The complex enzymology of mRNA decapping: Enzymes of four classes cleave pyrophosphate bonds

CapZyme-Seq Comprehensively Defines Promoter-Sequence Determinants for RNA 5′ Capping with NAD +

(2018) Irina O. Vvedenskaya et al.   MOLECULAR CELL

Structural and kinetic insights into stimulation of RppH-dependent RNA degradation by the metabolic enzyme DapF

(2018) Ang Gao et al.   NUCLEIC ACIDS RESEARCH

Multispecies reconstructions uncover widespread conservation, and lineage-specific elaborations in eukaryotic mRNA metabolism

(2018) Bridget P. Bannerman et al.   PLoS One

2'-O-methylation of the mRNA cap protects RNAs from decapping and degradation by DXO

(2018) Frédéric Picard-Jean et al.   PLoS One

Hydrolytic activity of human Nudt16 enzyme on dinucleotide cap analogs and short capped oligonucleotides

(2018) Renata Grzela et al.   RNA

Eukaryotic RNA 5′-End NAD + Capping and DeNADding

(2018) Megerditch Kiledjian   TRENDS IN CELL BIOLOGY

Diadenosine tetraphosphate (Ap4A) - an E. coli alarmone or a damage metabolite?

(2017) Dragana Despotović et al.   FEBS Journal

Impact of FHIT loss on the translation of cancer-associated mRNAs

(2017) Daniel L. Kiss et al.   Molecular Cancer

A Novel RNA Phosphorylation State Enables 5′ End-Dependent Degradation in Escherichia coli

(2017) Daniel J. Luciano et al.   MOLECULAR CELL

The evolution of function within the Nudix homology clan

(2017) John R. Srouji et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

The ApaH-like phosphatase TbALPH1 is the major mRNA decapping enzyme of trypanosomes

(2017) Susanne Kramer   PLoS Pathogens

Cap-like structures in bacterial RNA and epitranscriptomic modification

(2016) Andres Jäschke et al.   CURRENT OPINION IN MICROBIOLOGY

Gene expression in Kinetoplastids

(2016) CE Clayton   CURRENT OPINION IN MICROBIOLOGY

Polycistronic trypanosome mRNAs are a target for the exosome

(2016) Susanne Kramer et al.   MOLECULAR AND BIOCHEMICAL PARASITOLOGY

Gene expression regulatory networks inTrypanosoma brucei: insights into the role of the mRNA-binding proteome

(2016) Smiths Lueong et al.   MOLECULAR MICROBIOLOGY

The mechanism of RNA 5′ capping with NAD+, NADH and desphospho-CoA

(2016) Jeremy G. Bird et al.   NATURE

Reversible methylation of m6Am in the 5′ cap controls mRNA stability

(2016) Jan Mauer et al.   NATURE

Structure and function of the bacterial decapping enzyme NudC

(2016) Katharina Höfer et al.   Nature Chemical Biology

mRNA capping: biological functions and applications

(2016) Anand Ramanathan et al.   NUCLEIC ACIDS RESEARCH

Identification of NAD+capped mRNAs inSaccharomyces cerevisiae

(2016) Robert W. Walters et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structural basis for m7G recognition and 2′-O-methyl discrimination in capped RNAs by the innate immune receptor RIG-I

(2016) Swapnil C. Devarkar et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Nudt3 is an mRNA decapping enzyme that modulates cell migration

(2016) Ewa Grudzien-Nogalska et al.   RNA

New insights into decapping enzymes and selective mRNA decay

(2016) Ewa Grudzien-Nogalska et al.   Wiley Interdisciplinary Reviews-RNA

NUDT2 Disruption Elevates Diadenosine Tetraphosphate (Ap4A) and Down-Regulates Immune Response and Cancer Promotion Genes

(2016) Andrew S. Marriott et al.   PLoS One

Caps Off to Poxviruses

(2015) Robert H. Silverman   Cell Host & Microbe

Structures of RNA Complexes with theEscherichia coliRNA Pyrophosphohydrolase RppH Unveil the Basis for Specific 5′-End-dependent mRNA Decay

(2015) Nikita Vasilyev et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Specificity and Evolutionary Conservation of theEscherichia coliRNA Pyrophosphohydrolase RppH

(2015) Patricia L. Foley et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Binding of the 5′-Triphosphate End of mRNA to the γ-Subunit of Translation Initiation Factor 2 of the Crenarchaeon Sulfolobus solfataricus

(2015) Valentina Arkhipova et al.   JOURNAL OF MOLECULAR BIOLOGY

Structural and biochemical studies of the distinct activity profiles of Rai1 enzymes

(2015) Vivien Ya-Fan Wang et al.   NUCLEIC ACIDS RESEARCH

Novel insights into RNP granules by employing the trypanosome's microtubule skeleton as a molecular sieve

