Muscle Lipid Metabolism: Role of Lipid Droplets and Perilipins

Physiological Aging: Links Among Adipose Tissue Dysfunction, Diabetes, and Frailty

(2017) Michael B. Stout et al.   PHYSIOLOGY

Increases in skeletal muscle ATGL and its inhibitor G0S2 following 8 weeks of endurance training in metabolically different rat skeletal muscles

(2016) Patrick C. Turnbull et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

AMPK-dependent phosphorylation of lipid droplet protein PLIN2 triggers its degradation by CMA

(2016) Susmita Kaushik et al.   Autophagy

Lipid droplets, lipophagy, and beyond

(2016) Chao-Wen Wang   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Reactive oxygen species and calcium signals in skeletal muscle: A crosstalk involved in both normal signaling and disease

(2016) Alejandra Espinosa et al.   CELL CALCIUM

Decoration of intramyocellular lipid droplets with PLIN5 modulates fasting-induced insulin resistance and lipotoxicity in humans

(2016) Anne Gemmink et al.   DIABETOLOGIA

MECHANISMS IN ENDOCRINOLOGY: Skeletal muscle lipotoxicity in insulin resistance and type 2 diabetes: a causal mechanism or an innocent bystander?

(2016) Charlotte Brøns et al.   EUROPEAN JOURNAL OF ENDOCRINOLOGY

Lipid droplet dynamics in skeletal muscle

(2016) Madeleen Bosma   EXPERIMENTAL CELL RESEARCH

PPARα-ATGL pathway improves muscle mitochondrial metabolism: implication in aging

(2016) Dipsikha Biswas et al.   FASEB JOURNAL

Obesity Epidemiology Worldwide

(2016) Cassandra Arroyo-Johnson et al.   GASTROENTEROLOGY CLINICS OF NORTH AMERICA

A Role for Ceramides, but Not Sphingomyelins, as Antagonists of Insulin Signaling and Mitochondrial Metabolism in C2C12 Myotubes

(2016) Min Park et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mature lipid droplets are accessible to ER luminal proteins

(2016) Shirish Mishra et al.   JOURNAL OF CELL SCIENCE

Muscle wasting and aging: Experimental models, fatty infiltrations, and prevention

(2016) Thomas Brioche et al.   MOLECULAR ASPECTS OF MEDICINE

Exercise-stimulated glucose uptake — regulation and implications for glycaemic control

(2016) Lykke Sylow et al.   Nature Reviews Endocrinology

Adipose triglyceride lipase decrement affects skeletal muscle homeostasis during aging through FAs-PPARα-PGC-1α antioxidant response

(2016) Katia Aquilano et al.   Oncotarget

mTORC2 and AMPK differentially regulate muscle triglyceride content via Perilipin 3

(2016) Maximilian Kleinert et al.   Molecular Metabolism

Adipose tissue depot specific differences of PLIN protein content in endurance trained rats

(2016) Sofhia V. Ramos et al.   Adipocyte

Mitochondrial ROS regulate oxidative damage and mitophagy but not age-related muscle fiber atrophy

(2016) Giorgos K. Sakellariou et al.   Scientific Reports

Perilipin 5 fine-tunes lipid oxidation to metabolic demand and protects against lipotoxicity in skeletal muscle

(2016) Claire Laurens et al.   Scientific Reports

ATGL-mediated triglyceride turnover and the regulation of mitochondrial capacity in skeletal muscle

(2015) Ruth C. R. Meex et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Piecing together the puzzle of perilipin proteins and skeletal muscle lipolysis

(2015) Rebecca E.K. MacPherson et al.   Applied Physiology Nutrition and Metabolism

Lipidomic and proteomic analysis of Caenorhabditis elegans lipid droplets and identification of ACS-4 as a lipid droplet-associated protein

(2015) Tracy L. Vrablik et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Lipid droplet–organelle interactions: emerging roles in lipid metabolism

(2015) Antonio Daniel Barbosa et al.   CURRENT OPINION IN CELL BIOLOGY

Perilipin 5–Driven Lipid Droplet Accumulation in Skeletal Muscle Stimulates the Expression of Fibroblast Growth Factor 21

(2015) Lydia-Ann L.S. Harris et al.   DIABETES

Extremely rapid increase in fatty acid transport and intramyocellular lipid accumulation but markedly delayed insulin resistance after high fat feeding in rats

