Eukaryotic lipid droplets: metabolic hubs, and immune first responders

Not too fat to fight: The emerging role of macrophage fatty acid metabolism in immunity to Mycobacterium tuberculosis

(2021) Thomas Laval et al.   IMMUNOLOGICAL REVIEWS

Lipid Droplet Contact Sites in Health and Disease

(2021) Eva Herker et al.   TRENDS IN CELL BIOLOGY

An ESCRT-dependent step in fatty acid transfer from lipid droplets to mitochondria through VPS13D−TSG101 interactions

(2021) Jingru Wang et al.   Nature Communications

Lipid Droplet Motility Increases Following Viral Immune Stimulation

(2021) Ebony A. Monson et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

FIT2 organizes lipid droplet biogenesis with ER tubule-forming proteins and septins

(2021) Fang Chen et al.   JOURNAL OF CELL BIOLOGY

The antiviral enzyme viperin inhibits cholesterol biosynthesis

(2021) Timothy J. Grunkemeyer et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Lipid droplets and the host–pathogen dynamic: FATal attraction?

(2021) Marta Bosch et al.   JOURNAL OF CELL BIOLOGY

Intracellular lipid droplet accumulation occurs early following viral infection and is required for an efficient interferon response

(2021) E. A. Monson et al.   Nature Communications

Drosophila STING protein has a role in lipid metabolism

(2021) Katarina Akhmetova et al.   eLife

Mechanism of lipid droplet formation by the yeast Sei1/Ldb16 Seipin complex

(2021) Yoel A. Klug et al.   Nature Communications

Partitioning of MLX-Family Transcription Factors to Lipid Droplets Regulates Metabolic Gene Expression

(2020) Niklas Mejhert et al.   MOLECULAR CELL

Lipid droplets, bioenergetic fluxes, and metabolic flexibility

(2020) Marta Bosch et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Novel contact sites between lipid droplets, early endosomes, and the endoplasmic reticulum

(2020) Robert G. Parton et al.   JOURNAL OF LIPID RESEARCH

Antimicrobial peptides: Application informed by evolution

(2020) Brian P. Lazzaro et al.   SCIENCE

The cell biology of lipid droplets: More than just a phase

(2020) Robin W. Klemm et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Metabolic reprogramming by Zika virus provokes inflammation in human placenta

(2020) Qian Chen et al.   Nature Communications

Mammalian histones facilitate antimicrobial synergy by disrupting the bacterial proton gradient and chromosome organization

(2020) Tory Doolin et al.   Nature Communications

The ATGL lipase cooperates with ABHD5 to mobilize lipids for hepatitis C virus assembly

(2020) Gabrielle Vieyres et al.   PLoS Pathogens

Viperin Reveals Its True Function

(2020) Efraín E. Rivera-Serrano et al.   Annual Review of Virology

Regulation of lipid metabolism in pancreatic beta cells by interferon gamma: A link to anti-viral function

(2020) Nguyen T.T. Truong et al.   CYTOKINE

Hijacking of Lipid Droplets by Hepatitis C, Dengue and Zika Viruses—From Viral Protein Moonlighting to Extracellular Release

(2020) Alexandra P.M. Cloherty et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Triacylglycerol synthesis enhances macrophage inflammatory function

(2020) Angela Castoldi et al.   Nature Communications

Viperin binds STING and enhances the type‐I interferon response following dsDNA detection

(2020) Keaton M Crosse et al.   IMMUNOLOGY AND CELL BIOLOGY

The vitals of NETs

(2020) Chuyi Tan et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Triacylglycerols: Fuelling the Hibernating Mycobacterium tuberculosis

(2019) Rahul Kumar Maurya et al.   Frontiers in Cellular and Infection Microbiology

HCV Pit Stop at the Lipid Droplet: Refuel Lipids and Put on a Lipoprotein Coat before Exit

(2019) Gabrielle Vieyres et al.   Cells

West Nile Virus Capsid Protein Interacts With Biologically Relevant Host Lipid Systems

(2019) Ana S. Martins et al.   Frontiers in Cellular and Infection Microbiology

Viperin interacts with the kinase IRAK1 and the E3 ubiquitin ligase TRAF6,  coupling innate immune signaling to antiviral ribonucleotide synthesis

(2019) Arti B. Dumbrepatil et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

NF-κB Shapes Metabolic Adaptation by Attenuating Foxo-Mediated Lipolysis in Drosophila

(2019) Maral Molaei et al.   DEVELOPMENTAL CELL

Viral Generated Inter-Organelle Contacts Redirect Lipid Flux for Genome Replication