(2015) Melanie Fritz et al.   NUCLEIC ACIDS RESEARCH

The messenger RNA decapping and recapping pathway inTrypanosoma

(2015) Anna V. Ignatochkina et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The human decapping scavenger enzyme DcpS modulates microRNA turnover

(2015) Oussama Meziane et al.   Scientific Reports

Structural Basis for the Specificity of Human NUDT16 and Its Regulation by Inosine Monophosphate

(2015) Lionel Trésaugues et al.   PLoS One

Messenger RNA Degradation in Bacterial Cells

(2014) Monica P. Hui et al.   Annual Review of Genetics

Structure and Function of Pre-mRNA 5′-End Capping Quality Control and 3′-End Processing

(2014) Ashley R. Jurado et al.   BIOCHEMISTRY

The FHIT gene product: tumor suppressor and genome “caretaker”

(2014) Catherine E. Waters et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

mRNA quality control at the 5’ end

(2014) Li-ting Zhai et al.   Journal of Zhejiang University-SCIENCE B

NAD captureSeq indicates NAD as a bacterial cap for a subset of regulatory RNAs

(2014) Hana Cahová et al.   NATURE

Elimination of cap structures generated by mRNA decay involves the new scavenger mRNA decapping enzyme Aph1/FHIT together with DcpS

(2014) Valerio Taverniti et al.   NUCLEIC ACIDS RESEARCH

RppH-dependent pyrophosphohydrolysis of mRNAs is regulated by direct interaction with DapF in Escherichia coli

(2014) Chang-Ro Lee et al.   NUCLEIC ACIDS RESEARCH

Crystal Structures of the Novel Cytosolic 5′-Nucleotidase IIIB Explain Its Preference for m7GMP

(2014) Thomas Monecke et al.   PLoS One

DcpS, a general modulator of cap-binding protein-dependent processes?

(2014) Sophie Bail et al.   RNA Biology

The Cytoplasmic Capping Complex Assembles on Adapter Protein Nck1 Bound to the Proline-Rich C-Terminus of Mammalian Capping Enzyme

(2014) Chandrama Mukherjee et al.   PLOS BIOLOGY

A Genome-Wide Tethering Screen Reveals Novel Potential Post-Transcriptional Regulators in Trypanosoma brucei

(2014) Esteban D. Erben et al.   PLoS Pathogens

Analysis of decapping scavenger cap complex using modified cap analogs reveals molecular determinants for efficient cap binding

(2013) Anna Wypijewska del Nogal et al.   FEBS Journal

Structural characterization of human histidine triad nucleotide-binding protein 2, a member of the histidine triad superfamily

(2013) Kimberly M. Maize et al.   FEBS Journal

A Mammalian Pre-mRNA 5′ End Capping Quality Control Mechanism and an Unexpected Link of Capping to Pre-mRNA Processing

(2013) Xinfu Jiao et al.   MOLECULAR CELL

The Decapping Scavenger Enzyme DCS-1 Controls MicroRNA Levels in Caenorhabditis elegans

(2013) Gabriel D. Bossé et al.   MOLECULAR CELL

Evolution of Bacterial-Like Phosphoprotein Phosphatases in Photosynthetic Eukaryotes Features Ancestral Mitochondrial or Archaeal Origin and Possible Lateral Gene Transfer

(2013) R. G. Uhrig et al.   PLANT PHYSIOLOGY

Specificity of RppH-dependent RNA degradation in Bacillus subtilis

(2013) P.-k. Hsieh et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Bacillus subtilis RNA deprotection enzyme RppH recognizes guanosine in the second position of its substrates

(2013) J. Piton et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Multiple Nudix family proteins possess mRNA decapping activity

(2013) M.-G. Song et al.   RNA

Arabidopsis PPP family of serine/threonine protein phosphatases: many targets but few engines

(2013) R. Glen Uhrig et al.   TRENDS IN PLANT SCIENCE

7-Methylguanosine Diphosphate (m7GDP) Is Not Hydrolyzed but Strongly Bound by Decapping Scavenger (DcpS) Enzymes and Potently Inhibits Their Activity

(2012) Anna Wypijewska et al.   BIOCHEMISTRY

Substrate ambiguity among the nudix hydrolases: biologically significant, evolutionary remnant, or both?

(2012) Alexander G. McLennan   CELLULAR AND MOLECULAR LIFE SCIENCES

RNA Degradation in Saccharomyces cerevisae

(2012) Roy Parker   GENETICS

mRNA splicing in trypanosomes

(2012) Christian Preußer et al.   INTERNATIONAL JOURNAL OF MEDICAL MICROBIOLOGY

Identification ofDrosophilaand Human 7-Methyl GMP-specific Nucleotidases

(2012) Juliane Buschmann et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Revised Classification of Eukaryotes

(2012) Sina M. Adl et al.   JOURNAL OF EUKARYOTIC MICROBIOLOGY

Dxo1 is a new type of eukaryotic enzyme with both decapping and 5′-3′ exoribonuclease activity