(2015) Arend Bonen et al.   DIABETOLOGIA

Muscle-Specific Deletion of Comparative Gene Identification-58 (CGI-58) Causes Muscle Steatosis but Improves Insulin Sensitivity in Male Mice

(2015) Ping Xie et al.   ENDOCRINOLOGY

Chanarin-Dorfman syndrome: Genotype-Phenotype Correlation

(2015) Banu Guzel Nur et al.   European Journal of Medical Genetics

Changes in mitochondrial perilipin 3 and perilipin 5 protein content in rat skeletal muscle following endurance training and acute stimulated contraction

(2015) S. V. Ramos et al.   EXPERIMENTAL PHYSIOLOGY

Fatty acid transport and transporters in muscle are critically regulated by Akt2

(2015) Swati S. Jain et al.   FEBS LETTERS

Perilipin 5 mediated lipid droplet remodelling revealed by coherent Raman imaging

(2015) Nils Billecke et al.   Integrative Biology

Perilipin 3 Differentially Regulates Skeletal Muscle Lipid Oxidation in Active, Sedentary, and Type 2 Diabetic Males

(2015) Jeffrey D. Covington et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Degradation of lipid droplet-associated proteins by chaperone-mediated autophagy facilitates lipolysis

(2015) Susmita Kaushik et al.   NATURE CELL BIOLOGY

Metabolic functions of FABPs—mechanisms and therapeutic implications

(2015) Gökhan S. Hotamisligil et al.   Nature Reviews Endocrinology

Myotubes from Severely Obese Type 2 Diabetic Subjects Accumulate Less Lipids and Show Higher Lipolytic Rate than Myotubes from Severely Obese Non-Diabetic Subjects

(2015) Siril S. Bakke et al.   PLoS One

Effects of acute lipid overload on skeletal muscle insulin resistance, metabolic flexibility, and mitochondrial performance

(2014) John J. Dubé et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

PLIN1 deficiency affects testicular gene expression at the meiotic stage in the first wave of spermatogenesis

(2014) Min Chen et al.   GENE

Exercise training decreases activation of the mitochondrial fission protein dynamin-related protein-1 in insulin-resistant human skeletal muscle

(2014) Ciaran E. Fealy et al.   JOURNAL OF APPLIED PHYSIOLOGY

Comparative Gene Identification-58 (CGI-58) Promotes Autophagy as a Putative Lysophosphatidylglycerol Acyltransferase

(2014) Jun Zhang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Autophagy involved in lipopolysaccharide-induced foam cell formation is mediated by adipose differentiation-related protein

(2014) Xuyang Feng et al.   Lipids in Health and Disease

Lipid droplet-associated proteins in high-fat fed mice with the effects of voluntary running and diet change

(2014) Rita Rinnankoski-Tuikka et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Insulin Stimulates Syntaxin4 SNARE Complex Assembly via a Novel Regulatory Mechanism

(2014) D. Kioumourtzoglou et al.   MOLECULAR AND CELLULAR BIOLOGY

Cellular Localization and Associations of the Major Lipolytic Proteins in Human Skeletal Muscle at Rest and during Exercise

(2014) Rachael R. Mason et al.   PLoS One

Insulin Receptor Signaling in Normal and Insulin-Resistant States

(2014) J. Boucher et al.   Cold Spring Harbor Perspectives in Biology

Skeletal muscle PLIN proteins, ATGL and CGI-58, interactions at rest and following stimulated contraction

(2013) Rebecca E. K. MacPherson et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

Overexpression of PLIN5 in skeletal muscle promotes oxidative gene expression and intramyocellular lipid content without compromising insulin sensitivity

(2013) M. Bosma et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Global estimates of diabetes prevalence for 2013 and projections for 2035

(2013) L. Guariguata et al.   DIABETES RESEARCH AND CLINICAL PRACTICE

Insulin-Dependent H2O2 Production Is Higher in Muscle Fibers of Mice Fed with a High-Fat Diet

(2013) Alejandra Espinosa et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Exercise, GLUT4, and Skeletal Muscle Glucose Uptake

(2013) Erik A. Richter et al.   PHYSIOLOGICAL REVIEWS

Increased Plin2 Expression in Human Skeletal Muscle Is Associated with Sarcopenia and Muscle Weakness

(2013) Maria Conte et al.   PLoS One

Plin2 Inhibits Cellular Glucose Uptake through Interactions with SNAP23, a SNARE Complex Protein

