Article
Biology
Anton Malkov, Irina Popova, Anton Ivanov, Sung-Soo Jang, Seo Yeon Yoon, Alexander Osypov, Yadong Huang, Yuri Zilberter, Misha Zilberter
Summary: The activation of NADPH oxidase 2 (NOX2) is identified as the primary mechanism behind A beta(1-42)-related glucose hypometabolism and network dysfunction. Inhibiting NOX2 may prevent the pathological changes associated with AD-related brain glucose hypometabolism.
COMMUNICATIONS BIOLOGY
(2021)
Article
Materials Science, Biomaterials
Mousumi Baruah, Anal Jana, Mudassar Ali, Koyeli Mapa, Animesh Samanta
Summary: The innate immune system eliminates pathogens through phagocytosis and the production of reactive oxygen species (ROS), such as the pro-inflammatory oxidant hypochlorous acid (HOCl). This study developed a pentacyclic pyridinium probe, PM-S, to efficiently detect HOCl in the Nox2 pathway. The probe showed advantages in terms of stability, sensitivity, and specificity to mitochondria, providing a novel platform for monitoring the inflammatory process.
JOURNAL OF MATERIALS CHEMISTRY B
(2022)
Article
Multidisciplinary Sciences
Leroy C. Joseph, Michael Reyes, Edwin A. Homan, Blake Gowen, Uma Mahesh R. Avula, Chris N. Goulbourne, Elaine Y. Wan, John W. Elrod, John P. Morrow
Summary: The study reveals that high fat diet-induced mitochondrial dysfunction contributes to arrhythmia through alterations in mechanisms, and suggests that MCU and CaMKII could be therapeutic targets for arrhythmia caused by metabolic abnormalities.
SCIENTIFIC REPORTS
(2021)
Article
Nutrition & Dietetics
Kotoko Arisawa, Miyuki Kaneko, Ayumi Matsuoka, Natsuki Ozawa, Rie Kawawa, Tomoko Ishikawa, Ikuyo Ichi, Yoko Fujiwara
Summary: Postmenopausal women are more susceptible to obesity and chronic disease. Piceatannol (PIC), a natural analog of resveratrol, can inhibit adipogenesis and have an antiobesity effect. This study investigated the effect of PIC on postmenopausal obesity and its mechanism, showing that PIC can decrease visceral fat volume in ovary-removed mice and promote lipolysis in white adipose tissue (WAT) while inducing the expression of uncoupled protein 1 in brown adipose tissue (BAT).
Article
Multidisciplinary Sciences
Seon Kyeong Park, Hyo Lim Lee, Jin Yong Kang, Jong Min Kim, Ho Jin Heo
Summary: This study demonstrates that the ethyl acetate fraction from peanut sprout (EFPS) can improve cognitive functions in high-fat diet-induced diabetic mice, while also improving glucose tolerance, serum lipid profile, reducing body weight, alleviating oxidative stress and restoring brain mitochondrial dysfunction.
SCIENTIFIC REPORTS
(2022)
Review
Food Science & Technology
Ruth C. R. Meex, Ellen E. Blaak
Summary: NAFLD, the most common liver disease, is associated with diet, fatty acid intake, and mitochondrial dysfunction. SFA plays a crucial role in the development and progression of NAFLD, leading to inflammation and liver damage.
MOLECULAR NUTRITION & FOOD RESEARCH
(2021)
Article
Medicine, Research & Experimental
Arianna Fozzato, Lauryn E. New, Joanne C. Griffiths, Bianca Patel, Susan A. Deuchars, Beatrice M. Filippi
Summary: The dysregulation of mitochondrial dynamics in the NTS is associated with altered brown adipose tissue (BAT) activity and metabolic disorders. Inhibiting mitochondrial fragmentation in NTS astrocytes can partially restore BAT glucose uptake, reduce insulin resistance, and protect against obesity and diabetes.
