Methods of Delivering Mechanical Stimuli to Organ-on-a-Chip

The effect of physiological stretch and the valvular endothelium on mitral valve proteomes

(2019) Mir S Ali et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

Three-Motorized-Stage Cyclic Stretching System for Cell Monitoring Based on Chamber Local Displacement Waveforms

(2019) Wenjing Huang et al.   Applied Sciences-Basel

Role of boundary conditions in determining cell alignment in response to stretch

(2018) Kellen Chen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Targeting extracellular matrix stiffness to attenuate disease: From molecular mechanisms to clinical trials

(2018) Marsha C. Lampi et al.   Science Translational Medicine

Medium throughput breathing human primary cell alveolus-on-chip model

(2018) Janick D. Stucki et al.   Scientific Reports

Advances in organ-on-a-chip engineering

(2018) Boyang Zhang et al.   Nature Reviews Materials

An investigation of regional variations in the biaxial mechanical properties and stress relaxation behaviors of porcine atrioventricular heart valve leaflets

(2018) Devin Laurence et al.   JOURNAL OF BIOMECHANICS

Organs-on-a-Chip Module: A Review from the Development and Applications Perspective

(2018) Juan Eduardo Sosa-Hernández et al.   Micromachines

Tissue mechanics regulate brain development, homeostasis and disease

(2017) J. Matthew Barnes et al.   JOURNAL OF CELL SCIENCE

Cyclic compression stimulates osteoblast differentiation via activation of the Wnt/β-catenin signaling pathway

(2017) Xi Chen et al.   Molecular Medicine Reports

Mature induced-pluripotent-stem-cell-derived human podocytes reconstitute kidney glomerular-capillary-wall function on a chip

(2017) Samira Musah et al.   Nature Biomedical Engineering

Aptamer-Based Microfluidic Electrochemical Biosensor for Monitoring Cell-Secreted Trace Cardiac Biomarkers

(2016) Su Ryon Shin et al.   ANALYTICAL CHEMISTRY

Three-dimensional biomimetic model to reconstitute sprouting lymphangiogenesis in vitro

(2016) Sudong Kim et al.   BIOMATERIALS

In situ , dual-mode monitoring of organ-on-a-chip with smartphone-based fluorescence microscope

(2016) Soohee Cho et al.   BIOSENSORS & BIOELECTRONICS

A pumpless multi-organ-on-a-chip (MOC) combined with a pharmacokinetic-pharmacodynamic (PK-PD) model

(2016) Hyuna Lee et al.   BIOTECHNOLOGY AND BIOENGINEERING

Interstitial flow differentially increases patient-derived glioblastoma stem cell invasion via CXCR4, CXCL12, and CD44-mediated mechanisms

(2016) Kathryn M. Kingsmore et al.   Integrative Biology

Hepatocytes cocultured with Sertoli cells in bioreactor favors Sertoli barrier tightness in rat

(2016) P. Zeller et al.   JOURNAL OF APPLIED TOXICOLOGY

Interstitial flow regulates the angiogenic response and phenotype of endothelial cells in a 3D culture model

(2016) Sudong Kim et al.   LAB ON A CHIP

Real-time monitoring of metabolic function in liver-on-chip microdevices tracks the dynamics of mitochondrial dysfunction

(2016) Danny Bavli et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Modeling Hematopoiesis and Responses to Radiation Countermeasures in a Bone Marrow-on-a-Chip

(2016) Yu-suke Torisawa et al.   TISSUE ENGINEERING PART C-METHODS

A novel microfluidic model can mimic organ-specific metastasis of circulating tumor cells

(2016) Jing Kong et al.   Oncotarget

Mechanoregulation of Wound Healing and Skin Homeostasis

(2016) Joanna Rosińczuk et al.   Biomed Research International

Drug testing and flow cytometry analysis on a large number of uniform sized tumor spheroids using a microfluidic device

(2016) Bishnubrata Patra et al.   Scientific Reports

Intrinsic FGF2 and FGF5 promotes angiogenesis of human aortic endothelial cells in 3D microfluidic angiogenesis system

(2016) Ha-Rim Seo et al.   Scientific Reports

High-throughput compound evaluation on 3D networks of neurons and glia in a microfluidic platform

(2016) Nienke R. Wevers et al.   Scientific Reports

Chip-based human liver–intestine and liver–skin co-cultures – A first step toward systemic repeated dose substance testing in vitro

(2015) Ilka Maschmeyer et al.   EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

Differentiation of neuroepithelial stem cells into functional dopaminergic neurons in 3D microfluidic cell culture

(2015) Edinson Lucumi Moreno et al.   LAB ON A CHIP

A novel miniature dynamic microfluidic cell culture platform using electro-osmosis diode pumping

(2014) Jeffrey S. Allen et al.   Biomicrofluidics

Cellular and physical mechanisms of branching morphogenesis

(2014) Victor D. Varner et al.   DEVELOPMENT

Tissue-engineered microenvironment systems for modeling human vasculature

(2014) Anna Tourovskaia et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

Biological factors in plasma from diabetes mellitus patients enhance hyperglycaemia and pulsatile shear stress-induced endothelial cell apoptosis

(2014) X. F. Liu et al.   Integrative Biology

Mechanotransduction and fibrosis

(2014) Dominik Duscher et al.   JOURNAL OF BIOMECHANICS

Microfluidic organs-on-chips

(2014) Sangeeta N Bhatia et al.   NATURE BIOTECHNOLOGY

Fluid shear stress threshold regulates angiogenic sprouting

(2014) P. A. Galie et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mechanoregulation of Angiogenesis in Wound Healing

(2014) Luca Lancerotto et al.   Advances in Wound Care

Mechanobiology and Developmental Control

(2013) Tadanori Mammoto et al.   Annual Review of Cell and Developmental Biology

Human kidney proximal tubule-on-a-chip for drug transport and nephrotoxicity assessment

(2013) Kyung-Jin Jang et al.   Integrative Biology

Microfluidic platforms for mechanobiology

(2013) William J. Polacheck et al.   LAB ON A CHIP

Integrating biological vasculature into a multi-organ-chip microsystem

(2013) Katharina Schimek et al.   LAB ON A CHIP

Gradient static-strain stimulation in a microfluidic chip for 3D cellular alignment

(2013) Hsin-Yi Hsieh et al.   LAB ON A CHIP

Effects of mechanical stimulation induced by compression and medium perfusion on cardiac tissue engineering

(2012) Michal Shachar et al.   BIOTECHNOLOGY PROGRESS

Interstitial Flow in a 3D Microenvironment Increases Glioma Invasion by a CXCR4-Dependent Mechanism

(2012) J. M. Munson et al.   CANCER RESEARCH

Mechanism of a flow-gated angiogenesis switch: early signaling events at cell–matrix and cell–cell junctions

(2012) Vernella Vickerman et al.   Integrative Biology

Chip-Based Comparison of the Osteogenesis of Human Bone Marrow- and Adipose Tissue-Derived Mesenchymal Stem Cells under Mechanical Stimulation

(2012) Sang-Hyug Park et al.   PLoS One

In vitro microvessels for the study of angiogenesis and thrombosis

(2012) Y. Zheng et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Human Disease Model of Drug Toxicity–Induced Pulmonary Edema in a Lung-on-a-Chip Microdevice

(2012) Dongeun Huh et al.   Science Translational Medicine

Influence of perfusion and compression on the proliferation and differentiation of bone mesenchymal stromal cells seeded on polyurethane scaffolds

(2011) Chaoxu Liu et al.   BIOMATERIALS

Tumor Cell Invasion Is Promoted by Interstitial Flow-Induced Matrix Priming by Stromal Fibroblasts

(2011) A. C. Shieh et al.   CANCER RESEARCH

Migration dynamics of breast cancer cells in a tunable 3D interstitial flow chamber

(2011) Ulrike Haessler et al.   Integrative Biology

Balancing forces: architectural control of mechanotransduction

(2011) Christopher C. DuFort et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Fluid forces control endothelial sprouting

(2011) J. W. Song et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Fluid-shear-stress-induced translocation of aquaporin-2 and reorganization of actin cytoskeleton in renal tubular epithelial cells

(2010) Kyung-Jin Jang et al.   Integrative Biology

Reconstituting Organ-Level Lung Functions on a Chip

(2010) D. Huh et al.   SCIENCE

A tissue-engineered model of the intestinal lacteal for evaluating lipid transport by lymphatics

(2009) J. Brandon Dixon et al.   BIOTECHNOLOGY AND BIOENGINEERING

A multichamber fluidic device for 3D cultures under interstitial flow with live imaging: Development, characterization, and applications

(2009) Carmen Bonvin et al.   BIOTECHNOLOGY AND BIOENGINEERING

Integrated microfluidic chip for endothelial cells culture and analysis exposed to a pulsatile and oscillatory shear stress

(2009) Jianbo Shao et al.   LAB ON A CHIP

A multi-layer microfluidic device for efficient culture and analysis of renal tubular cells

(2009) Kyung-Jin Jang et al.   LAB ON A CHIP