Sarallah Rezazadeh et al. NUCLEIC ACIDS RESEARCH
- EP300 and SIRT1/6 Co-Regulate Lapatinib Sensitivity Via Modulating FOXO3-Acetylation and Activity in Breast Cancer
- (2019) Zimam Mahmud et al. Cancers
- Transcriptional activation of SIRT6 via FKHRL1/FOXO3a inhibits the Warburg effect in glioblastoma cells
- (2019) Zhen Dong et al. CELLULAR SIGNALLING
- Sirtuin6 (SIRT6) Promotes the EMT of Hepatocellular Carcinoma by Stimulating Autophagic Degradation of E-Cadherin
- (2019) Li Li Han et al. MOLECULAR CANCER RESEARCH
- Non-canonical mTORC2 Signaling Regulates Brown Adipocyte Lipid Catabolism through SIRT6-FoxO1
- (2019) Su Myung Jung et al. MOLECULAR CELL
- NQO1 potentiates apoptosis evasion and upregulates XIAP via inhibiting proteasome-mediated degradation SIRT6 in hepatocellular carcinoma
- (2019) Hong-Zhong Zhou et al. Cell Communication and Signaling
- Sirtuin 6 inhibits colon cancer progression by modulating PTEN/AKT signaling
- (2018) Junhong Tian et al. BIOMEDICINE & PHARMACOTHERAPY
- Human T Cell Development, Localization, and Function throughout Life
- (2018) Brahma V. Kumar et al. IMMUNITY
- DNA Damage, Mutagenesis and Cancer
- (2018) Ashis Basu INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Overexpression of Sirt6 is a novel biomarker of malignant human colon carcinoma
- (2018) Chang-hui Geng et al. JOURNAL OF CELLULAR BIOCHEMISTRY
- SIRT6 Acts as a Negative Regulator in Dengue Virus-Induced Inflammatory Response by Targeting the DNA Binding Domain of NF-κB p65
- (2018) Pengcheng Li et al. Frontiers in Cellular and Infection Microbiology
- Immunosenescence and Inflamm-Aging As Two Sides of the Same Coin: Friends or Foes?
- (2018) Tamas Fulop et al. Frontiers in Immunology
- SIRT6 deficiency results in developmental retardation in cynomolgus monkeys
- (2018) Weiqi Zhang et al. NATURE
- SIRT6 haploinsufficiency induces BRAFV600E melanoma cell resistance to MAPK inhibitors via IGF signalling
- (2018) Thomas Strub et al. Nature Communications
- SIRT6 drives epithelial-to-mesenchymal transition and metastasis in non-small cell lung cancer via snail-dependent transrepression of KLF4
- (2018) Ziming Li et al. JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
- SIRT6 overexpression induces apoptosis of nasopharyngeal carcinoma by inhibiting NF-κB signaling
- (2018) Lei Ouyang et al. OncoTargets and Therapy
- Myeloid sirtuin 6 deficiency accelerates experimental rheumatoid arthritis by enhancing macrophage activation and infiltration into synovium
- (2018) Seong Ji Woo et al. EBioMedicine
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- (2018) Jun Sang Bae et al. Frontiers in Oncology
- Depletion of SIRT6 enzymatic activity increases acute myeloid leukemia cells’ vulnerability to DNA-damaging agents
- (2017) Antonia Cagnetta et al. HAEMATOLOGICA
- Metabolic Pathways of the Warburg Effect in Health and Disease: Perspectives of Choice, Chain or Chance
- (2017) Jorge Burns et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Fabp4-Cre-mediated Sirt6 deletion impairs adipose tissue function and metabolic homeostasis in mice
- (2017) Xiwen Xiong et al. JOURNAL OF ENDOCRINOLOGY
- Suppression of SIRT6 by miR-33a facilitates tumor growth of glioma through apoptosis and oxidative stress resistance
- (2017) Mingze Chang et al. ONCOLOGY REPORTS
- SIRT6: Novel Mechanisms and Links to Aging and Disease
- (2017) Luisa Tasselli et al. TRENDS IN ENDOCRINOLOGY AND METABOLISM
- Telomere Dynamics in Immune Senescence and Exhaustion Triggered by Chronic Viral Infection
- (2017) Marcia Bellon et al. Viruses-Basel
- Physical activity and telomere length: Impact of aging and potential mechanisms of action
- (2017) Nicole C. Arsenis et al. Oncotarget
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- (2017) Xiaoyu Zhang et al. eLife
- Depletion of SIRT6 enzymatic activity increases acute myeloid leukemia cells’ vulnerability to DNA-damaging agents
- (2017) Antonia Cagnetta et al. HAEMATOLOGICA
- A Chemical Biology Approach to Reveal Sirt6-targeted Histone H3 Sites in Nucleosomes
- (2016) Wesley Wei Wang et al. ACS Chemical Biology
- Sirt6 regulates dendritic cell differentiation, maturation, and function
- (2016) Denise Lasigliè et al. Aging-US
- Sirtuin 6 Modulates Hypoxia-Induced Autophagy in Nasal Polyp Fibroblasts via Inhibition of Glycolysis
- (2016) Chia-Tung Shun et al. American Journal of Rhinology & Allergy
- SIRT6 Suppresses Pancreatic Cancer through Control of Lin28b
- (2016) Sita Kugel et al. CELL
- Calorie restriction-induced SIRT6 activation delays aging by suppressing NF-κB signaling
- (2016) Nannan Zhang et al. CELL CYCLE
- SIRT6 safeguards human mesenchymal stem cells from oxidative stress by coactivating NRF2
- (2016) Huize Pan et al. CELL RESEARCH
- SIRT6 Overexpression Potentiates Apoptosis Evasion in Hepatocellular Carcinoma via BCL2-Associated X Protein-Dependent Apoptotic Pathway
- (2016) L.-K. Ran et al. CLINICAL CANCER RESEARCH
- Are sirtuins markers of ovarian aging?