Article
Biochemistry & Molecular Biology
Yurou Cao, Shiyi He, Meng Ding, Wenzhi Gu, Tongquan Wang, Shihu Zhang, Jiadong Feng, Qiufang Li, Lan Zheng
Summary: Skuld (skd) is a subunit of the Mediator complex subunit complex and plays a role in systemic energy metabolism and cardiac function. Knockdown of cardiac-specific skd leads to impaired cardiac function, metabolic impairment, and premature aging. Regular exercise improves cardiac function, metabolism, and delays aging in hearts with reduced skd expression and high-fat diet. Skd may be a potential therapeutic target for heart disease.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Nutrition & Dietetics
Mon-Chien Lee, Yi-Ju Hsu, Hsin-Ching Sung, Ya-Ting Wen, Li Wei, Chi-Chang Huang
Summary: Women during pregnancy and the postpartum period, especially those with excessive caloric intake, have a higher risk of obesity and metabolic diseases. This study found that mice with low-fitness phenotype were more likely to develop metabolic abnormalities and obesity after dietary induction following delivery, while mice with high-fitness phenotype had a protective mechanism.
Article
Cell Biology
Fei Niu, Bin Zhang, Jie Feng, Xiang Mao, Xiao-Jian Xu, Jin-Qian Dong, Bai-Yun Liu
Summary: In a rat model of traumatic brain injury, treatment with dexamethasone led to significant changes in the expression of various proteins related to mitochondrial dysfunction and synaptogenesis signaling pathway. This suggests that dexamethasone may have an impact on nerve injury after traumatic brain injury treatment.
NEURAL REGENERATION RESEARCH
(2021)
Article
Cardiac & Cardiovascular Systems
Aoxue Li, Ningning Zheng, Xudong Ding
Summary: Metabolic syndrome is a collection of cardiovascular risk factors, and oxidative stress plays a crucial role in it; oxidative stress can disrupt cardiac function through various pathways, leading to heart diseases and apoptosis of cardiomyocytes.
HEART FAILURE REVIEWS
(2022)
Article
Multidisciplinary Sciences
Shaakir Salam, Sara Tacconelli, Bradley N. Smith, Jacqueline C. Mitchell, Elizabeth Glennon, Nikolas Nikolaou, Corinne Houart, Caroline Vance
Summary: The research found that FUS plays a crucial role in regulating synaptic and mitochondrial function, indicating its importance in maintaining neuronal health. Overexpressing mutant FUS leads to changes in synaptic and neuronal structure. Additionally, the study showed interactions between FUS and the mitochondrial tethering protein Syntaphilin (SNPH), with mutations in FUS affecting this relationship.
SCIENTIFIC REPORTS
(2021)
Article
Biochemistry & Molecular Biology
Dong Yue, Chaorong Zeng, Samuel Kumi Okyere, Zhengli Chen, Yanchun Hu
Summary: The study investigated the protective effects of glycine nano-selenium on neurobehavioral abnormalities and oxidative stress in PD rats induced by MPTP. Results showed that MPTP induced neurobehavioral abnormalities and oxidative stress in rats, while glycine nano-selenium administration improved behavior, increased TH+ neurons, and reduced oxidative stress levels. This suggests that glycine nano-selenium could be a potential treatment for PD by reducing oxidative stress in the brain.
JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Qian Chai, Jiajing Miao, Meili Liu, Ziying Zhang, Ziang Meng, Weihua Wu
Summary: Knockdown of SGLT1 restores cell proliferation and suppresses cytotoxicity in cardiomyocytes exposed to fluctuating glucose levels, reversing oxidative stress and combating mitochondrial dysfunction to ameliorate apoptosis of the cells.
BIOCHEMISTRY AND CELL BIOLOGY
(2021)
Article
Endocrinology & Metabolism
Nicolas Manzke Glanzel, Mateus Grings, Nevton Teixeira da Rosa-Junior, Leila Maria Cereta de Carvalho, Al-Walid Mohsen, Peter Wipf, Moacir Wajner, Jerry Vockley, Guilhian Leipnitz
Summary: Sulfite oxidase (SO) deficiency causes tissue sulfite accumulation and patients present with seizures and neurological damage. Treatment is mainly supportive. Study shows that treatment with JP4-039 can prevent or attenuate oxidative stress and apoptosis induced by sulfite injection.