(2019) Orly Laufman et al.   CELL

Seipin Facilitates Triglyceride Flow to Lipid Droplet and Counteracts Droplet Ripening via Endoplasmic Reticulum Contact

(2019) Veijo T. Salo et al.   DEVELOPMENTAL CELL

Subcellular antibiotic visualization reveals a dynamic drug reservoir in infected macrophages

(2019) Daniel J. Greenwood et al.   SCIENCE

Spatiotemporal Coupling of the Hepatitis C Virus Replication Cycle by Creating a Lipid Droplet- Proximal Membranous Replication Compartment

(2019) Ji-Young Lee et al.   Cell Reports

Virus Impact on Lipids and Membranes

(2019) Ellen Ketter et al.   Annual Review of Virology

A twist of FATe: Lipid droplets and inflammatory lipid mediators

(2019) Eva Jarc et al.   BIOCHIMIE

Lipid Droplet-Derived Monounsaturated Fatty Acids Traffic via PLIN5 to Allosterically Activate SIRT1

(2019) Charles P. Najt et al.   MOLECULAR CELL

Flaviviruses Exploit the Lipid Droplet Protein AUP1 to Trigger Lipophagy and Drive Virus Production

(2018) Jingshu Zhang et al.   Cell Host & Microbe

Mitochondria Bound to Lipid Droplets Have Unique Bioenergetics, Composition, and Dynamics that Support Lipid Droplet Expansion

(2018) Ilan Y. Benador et al.   Cell Metabolism

A Proximity Labeling Strategy Provides Insights into the Composition and Dynamics of Lipid Droplet Proteomes

(2018) Kirill Bersuker et al.   DEVELOPMENTAL CELL

The assembly of lipid droplets and their roles in challenged cells

(2018) W Mike Henne et al.   EMBO JOURNAL

Patatin-like phospholipase domain–containing protein 3 promotes transfers of essential fatty acids from triglycerides to phospholipids in hepatic lipid droplets.

(2018) Michael A. Mitsche et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Lipid droplet density alters the early innate immune response to viral infection

(2018) Ebony A. Monson et al.   PLoS One

Lipid droplet formation in Mycobacterium tuberculosis infected macrophages requires IFN-γ/HIF-1α signaling and supports host defense

(2018) Matthew Knight et al.   PLoS Pathogens

Necrosis Driven Triglyceride Synthesis Primes Macrophages for Inflammation During Mycobacterium tuberculosis Infection

(2018) Neetika Jaisinghani et al.   Frontiers in Immunology

A naturally occurring antiviral ribonucleotide encoded by the human genome

(2018) Anthony S. Gizzi et al.   NATURE

Dynamics and functions of lipid droplets

(2018) James A. Olzmann et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Mycobacterium tuberculosis induces decelerated bioenergetic metabolism in human macrophages

(2018) Bridgette M Cumming et al.   eLife

Caveolin-1 regulates lipid droplet metabolism in endothelial cells via autocrine prostacyclin–stimulated, cAMP-mediated lipolysis

(2017) Andrew Kuo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Host lipid droplets: An important source of lipids salvaged by the intracellular parasite Toxoplasma gondii

(2017) Sabrina J. Nolan et al.   PLoS Pathogens

Lipid droplet hijacking by intracellular pathogens

(2016) Philippe Roingeard et al.   CELLULAR MICROBIOLOGY

Interferon-β promotes macrophage foam cell formation by altering both cholesterol influx and efflux mechanisms

(2016) Marieke C.S. Boshuizen et al.   CYTOKINE

Characterization of Eicosanoids Produced by Adipocyte Lipolysis

(2016) Allison Gartung et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Targeting cAMP/PKA pathway for glycemic control and type 2 diabetes therapy

(2016) Haihua Yang et al.   JOURNAL OF MOLECULAR ENDOCRINOLOGY

Slowing ageing by design: the rise of NAD+ and sirtuin-activating compounds

(2016) Michael S. Bonkowski et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Lipid Droplet Formation, Their Localization and Dynamics during Leishmania major Macrophage Infection

(2016) Sameh Rabhi et al.   PLoS One

How Low Cholesterol Is Good for Anti-viral Immunity

(2015) Luke A.J. O’Neill   CELL

Limiting Cholesterol Biosynthetic Flux Spontaneously Engages Type I IFN Signaling

(2015) Autumn G. York et al.   CELL

Metabolic reprogramming in macrophages and dendritic cells in innate immunity

(2015) Beth Kelly et al.   CELL RESEARCH

Lipid droplet dynamics at early stages ofMycobacterium marinuminfection inDictyostelium

