Changes in conformational equilibria regulate the activity of the Dcp2 decapping enzyme

mRNA decapping in 3D

(2016) Jeff Coller   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Structure of the active form of Dcp1–Dcp2 decapping enzyme bound to m7GDP and its Edc3 activator

(2016) Clément Charenton et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Structure of the Dcp2–Dcp1 mRNA-decapping complex in the activated conformation

(2016) Eugene Valkov et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Structural basis of mRNA-cap recognition by Dcp1–Dcp2

(2016) Jeffrey S Mugridge et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

The oligomeric architecture of the archaeal exosome is important for processive and efficient RNA degradation

(2016) Maxime J. C. Audin et al.   NUCLEIC ACIDS RESEARCH

TheS. pombemRNA decapping complex recruits cofactors and an Edc1-like activator through a single dynamic surface

(2016) Jan Philip Wurm et al.   RNA

A general method for rapid and cost-efficient large-scale production of 5′ capped RNA

(2016) Anna-Lisa Fuchs et al.   RNA

mRNA decapping in 3D

(2016) Jeff Coller   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Structure of the active form of Dcp1–Dcp2 decapping enzyme bound to m7GDP and its Edc3 activator

(2016) Clément Charenton et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Structure of the Dcp2–Dcp1 mRNA-decapping complex in the activated conformation

(2016) Eugene Valkov et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Structural basis of mRNA-cap recognition by Dcp1–Dcp2

(2016) Jeffrey S Mugridge et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Methyl-specific isotopic labeling: a molecular tool box for solution NMR studies of large proteins

(2015) Rime Kerfah et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

An excess of catalytically required motions inhibits the scavenger decapping enzyme

(2015) Ancilla Neu et al.   Nature Chemical Biology

Integrative, dynamic structural biology at atomic resolution—it's about time

(2015) Henry van den Bedem et al.   NATURE METHODS

Structural Basis for Protein Antiaggregation Activity of the Trigger Factor Chaperone

(2014) T. Saio et al.   SCIENCE

The Archaeal Exosome: Identification and Quantification of Site-Specific Motions That Correlate with Cap and RNA Binding

(2013) Maxime J. C. Audin et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Dectin-1 is an extracellular pathogen sensor for the induction and processing of IL-1β via a noncanonical caspase-8 inflammasome

(2012) Sonja I Gringhuis et al.   NATURE IMMUNOLOGY

Interdomain dynamics and coactivation of the mRNA decapping enzyme Dcp2 are mediated by a gatekeeper tryptophan

(2012) S. N. Floor et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The structural basis of Edc3- and Scd6-mediated activation of the Dcp1:Dcp2 mRNA decapping complex

(2011) Simon A Fromm et al.   EMBO JOURNAL

A split active site couples cap recognition by Dcp2 to activation

(2010) Stephen N Floor et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Dcp1 links coactivators of mRNA decapping to Dcp2 by proline recognition

(2010) M. S. Borja et al.   RNA

Dynamic Regulation of Archaeal Proteasome Gate Opening As Studied by TROSY NMR

(2010) T. L. Religa et al.   SCIENCE

Structural Basis of Dcp2 Recognition and Activation by Dcp1

(2008) Meipei She et al.   MOLECULAR CELL

The bacterial enzyme RppH triggers messenger RNA degradation by 5′ pyrophosphate removal

(2008) Atilio Deana et al.   NATURE