Hijacking of Lipid Droplets by Hepatitis C, Dengue and Zika Viruses—From Viral Protein Moonlighting to Extracellular Release

Lipid droplets can promote drug accumulation and activation

(2020) Ramin Dubey et al.   Nature Chemical Biology

Human organoids: model systems for human biology and medicine

(2020) Jihoon Kim et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Metabolic reprogramming by Zika virus provokes inflammation in human placenta

(2020) Qian Chen et al.   Nature Communications

SREBP-dependent lipidomic reprogramming as a broad-spectrum antiviral target

(2019) Shuofeng Yuan et al.   Nature Communications

HCV Pit Stop at the Lipid Droplet: Refuel Lipids and Put on a Lipoprotein Coat before Exit

(2019) Gabrielle Vieyres et al.   Cells

Zika Virus NS5 Forms Supramolecular Nuclear Bodies That Sequester Importin-α and Modulate the Host Immune and Pro-Inflammatory Response in Neuronal Cells

(2019) Ivan H. W. Ng et al.   ACS Infectious Diseases

Emerging Function and Clinical Values of Exosomal microRNAs in Cancer

(2019) Man Wang et al.   Molecular Therapy-Nucleic Acids

Functional correlation between subcellular localizations of Japanese encephalitis virus capsid protein and virus production

(2019) Kotaro Ishida et al.   JOURNAL OF VIROLOGY

Spatiotemporal Coupling of the Hepatitis C Virus Replication Cycle by Creating a Lipid Droplet- Proximal Membranous Replication Compartment

(2019) Ji-Young Lee et al.   Cell Reports

The Role of Exo-miRNAs in Cancer: A Focus on Therapeutic and Diagnostic Applications

(2019) Francesco Ingenito et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Lipid droplet size directs lipolysis and lipophagy catabolism in hepatocytes

(2019) Micah B. Schott et al.   JOURNAL OF CELL BIOLOGY

Hepatitis C virus nonstructural protein 5A perturbs lipid metabolism by modulating AMPK/SREBP-1c signaling

(2019) Ziyu Meng et al.   Lipids in Health and Disease

LDAF1 and Seipin Form a Lipid Droplet Assembly Complex

(2019) Jeeyun Chung et al.   DEVELOPMENTAL CELL

Nuclear localization of Zika virus NS5 contributes to suppression of type I interferon production and response

(2019) Zikai Zhao et al.   JOURNAL OF GENERAL VIROLOGY

Complex lipid metabolic remodeling is required for efficient hepatitis C virus replication

(2018) Sarah Hofmann et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

The Inner Nuclear Membrane Is a Metabolically Active Territory that Generates Nuclear Lipid Droplets

(2018) Anete Romanauska et al.   CELL

Flaviviruses Exploit the Lipid Droplet Protein AUP1 to Trigger Lipophagy and Drive Virus Production

(2018) Jingshu Zhang et al.   Cell Host & Microbe

Lipid droplet autophagy during energy mobilization lipid homeostasis and protein quality control

(2018) Liza A Pon   Frontiers in Bioscience-Landmark

The effect of diet and exercise on lipid droplet dynamics in human muscle tissue

(2018) Sabine Daemen et al.   JOURNAL OF EXPERIMENTAL BIOLOGY

Crystal Structure of the Capsid Protein from Zika Virus

(2018) Zifang Shang et al.   JOURNAL OF MOLECULAR BIOLOGY

SREBPs in Lipid Metabolism, Insulin Signaling, and Beyond

(2018) Russell A. DeBose-Boyd et al.   TRENDS IN BIOCHEMICAL SCIENCES

Hepatitis C Virus (HCV)–Apolipoprotein Interactions and Immune Evasion and Their Impact on HCV Vaccine Design

(2018) Florian Wrensch et al.   Frontiers in Immunology

Dynamics and functions of lipid droplets

(2018) James A. Olzmann et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The role of exosomes in hepatitis, liver cirrhosis and hepatocellular carcinoma

(2017) Jiliang Shen et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Proposed revision to the taxonomy of the genus Pestivirus, family Flaviviridae

(2017) Donald B. Smith et al.   JOURNAL OF GENERAL VIROLOGY

Endoplasmic Reticulum Protein SCAP Inhibits Dengue Virus NS2B3 Protease by Suppressing Its K27-Linked Polyubiquitylation

(2017) Heng Liu et al.   JOURNAL OF VIROLOGY

Lifestyle recommendations for the prevention and management of metabolic syndrome: an international panel recommendation