(2015) Caroline Barisch et al.   CELLULAR MICROBIOLOGY

Protein Crowding Is a Determinant of Lipid Droplet Protein Composition

(2015) Nora Kory et al.   DEVELOPMENTAL CELL

Fatty Acid Trafficking in Starved Cells: Regulation by Lipid Droplet Lipolysis, Autophagy, and Mitochondrial Fusion Dynamics

(2015) Angelika S. Rambold et al.   DEVELOPMENTAL CELL

ATGL-Catalyzed Lipolysis Regulates SIRT1 to Control PGC-1α/PPAR-α Signaling

(2015) Salmaan Ahmed Khan et al.   DIABETES

Intercellular interplay between Sirt1 signalling and cell metabolism in immune cell biology

(2015) Xi Chen et al.   IMMUNOLOGY

Chlamydia trachomatisScavenges Host Fatty Acids for Phospholipid Synthesis via an Acyl-Acyl Carrier Protein Synthetase

(2015) Jiangwei Yao et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Degradation of lipid droplet-associated proteins by chaperone-mediated autophagy facilitates lipolysis

(2015) Susmita Kaushik et al.   NATURE CELL BIOLOGY

Chlamydia trachomatis Infection Leads to Defined Alterations to the Lipid Droplet Proteome in Epithelial Cells

(2015) Hector Alex Saka et al.   PLoS One

Dermal adipocytes protect against invasive Staphylococcus aureus skin infection

(2015) L.-j. Zhang et al.   SCIENCE

Viral activation of cellular metabolism

(2015) Erica L. Sanchez et al.   VIROLOGY

AMPK activation promotes lipid droplet dispersion on detyrosinated microtubules to increase mitochondrial fatty acid oxidation

(2015) Albert Herms et al.   Nature Communications

Chlamydia trachomatis growth depends on eukaryotic cholesterol esterification and is affected by Acyl-CoA:cholesterol acyltransferase inhibition

(2015) Jan Peters et al.   Pathogens and Disease

Remodeling of host phosphatidylcholine byChlamydiaacyltransferase is regulated by acyl-CoA binding protein ACBD6 associated with lipid droplets

(2015) Eric Soupene et al.   MicrobiologyOpen

The Broad-Spectrum Antiviral Compound ST-669 Restricts Chlamydial Inclusion Development and Bacterial Growth and Localizes to Host Cell Lipid Droplets within Treated Cells

(2014) Kelsi M. Sandoz et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Neutral Lipid Stores and Lipase PNPLA5 Contribute to Autophagosome Biogenesis

(2014) Nicolas Dupont et al.   CURRENT BIOLOGY

Biogenesis of the multifunctional lipid droplet: Lipids, proteins, and sites

(2014) Albert Pol et al.   JOURNAL OF CELL BIOLOGY

Chlamydia pneumoniae-Induced Foam Cell Formation Requires MyD88-Dependent and -Independent Signaling and Is Reciprocally Modulated by Liver X Receptor Activation

(2014) S. Chen et al.   JOURNAL OF IMMUNOLOGY

Adipose triglyceride lipase regulates eicosanoid production in activated human mast cells

(2014) Andrea Dichlberger et al.   JOURNAL OF LIPID RESEARCH

Rab18 Facilitates Dengue Virus Infection by Targeting Fatty Acid Synthase to Sites of Viral Replication

(2014) W.-C. Tang et al.   JOURNAL OF VIROLOGY

Cell-to-Cell Heterogeneity in Lipid Droplets Suggests a Mechanism to Reduce Lipotoxicity

(2013) Albert Herms et al.   CURRENT BIOLOGY

Diacylglycerol Acyltransferase-1 Localizes Hepatitis C Virus NS5A Protein to Lipid Droplets and Enhances NS5A Interaction with the Viral Capsid Core

(2013) Gregory Camus et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Acyl-CoA synthetase 3 promotes lipid droplet biogenesis in ER microdomains

(2013) Adam Kassan et al.   JOURNAL OF CELL BIOLOGY

Dengue virus capsid protein interacts specifically with very low-density lipoproteins

(2013) André F. Faustino et al.   Nanomedicine-Nanotechnology Biology and Medicine

Lipid Droplet-Binding Protein TIP47 Regulates Hepatitis C Virus RNA Replication through Interaction with the Viral NS5A Protein

(2013) Dorothee A. Vogt et al.   PLoS Pathogens

Rab18 Binds to Hepatitis C Virus NS5A and Promotes Interaction between Sites of Viral Replication and Lipid Droplets

(2013) Shadi Salloum et al.   PLoS Pathogens

Metabolic host responses to infection by intracellular bacterial pathogens

(2013) Wolfgang Eisenreich et al.   Frontiers in Cellular and Infection Microbiology

