Sirt6 promotes tumorigenesis and drug resistance of diffuse large B-cell lymphoma by mediating PI3K/Akt signaling

SIRT6/HIF-1α axis promotes papillary thyroid cancer progression by inducing epithelial–mesenchymal transition

(2019) Zhou Yang et al.   Cancer Cell International

CUL4B regulates autophagy via JNK signaling in diffuse large B-cell lymphoma

(2019) Ying Li et al.   CELL CYCLE

Targeting PI3K in cancer: mechanisms and advances in clinical trials

(2019) Jing Yang et al.   Molecular Cancer

SIRT6 promotes the Warburg effect of papillary thyroid cancer cell BCPAP through reactive oxygen species

(2019) Weiping Yu et al.   OncoTargets and Therapy

Novel and emerging therapies for B cell lymphoma

(2019) Sabarish Ayyappan et al.   Journal of Hematology & Oncology

The rise of apoptosis: targeting apoptosis in hematologic malignancies

(2018) Rebecca Valentin et al.   BLOOD

Rituximab plus Bendamustine as front line treatment in frail elderly (>70 years) patients with diffuse large B-cell non-Hodgkin's lymphoma: a phase II multicenter study of the Fondazione Italiana Linfomi

(2018) Sergio Storti et al.   HAEMATOLOGICA

Inhibition of maternal embryonic leucine zipper kinase with OTSSP167 displays potent anti-leukemic effects in chronic lymphocytic leukemia

(2018) Ya Zhang et al.   ONCOGENE

Rituximab plus Bendamustine as front line treatment in frail elderly (>70 years) patients with diffuse large B-cell non-Hodgkin's lymphoma: a phase II multicenter study of the Fondazione Italiana Linfomi

(2018) Sergio Storti et al.   HAEMATOLOGICA

Nuclear FOXO1 promotes lymphomagenesis in germinal center B cells

(2018) Eleni Kabrani et al.   BLOOD

The 2016 updated WHO classification of lymphoid neoplasias

(2017) Leticia Quintanilla-Martinez   HEMATOLOGICAL ONCOLOGY

Klotho, an anti-aging gene, acts as a tumor suppressor and inhibitor of IGF-1R signaling in diffuse large B cell lymphoma

(2017) Xiangxiang Zhou et al.   Journal of Hematology & Oncology

Pathophysiological significance and therapeutic targeting of germinal center kinase in diffuse large B-cell lymphoma

(2016) J. M. Matthews et al.   BLOOD

SIRT6 Overexpression Potentiates Apoptosis Evasion in Hepatocellular Carcinoma via BCL2-Associated X Protein-Dependent Apoptotic Pathway

(2016) L.-K. Ran et al.   CLINICAL CANCER RESEARCH

Interleukin-9 promotes cell survival and drug resistance in diffuse large B-cell lymphoma

(2016) Xiao Lv et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Genetic lesions in diffuse large B-cell lymphomas

(2015) M. Testoni et al.   ANNALS OF ONCOLOGY

FOXO1 activation is an effector of SYK and AKT inhibition in tonic BCR signal-dependent diffuse large B-cell lymphomas

(2015) M. Szydlowski et al.   BLOOD

Evidence for a role of the histone deacetylase SIRT6 in DNA damage response of multiple myeloma cells

(2015) Michele Cea et al.   BLOOD

Novel drug targets for personalized precision medicine in relapsed/refractory diffuse large B-cell lymphoma: a comprehensive review

(2015) Rosalba Camicia et al.   Molecular Cancer

Diffuse large B-cell lymphoma: optimizing outcome in the context of clinical and biologic heterogeneity

(2014) Laurie H. Sehn et al.   BLOOD

A phase 1/1b study of rituximab, bendamustine, and ibrutinib in patients with untreated and relapsed/refractory non-Hodgkin lymphoma

(2014) K. Maddocks et al.   BLOOD

SIRT6 Promotes COX-2 Expression and Acts as an Oncogene in Skin Cancer

(2014) M. Ming et al.   CANCER RESEARCH

Partitioning Circadian Transcription by SIRT6 Leads to Segregated Control of Cellular Metabolism

(2014) Selma Masri et al.   CELL

Discovery of Novel and Selective SIRT6 Inhibitors

(2014) Marco Daniele Parenti et al.   JOURNAL OF MEDICINAL CHEMISTRY

MDM2-mediated degradation of SIRT6 phosphorylated by AKT1 promotes tumorigenesis and trastuzumab resistance in breast cancer

(2014) U. Thirumurthi et al.   Science Signaling

Chromatin and beyond: the multitasking roles for SIRT6

(2014) Sita Kugel et al.   TRENDS IN BIOCHEMICAL SCIENCES

SYK Inhibition Modulates Distinct PI3K/AKT- Dependent Survival Pathways and Cholesterol Biosynthesis in Diffuse Large B Cell Lymphomas

(2013) Linfeng Chen et al.   CANCER CELL

Sirtuin-6-dependent genetic and epigenetic alterations are associated with poor clinical outcome in hepatocellular carcinoma patients

(2013) Jens U. Marquardt et al.   HEPATOLOGY

Genome-wide analysis of FOXO3 mediated transcription regulation through RNA polymerase II profiling

(2013) A. Eijkelenboom et al.   Molecular Systems Biology

Diffuse large B-cell lymphoma—treatment approaches in the molecular era

(2013) Mark Roschewski et al.   Nature Reviews Clinical Oncology

Genetic heterogeneity of diffuse large B-cell lymphoma

(2013) Jenny Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

PTEN loss defines a PI3K/AKT pathway-dependent germinal center subtype of diffuse large B-cell lymphoma

(2013) M. Pfeifer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

USP10 Antagonizes c-Myc Transcriptional Activation through SIRT6 Stabilization to Suppress Tumor Formation

(2013) Zhenghong Lin et al.   Cell Reports

Inhibition of SIRT6 in prostate cancer reduces cell viability and increases sensitivity to chemotherapeutics

(2013) Yewei Liu et al.   Protein & Cell

The Histone Deacetylase SIRT6 Is a Tumor Suppressor that Controls Cancer Metabolism

(2012) Carlos Sebastián et al.   CELL

A self-reinforcing regulatory network triggered by limiting IL-7 activates pre-BCR signaling and differentiation

(2012) Kyoko Ochiai et al.   NATURE IMMUNOLOGY

Anti-CD20 Antibody Therapy for B-Cell Lymphomas

(2012) David G. Maloney   NEW ENGLAND JOURNAL OF MEDICINE

FoxO transcription factors; Regulation by AKT and 14-3-3 proteins

(2011) Guri Tzivion et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

PI3K  inhibitor, GS-1101 (CAL-101), attenuates pathway signaling, induces apoptosis, and overcomes signals from the microenvironment in cellular models of Hodgkin lymphoma

(2011) S. A. Meadows et al.   BLOOD

SIRT6 Promotes DNA Repair Under Stress by Activating PARP1

(2011) Z. Mao et al.   SCIENCE

Chromatin regulation and genome maintenance by mammalian SIRT6

(2010) Ruth I. Tennen et al.   TRENDS IN BIOCHEMICAL SCIENCES

Recent progress in the biology and physiology of sirtuins

(2009) Toren Finkel et al.   NATURE

Checkpoint Kinase 1 Down-Regulation by an Inducible Small Interfering RNA Expression System Sensitized In vivo Tumors to Treatment with 5-Fluorouracil

(2008) M. Ganzinelli et al.   CLINICAL CANCER RESEARCH