- (2016) Jinjin Zhang et al. GENE
- Histone Deacetylase SIRT1 Negatively Regulates the Differentiation of Interleukin-9-Producing CD4 + T Cells
- (2016) Yu Wang et al. IMMUNITY
- Overexpression of sirtuin 6 suppresses allergic airway inflammation through deacetylation of GATA3
- (2016) Hyun-Young Jang et al. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
- Identifying the functional contribution of the defatty-acylase activity of SIRT6
- (2016) Xiaoyu Zhang et al. Nature Chemical Biology
- SIRT6 deacetylates H3K18ac at pericentric chromatin to prevent mitotic errors and cellular senescence
- (2016) Luisa Tasselli et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- SIRT6 Depletion Suppresses Tumor Growth by Promoting Cellular Senescence Induced by DNA Damage in HCC
- (2016) Namgyu Lee et al. PLoS One
- SIRT6 deacetylates PKM2 to suppress its nuclear localization and oncogenic functions
- (2016) Abhishek Bhardwaj et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- SIRT6 deacetylates H3K18ac at pericentric chromatin to prevent mitotic errors and cellular senescence
- (2016) Luisa Tasselli et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- Upregulation of SIRT6 predicts poor prognosis and promotes metastasis of non-small cell lung cancer via the ERK1/2/MMP9 pathway
- (2016) Lihong Bai et al. Oncotarget
- Lysine fatty acylation promotes lysosomal targeting of TNF-α
- (2016) Hong Jiang et al. Scientific Reports
- JNK Phosphorylates SIRT6 to Stimulate DNA Double-Strand Break Repair in Response to Oxidative Stress by Recruiting PARP1 to DNA Breaks
- (2016) Michael Van Meter et al. Cell Reports
- From inflamm-aging to immune-paralysis: a slippery slope during aging for immune-adaptation
- (2015) T. Fulop et al. BIOGERONTOLOGY
- Evidence for a role of the histone deacetylase SIRT6 in DNA damage response of multiple myeloma cells
- (2015) Michele Cea et al. BLOOD
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- (2015) Bor-Jang Hwang et al. BMC MOLECULAR BIOLOGY
- SIRT6 rescues the age related decline in base excision repair in a PARP1-dependent manner
- (2015) Zhu Xu et al. CELL CYCLE
- Quinazolinedione SIRT6 inhibitors sensitize cancer cells to chemotherapeutics
- (2015) Giovanna Sociali et al. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
- Immunometabolism: Cellular Metabolism Turns Immune Regulator
- (2015) Róisín M. Loftus et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- The RUNX2 Transcription Factor Negatively Regulates SIRT6 Expression to Alter Glucose Metabolism in Breast Cancer Cells
- (2015) Moran Choe et al. JOURNAL OF CELLULAR BIOCHEMISTRY
- SIRT6 expression is associated with poor prognosis and chemosensitivity in patients with non-small cell lung cancer
- (2015) Yoko Azuma et al. JOURNAL OF SURGICAL ONCOLOGY
- E2F1 enhances glycolysis through suppressing Sirt6 transcription in cancer cells
- (2015) Minghui Wu et al. Oncotarget
- Overexpression of Sirtuin 6 suppresses cellular senescence and NF-κB mediated inflammatory responses in osteoarthritis development
- (2015) Yaosen Wu et al. Scientific Reports
- Sirt6 depletion causes spindle defects and chromosome misalignment during meiosis of mouse oocyte
- (2015) Longsen Han et al. Scientific Reports
- Icariin Intervenes in Cardiac Inflammaging through Upregulation of SIRT6 Enzyme Activity and Inhibition of the NF-Kappa B Pathway
- (2015) Yang Chen et al. Biomed Research International
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- (2014) Xin Chen et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Aging and Cytomegalovirus Infection Differentially and Jointly Affect Distinct Circulating T Cell Subsets in Humans
- (2014) A. M. Wertheimer et al. JOURNAL OF IMMUNOLOGY
- Erasers of Histone Acetylation: The Histone Deacetylase Enzymes
- (2014) E. Seto et al. Cold Spring Harbor Perspectives in Biology
- SIRT6 represses LINE1 retrotransposons by ribosylating KAP1 but this repression fails with stress and age
- (2014) Michael Van Meter et al. Nature Communications
- Overexpression of Sirtuin 6 Suppresses Inflammatory Responses and Bone Destruction in Mice With Collagen-Induced Arthritis
- (2013) Hwa-Suk Lee et al. ARTHRITIS AND RHEUMATISM