Lipid Droplets and Cellular Lipid Metabolism

(2012) Tobias C. Walther et al.   Annual Review of Biochemistry

Lipid Droplets Control the Maternal Histone Supply of Drosophila Embryos

(2012) Zhihuan Li et al.   CURRENT BIOLOGY

Fat-specific protein 27 modulates nuclear factor of activated T cells 5 and the cellular response to stress

(2012) Masami Ueno et al.   JOURNAL OF LIPID RESEARCH

Transcriptomic Signature of Leishmania Infected Mice Macrophages: A Metabolic Point of View

(2012) Imen Rabhi et al.   PLoS Neglected Tropical Diseases

A novel role for lipid droplets in the organismal antibacterial response

(2012) Preetha Anand et al.   eLife

Emerging Roles for Lipid Droplets in Immunity and Host-Pathogen Interactions

(2011) Hector Alex Saka et al.   Annual Review of Cell and Developmental Biology

The antiviral protein viperin inhibits hepatitis C virus replication via interaction with nonstructural protein 5A

(2011) Karla J. Helbig et al.   HEPATOLOGY

Antiviral Protein Viperin Promotes Toll-like Receptor 7- and Toll-like Receptor 9-Mediated Type I Interferon Production in Plasmacytoid Dendritic Cells

(2011) Tatsuya Saitoh et al.   IMMUNITY

Diverse Bacteria Promote Macrophage Foam Cell Formation Via Toll-Like Receptor-Dependent Lipid Body Biosynthesis

(2011) Giovanna Nicolaou et al.   Journal of Atherosclerosis and Thrombosis

Extracellular Histones Are Mediators of Death through TLR2 and TLR4 in Mouse Fatal Liver Injury

(2011) J. Xu et al.   JOURNAL OF IMMUNOLOGY

SIRT1 controls lipolysis in adipocytes via FOXO1-mediated expression of ATGL

(2011) Partha Chakrabarti et al.   JOURNAL OF LIPID RESEARCH

ATGL-mediated fat catabolism regulates cardiac mitochondrial function via PPAR-α and PGC-1

(2011) Guenter Haemmerle et al.   NATURE MEDICINE

Lipid body function in eicosanoid synthesis: An update

(2011) Patricia T. Bozza et al.   PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS

Endocannabinoid Hydrolysis Generates Brain Prostaglandins That Promote Neuroinflammation

(2011) D. K. Nomura et al.   SCIENCE

Mycobacterium tuberculosis Uses Host Triacylglycerol to Accumulate Lipid Droplets and Acquires a Dormancy-Like Phenotype in Lipid-Loaded Macrophages

(2011) Jaiyanth Daniel et al.   PLoS Pathogens

Dengue Virus-Induced Autophagy Regulates Lipid Metabolism

(2010) Nicholas S. Heaton et al.   Cell Host & Microbe

Modulation of lipid droplets by Mycobacterium leprae in Schwann cells: a putative mechanism for host lipid acquisition and bacterial survival in phagosomes

(2010) Katherine A. Mattos et al.   CELLULAR MICROBIOLOGY

Caseation of human tuberculosis granulomas correlates with elevated host lipid metabolism

(2010) Mi-Jeong Kim et al.   EMBO Molecular Medicine

Dengue virus nonstructural protein 3 redistributes fatty acid synthase to sites of viral replication and increases cellular fatty acid synthesis

(2010) N. S. Heaton et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Acyl-coenzyme A:cholesterol acyltransferases

(2009) Ta-Yuan Chang et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Lipid Droplets Finally Get a Little R-E-S-P-E-C-T

(2009) Robert V. Farese et al.   CELL

A Role for Lipid Bodies in the Cross-presentation of Phagocytosed Antigens by MHC Class I in Dendritic Cells

(2009) Laurence Bougnères et al.   IMMUNITY

SIRT1 Suppresses Activator Protein-1 Transcriptional Activity and Cyclooxygenase-2 Expression in Macrophages

(2009) Ran Zhang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Autophagy regulates lipid metabolism

(2009) Rajat Singh et al.   NATURE

The N-terminal Amphipathic α-Helix of Viperin Mediates Localization to the Cytosolic Face of the Endoplasmic Reticulum and Inhibits Protein Secretion

(2008) Ella R. Hinson et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cytoplasmic lipid droplets are translocated into the lumen of the Chlamydia trachomatis parasitophorous vacuole

(2008) J. L. Cocchiaro et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Foamy Macrophages from Tuberculous Patients' Granulomas Constitute a Nutrient-Rich Reservoir for M. tuberculosis Persistence

(2008) Pascale Peyron et al.   PLoS Pathogens