Exendin-4 protects pancreatic beta cells from palmitate-induced apoptosis by interfering with GPR40 and the MKK4/7 stress kinase signalling pathway

Reevaluation of Fatty Acid Receptor 1 as a Drug Target for the Stimulation of Insulin Secretion in Humans

(2013) R. Wagner et al.   DIABETES

The incretin hormones: from scientific discovery to practical therapeutics

(2012) S. Mudaliar et al.   DIABETOLOGIA

Thiazolidinediones Induce Osteocyte Apoptosis by a G Protein-coupled Receptor 40-dependent Mechanism

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TAK-875 versus placebo or glimepiride in type 2 diabetes mellitus: a phase 2, randomised, double-blind, placebo-controlled trial

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Glucokinase activation repairs defective bioenergetics of islets of Langerhans isolated from type 2 diabetics

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Incretin Effects on  -Cell Function, Replication, and Mass: The human perspective

(2011) A. J. Garber   DIABETES CARE

Cell death-inducing DFF45-like effector b (Cideb) is present in pancreatic beta-cells and involved in palmitate induced beta-cell apoptosis

(2011) H. Li et al.   DIABETES-METABOLISM RESEARCH AND REVIEWS

Macrophage migration inhibitory factor deficiency protects pancreatic islets from palmitic acid-induced apoptosis

(2011) Tamara Saksida et al.   IMMUNOLOGY AND CELL BIOLOGY

Inhibition of GPR40 protects MIN6 β cells from palmitate-induced ER stress and apoptosis

(2011) Jinwei Wu et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Management of type 2 diabetes: new and future developments in treatment

(2011) Abd A Tahrani et al.   LANCET

Suppression of FoxO1/cell death-inducing DNA fragmentation factor α-like effector A (Cidea) axis protects mouse β-cells against palmitic acid-induced apoptosis

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Lipid-induced pancreatic β-cell dysfunction: focus on in vivo studies

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Causes and cures for endoplasmic reticulum stress in lipotoxic β-cell dysfunction

(2010) M. Cnop et al.   DIABETES OBESITY & METABOLISM

Exendin-4 Prevents c-Jun N-Terminal Protein Kinase Activation by Tumor Necrosis Factor-α (TNFα) and Inhibits TNFα-Induced Apoptosis in Insulin-Secreting Cells

(2010) Annalisa Natalicchio et al.   ENDOCRINOLOGY

Exendin-4 Protects Pancreatic Beta Cells from the Cytotoxic Effect of Rapamycin by Inhibiting JNK and p38 Phosphorylation

(2010) Y. Kawasaki et al.   HORMONE AND METABOLIC RESEARCH

Sterol regulatory element-binding protein-1c knockdown protected INS-1E cells from lipotoxicity

(2009) J. Li et al.   DIABETES OBESITY & METABOLISM

Autophagy in human type 2 diabetes pancreatic beta cells

(2009) M. Masini et al.   DIABETOLOGIA

Suppression of p38 MAPK and JNK via Akt-mediated Inhibition of Apoptosis Signal-regulating Kinase 1 Constitutes a Core Component of the β-Cell Pro-survival Effects of Glucose-dependent Insulinotropic Polypeptide

(2009) Scott B. Widenmaier et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A protocol for islet isolation from mouse pancreas

(2009) Dong-Sheng Li et al.   Nature Protocols

Exendin-4 Protects  -Cells From Interleukin-1 -Induced Apoptosis by Interfering With the c-Jun NH2-Terminal Kinase Pathway

(2008) M. Ferdaoussi et al.   DIABETES

Role of the transcriptional factor C/EBPβ in free fatty acid-elicited β-cell failure

(2008) Valérie Plaisance et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

An overview of pancreatic beta-cell defects in human type 2 diabetes: Implications for treatment

(2007) Piero Marchetti et al.   REGULATORY PEPTIDES