(2012) Jeong Ho Chang et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Activation of 5'-3' exoribonuclease Xrn1 by cofactor Dcs1 is essential for mitochondrial function in yeast

(2012) F. Sinturel et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Identification of Cytoplasmic Capping Targets Reveals a Role for Cap Homeostasis in Translation and mRNA Stability

(2012) Chandrama Mukherjee et al.   Cell Reports

Hit proteins, mitochondria and cancer

(2011) Juliette Martin et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

An RNA Pyrophosphohydrolase Triggers 5′-Exonucleolytic Degradation of mRNA in Bacillus subtilis

(2011) Jamie Richards et al.   MOLECULAR CELL

Two Ancient Bacterial-like PPP Family Phosphatases from Arabidopsis Are Highly Conserved Plant Proteins That Possess Unique Properties

(2011) R. G. Uhrig et al.   PLANT PHYSIOLOGY

Unraveling regulation and new components of human P-bodies through a protein interaction framework and experimental validation

(2011) D. Zheng et al.   RNA

The role of the 5'-3' exoribonuclease XRNA in transcriptome-wide mRNA degradation

(2011) T. Manful et al.   RNA

Differential utilization of decapping enzymes in mammalian mRNA decay pathways

(2011) Y. Li et al.   RNA

hNUDT16: a universal decapping enzyme for small nucleolar RNA and cytoplasmic mRNA

(2011) Guangwen Lu et al.   Protein & Cell

Multiple mRNA Decapping Enzymes in Mammalian Cells

(2010) Man-Gen Song et al.   MOLECULAR CELL

Identification of a quality-control mechanism for mRNA 5′-end capping

(2010) Xinfu Jiao et al.   NATURE

2′-O methylation of the viral mRNA cap evades host restriction by IFIT family members

(2010) Stephane Daffis et al.   NATURE

NUDT16 and ITPA play a dual protective role in maintaining chromosome stability and cell growth by eliminating dIDP/IDP and dITP/ITP from nucleotide pools in mammals

(2010) Nona Abolhassani et al.   NUCLEIC ACIDS RESEARCH

Regulation of mRNA decapping

(2010) You Li et al.   Wiley Interdisciplinary Reviews-RNA

Eukaryotic snoRNAs: A paradigm for gene expression flexibility

(2009) Giorgio Dieci et al.   GENOMICS

Identification of a Cytoplasmic Complex That Adds a Cap onto 5'-Monophosphate RNA

(2009) Y. Otsuka et al.   MOLECULAR AND CELLULAR BIOLOGY

Hypermethylated cap 4 maximizesTrypanosoma bruceitranslation

(2009) Jesse R. Zamudio et al.   MOLECULAR MICROBIOLOGY

Structure and function of the 5′→3′ exoribonuclease Rat1 and its activating partner Rai1

(2009) Song Xiang et al.   NATURE

LC/MS analysis of cellular RNA reveals NAD-linked RNA

(2009) Y Grace Chen et al.   Nature Chemical Biology

Mutational analysis of a Dcp2-binding element reveals general enhancement of decapping by 5′-end stem-loop structures

(2009) You Li et al.   NUCLEIC ACIDS RESEARCH

TriTrypDB: a functional genomic resource for the Trypanosomatidae

(2009) Martin Aslett et al.   NUCLEIC ACIDS RESEARCH

A chemical screen for biological small molecule-RNA conjugates reveals CoA-linked RNA

(2009) W. E. Kowtoniuk et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The African swine fever virus g5R protein possesses mRNA decapping activity

(2009) Susan Parrish et al.   VIROLOGY

Heat shock causes a decrease in polysomes and the appearance of stress granules in trypanosomes independently of eIF2  phosphorylation at Thr169

(2008) S. Kramer et al.   JOURNAL OF CELL SCIENCE

Identification of the heptameric Lsm complex that binds U6 snRNA in Trypanosoma brucei

(2008) Itai Dov Tkacz et al.   MOLECULAR AND BIOCHEMICAL PARASITOLOGY

The bacterial enzyme RppH triggers messenger RNA degradation by 5′ pyrophosphate removal

(2008) Atilio Deana et al.   NATURE

Evolutionary conservation supports ancient origin for Nudt16, a nuclear-localized, RNA-binding, RNA-decapping enzyme

(2008) Melissa J. Taylor et al.   NUCLEIC ACIDS RESEARCH

A role for Caf1 in mRNA deadenylation and decay in trypanosomes and human cells

(2008) Angela Schwede et al.   NUCLEIC ACIDS RESEARCH

Translation initiation factor a/eIF2(- ) counteracts 5' to 3' mRNA decay in the archaeon Sulfolobus solfataricus

(2008) D. Hasenohrl et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

DcpS scavenger decapping enzyme can modulate pre-mRNA splicing

(2008) V. Shen et al.   RNA

Correlation of intracellular diadenosine triphosphate (Ap3A) with apoptosis in Fhit-positive HEK293 cells

(2007) David I. Fisher et al.   CANCER LETTERS