Investigating Nonalcoholic Fatty Liver Disease in a Liver-on-a-Chip Microfluidic Device

Engineered In Vitro Disease Models

(2015) Kambez H. Benam et al.   Annual Review of Pathology-Mechanisms of Disease

3D liver models on a microplatform: well-defined culture, engineering of liver tissue and liver-on-a-chip

(2015) Da Yoon No et al.   LAB ON A CHIP

Multi-cellular 3D human primary liver cell culture elevates metabolic activity under fluidic flow

(2015) Mandy B. Esch et al.   LAB ON A CHIP

Contributions of microbiome and mechanical deformation to intestinal bacterial overgrowth and inflammation in a human gut-on-a-chip

(2015) Hyun Jung Kim et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Microfluidic Organ/Body-on-a-Chip Devices at the Convergence of Biology and Microengineering

(2015) Ana Perestrelo et al.   SENSORS

Biological and medical applications of a brain-on-a-chip

(2014) David Pamies et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

Protective Effect of the Y220C Mutant p53 Against Steatosis: Good News?

(2014) Manuele Gori et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Organ-on-a-chip platforms for studying drug delivery systems

(2014) Nupura S. Bhise et al.   JOURNAL OF CONTROLLED RELEASE

Microfluidic organs-on-chips

(2014) Sangeeta N Bhatia et al.   NATURE BIOTECHNOLOGY

MicroRNAs in Nonalcoholic Fatty Liver Disease: Novel Biomarkers and Prognostic Tools during the Transition from Steatosis to Hepatocarcinoma

(2014) Manuele Gori et al.   Biomed Research International

A review of microfabrication and hydrogel engineering for micro-organs on chips

(2013) Marine Verhulsel et al.   BIOMATERIALS

Human-on-chip for therapy development and fundamental science

(2013) Camilla Luni et al.   CURRENT OPINION IN BIOTECHNOLOGY

Fabrication and characterization of microfluidic liver-on-a-chip using microsomal enzymes

(2013) Jungwoo Lee et al.   ENZYME AND MICROBIAL TECHNOLOGY

Evaluation of a Liver Microfluidic Biochip to Predict In Vivo Clearances of Seven Drugs in Rats

(2013) Regis Baudoin et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Organs on Chips 2013

(2013) David J. Beebe et al.   LAB ON A CHIP

A dynamic multi-organ-chip for long-term cultivation and substance testing proven by 3D human liver and skin tissue co-culture

(2013) Ilka Wagner et al.   LAB ON A CHIP

Effect of intracellular lipid accumulation in a new model of non-alcoholic fatty liver disease

(2012) Norberto C Chavez-Tapia et al.   BMC GASTROENTEROLOGY

Organs-on-chips: breaking the in vitro impasse

(2012) Andries D. van der Meer et al.   Integrative Biology

Microengineered physiological biomimicry: Organs-on-Chips

(2012) Dongeun Huh et al.   LAB ON A CHIP

“Artificial micro organs”—a microfluidic device for dielectrophoretic assembly of liver sinusoids

(2011) Julia Schütte et al.   BIOMEDICAL MICRODEVICES

Biomimetic tissues on a chip for drug discovery

(2011) Amir M. Ghaemmaghami et al.   DRUG DISCOVERY TODAY

ROS-Mediated p53 Induction of Lpin1 Regulates Fatty Acid Oxidation in Response to Nutritional Stress

(2011) Wissam Assaily et al.   MOLECULAR CELL

From 3D cell culture to organs-on-chips

(2011) Dongeun Huh et al.   TRENDS IN CELL BIOLOGY

Nonalcoholic fatty liver disease and hepatocellular carcinoma: A weighty connection

(2010) Brad Q. Starley et al.   HEPATOLOGY

Lipolysis – A highly regulated multi-enzyme complex mediates the catabolism of cellular fat stores

(2010) Achim Lass et al.   PROGRESS IN LIPID RESEARCH

NAFLD as a Risk Factor for the Development of Diabetes and the Metabolic Syndrome: An Eleven-Year Follow-up Study

(2009) Leon A Adams et al.   AMERICAN JOURNAL OF GASTROENTEROLOGY

Hydrogels as extracellular matrix mimics for 3D cell culture

(2009) Mark W. Tibbitt et al.   BIOTECHNOLOGY AND BIOENGINEERING

Differential effect of oleic and palmitic acid on lipid accumulation and apoptosis in cultured hepatocytes

(2009) Matteo Ricchi et al.   JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY

Molecular mechanisms involved in NAFLD progression

(2009) Mariano Malaguarnera et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Towards a human-on-chip: Culturing multiple cell types on a chip with compartmentalized microenvironments

(2009) Chi Zhang et al.   LAB ON A CHIP

Oxidative stress induced lipid accumulation via SREBP1c activation in HepG2 cells

(2008) Mika Sekiya et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

The lysosomal-mitochondrial axis in free fatty acid-induced hepatic lipotoxicity

(2008) ZhengZheng Li et al.   HEPATOLOGY

Nonalcoholic Fatty Liver Disease: Pathogenesis, Identification, Progression, and Management

(2008) Eric Yan et al.   NUTRITION REVIEWS

The Epidemiology of Nonalcoholic Fatty Liver Disease: A Global Perspective

(2008) Mariana Lazo et al.   SEMINARS IN LIVER DISEASE

Molecular basis and mechanisms of progression of non-alcoholic steatohepatitis

(2008) Fabio Marra et al.   TRENDS IN MOLECULAR MEDICINE