(2017) Pablo Pérez-Martínez et al.   NUTRITION REVIEWS

Hepatitis C Virus-Induced Autophagy and Host Innate Immune Response

(2017) et al.   Viruses-Basel

The lipid droplet: A conserved cellular organelle

(2017) Congyan Zhang et al.   Protein & Cell

The Role of Secretory Autophagy in Zika Virus Transfer through the Placental Barrier

(2017) Zhong-Wei Zhang et al.   Frontiers in Cellular and Infection Microbiology

Modulation of Lipid Droplet Metabolism—A Potential Target for Therapeutic Intervention in Flaviviridae Infections

(2017) Jingshu Zhang et al.   Frontiers in Microbiology

Treatment-Induced Viral Cure of Hepatitis C Virus-Infected Patients Involves a Dynamic Interplay among three Important Molecular Players in Lipid Homeostasis: Circulating microRNA (miR)-24, miR-223, and Proprotein Convertase Subtilisin/Kexin Type 9

(2017) Anastasia Hyrina et al.   EBioMedicine

Human Subtilisin Kexin Isozyme-1 (SKI-1)/Site-1 Protease (S1P) regulates cytoplasmic lipid droplet abundance: A potential target for indirect-acting anti-dengue virus agents

(2017) Anastasia Hyrina et al.   PLoS One

Lipoprotein carriers of microRNAs

(2016) Danielle L. Michell et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Zika Virus NS4A and NS4B Proteins Deregulate Akt-mTOR Signaling in Human Fetal Neural Stem Cells to Inhibit Neurogenesis and Induce Autophagy

(2016) Qiming Liang et al.   Cell Stem Cell

PIKfyve inhibition increases exosome release and induces secretory autophagy

(2016) Nina Pettersen Hessvik et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Lipid droplet hijacking by intracellular pathogens

(2016) Philippe Roingeard et al.   CELLULAR MICROBIOLOGY

New developments in proprotein convertase subtilisin–kexin 9ʼs biology and clinical implications

(2016) Nabil G. Seidah   CURRENT OPINION IN LIPIDOLOGY

Dedicated SNAREs and specialized TRIM cargo receptors mediate secretory autophagy

(2016) Tomonori Kimura et al.   EMBO JOURNAL

PML isoform II plays a critical role in nuclear lipid droplet formation

(2016) Yuki Ohsaki et al.   JOURNAL OF CELL BIOLOGY

Feedback Loop Regulation of SCAP/SREBP-1 by miR-29 Modulates EGFR Signaling-Driven Glioblastoma Growth

(2016) Peng Ru et al.   Cell Reports

Autophagy-associated dengue vesicles promote viral transmission avoiding antibody neutralization

(2016) Yan-Wei Wu et al.   Scientific Reports

SKI-1/S1P inhibitor PF-429242 impairs the onset of HCV infection

(2015) Matthieu Blanchet et al.   ANTIVIRAL RESEARCH

Expanding Roles for Lipid Droplets

(2015) Michael A. Welte   CURRENT BIOLOGY

Dynamic Interaction of Stress Granules, DDX3X, and IKK-α Mediates Multiple Functions in Hepatitis C Virus Infection

(2015) Véronique Pène et al.   JOURNAL OF VIROLOGY

Dengue Virus Evolution under a Host-Targeted Antiviral

(2015) Emily Plummer et al.   JOURNAL OF VIROLOGY

Knockdown of Autophagy Inhibits Infectious Hepatitis C Virus Release by the Exosomal Pathway

(2015) Shubham Shrivastava et al.   JOURNAL OF VIROLOGY

Hepatitis C virus and lipid droplets: finding a niche

(2015) Ana Filipe et al.   TRENDS IN MOLECULAR MEDICINE

Flaviviridae Replication Organelles: Oh, What a Tangled Web We Weave

(2015) David Paul et al.   Annual Review of Virology

An evolutionary perspective on protein moonlighting

(2014) Shelley D. Copley   BIOCHEMICAL SOCIETY TRANSACTIONS

Hepatitis C Virus RNA Replication and Assembly: Living on the Fat of the Land

(2014) David Paul et al.   Cell Host & Microbe

PCSK9 and LDLR degradation

(2014) Thomas A. Lagace   CURRENT OPINION IN LIPIDOLOGY

Inhibition of microRNA-24 expression in liver prevents hepatic lipid accumulation and hyperlipidemia

(2014) Raymond Ng et al.   HEPATOLOGY

MicroRNA-223 coordinates cholesterol homeostasis

(2014) Kasey C. Vickers et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Exosomes from Hepatitis C Infected Patients Transmit HCV Infection and Contain Replication Competent Viral RNA in Complex with Ago2-miR122-HSP90

