标题
Eukaryotic lipid droplets: metabolic hubs, and immune first responders
作者
关键词
lipid droplet, innate immunity, metabolism, infection
出版物
TRENDS IN ENDOCRINOLOGY AND METABOLISM
Volume 33, Issue 3, Pages 218-229
出版商
Elsevier BV
发表日期
2022-01-20
DOI
10.1016/j.tem.2021.12.006
参考文献
相关参考文献
注意：仅列出部分参考文献，下载原文获取全部文献信息。- Not too fat to fight: The emerging role of macrophage fatty acid metabolism in immunity to Mycobacterium tuberculosis
- (2021) Thomas Laval et al. IMMUNOLOGICAL REVIEWS
- Lipid Droplet Contact Sites in Health and Disease
- (2021) Eva Herker et al. TRENDS IN CELL BIOLOGY
- An ESCRT-dependent step in fatty acid transfer from lipid droplets to mitochondria through VPS13D−TSG101 interactions
- (2021) Jingru Wang et al. Nature Communications
- Lipid Droplet Motility Increases Following Viral Immune Stimulation
- (2021) Ebony A. Monson et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- FIT2 organizes lipid droplet biogenesis with ER tubule-forming proteins and septins
- (2021) Fang Chen et al. JOURNAL OF CELL BIOLOGY
- The antiviral enzyme viperin inhibits cholesterol biosynthesis
- (2021) Timothy J. Grunkemeyer et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Lipid droplets and the host–pathogen dynamic: FATal attraction?
- (2021) Marta Bosch et al. JOURNAL OF CELL BIOLOGY
- Intracellular lipid droplet accumulation occurs early following viral infection and is required for an efficient interferon response
- (2021) E. A. Monson et al. Nature Communications
- Drosophila STING protein has a role in lipid metabolism
- (2021) Katarina Akhmetova et al. eLife
- Mechanism of lipid droplet formation by the yeast Sei1/Ldb16 Seipin complex
- (2021) Yoel A. Klug et al. Nature Communications
- Partitioning of MLX-Family Transcription Factors to Lipid Droplets Regulates Metabolic Gene Expression
- (2020) Niklas Mejhert et al. MOLECULAR CELL
- Lipid droplets, bioenergetic fluxes, and metabolic flexibility
- (2020) Marta Bosch et al. SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
- Novel contact sites between lipid droplets, early endosomes, and the endoplasmic reticulum
- (2020) Robert G. Parton et al. JOURNAL OF LIPID RESEARCH
- Antimicrobial peptides: Application informed by evolution
- (2020) Brian P. Lazzaro et al. SCIENCE
- The cell biology of lipid droplets: More than just a phase
- (2020) Robin W. Klemm et al. SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
- Metabolic reprogramming by Zika virus provokes inflammation in human placenta
- (2020) Qian Chen et al. Nature Communications
- Mammalian histones facilitate antimicrobial synergy by disrupting the bacterial proton gradient and chromosome organization
- (2020) Tory Doolin et al. Nature Communications
- The ATGL lipase cooperates with ABHD5 to mobilize lipids for hepatitis C virus assembly
- (2020) Gabrielle Vieyres et al. PLoS Pathogens
- Viperin Reveals Its True Function
- (2020) Efraín E. Rivera-Serrano et al. Annual Review of Virology
- Regulation of lipid metabolism in pancreatic beta cells by interferon gamma: A link to anti-viral function
- (2020) Nguyen T.T. Truong et al. CYTOKINE
- Hijacking of Lipid Droplets by Hepatitis C, Dengue and Zika Viruses—From Viral Protein Moonlighting to Extracellular Release
- (2020) Alexandra P.M. Cloherty et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Triacylglycerol synthesis enhances macrophage inflammatory function
- (2020) Angela Castoldi et al. Nature Communications
- Viperin binds STING and enhances the type‐I interferon response following dsDNA detection
- (2020) Keaton M Crosse et al. IMMUNOLOGY AND CELL BIOLOGY
- The vitals of NETs
- (2020) Chuyi Tan et al. JOURNAL OF LEUKOCYTE BIOLOGY
- Triacylglycerols: Fuelling the Hibernating Mycobacterium tuberculosis
- (2019) Rahul Kumar Maurya et al. Frontiers in Cellular and Infection Microbiology
- HCV Pit Stop at the Lipid Droplet: Refuel Lipids and Put on a Lipoprotein Coat before Exit
- (2019) Gabrielle Vieyres et al. Cells
- West Nile Virus Capsid Protein Interacts With Biologically Relevant Host Lipid Systems
- (2019) Ana S. Martins et al. Frontiers in Cellular and Infection Microbiology
- Viperin interacts with the kinase IRAK1 and the E3 ubiquitin ligase TRAF6, coupling innate immune signaling to antiviral ribonucleotide synthesis
