Progression of Chronic Liver Inflammation and Fibrosis Driven by Activation of c-JUN Signaling inSirt6Mutant Mice

Repairing split ends: SIRT6, mono-ADP ribosylation and DNA repair

(2016) Michael Van Meter et al.   Aging-US

Inactivation of the Deubiquitinase CYLD in Hepatocytes Causes Apoptosis, Inflammation, Fibrosis, and Cancer

(2012) Kostas Nikolaou et al.   CANCER CELL

SIRT3 Is a Mitochondrial Tumor Suppressor: A Scientific Tale That Connects Aberrant Cellular ROS, the Warburg Effect, and Carcinogenesis

(2012) M. C. Haigis et al.   CANCER RESEARCH

Fibrocytes: emerging effector cells in chronic inflammation

(2012) Hong Peng et al.   CURRENT OPINION IN PHARMACOLOGY

A Liver Full of JNK: Signaling in Regulation of Cell Function and Disease Pathogenesis, and Clinical Approaches

(2012) Ekihiro Seki et al.   GASTROENTEROLOGY

NASH is an Infl ammatory Disorder: Pathogenic, Prognostic and Therapeutic Implications

(2012) Geoffrey C. Farrell et al.   Gut and Liver

SIRT3 interacts with the daf-16 homolog FOXO3a in the Mitochondria, as well as increases FOXO3a Dependent Gene expression

(2012) Kristi Muldoon Jacobs et al.   International Journal of Biological Sciences

SIRT1, Is It a Tumor Promoter or Tumor Suppressor?

(2012) Chu-Xia Deng   International Journal of Biological Sciences

Comparative Analysis of Cytotoxic T Lymphocyte Response Induced by Dendritic Cells Loaded with Hepatocellular Carcinoma -Derived RNA or Cell Lysate

(2012) Ke Pan et al.   International Journal of Biological Sciences

Liver Steatosis and Increased ChREBP Expression in Mice Carrying a Liver Specific SIRT1 Null Mutation under a Normal Feeding Condition

(2012) Rui-Hong Wang et al.   International Journal of Biological Sciences

Signal Transducer and Activator of Transcription 3 in Liver Diseases: A Novel Therapeutic Target

(2012) Hua Wang et al.   International Journal of Biological Sciences

Dual Roles of Immune Cells and Their Factors in Cancer Development and Progression

(2012) Brian F. Zamarron et al.   International Journal of Biological Sciences

Mammalian Sirtuins and Energy Metabolism

(2012) Xiaoling Li et al.   International Journal of Biological Sciences

Hepatoprotective and anti-inflammatory cytokines in alcoholic liver disease

(2012) Bin Gao   JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY

The sirtuin SIRT6 regulates lifespan in male mice

(2012) Yariv Kanfi et al.   NATURE

Sirtuins mediate mammalian metabolic responses to nutrient availability

(2012) Angeliki Chalkiadaki et al.   Nature Reviews Endocrinology

Over Expression of Wild Type or a Catalytically Dead Mutant of SIRTUIN 6 Does Not Influence NFκB Responses

(2012) Rachel Grimley et al.   PLoS One

Targeting inflammation by modulating the Jun/AP-1 pathway

(2011) H. B. Schonthaler et al.   ANNALS OF THE RHEUMATIC DISEASES

SIRT2 Maintains Genome Integrity and Suppresses Tumorigenesis through Regulating APC/C Activity

(2011) Hyun-Seok Kim et al.   CANCER CELL

SIRT3 Opposes Reprogramming of Cancer Cell Metabolism through HIF1α Destabilization

(2011) Lydia W.S. Finley et al.   CANCER CELL

FAS/FAS-L dependent killing of activated human monocytes and macrophages by CD4+CD25− responder T cells, but not CD4+CD25+ regulatory T cells

(2011) Ann L. Jagger et al.   JOURNAL OF AUTOIMMUNITY

The clinical challenges of acute on chronic liver failure

(2011) Ivo W. Graziadei   LIVER INTERNATIONAL

Mammalian Sirtuins: Biological Insights and Disease Relevance

(2010) Marcia C. Haigis et al.   Annual Review of Pathology-Mechanisms of Disease

SIRT3 Is a Mitochondria-Localized Tumor Suppressor Required for Maintenance of Mitochondrial Integrity and Metabolism during Stress

(2010) Hyun-Seok Kim et al.   CANCER CELL

Hepatic-Specific Disruption of SIRT6 in Mice Results in Fatty Liver Formation Due to Enhanced Glycolysis and Triglyceride Synthesis

(2010) Hyun-Seok Kim et al.   Cell Metabolism

The Role of Chemokines in the Recruitment of Lymphocytes to the Liver

(2010) Ye H. Oo et al.   DIGESTIVE DISEASES

SIRT6 Deficiency Results in Severe Hypoglycemia by Enhancing Both Basal and Insulin-stimulated Glucose Uptake in Mice

(2010) Cuiying Xiao et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Myeloid Deletion of SIRT1 Induces Inflammatory Signaling in Response to Environmental Stress

(2010) T. T. Schug et al.   MOLECULAR AND CELLULAR BIOLOGY

Neural sirtuin 6 (Sirt6) ablation attenuates somatic growth and causes obesity

(2010) B. Schwer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Bone development and inflammatory disease is regulated by AP-1 (Fos/Jun)

(2009) E F Wagner   ANNALS OF THE RHEUMATIC DISEASES

SIRT5 Deacetylates Carbamoyl Phosphate Synthetase 1 and Regulates the Urea Cycle

(2009) Takashi Nakagawa et al.   CELL

SIRT6 Links Histone H3 Lysine 9 Deacetylation to NF-κB-Dependent Gene Expression and Organismal Life Span

(2009) Tiara L.A. Kawahara et al.   CELL

SIRT1 Suppresses Activator Protein-1 Transcriptional Activity and Cyclooxygenase-2 Expression in Macrophages

(2009) Ran Zhang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Recent progress in the biology and physiology of sirtuins

(2009) Toren Finkel et al.   NATURE

Intracellular NAD levels regulate tumor necrosis factor protein synthesis in a sirtuin-dependent manner

(2009) Frédéric Van Gool et al.   NATURE MEDICINE

Impaired DNA Damage Response, Genome Instability, and Tumorigenesis in SIRT1 Mutant Mice

(2008) Rui-Hong Wang et al.   CANCER CELL

Sirt7 Increases Stress Resistance of Cardiomyocytes and Prevents Apoptosis and Inflammatory Cardiomyopathy in Mice

(2008) Olesya Vakhrusheva et al.   CIRCULATION RESEARCH

Cell Type–Dependent Pro- and Anti-Inflammatory Role of Signal Transducer and Activator of Transcription 3 in Alcoholic Liver Injury

(2008) Norio Horiguchi et al.   GASTROENTEROLOGY

SIRT6 is a histone H3 lysine 9 deacetylase that modulates telomeric chromatin

(2008) Eriko Michishita et al.   NATURE

A role for the mitochondrial deacetylase Sirt3 in regulating energy homeostasis

(2008) B.-H. Ahn et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA