Molecular mechanisms underlying chemical liver injury

Managing alcohol dependence and alcohol-related liver disease: a problem for the hepatologist, psychiatrist or economist?

(2013) M. A. Stubbs et al.   CLINICAL MEDICINE

Overview of lipid peroxidation products and hepatic protein modification in alcoholic liver disease

(2011) Rebecca L. Smathers et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Lysosomal Proteolysis Is the Primary Degradation Pathway for Cytosolic Ferritin and Cytosolic Ferritin Degradation Is Necessary for Iron Exit

(2010) Yinghui Zhang et al.   ANTIOXIDANTS & REDOX SIGNALING

Linking long-term toxicity of xeno-chemicals with short-term biological adaptation

(2010) Robert Barouki   BIOCHIMIE

Role of Human GlutathioneS-Transferases in the Inactivation of Reactive Metabolites of Clozapine

(2010) Sanja Dragovic et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Risk assessment and mitigation strategies for reactive metabolites in drug discovery and development

(2010) Richard A. Thompson et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Handling reactive metabolite positives in drug discovery: What has retrospective structure–toxicity analyses taught us?

(2010) Amit S. Kalgutkar   CHEMICO-BIOLOGICAL INTERACTIONS

Pathology of Immune-Mediated Liver Injury

(2010) Hans-Peter Dienes et al.   DIGESTIVE DISEASES

Involvement of the Immune System in Idiosyncratic Drug Reactions

(2010) Xiachu Zhang et al.   Drug Metabolism and Pharmacokinetics

Cytochrome P450 regulation: the interplay between its heme and apoprotein moieties in synthesis, assembly, repair, and disposal

(2010) Maria Almira Correia et al.   DRUG METABOLISM REVIEWS

Reactive oxygen species, cellular redox systems, and apoptosis

(2010) Magdalena L. Circu et al.   FREE RADICAL BIOLOGY AND MEDICINE

Drug-induced acute liver failure: Results of a U.S. multicenter, prospective study

(2010) Adrian Reuben et al.   HEPATOLOGY

The DNA Damage Response: Making It Safe to Play with Knives

(2010) Alberto Ciccia et al.   MOLECULAR CELL

Mechanisms of Pathogenesis in Drug Hepatotoxicity Putting the Stress on Mitochondria

(2010) D. P. Jones et al.   MOLECULAR INTERVENTIONS

A map of human genome variation from population-scale sequencing

(2010) Richard M. Durbin et al.   NATURE

Drug-induced liver injury: past, present and future

(2010) Ann K Daly   PHARMACOGENOMICS

Hepatocyte Death: A Clear and Present Danger

(2010) Harmeet Malhi et al.   PHYSIOLOGICAL REVIEWS

Genetic Determinants of Drug-induced Cholestasis and Intrahepatic Cholestasis of Pregnancy

(2010) Christiane Pauli-Magnus et al.   SEMINARS IN LIVER DISEASE

The Role of Inflammation in Cholestasis: Clinical and Basic Aspects

(2010) Astrid Kosters et al.   SEMINARS IN LIVER DISEASE

Apoptosis as a Mechanism for Liver Disease Progression

(2010) Maria Eugenia Guicciardi et al.   SEMINARS IN LIVER DISEASE

Cell Death Mechanisms and Their Implications in Toxicology

(2010) Sten Orrenius et al.   TOXICOLOGICAL SCIENCES

Mechanisms of Immune-Mediated Liver Injury

(2010) David H. Adams et al.   TOXICOLOGICAL SCIENCES

Aflatoxin: A 50-Year Odyssey of Mechanistic and Translational Toxicology

(2010) T. W. Kensler et al.   TOXICOLOGICAL SCIENCES

Chemical Biology of Peroxynitrite: Kinetics, Diffusion, and Radicals

(2009) Gerardo Ferrer-Sueta et al.   ACS Chemical Biology

Oxidized Mitochondrial Protein Degradation and Repair in Aging and Oxidative Stress

(2009) Nicolas Ugarte et al.   ANTIOXIDANTS & REDOX SIGNALING

Involvement of thio-, peroxi-, and glutaredoxins in cellular redox-dependent processes

(2009) E. V. Kalinina et al.   BIOCHEMISTRY-MOSCOW

Nrf2 plays an important role in coordinated regulation of Phase II drug metabolism enzymes and Phase III drug transporters

(2009) Guoxiang Shen et al.   BIOPHARMACEUTICS & DRUG DISPOSITION

Metabolites in Safety Testing (MIST): Considerations of Mechanisms of Toxicity with Dose, Abundance, and Duration of Treatment

(2009) Dennis A. Smith et al.   CHEMICAL RESEARCH IN TOXICOLOGY

The Biochemistry of Drug Metabolism - An Introduction

(2009) Bernard Testa et al.   CHEMISTRY & BIODIVERSITY

The effects of splicing variant of PXR PAR-2 on CYP3A4 and MDR1 mRNA expressions

(2009) Yan Liu et al.   CLINICA CHIMICA ACTA

Pharmacokinetics of Acetaminophen-Protein Adducts in Adults with Acetaminophen Overdose and Acute Liver Failure

(2009) L. P. James et al.   DRUG METABOLISM AND DISPOSITION

Acetaminophen Hepatotoxicity and Acute Liver Failure

(2009) Linda J. Chun et al.   JOURNAL OF CLINICAL GASTROENTEROLOGY

Toward an “omic” physiopathology of reactive chemicals: Thirty years of mass spectrometric study of the protein adducts with endogenous and xenobiotic compounds

(2009) Federico Maria Rubino et al.   MASS SPECTROMETRY REVIEWS

Interplay of Transporters and Enzymes in Drug and Metabolite Processing

(2009) K. Sandy Pang et al.   MOLECULAR PHARMACEUTICS

Cytoplasmic functions of the tumour suppressor p53

(2009) Douglas R. Green et al.   NATURE

HLA-B*5701 genotype is a major determinant of drug-induced liver injury due to flucloxacillin

(2009) Ann K Daly et al.   NATURE GENETICS

Transduction of Redox Signaling by Electrophile-Protein Reactions

(2009) T. K. Rudolph et al.   Science Signaling

Microanatomy of the liver immune system

(2009) Eszter Nemeth et al.   Seminars in Immunopathology

Alcohol-induced Modulation of Signaling Pathways in Liver Parenchymal and Nonparenchymal Cells: Implications for Immunity

(2009) Bharath Nath et al.   SEMINARS IN LIVER DISEASE

Oxidative Stress and Alcoholic Liver Disease

(2009) Defeng Wu et al.   SEMINARS IN LIVER DISEASE

Functional pharmacogenetics/genomics of human cytochromes P450 involved in drug biotransformation

(2008) Ulrich M. Zanger et al.   ANALYTICAL AND BIOANALYTICAL CHEMISTRY

Inhibition and induction of human cytochrome P450 enzymes: current status

(2008) Olavi Pelkonen et al.   ARCHIVES OF TOXICOLOGY

How mitochondria produce reactive oxygen species

(2008) Michael P. Murphy   BIOCHEMICAL JOURNAL

Regulation of proteasome-mediated protein degradation during oxidative stress and aging

(2008) Nicolle Breusing et al.   BIOLOGICAL CHEMISTRY

The Biochemistry of Drug Metabolism - An Introduction

(2008) Bernard Testa et al.   CHEMISTRY & BIODIVERSITY

Drugs Behave as Substrates, Inhibitors and Inducers of Human Cytochrome P450 3A4

(2008) Shu-Feng Zhou   CURRENT DRUG METABOLISM

Unique Transcription Start Sites and Distinct Promoter Regions Differentiate the Pregnane X Receptor (PXR) Isoforms PXR 1 and PXR 2

(2008) L. M. Tompkins et al.   DRUG METABOLISM AND DISPOSITION

Interplay of conjugating enzymes with OATP uptake transporters and ABCC/MRP efflux pumps in the elimination of drugs

(2008) Anne T Nies et al.   Expert Opinion on Drug Metabolism & Toxicology

Glutathione and apoptosis

(2008) Magdalena L. Circu et al.   FREE RADICAL RESEARCH

Glutathione: Overview of its protective roles, measurement, and biosynthesis

(2008) Henry Jay Forman et al.   MOLECULAR ASPECTS OF MEDICINE

Glutathione in liver diseases and hepatotoxicity

(2008) Liyun Yuan et al.   MOLECULAR ASPECTS OF MEDICINE

Regulation of glutathione synthesis

(2008) Shelly C. Lu   MOLECULAR ASPECTS OF MEDICINE

Bile acid transporters in health and disease

(2008) A. Kosters et al.   XENOBIOTICA

Idiosyncratic Drug Reactions: Past, Present, and Future

(2007) Jack Uetrecht   CHEMICAL RESEARCH IN TOXICOLOGY

Protein Damage by Reactive Electrophiles: Targets and Consequences

(2007) Daniel C. Liebler   CHEMICAL RESEARCH IN TOXICOLOGY

4-Hydroxynonenal–protein adducts: A reliable biomarker of lipid oxidation in liver diseases

(2007) Giuseppe Poli et al.   MOLECULAR ASPECTS OF MEDICINE