Augmentation of Glucotoxicity, Oxidative Stress, Apoptosis and Mitochondrial Dysfunction in HepG2 Cells by Palmitic Acid
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Title
Augmentation of Glucotoxicity, Oxidative Stress, Apoptosis and Mitochondrial Dysfunction in HepG2 Cells by Palmitic Acid
Authors
Keywords
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Journal
Nutrients
Volume 11, Issue 9, Pages 1979
Publisher
MDPI AG
Online
2019-08-23
DOI
10.3390/nu11091979
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- (2008) Miriam Cnop BIOCHEMICAL SOCIETY TRANSACTIONS
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