(2014) Terence N. Bukong et al.   PLoS Pathogens

“Small Talk” in the Innate Immune System via RNA-Containing Extracellular Vesicles

(2014) Susanne G. van der Grein et al.   Frontiers in Immunology

Functional Characterization of Bovine Viral Diarrhea Virus Nonstructural Protein 5A by Reverse Genetic Analysis and Live Cell Imaging

(2013) O. Isken et al.   JOURNAL OF VIROLOGY

Exosomes mediate the cell-to-cell transmission of IFN-α-induced antiviral activity

(2013) Jianhua Li et al.   NATURE IMMUNOLOGY

Hepatitis C virus infection activates an innate pathway involving IKK-α in lipogenesis and viral assembly

(2013) Qisheng Li et al.   NATURE MEDICINE

MicroRNA-33 regulates sterol regulatory element-binding protein 1 expression in mice

(2013) Takahiro Horie et al.   Nature Communications

Nuclear lipid droplets: A novel nuclear domain

(2012) J.P. Layerenza et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Host-targeting agents for prevention and treatment of chronic hepatitis C – Perspectives and challenges

(2012) Mirjam B. Zeisel et al.   JOURNAL OF HEPATOLOGY

Deficiency of the Promyelocytic Leukemia Protein Fosters Hepatitis C-Associated Hepatocarcinogenesis in Mice

(2012) Kerstin Herzer et al.   PLoS One

Human Subtilase SKI-1/S1P Is a Master Regulator of the HCV Lifecycle and a Potential Host Cell Target for Developing Indirect-Acting Antiviral Agents

(2012) Andrea D. Olmstead et al.   PLoS Pathogens

Autophagy-based unconventional secretory pathway for extracellular delivery of IL-1β

(2011) Nicolas Dupont et al.   EMBO JOURNAL

Role of low-density lipoprotein receptor in the hepatitis C virus life cycle

(2011) Anna Albecka et al.   HEPATOLOGY

Dual Role of Ancient Ubiquitous Protein 1 (AUP1) in Lipid Droplet Accumulation and Endoplasmic Reticulum (ER) Protein Quality Control

(2011) Elizabeth J. Klemm et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Activation of the Ras/Raf/MEK Pathway Facilitates Hepatitis C Virus Replication via Attenuation of the Interferon-JAK-STAT Pathway

(2011) Q. Zhang et al.   JOURNAL OF VIROLOGY

Hepatitis C virus nonstructural protein-5A activates sterol regulatory element-binding protein-1c through transcription factor Sp1

(2010) Zhonghua Xiang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Dengue Virus-Induced Autophagy Regulates Lipid Metabolism

(2010) Nicholas S. Heaton et al.   Cell Host & Microbe

The GB viruses: a review and proposed classification of GBV-A, GBV-C (HGV), and GBV-D in genus Pegivirus within the family Flaviviridae

(2010) J. T. Stapleton et al.   JOURNAL OF GENERAL VIROLOGY

Hepatitis C virus replication cycle

(2010) Ralf Bartenschlager et al.   JOURNAL OF HEPATOLOGY

The origin of the autophagosomal membrane

(2010) Sharon A. Tooze et al.   NATURE CELL BIOLOGY

Efficient hepatitis C virus particle formation requires diacylglycerol acyltransferase-1

(2010) Eva Herker et al.   NATURE MEDICINE

Assembly of infectious hepatitis C virus particles

(2010) Ralf Bartenschlager et al.   TRENDS IN MICROBIOLOGY

PCSK9 impedes hepatitis C virus infectionin vitroand modulates liver CD81 expression

(2009) Patrick Labonté et al.   HEPATOLOGY

Hepatitis C virus infection and its clearance alter circulating lipids: Implications for long-term follow-up

(2009) Kathleen E. Corey et al.   HEPATOLOGY

Hepatitis C Virus Nonstructural 4B Protein Modulates Sterol Regulatory Element-binding Protein Signaling via the AKT Pathway

(2009) Chul-Yong Park et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Localization determines function: N-terminally truncated NS5A fragments accumulate in the nucleus and impair HCV replication

(2009) Daniel Sauter et al.   JOURNAL OF HEPATOLOGY

The autophagy machinery is required to initiate hepatitis C virus replication

(2009) M. Dreux et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Nuclear localization of dengue virus capsid protein is required for DAXX interaction and apoptosis

(2009) Janjuree Netsawang et al.   VIRUS RESEARCH

Dengue Virus Capsid Protein Usurps Lipid Droplets for Viral Particle Formation

(2009) Marcelo M. Samsa et al.   PLoS Pathogens