Saturated fatty acids activate TLR-mediated proinflammatory signaling pathways

Lipoteichoic Acid Induces HO-1 Expression via the TLR2/MyD88/c-Src/NADPH Oxidase Pathway and Nrf2 in Human Tracheal Smooth Muscle Cells

(2014) I.-T. Lee et al.   JOURNAL OF IMMUNOLOGY

Inflammation and Lipid Signaling in the Etiology of Insulin Resistance

(2012) Christopher K. Glass et al.   Cell Metabolism

Mitochondrial ROS production under cellular stress: comparison of different detection methods

(2011) Andrey V. Kuznetsov et al.   ANALYTICAL AND BIOANALYTICAL CHEMISTRY

Structural Biology of the Toll-Like Receptor Family

(2011) Jin Young Kang et al.   Annual Review of Biochemistry

Lipid-induced insulin resistance mediated by the proinflammatory receptor TLR4 requires saturated fatty acid–induced ceramide biosynthesis in mice

(2011) William L. Holland et al.   JOURNAL OF CLINICAL INVESTIGATION

Inhibition of pattern recognition receptor-mediated inflammation by bioactive phytochemicals

(2011) Ling Zhao et al.   NUTRITION REVIEWS

Toll-like receptor 2-deficient mice are protected from insulin resistance and beta cell dysfunction induced by a high-fat diet

(2010) J. A. Ehses et al.   DIABETOLOGIA

Absence of Tlr2 protects against high-fat diet-induced inflammation and results in greater insulin-stimulated glucose transport in cultured adipocytes

(2010) Jeremy E. Davis et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

The NLRP3 Inflammasome: A Sensor for Metabolic Danger?

(2010) K. Schroder et al.   SCIENCE

Saturated Fatty Acids Do Not Directly Stimulate Toll-Like Receptor Signaling

(2009) Clett Erridge et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

MyD88 Signaling in the CNS Is Required for Development of Fatty Acid-Induced Leptin Resistance and Diet-Induced Obesity

(2009) André Kleinridders et al.   Cell Metabolism

Tlr2 is critical for diet-induced metabolic syndrome in a murine model

(2009) Ryan W. Himes et al.   FASEB JOURNAL

Fatty Acids Modulate Toll-like Receptor 4 Activation through Regulation of Receptor Dimerization and Recruitment into Lipid Rafts in a Reactive Oxygen Species-dependent Manner

(2009) Scott W. Wong et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

NADPH Oxidase 2 Interaction with TLR2 Is Required for Efficient Innate Immune Responses to Mycobacteria via Cathelicidin Expression

(2009) C.-S. Yang et al.   JOURNAL OF IMMUNOLOGY

The structural basis of lipopolysaccharide recognition by the TLR4–MD-2 complex

(2009) Beom Seok Park et al.   NATURE

Modulation of pattern recognition receptor-mediated inflammation and risk of chronic diseases by dietary fatty acids

(2009) Joo Y Lee et al.   NUTRITION REVIEWS

Silica crystals and aluminum salts activate the NALP3 inflammasome through phagosomal destabilization

(2008) Veit Hornung et al.   NATURE IMMUNOLOGY

Tlr-4 Deficiency Selectively Protects Against Obesity Induced by Diets High in Saturated Fat

(2008) Jeremy E. Davis et al.   Obesity