A low-complexity region in human XRN1 directly recruits deadenylation and decapping factors in 5′–3′ messenger RNA decay

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System-wide Profiling of RNA-Binding Proteins Uncovers Key Regulators of Virus Infection

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Reconstitution of recombinant human CCR4-NOT reveals molecular insights into regulated deadenylation

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Nanos genes and their role in development and beyond

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Tryptophan-Mediated Interactions between Tristetraprolin and the CNOT9 Subunit Are Required for CCR4-NOT Deadenylase Complex Recruitment

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mRNA Deadenylation Is Coupled to Translation Rates by the Differential Activities of Ccr4-Not Nucleases

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PABP Cooperates with the CCR4-NOT Complex to Promote mRNA Deadenylation and Block Precocious Decay

(2018) Hyerim Yi et al.   MOLECULAR CELL

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Structural and biochemical analysis of a NOT1 MIF4G-like domain of the CCR4-NOT complex

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Transcript Buffering: A Balancing Act between mRNA Synthesis and mRNA Degradation

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Structural and molecular mechanisms for the control of eukaryotic 5′–3′ mRNA decay

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A unique surface on Pat1 C-terminal domain directly interacts with Dcp2 decapping enzyme and Xrn1 5′–3′ mRNA exonuclease in yeast

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Drosophila Bag-of-marbles directly interacts with the CAF40 subunit of the CCR4–NOT complex to elicit repression of mRNA targets

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A CAF40-binding motif facilitates recruitment of the CCR4-NOT complex to mRNAs targeted by Drosophila Roquin

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RiboDiff: detecting changes of mRNA translation efficiency from ribosome footprints

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Distinct modes of recruitment of the CCR4–NOT complex byDrosophilaand vertebrate Nanos

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mTAIL-seq reveals dynamic poly(A) tail regulation in oocyte-to-embryo development

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The transcription factor ERG recruits CCR4–NOT to control mRNA decay and mitotic progression

(2016) Xavier Rambout et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Structure of the Dcp2–Dcp1 mRNA-decapping complex in the activated conformation

(2016) Eugene Valkov et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

The transcription factor ERG recruits CCR4–NOT to control mRNA decay and mitotic progression

(2016) Xavier Rambout et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Structure of the Dcp2–Dcp1 mRNA-decapping complex in the activated conformation

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The Ccr4-Not complex is a key regulator of eukaryotic gene expression

(2016) Martine A. Collart   Wiley Interdisciplinary Reviews-RNA

The enzyme activities of Caf1 and Ccr4 are both required for deadenylation by the human Ccr4–Not nuclease module

(2015) Maryati Maryati et al.   BIOCHEMICAL JOURNAL

Viral Nucleases Induce an mRNA Degradation-Transcription Feedback Loop in Mammalian Cells

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Structural basis for the Nanos-mediated recruitment of the CCR4-NOT complex and translational repression

(2014) D. Bhandari et al.   GENES & DEVELOPMENT

Coupling mRNA Synthesis and Decay

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Poly(A)-tail profiling reveals an embryonic switch in translational control

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The activation of the decapping enzyme DCP2 by DCP1 occurs on the EDC4 scaffold and involves a conserved loop in DCP1

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RNA decay machines: Deadenylation by the Ccr4–Not and Pan2–Pan3 complexes

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Gene Expression Is Circular: Factors for mRNA Degradation Also Foster mRNA Synthesis

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Roquin Promotes Constitutive mRNA Decay via a Conserved Class of Stem-Loop Recognition Motifs

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The SMG5-SMG7 heterodimer directly recruits the CCR4-NOT deadenylase complex to mRNAs containing nonsense codons via interaction with POP2

(2013) B. Loh et al.   GENES & DEVELOPMENT

Global Analysis of Eukaryotic mRNA Degradation Reveals Xrn1-Dependent Buffering of Transcript Levels

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Structural basis for the recruitment of the human CCR4–NOT deadenylase complex by tristetraprolin

(2013) Marc R Fabian et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

TopHat2: accurate alignment of transcriptomes in the presence of insertions, deletions and gene fusions

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The CCR4 Deadenylase Acts with Nanos and Pumilio in the Fine-Tuning of Mei-P26 Expression to Promote Germline Stem Cell Self-Renewal

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Structural and functional control of the eukaryotic mRNA decapping machinery

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Architecture of the Nuclease Module of the Yeast Ccr4-Not Complex: the Not1-Caf1-Ccr4 Interaction

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(2012) Ben Langmead et al.   NATURE METHODS

The ribosome profiling strategy for monitoring translation in vivo by deep sequencing of ribosome-protected mRNA fragments

(2012) Nicholas T Ingolia et al.   Nature Protocols

A direct interaction between DCP1 and XRN1 couples mRNA decapping to 5′ exonucleolytic degradation

(2012) Joerg E Braun et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

The structural basis for the interaction between the CAF1 nuclease and the NOT1 scaffold of the human CCR4–NOT deadenylase complex

(2012) Alain-Pierre Petit et al.   NUCLEIC ACIDS RESEARCH

Differential expression analysis of multifactor RNA-Seq experiments with respect to biological variation

(2012) Davis J. McCarthy et al.   NUCLEIC ACIDS RESEARCH

The 5′ → 3′ exoribonuclease XRN1/Pacman and its functions in cellular processes and development

(2012) Christopher Iain Jones et al.   Wiley Interdisciplinary Reviews-RNA

Ribosome Profiling of Mouse Embryonic Stem Cells Reveals the Complexity and Dynamics of Mammalian Proteomes

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CNOT2 depletion disrupts and inhibits the CCR4-NOT deadenylase complex and induces apoptotic cell death

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Deciphering correct strategies for multiprotein complex assembly by co-expression: Application to complexes as large as the histone octamer

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Not1 mediates recruitment of the deadenylase Caf1 to mRNAs targeted for degradation by tristetraprolin

(2011) Heike Sandler et al.   NUCLEIC ACIDS RESEARCH

Pat1 proteins: a life in translation, translation repression and mRNA decay

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The C-terminal α–α superhelix of Pat is required for mRNA decapping in metazoa

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Human Pat1b Connects Deadenylation with mRNA Decapping and Controls the Assembly of Processing Bodies

(2010) S. Ozgur et al.   MOLECULAR AND CELLULAR BIOLOGY

NANOS2 interacts with the CCR4-NOT deadenylation complex and leads to suppression of specific RNAs

(2010) Atsushi Suzuki et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mechanisms of deadenylation-dependent decay

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Human Ccr4–Not complexes contain variable deadenylase subunits

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Multifunctional deadenylase complexes diversify mRNA control

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