Perilipin 5 Reduces Oxidative Damage Associated With Lipotoxicity by Activating the PI3K/ERK-Mediated Nrf2-ARE Signaling Pathway in INS-1 Pancreatic β-Cells
Published 2020 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
Perilipin 5 Reduces Oxidative Damage Associated With Lipotoxicity by Activating the PI3K/ERK-Mediated Nrf2-ARE Signaling Pathway in INS-1 Pancreatic β-Cells
Authors
Keywords
-
Journal
Frontiers in Endocrinology
Volume 11, Issue -, Pages -
Publisher
Frontiers Media SA
Online
2020-03-31
DOI
10.3389/fendo.2020.00166
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- Perilipin 5 Deletion in Hepatocytes Remodels Lipid Metabolism and Causes Hepatic Insulin Resistance in Mice
- (2019) Stacey N. Keenan et al. DIABETES
- Palmitate decreases migration and proliferation and increases oxidative stress and inflammation in smooth muscle cells. Role of the Nrf2 signaling pathway
- (2019) Josefa Girona et al. AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
- Connecting pancreatic islet lipid metabolism with insulin secretion and the development of type 2 diabetes
- (2019) Yumi Imai et al. Annals of the New York Academy of Sciences
- Perilipin 5 deficiency promotes atherosclerosis progression through accelerating inflammation, apoptosis, and oxidative stress
- (2019) Peng‐Li Zhou et al. JOURNAL OF CELLULAR BIOCHEMISTRY
- Perilipin5 protects against lipotoxicity and alleviates endoplasmic reticulum stress in pancreatic β-cells
- (2019) Yunxia Zhu et al. Nutrition & Metabolism
- Oleic acid-induced perilipin 5 expression and lipid droplets formation are regulated by the PI3K/PPARα pathway in HepG2 cells
- (2019) Wenxia Zhong et al. Applied Physiology Nutrition and Metabolism
- Plin5 deficiency exacerbates pressure overload-induced cardiac hypertrophy and heart failure by enhancing myocardial fatty acid oxidation and oxidative stress
- (2019) Chao Wang et al. FREE RADICAL BIOLOGY AND MEDICINE
- Perilipin 5 Protects against Cellular Oxidative Stress by Enhancing Mitochondrial Function in HepG2 Cells
- (2019) Tan et al. Cells
- Lipid droplet proteins and metabolic diseases
- (2018) Shimeng Xu et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
- Mitochondria Bound to Lipid Droplets Have Unique Bioenergetics, Composition, and Dynamics that Support Lipid Droplet Expansion
- (2018) Ilan Y. Benador et al. Cell Metabolism
- Perilipin 5 Deletion Unmasks an Endoplasmic Reticulum Stress–Fibroblast Growth Factor 21 Axis in Skeletal Muscle
- (2018) Magdalene K. Montgomery et al. DIABETES
- Phosphoinositide 3-Kinase/Akt Signaling and Redox Metabolism in Cancer
- (2018) Nikos Koundouros et al. Frontiers in Oncology
- Deficiency in perilipin 5 reduces mitochondrial function and membrane depolarization in mouse hearts
- (2017) Linda Andersson et al. INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
- The lipid droplet: A conserved cellular organelle
- (2017) Congyan Zhang et al. Protein & Cell
- Plin5 alleviates myocardial ischaemia/reperfusion injury by reducing oxidative stress through inhibiting the lipolysis of lipid droplets
- (2017) Pengfei Zheng et al. Scientific Reports
- Thrombospondin 1 protects pancreatic β-cells from lipotoxicity via the PERK–NRF2 pathway
- (2016) Daniel A Cunha et al. CELL DEATH AND DIFFERENTIATION
- Perilipin 5 restores the formation of lipid droplets in activated hepatic stellate cells and inhibits their activation
- (2016) Jianguo Lin et al. LABORATORY INVESTIGATION
- Nuclear Perilipin 5 integrates lipid droplet lipolysis with PGC-1α/SIRT1-dependent transcriptional regulation of mitochondrial function
- (2016) Violeta I. Gallardo-Montejano et al. Nature Communications
- Perilipin 5 fine-tunes lipid oxidation to metabolic demand and protects against lipotoxicity in skeletal muscle
- (2016) Claire Laurens et al. Scientific Reports
- The Keap1–Nrf2 system and diabetes mellitus
- (2015) Akira Uruno et al. ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
