The evolution of function within the Nudix homology clan

Structure and function of the bacterial decapping enzyme NudC

(2016) Katharina Höfer et al.   Nature Chemical Biology

Modulation of NADH Levels by Arabidopsis Nudix Hydrolases, AtNUDX6 and 7, and the Respective Proteins Themselves Play Distinct Roles in the Regulation of Various Cellular Responses Involved in Biotic/Abiotic Stresses

(2016) Takahisa Ogawa et al.   PLANT AND CELL PHYSIOLOGY

Substrate specificity characterization for eight putative nudix hydrolases. Evaluation of criteria for substrate identification within the Nudix family

(2016) Vi N. Nguyen et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

ADP-ribose–derived nuclear ATP synthesis by NUDIX5 is required for chromatin remodeling

(2016) Roni H. G. Wright et al.   SCIENCE

Nudix Effectors: A Common Weapon in the Arsenal of Plant Pathogens

(2016) Suomeng Dong et al.   PLoS Pathogens

The proposed channel-enzyme transient receptor potential melastatin 2 does not possess ADP ribose hydrolase activity

(2016) Iordan Iordanov et al.   eLife

ADP-Ribose Activates the TRPM2 Channel from the Sea Anemone Nematostella vectensis Independently of the NUDT9H Domain

(2016) Frank J. P. Kühn et al.   PLoS One

Nudix hydrolases degrade protein-conjugated ADP-ribose

(2015) Casey M. Daniels et al.   Scientific Reports

Structural Basis for the Specificity of Human NUDT16 and Its Regulation by Inosine Monophosphate

(2015) Lionel Trésaugues et al.   PLoS One

Structural and Enzymatic Characterization of a Nucleoside Diphosphate Sugar Hydrolase from Bdellovibrio bacteriovorus

(2015) Andres H. de la Peña et al.   PLoS One

Distribution of protein poly(ADP-ribosyl)ation systems across all domains of life

(2014) Dragutin Perina et al.   DNA REPAIR

Crystal structure of wild-type and mutant human Ap4A hydrolase

(2013) Honghua Ge et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

A cross-kingdom Nudix enzyme that pre-empts damage in thiamin metabolism

(2013) Aymeric Goyer et al.   BIOCHEMICAL JOURNAL

Mycobacterium tuberculosisMutT1 (Rv2985) and ADPRase (Rv1700) Proteins Constitute a Two-stage Mechanism of 8-Oxo-dGTP and 8-Oxo-GTP Detoxification and Adenosine to Cytidine Mutation Avoidance

(2013) Aravind Goud G. Patil et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

MAFFT Multiple Sequence Alignment Software Version 7: Improvements in Performance and Usability

(2013) K. Katoh et al.   MOLECULAR BIOLOGY AND EVOLUTION

The Structure–Function Linkage Database

(2013) Eyal Akiva et al.   NUCLEIC ACIDS RESEARCH

SCOPe: Structural Classification of Proteins—extended, integrating SCOP and ASTRAL data and classification of new structures

(2013) Naomi K. Fox et al.   NUCLEIC ACIDS RESEARCH

Pfam: the protein families database

(2013) Robert D. Finn et al.   NUCLEIC ACIDS RESEARCH

Multiple Nudix family proteins possess mRNA decapping activity

(2013) M.-G. Song et al.   RNA

Enzymatic and Molecular Characterization of Arabidopsis ppGpp Pyrophosphohydrolase, AtNUDX26

(2012) Daisuke ITO et al.   BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY

Human MTH3 (NUDT18) Protein Hydrolyzes Oxidized Forms of Guanosine and Deoxyguanosine Diphosphates

(2012) Yasumitsu Takagi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Hydrolase Controls Cellular NAD, Sirtuin, and Secondary Metabolites

(2012) M. Shimizu et al.   MOLECULAR AND CELLULAR BIOLOGY

Dendroscope 3: An Interactive Tool for Rooted Phylogenetic Trees and Networks

(2012) Daniel H. Huson et al.   SYSTEMATIC BIOLOGY

Structure of a Nudix hydrolase (MutT) in the Mg2+-bound state fromBartonella henselae, the bacterium responsible for cat scratch fever

(2011) Garry W. Buchko et al.   Acta Crystallographica Section F-Structural Biology and Crystallization Communications

Analysis of DBC1 and its homologs suggests a potential mechanism for regulation of Sirtuin domain deacetylases by NAD metabolites

(2011) Vivek Anantharaman et al.   CELL CYCLE

Crystal structure of human MTH1 and the 8-oxo-dGMP product complex

(2011) Linda M. Svensson et al.   FEBS LETTERS

The Nudix Hydrolase CDP-Chase, a CDP-Choline Pyrophosphatase, Is an Asymmetric Dimer with Two Distinct Enzymatic Activities

(2011) K. C. Duong-Ly et al.   JOURNAL OF BACTERIOLOGY

The UniProt-GO Annotation database in 2011

(2011) E. C. Dimmer et al.   NUCLEIC ACIDS RESEARCH

Interactive Tree Of Life v2: online annotation and display of phylogenetic trees made easy