- SIRT6 modulates paclitaxel and epirubicin resistance and survival in breast cancer
- (2013) Mattaka Khongkow et al. CARCINOGENESIS
- Metabolic Pathways in Immune Cell Activation and Quiescence
- (2013) Erika L. Pearce et al. IMMUNITY
- The Role of SIRT6 Protein in Aging and Reprogramming of Human Induced Pluripotent Stem Cells
- (2013) Amit Sharma et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- FoxO3 Transcription Factor and Sirt6 Deacetylase Regulate Low Density Lipoprotein (LDL)-cholesterol Homeostasis via Control of the Proprotein Convertase Subtilisin/Kexin Type 9 (Pcsk9) Gene Expression
- (2013) Rongya Tao et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Activation of the Protein Deacetylase SIRT6 by Long-chain Fatty Acids and Widespread Deacylation by Mammalian Sirtuins
- (2013) Jessica L. Feldman et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Cellular senescence and the senescent secretory phenotype: therapeutic opportunities
- (2013) Tamara Tchkonia et al. JOURNAL OF CLINICAL INVESTIGATION
- SIRT6 Recruits SNF2H to DNA Break Sites, Preventing Genomic Instability through Chromatin Remodeling
- (2013) Debra Toiber et al. MOLECULAR CELL
- SIRT6 regulates TNF-α secretion through hydrolysis of long-chain fatty acyl lysine
- (2013) Hong Jiang et al. NATURE
- SIRT6 exhibits nucleosome-dependent deacetylase activity
- (2013) R. Gil et al. NUCLEIC ACIDS RESEARCH
- USP10 Antagonizes c-Myc Transcriptional Activation through SIRT6 Stabilization to Suppress Tumor Formation
- (2013) Zhenghong Lin et al. Cell Reports
- Inhibition of SIRT6 in prostate cancer reduces cell viability and increases sensitivity to chemotherapeutics
- (2013) Yewei Liu et al. Protein & Cell
- Noncanonical Autophagy Is Required for Type I Interferon Secretion in Response to DNA-Immune Complexes
- (2012) Jill Henault et al. IMMUNITY
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- (2012) Inga Bauer et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Progression of Chronic Liver Inflammation and Fibrosis Driven by Activation of c-JUN Signaling inSirt6Mutant Mice
- (2012) Cuiying Xiao et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- EGFR-Induced and PKCε Monoubiquitylation-Dependent NF-κB Activation Upregulates PKM2 Expression and Promotes Tumorigenesis
- (2012) Weiwei Yang et al. MOLECULAR CELL
- The sirtuin SIRT6 regulates lifespan in male mice
- (2012) Yariv Kanfi et al. NATURE
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- (2012) Lihua Min et al. NATURE CELL BIOLOGY
- The sirtuin SIRT6 blocks IGF-Akt signaling and development of cardiac hypertrophy by targeting c-Jun
- (2012) Nagalingam R Sundaresan et al. NATURE MEDICINE
- IKK and NF- B Transcription Govern Lymphoma Cell Survival through AKT-Induced Plasma Membrane Trafficking of GLUT1
- (2011) T. G. Sommermann et al. CANCER RESEARCH
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- (2011) Eriko Michishita et al. CELL CYCLE
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- (2011) Patricia W. Pan et al. JOURNAL OF BIOLOGICAL CHEMISTRY
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- (2011) Z. Mao et al. SCIENCE
- SIRT6 is required for maintenance of telomere position effect in human cells
- (2011) Ruth I. Tennen et al. Nature Communications
- Foxo Transcription Factors Control Regulatory T Cell Development and Function
- (2010) Yann M. Kerdiles et al. IMMUNITY
- SIRT6 Links Histone H3 Lysine 9 Deacetylation to NF-κB-Dependent Gene Expression and Organismal Life Span
- (2009) Tiara L.A. Kawahara et al. CELL
- Intracellular NAD levels regulate tumor necrosis factor protein synthesis in a sirtuin-dependent manner
- (2009) Frédéric Van Gool et al. NATURE MEDICINE
- The B Cell Receptor Governs the Subcellular Location of Toll-like Receptor 9 Leading to Hyperresponses to DNA-Containing Antigens
- (2008) Akanksha Chaturvedi et al. IMMUNITY
- SIRT6 is a histone H3 lysine 9 deacetylase that modulates telomeric chromatin
- (2008) Eriko Michishita et al. NATURE
- Is Akt the “Warburg kinase”?—Akt-energy metabolism interactions and oncogenesis
- (2008) R. Brooks Robey et al. SEMINARS IN CANCER BIOLOGY
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