(2013) Subramanian Senthivinayagam et al.   PLoS One

Perilipin 2 Improves Insulin Sensitivity in Skeletal Muscle Despite Elevated Intramuscular Lipid Levels

(2012) M. Bosma et al.   DIABETES

A Dual Mechanism of Action for Skeletal Muscle FAT/CD36 During Exercise

(2012) Brennan K. Smith et al.   EXERCISE AND SPORT SCIENCES REVIEWS

In Vivo, Fatty Acid Translocase (CD36) Critically Regulates Skeletal Muscle Fuel Selection, Exercise Performance, and Training-induced Adaptation of Fatty Acid Oxidation

(2012) Jay T. McFarlan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Perilipin 5, a Lipid Droplet-binding Protein, Protects Heart from Oxidative Burden by Sequestering Fatty Acid from Excessive Oxidation

(2012) Kenta Kuramoto et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Perilipin family members preferentially sequester to either triacylglycerol-specific or cholesteryl-ester-specific intracellular lipid storage droplets

(2012) Kai Hsieh et al.   JOURNAL OF CELL SCIENCE

Regulation of skeletal muscle lipolysis and oxidative metabolism by the co-lipase CGI-58

(2012) Pierre-Marie Badin et al.   JOURNAL OF LIPID RESEARCH

Insulin and contraction-induced movement of fatty acid transport proteins to skeletal muscle transverse-tubules is distinctly different than to the sarcolemma

(2012) Leslie E. Stefanyk et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Subcellular localization of skeletal muscle lipid droplets and PLIN family proteins OXPAT and ADRP at rest and following contraction in rat soleus muscle

(2011) Rebecca E. K. MacPherson et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

Fatty acid transport proteins, implications in physiology and disease

(2011) Melissa Kazantzis et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Skeletal Muscle Triglycerides, Diacylglycerols, and Ceramides in Insulin Resistance: Another Paradox in Endurance-Trained Athletes?

(2011) F. Amati et al.   DIABETES

Increasing skeletal muscle fatty acid transport protein 1 (FATP1) targets fatty acids to oxidation and does not predispose mice to diet-induced insulin resistance

(2011) G. P. Holloway et al.   DIABETOLOGIA

Contraction-induced skeletal muscle FAT/CD36 trafficking and FA uptake is AMPK independent

(2011) J. Jeppesen et al.   JOURNAL OF LIPID RESEARCH

IP3-dependent, post-tetanic calcium transients induced by electrostimulation of adult skeletal muscle fibers

(2010) Mariana Casas et al.   JOURNAL OF GENERAL PHYSIOLOGY

Free fatty acid-induced muscle insulin resistance and glucose uptake dysfunction: Evidence for PKC activation and oxidative stress-activated signaling pathways

(2009) Rafik Ragheb et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

PAT proteins, an ancient family of lipid droplet proteins that regulate cellular lipid stores

(2009) Perry E. Bickel et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

The incidence of co-morbidities related to obesity and overweight: A systematic review and meta-analysis

(2009) Daphne P Guh et al.   BMC PUBLIC HEALTH

Autophagy Is Required to Maintain Muscle Mass

(2009) Eva Masiero et al.   Cell Metabolism

Higher intramuscular triacylglycerol in women does not impair insulin sensitivity and proximal insulin signaling

(2009) Louise Høeg et al.   JOURNAL OF APPLIED PHYSIOLOGY

Adipocyte Differentiation-Related Protein and OXPAT in Rat and Human Skeletal Muscle: Involvement in Lipid Accumulation and Type 2 Diabetes Mellitus

(2009) Ronnie Minnaard et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Relationship between plasma free fatty acid, intramyocellular triglycerides and long-chain acylcarnitines in resting humans

(2009) Jill A. Kanaley et al.   JOURNAL OF PHYSIOLOGY-LONDON

Autophagy regulates lipid metabolism

(2009) Rajat Singh et al.   NATURE

Exercise-induced alterations in intramyocellular lipids and insulin resistance: the athlete's paradox revisited

(2008) John J. Dubé et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Ca2+ and insulin-mediated glucose uptake

(2008) J LANNER et al.   CURRENT OPINION IN PHARMACOLOGY

Adipose triglyceride lipase and the lipolytic catabolism of cellular fat stores

(2008) Rudolf Zechner et al.   JOURNAL OF LIPID RESEARCH