Chronic glucolipotoxic conditions in pancreatic islets impair insulin secretion due to dysregulated calcium dynamics, glucose responsiveness and mitochondrial activity

High-dose clevudine impairs mitochondrial function and glucose-stimulated insulin secretion in INS-1E cells

(2012) Yoon-Ok Jang et al.   BMC GASTROENTEROLOGY

Glucose and Fatty Acids Synergize to Promote B-Cell Apoptosis through Activation of Glycogen Synthase Kinase 3β Independent of JNK Activation

(2011) Katsuya Tanabe et al.   PLoS One

Adenylyl cyclase 8 is central to glucagon-like peptide 1 signalling and effects of chronically elevated glucose in rat and human pancreatic beta cells

(2010) B. Roger et al.   DIABETOLOGIA

Glucolipotoxicity Alters Lipid Partitioning and Causes Mitochondrial Dysfunction, Cholesterol, and Ceramide Deposition and Reactive Oxygen Species Production in INS832/13 ß-Cells

(2010) Wissal El-Assaad et al.   ENDOCRINOLOGY

Effects of palmitate on ER and cytosolic Ca2+ homeostasis in β-cells

(2009) Kamila S. Gwiazda et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

From the Triumvirate to the Ominous Octet: A New Paradigm for the Treatment of Type 2 Diabetes Mellitus

(2009) R. A. DeFronzo   DIABETES

Mechanisms of biphasic insulin-granule exocytosis - roles of the cytoskeleton, small GTPases and SNARE proteins

(2009) Z. Wang et al.   JOURNAL OF CELL SCIENCE

Reduction of islet pyruvate carboxylase activity might be related to the development of type 2 diabetes mellitus in Agouti-K mice

(2009) J Han et al.   JOURNAL OF ENDOCRINOLOGY

Glucolipotoxicity of the pancreatic β-cell: myth or reality?

(2008) Vincent Poitout   BIOCHEMICAL SOCIETY TRANSACTIONS

Glucose-Induced Cyclic AMP Oscillations Regulate Pulsatile Insulin Secretion

(2008) Oleg Dyachok et al.   Cell Metabolism

Rosiglitazone counteracts palmitate-induced β-cell dysfunction by suppression of MAP kinase, inducible nitric oxide synthase and caspase 3 activities

(2008) S. Meidute Abaraviciene et al.   CELLULAR AND MOLECULAR LIFE SCIENCES