JOURNAL OF INHERITED METABOLIC DISEASE
(2021)
Article
Medicine, Research & Experimental
Marcello Ziosi, Ivano Di Meo, Giulio Kleiner, Xing-Huang Gao, Emanuele Barca, Maria J. Sanchez-Quintero, Saba Tadesse, Hongfeng Jiang, Changhong Qiao, Richard J. Rodenburg, Emmanuel Scalais, Markus Schuelke, Belinda Willard, Maria Hatzoglou, Valeria Tiranti, Catarina M. Quinzii
EMBO MOLECULAR MEDICINE
(2017)
Article
Pharmacology & Pharmacy
Giulia M. Camerino, Olimpia Musumeci, Elena Conte, Kejla Musaraj, Adriano Fonzino, Emanuele Barca, Marco Marino, Carmelo Rodolico, Domenico Tricarico, Claudia Camerino, Maria R. Carratu, Jean-Francois Desaphy, Annamaria De Luca, Antonio Toscano, Sabata Pierno
FRONTIERS IN PHARMACOLOGY
(2017)
Article
Biochemistry & Molecular Biology
Giulio Kleiner, Emanuele Barca, Marcello Ziosi, Valentina Emmanuele, Yimeng Xu, Agustin Hidalgo-Gutierrez, Changhong Qiao, Saba Tadesse, Estela Area-Gomez, Luis C. Lopez, Catarina M. Quinzii
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2018)
Review
Neurosciences
Emanuele Barca, Valentina Emmanuele, Salvatore DiMauro, Antonio Toscano, Catarina M. Quinzii
CURRENT NEUROPHARMACOLOGY
(2019)
Article
Clinical Neurology
Olimpia Musumeci, Emanuele Barca, Costanza Lamperti, Serenella Servidei, Giacomo Pietro Comi, Maurizio Moggio, Tiziana Mongini, Gabriele Siciliano, Massimiliano Filosto, Elena Pegoraro, Guido Primiano, Dario Ronchi, Liliana Vercelli, Daniele Orsucci, Luca Bello, Massimo Zeviani, Michelangelo Mancuso, Antonio Toscano
FRONTIERS IN NEUROLOGY
(2019)
Article
Genetics & Heredity
Tatyana N. Tarasenko, Maxim Jestin, Shingo Matsumoto, Keita Saito, Sean Hwang, Oksana Gavrilova, Niraj Trivedi, Patricia M. Zerfas, Emanuele Barca, Salvatore DiMauro, Julien Senac, Charles P. Venditti, Murali Cherukuri, Peter J. McGuire
JOURNAL OF MOLECULAR MEDICINE-JMM
(2019)
Review
Clinical Neurology
Serena Galosi, Emanuele Barca, Rosalba Carrozzo, Tommaso Schirinzi, Catarina Maria Quinzii, Maria Lieto, Gessica Vasco, Ginevra Zanni, Michela Di Nottia, Daniele Galatolo, Alessandro Filla, Enrico Bertini, Filippo Maria Santorelli, Vincenzo Leuzzi, Richard Haas, Michio Hirano, Jennifer Friedman
PARKINSONISM & RELATED DISORDERS
(2019)
Review
Endocrinology & Metabolism
Michio Hirano, Andres Berardo, Emanuele Barca, Valentina Emmanuele, Catarina Quinzii, Camilla Simpson, Kristin Engelstad, Xiomara Q. Rosales, John L. P. Thompson
Summary: There is currently a lack of approved therapies for mitochondrial diseases in many parts of the world, highlighting the need for collaboration between clinicians, drug developers, and regulatory agencies. Efforts are being made to educate and work together to meet the regulatory requirements for novel therapies, with a focus on clinical trials and the development of outcome measures and endpoints for clinical benefit.