(2011) I. Letunic et al.   NUCLEIC ACIDS RESEARCH

The Pfam protein families database

(2011) M. Punta et al.   NUCLEIC ACIDS RESEARCH

HMMER web server: interactive sequence similarity searching

(2011) R. D. Finn et al.   NUCLEIC ACIDS RESEARCH

Structural studies of the Nudix GDP-mannose hydrolase from E. coli reveals a new motif for mannose recognition

(2011) Agedi N. Boto et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

A novel methodology for large-scale phylogeny partition

(2011) Mattia C.F. Prosperi et al.   Nature Communications

Oxidation of the diphosphoinositol polyphosphate phosphohydrolase-like Nudix hydrolase Aps from Drosophila melanogaster induces thermolability—A possible regulatory switch?

(2010) Lucinda Winward et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Multiple mRNA Decapping Enzymes in Mammalian Cells

(2010) Man-Gen Song et al.   MOLECULAR CELL

FastTree 2 – Approximately Maximum-Likelihood Trees for Large Alignments

(2010) Morgan N. Price et al.   PLoS One

Structure of an N-terminally truncated Nudix hydrolase DR2204 fromDeinococcus radiodurans

(2009) A. M. D. Gonçalves et al.   Acta Crystallographica Section F-Structural Biology and Crystallization Communications

Characterization of mouse UDP-glucose pyrophosphatase, a Nudix hydrolase encoded by the Nudt14 gene

(2009) Candy A. Heyen et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Jalview Version 2--a multiple sequence alignment editor and analysis workbench

(2009) A. M. Waterhouse et al.   BIOINFORMATICS

A Comprehensive Bioinformatics Analysis of the Nudix Superfamily inArabidopsis thaliana

(2009) D. Gunawardana et al.   COMPARATIVE AND FUNCTIONAL GENOMICS

Structural and Dynamic Features of the MutT Protein in the Recognition of Nucleotides with the Mutagenic 8-Oxoguanine Base

(2009) Teruya Nakamura et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Evolution of double MutT/Nudix domain-containing proteins: similar domain architectures from independent gene duplication-fusion events

(2009) Jun Lin et al.   Journal of Genetics and Genomics

Diphosphoinositol Polyphosphates: Metabolic Messengers?

(2009) S. B. Shears   MOLECULAR PHARMACOLOGY

Biochemical and physiological characterization ofArabidopsis thalianaAtCoAse: a Nudix CoA hydrolyzing protein that improves plant development

(2009) Thomas Kupke et al.   PHYSIOLOGIA PLANTARUM

Crystal structure of human diphosphoinositol phosphatase 1

(2009) Ann-Gerd Thorsell et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

Structure and Biological Function of the RNA Pyrophosphohydrolase BdRppH from Bdellovibrio bacteriovorus

(2009) Simon A.J. Messing et al.   STRUCTURE

Structure and Function of an ADP-Ribose-Dependent Transcriptional Regulator of NAD Metabolism

(2009) Nian Huang et al.   STRUCTURE

Functional and Structural Characterization of DR_0079 fromDeinococcus radiodurans, a Novel Nudix Hydrolase with a Preference for Cytosine (Deoxy)ribonucleoside 5′-Di- and Triphosphates†

(2008) Garry W. Buchko et al.   BIOCHEMISTRY

mRNA Decapping Is Promoted by an RNA-Binding Channel in Dcp2

(2008) Mandar V. Deshmukh et al.   MOLECULAR CELL

Structural Basis of Dcp2 Recognition and Activation by Dcp1

(2008) Meipei She et al.   MOLECULAR CELL

Negative regulation of the deacetylase SIRT1 by DBC1

(2008) Wenhui Zhao et al.   NATURE

DBC1 is a negative regulator of SIRT1

(2008) Ja-Eun Kim et al.   NATURE

The bacterial enzyme RppH triggers messenger RNA degradation by 5′ pyrophosphate removal

(2008) Atilio Deana et al.   NATURE

SUPERFAMILY—sophisticated comparative genomics, data mining, visualization and phylogeny

(2008) Derek Wilson et al.   NUCLEIC ACIDS RESEARCH

The GOA database in 2009--an integrated Gene Ontology Annotation resource

(2008) D. Barrell et al.   NUCLEIC ACIDS RESEARCH

Molecular Characterization of Organelle-Type Nudix Hydrolases in Arabidopsis

(2008) T. Ogawa et al.   PLANT PHYSIOLOGY

The crystal structure of human cleavage and polyadenylation specific factor-5 reveals a dimeric Nudix protein with a conserved catalytic site

(2008) Lionel Trésaugues et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

Bifunctional NMN Adenylyltransferase/ADP-Ribose Pyrophosphatase: Structure and Function in Bacterial NAD Metabolism

(2008) Nian Huang et al.   STRUCTURE

Evolutionary determinants of divergent calcium selectivity of TRPM channels

(2007) Michael Mederos y Schnitzler et al.   FASEB JOURNAL