HIF-1-Dependent Reprogramming of Glucose Metabolic Pathway of Cancer Cells and Its Therapeutic Significance

Regulatory mechanisms of hypoxia-inducible factor 1 activity: Two decades of knowledge

(2018) Sho Koyasu et al.   CANCER SCIENCE

MicroRNA-31-5p enhances the Warburg effect via targeting FIH

(2018) Biying Zhu et al.   FASEB JOURNAL

Microenvironmental control of glucose metabolism in tumors by regulation of pyruvate dehydrogenase

(2018) Tereza Golias et al.   INTERNATIONAL JOURNAL OF CANCER

The emerging roles of the ubiquitination/deubiquitination system in tumor radioresistance regarding DNA damage responses, cell cycle regulation, hypoxic responses, and antioxidant properties: Insight into the development of novel radiosensitizing strategies

(2017) Yoko Goto et al.   MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS

UCHL1-HIF-1 axis-mediated antioxidant property of cancer cells as a therapeutic target for radiosensitization

(2017) Ryota Nakashima et al.   Scientific Reports

Metabolic Modulation of Clear-cell Renal Cell Carcinoma with Dichloroacetate, an Inhibitor of Pyruvate Dehydrogenase Kinase

(2016) Adam Kinnaird et al.   EUROPEAN UROLOGY

Hypoxia-inducible factor 1–mediated characteristic features of cancer cells for tumor radioresistance

(2016) Hiroshi Harada   JOURNAL OF RADIATION RESEARCH

LY6E: a conductor of malignant tumor growth through modulation of the PTEN/PI3K/Akt/HIF-1 axis

(2016) Chan Joo Yeom et al.   Oncotarget

Hypoxic repression of pyruvate dehydrogenase activity is necessary for metabolic reprogramming and growth of model tumours

(2016) Tereza Golias et al.   Scientific Reports

WSB1 promotes tumor metastasis by inducing pVHL degradation

(2015) Jung Jin Kim et al.   GENES & DEVELOPMENT

UCHL1 provides diagnostic and antimetastatic strategies due to its deubiquitinating effect on HIF-1α

(2015) Yoko Goto et al.   Nature Communications

Mitochondrial autophagy: Life and breath of the cell

(2014) Gregg L. Semenza   Autophagy

Aberrant IDH3α expression promotes malignant tumor growth by inducing HIF-1-mediated metabolic reprogramming and angiogenesis

(2014) L Zeng et al.   ONCOGENE

HIF1α deubiquitination by USP8 is essential for ciliogenesis in normoxia

(2013) Albino Troilo et al.   EMBO REPORTS

Hypoxia-Inducible Factors in Physiology and Medicine

(2012) Gregg L. Semenza   CELL

The monocarboxylate transporter family-Role and regulation

(2011) Andrew P. Halestrap et al.   IUBMB LIFE

Differential Sensitivity of Hypoxia Inducible Factor Hydroxylation Sites to Hypoxia and Hydroxylase Inhibitors

(2011) Ya-Min Tian et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

How Can We Overcome Tumor Hypoxia in Radiation Therapy?

(2011) Hiroshi HARADA   JOURNAL OF RADIATION RESEARCH

Inhibition of Pyruvate Kinase M2 by Reactive Oxygen Species Contributes to Cellular Antioxidant Responses

(2011) D. Anastasiou et al.   SCIENCE

Hypoxia-Inducible Factor 1 in Tumor Radioresistance

(2010) Hiroshi Harada et al.   Current Signal Transduction Therapy

High brain lactate is a hallmark of aging and caused by a shift in the lactate dehydrogenase A/B ratio

(2010) J. M. Ross et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

MicroRNA-210 Controls Mitochondrial Metabolism during Hypoxia by Repressing the Iron-Sulfur Cluster Assembly Proteins ISCU1/2

(2009) Stephen Y. Chan et al.   Cell Metabolism

Reactive Oxygen Species-generating Mitochondrial DNA Mutation Up-regulates Hypoxia-inducible Factor-1α Gene Transcription via Phosphatidylinositol 3-Kinase-Akt/Protein Kinase C/Histone Deacetylase Pathway

(2009) Nobuko Koshikawa et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Defining the role of hypoxia-inducible factor 1 in cancer biology and therapeutics

(2009) G L Semenza   ONCOGENE

The Warburg Effect: Why and How Do Cancer Cells Activate Glycolysis in the Presence of Oxygen?

(2008) Miguel Lopez-Lazaro   Anti-Cancer Agents in Medicinal Chemistry

The Akt/mTOR Pathway Assures the Synthesis of HIF-1α Protein in a Glucose- and Reoxygenation-dependent Manner in Irradiated Tumors

(2008) Hiroshi Harada et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mitochondrial Autophagy Is an HIF-1-dependent Adaptive Metabolic Response to Hypoxia

(2008) Huafeng Zhang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Tumor metabolism: cancer cells give and take lactate

(2008) Gregg L. Semenza   JOURNAL OF CLINICAL INVESTIGATION

Regulation of cancer cell metabolism by hypoxia-inducible factor 1

(2008) Gregg L. Semenza   SEMINARS IN CANCER BIOLOGY