JOURNAL OF INHERITED METABOLIC DISEASE
(2021)
Article
Endocrinology & Metabolism
Valentina Emmanuele, Jaya Ganesh, Georgirene Vladutiu, Richard Haas, Douglas Kerr, Russell P. Saneto, Bruce H. Cohen, Johan L. K. Van Hove, Fernando Scaglia, Charles Hoppel, Xiomara Q. Rosales, Emanuele Barca, Richard Buchsbaumm, John L. Thompson, Salvatore DiMauro, Michio Hirano
Summary: The objective of this study is to harmonize terminology in mitochondrial medicine by proposing revised clinical criteria for primary mitochondrial syndromes. The North American Mitochondrial Disease Consortium (NAMDC) established a Diagnostic Criteria Committee comprised of experts from various fields to reach a consensus on mitochondrial disease definitions. The revised criteria are expected to standardize the diagnosis and categorization of mitochondrial diseases.
MOLECULAR GENETICS AND METABOLISM
(2022)
Article
Surgery
Ruth Link-Gelles, Emily Lutterloh, Patricia Schnabel Ruppert, P. Bryon Backenson, kirsten St George, Eli S. Rosenberg, Bridget J. Anderson, Meghan Fuschino, Michael Popowich, Chitra Punjabi, Maria Souto, Kevin McKay, Samuel Rulli, Tabassum Insaf, Dustin Hill, Jessica Kumar, Irina Gelman, Jaume Jorba, Terry Fei Fan Ng, Nancy Gerloff, Nina B. Masters, Adriana Lopez, Kathleen Dooling, Shannon Stokley, Sarah Kidd, M. Steven Oberste, Janell Routh
AMERICAN JOURNAL OF TRANSPLANTATION
(2022)
Article
Public, Environmental & Occupational Health
Ruth Link-Gelles, Emily Lutterloh, Patricia Schnabel Ruppert, P. Bryon Backenson, Kirsten St George, Eli S. Rosenberg, Bridget J. Anderson, Meghan Fuschino, Michael Popowich, Chitra Punjabi, Maria Souto, Kevin McKay, Samuel Rulli, Tabassum Insaf, Dustin Hill, Jessica Kumar, Irina Gelman, Jaume Jorba, Terry Fei Fan Ng, Nancy Gerloff, Nina B. Masters, Adriana Lopez, Kathleen Dooling, Shannon Stokley, Sarah Kidd, M. Steven Oberste, Janell Routh
MMWR-MORBIDITY AND MORTALITY WEEKLY REPORT
(2022)
Article
Multidisciplinary Sciences
Stephanie E. Siegmund, Robert Grassucci, Stephen D. Carter, Emanuele Barca, Zachary J. Farino, Marti Juanola-Falgarona, Peijun Zhang, Kurenai Tanji, Michio Hirano, Eric A. Schon, Joachim Frank, Zachary Freyberg
Review
Clinical Neurology
Antonio Toscano, Emanuele Barca, Olimpia Musumeci
CURRENT OPINION IN NEUROLOGY
(2017)
Article
Cell Biology
Tatyana N. Tarasenko, Susan E. Pacheco, Mary Kay Koenig, Julio Gomez-Rodriguez, Senta M. Kapnick, Francisca Diaz, Patricia M. Zerfas, Emanuele Barca, Jessica Sudderth, Ralph J. DeBerardinis, Raul Covian, Robert S. Balaban, Salvatore DiMauro, Peter J. McGuire
Article
Clinical Neurology
Carlos Lopez-Gomez, Rebecca J. Levy, Maria J. Sanchez-Quintero, Marti Juanola-Falgarona, Emanuele Barca, Beatriz Garcia-Diaz, Saba Tadesse, Caterina Garone, Michio Hirano
ANNALS OF NEUROLOGY
(2017)