- Perilipin 5 improves hepatic lipotoxicity by inhibiting lipolysis
- (2015) Chao Wang et al. HEPATOLOGY
- Perilipin 5 Regulates Islet Lipid Metabolism and Insulin Secretion in a cAMP-Dependent Manner: Implication of Its Role in the Postprandial Insulin Secretion
- (2014) Michelle B. Trevino et al. DIABETES
- Skeletal muscle PLIN proteins, ATGL and CGI-58, interactions at rest and following stimulated contraction
- (2013) Rebecca E. K. MacPherson et al. AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY
- Growth receptor binding protein 10 inhibits glucose-stimulated insulin release from pancreatic β-cells associated with suppression of the insulin/insulin-like growth factor-1 signalling pathway
- (2013) Ling Li et al. CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY
- Nrf2 Protects Pancreatic -Cells From Oxidative and Nitrosative Stress in Diabetic Model Mice
- (2013) Y. Yagishita et al. DIABETES
- Linking Metabolic Abnormalities to Apoptotic Pathways in Beta Cells in Type 2 Diabetes
- (2013) Jibran Wali et al. Cells
- Perilipin 5, a Lipid Droplet-binding Protein, Protects Heart from Oxidative Burden by Sequestering Fatty Acid from Excessive Oxidation
- (2012) Kenta Kuramoto et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Redox Homeostasis in Pancreatic Cells
- (2012) Petr Ježek et al. Oxidative Medicine and Cellular Longevity
- Reactive Oxygen Species Stimulate Insulin Secretion in Rat Pancreatic Islets: Studies Using Mono-Oleoyl-Glycerol
- (2012) Marylana Saadeh et al. PLoS One
- The lipid droplet coat protein perilipin 5 also localizes to muscle mitochondria
- (2011) Madeleen Bosma et al. HISTOCHEMISTRY AND CELL BIOLOGY
- Unique Regulation of Adipose Triglyceride Lipase (ATGL) by Perilipin 5, a Lipid Droplet-associated Protein
- (2011) Hong Wang et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Perilipin 5, a lipid droplet-associated protein, provides physical and metabolic linkage to mitochondria
- (2011) Hong Wang et al. JOURNAL OF LIPID RESEARCH
- ROS Acts as a Double-Edged Sword in the Pathogenesis of Type 2 Diabetes Mellitus: Is Nrf2 a Potential Target for the Treatment?
- (2011) X. Wang et al. MINI-REVIEWS IN MEDICINAL CHEMISTRY
- Lipid-induced pancreatic β-cell dysfunction: focus on in vivo studies
- (2010) Adria Giacca et al. AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
- Mitogen-Activated Protein Kinases in Mammalian Oxidative Stress Responses
- (2010) Christopher Runchel et al. ANTIOXIDANTS & REDOX SIGNALING
- Hydrogen sulphide protects mouse pancreatic β-cells from cell death induced by oxidative stress, but not by endoplasmic reticulum stress
- (2010) S Taniguchi et al. BRITISH JOURNAL OF PHARMACOLOGY
- Interactions of Perilipin-5 (Plin5) with Adipose Triglyceride Lipase
- (2010) James G. Granneman et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Glucagon-Like Peptide-1 Agonists Protect Pancreatic β-Cells From Lipotoxic Endoplasmic Reticulum Stress Through Upregulation of BiP and JunB
- (2009) Daniel A. Cunha et al. DIABETES
- Perilipin Is Present in Islets of Langerhans and Protects against Lipotoxicity When Overexpressed in the β-Cell Line INS-1
- (2009) Jörgen Borg et al. ENDOCRINOLOGY
- Functional Interactions between Mldp (LSDP5) and Abhd5 in the Control of Intracellular Lipid Accumulation
- (2008) James G. Granneman et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Resveratrol induces glutathione synthesis by activation of Nrf2 and protects against cigarette smoke-mediated oxidative stress in human lung epithelial cells
- (2007) Aruna Kode et al. AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY
Find the ideal target journal for your manuscript
Explore over 38,000 international journals covering a vast array of academic fields.
SearchAsk a Question. Answer a Question.
Quickly pose questions to the entire community. Debate answers and get clarity on the most important issues facing researchers.
Get Started