FIT2 organizes lipid droplet biogenesis with ER tubule-forming proteins and septins

Membrane Curvature Catalyzes Lipid Droplet Assembly

(2020) Alexandre Santinho et al.   CURRENT BIOLOGY

FIT2 is an acyl–coenzyme A diphosphatase crucial for endoplasmic reticulum homeostasis

(2020) Michel Becuwe et al.   JOURNAL OF CELL BIOLOGY

Yeast FIT2 homolog is necessary to maintain cellular proteostasis and membrane lipid homeostasis

(2020) Wei Sheng Yap et al.   JOURNAL OF CELL SCIENCE

Architecture of Lipid Droplets in Endoplasmic Reticulum Is Determined by Phospholipid Intrinsic Curvature

(2018) Vineet Choudhary et al.   CURRENT BIOLOGY

Human SEIPIN Binds Anionic Phospholipids

(2018) Renhong Yan et al.   DEVELOPMENTAL CELL

Cryo–electron microscopy structure of the lipid droplet–formation protein seipin

(2018) Xuewu Sui et al.   JOURNAL OF CELL BIOLOGY

Lipid Droplets in Health and Disease

(2017) Gizem Onal et al.   Lipids in Health and Disease

Bacterial lipid droplets bind to DNA via an intermediary protein that enhances survival under stress

(2017) Congyan Zhang et al.   Nature Communications

Quantitative proteomics reveal proteins enriched in tubular endoplasmic reticulum of Saccharomyces cerevisiae

(2017) Xinbo Wang et al.   eLife

The cytoskeletal protein septin 11 is associated with human obesity and is involved in adipocyte lipid storage and metabolism

(2016) Natalia Moreno-Castellanos et al.   DIABETOLOGIA

Seipin regulates ER–lipid droplet contacts and cargo delivery

(2016) Veijo T Salo et al.   EMBO JOURNAL

Septin 9 induces lipid droplets growth by a phosphatidylinositol-5-phosphate and microtubule-dependent mechanism hijacked by HCV

(2016) Abdellah Akil et al.   Nature Communications

Seipin is required for converting nascent to mature lipid droplets

(2016) Huajin Wang et al.   eLife

Postnatal Deletion of Fat Storage-inducing Transmembrane Protein 2 (FIT2/FITM2) Causes Lethal Enteropathy

(2015) Vera J. Goh et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structures of the yeast dynamin-like GTPase Sey1p provide insight into homotypic ER fusion

(2015) Liming Yan et al.   JOURNAL OF CELL BIOLOGY

The seipin complex Fld1/Ldb16 stabilizes ER–lipid droplet contact sites

(2015) Alexandra Grippa et al.   JOURNAL OF CELL BIOLOGY

A conserved family of proteins facilitates nascent lipid droplet budding from the ER

(2015) Vineet Choudhary et al.   JOURNAL OF CELL BIOLOGY

Seipin performs dissectible functions in promoting lipid droplet biogenesis and regulating droplet morphology

(2015) Bethany R. Cartwright et al.   MOLECULAR BIOLOGY OF THE CELL

Extended-resolution structured illumination imaging of endocytic and cytoskeletal dynamics

(2015) D. Li et al.   SCIENCE

Cytosolic lipid droplets: From mechanisms of fat storage to disease

(2014) David A. Gross et al.   CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY

Functional Mutation Analysis Provides Evidence for a Role of REEP1 in Lipid Droplet Biology

(2014) Julia Falk et al.   HUMAN MUTATION

Fat Storage-inducing Transmembrane Protein 2 Is Required for Normal Fat Storage in Adipose Tissue

(2014) Diego A. Miranda et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Septins promote F-actin ring formation by crosslinking actin filaments into curved bundles

(2014) Manos Mavrakis et al.   NATURE CELL BIOLOGY

Arf1/COPI machinery acts directly on lipid droplets and enables their connection to the ER for protein targeting

(2014) Florian Wilfling et al.   eLife

Triacylglycerol Synthesis Enzymes Mediate Lipid Droplet Growth by Relocalizing from the ER to Lipid Droplets

(2013) Florian Wilfling et al.   DEVELOPMENTAL CELL

Acyl-CoA synthetase 3 promotes lipid droplet biogenesis in ER microdomains

(2013) Adam Kassan et al.   JOURNAL OF CELL BIOLOGY

Protein Correlation Profiles Identify Lipid Droplet Proteins with High Confidence

(2013) Natalie Krahmer et al.   MOLECULAR & CELLULAR PROTEOMICS

Genome engineering using the CRISPR-Cas9 system

(2013) F Ann Ran et al.   Nature Protocols

The Lipid Droplet as a Potential Therapeutic Target in NAFLD

(2013) Vera Goh et al.   SEMINARS IN LIVER DISEASE

A Conserved Role for Atlastin GTPases in Regulating Lipid Droplet Size

(2013) Robin W. Klemm et al.   Cell Reports

SEPT9 occupies the terminal positions in septin octamers and mediates polymerization-dependent functions in abscission

(2011) Moshe S. Kim et al.   JOURNAL OF CELL BIOLOGY

The yeast lipin orthologue Pah1p is important for biogenesis of lipid droplets

(2011) Oludotun Adeyo et al.   JOURNAL OF CELL BIOLOGY

Lipid droplets are functionally connected to the endoplasmic reticulum in Saccharomyces cerevisiae

(2011) N. Jacquier et al.   JOURNAL OF CELL SCIENCE

Direct binding of triglyceride to fat storage-inducing transmembrane proteins 1 and 2 is important for lipid droplet formation

(2011) D. A. Gross et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structures of the atlastin GTPase provide insight into homotypic fusion of endoplasmic reticulum membranes

(2011) X. Bian et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Seipin Is a Discrete Homooligomer

(2010) Derk Binns et al.   BIOCHEMISTRY

Mechanisms Determining the Morphology of the Peripheral ER

(2010) Yoko Shibata et al.   CELL

Quantitative Analysis of Lipid Droplet Fusion: Inefficient Steady State Fusion but Rapid Stimulation by Chemical Fusogens

(2010) Samantha Murphy et al.   PLoS One

Conditions of endoplasmic reticulum stress stimulate lipid droplet formation inSaccharomyces cerevisiae

(2009) Weihua Fei et al.   BIOCHEMICAL JOURNAL

A Class of Dynamin-like GTPases Involved in the Generation of the Tubular ER Network

(2009) Junjie Hu et al.   CELL

Consequences of Motor Copy Number on the Intracellular Transport of Kinesin-1-Driven Lipid Droplets

(2008) George T. Shubeita et al.   CELL

The Reticulon and Dp1/Yop1p Proteins Form Immobile Oligomers in the Tubular Endoplasmic Reticulum

(2008) Yoko Shibata et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Membrane Proteins of the Endoplasmic Reticulum Induce High-Curvature Tubules

(2008) J. Hu et al.   SCIENCE