- (2019) Arti B. Dumbrepatil et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- NF-κB Shapes Metabolic Adaptation by Attenuating Foxo-Mediated Lipolysis in Drosophila
- (2019) Maral Molaei et al. DEVELOPMENTAL CELL
- Viral Generated Inter-Organelle Contacts Redirect Lipid Flux for Genome Replication
- (2019) Orly Laufman et al. CELL
- Seipin Facilitates Triglyceride Flow to Lipid Droplet and Counteracts Droplet Ripening via Endoplasmic Reticulum Contact
- (2019) Veijo T. Salo et al. DEVELOPMENTAL CELL
- Subcellular antibiotic visualization reveals a dynamic drug reservoir in infected macrophages
- (2019) Daniel J. Greenwood et al. SCIENCE
- Spatiotemporal Coupling of the Hepatitis C Virus Replication Cycle by Creating a Lipid Droplet- Proximal Membranous Replication Compartment
- (2019) Ji-Young Lee et al. Cell Reports
- Virus Impact on Lipids and Membranes
- (2019) Ellen Ketter et al. Annual Review of Virology
- A twist of FATe: Lipid droplets and inflammatory lipid mediators
- (2019) Eva Jarc et al. BIOCHIMIE
- Lipid Droplet-Derived Monounsaturated Fatty Acids Traffic via PLIN5 to Allosterically Activate SIRT1
- (2019) Charles P. Najt et al. MOLECULAR CELL
- Flaviviruses Exploit the Lipid Droplet Protein AUP1 to Trigger Lipophagy and Drive Virus Production
- (2018) Jingshu Zhang et al. Cell Host & Microbe
- Mitochondria Bound to Lipid Droplets Have Unique Bioenergetics, Composition, and Dynamics that Support Lipid Droplet Expansion
- (2018) Ilan Y. Benador et al. Cell Metabolism
- A Proximity Labeling Strategy Provides Insights into the Composition and Dynamics of Lipid Droplet Proteomes
- (2018) Kirill Bersuker et al. DEVELOPMENTAL CELL
- The assembly of lipid droplets and their roles in challenged cells
- (2018) W Mike Henne et al. EMBO JOURNAL
- Patatin-like phospholipase domain–containing protein 3 promotes transfers of essential fatty acids from triglycerides to phospholipids in hepatic lipid droplets.
- (2018) Michael A. Mitsche et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Lipid droplet density alters the early innate immune response to viral infection
- (2018) Ebony A. Monson et al. PLoS One
- Lipid droplet formation in Mycobacterium tuberculosis infected macrophages requires IFN-γ/HIF-1α signaling and supports host defense
- (2018) Matthew Knight et al. PLoS Pathogens
- Necrosis Driven Triglyceride Synthesis Primes Macrophages for Inflammation During Mycobacterium tuberculosis Infection
- (2018) Neetika Jaisinghani et al. Frontiers in Immunology
- A naturally occurring antiviral ribonucleotide encoded by the human genome
- (2018) Anthony S. Gizzi et al. NATURE
- Dynamics and functions of lipid droplets
- (2018) James A. Olzmann et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- Mycobacterium tuberculosis induces decelerated bioenergetic metabolism in human macrophages
- (2018) Bridgette M Cumming et al. eLife
- Caveolin-1 regulates lipid droplet metabolism in endothelial cells via autocrine prostacyclin–stimulated, cAMP-mediated lipolysis
- (2017) Andrew Kuo et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Host lipid droplets: An important source of lipids salvaged by the intracellular parasite Toxoplasma gondii
- (2017) Sabrina J. Nolan et al. PLoS Pathogens
- Lipid droplet hijacking by intracellular pathogens
- (2016) Philippe Roingeard et al. CELLULAR MICROBIOLOGY
- Interferon-β promotes macrophage foam cell formation by altering both cholesterol influx and efflux mechanisms
- (2016) Marieke C.S. Boshuizen et al. CYTOKINE
- Characterization of Eicosanoids Produced by Adipocyte Lipolysis
- (2016) Allison Gartung et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Targeting cAMP/PKA pathway for glycemic control and type 2 diabetes therapy
- (2016) Haihua Yang et al. JOURNAL OF MOLECULAR ENDOCRINOLOGY
- Slowing ageing by design: the rise of NAD+ and sirtuin-activating compounds
- (2016) Michael S. Bonkowski et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- Lipid Droplet Formation, Their Localization and Dynamics during Leishmania major Macrophage Infection
- (2016) Sameh Rabhi et al. PLoS One
- How Low Cholesterol Is Good for Anti-viral Immunity
- (2015) Luke A.J. O’Neill CELL
- Limiting Cholesterol Biosynthetic Flux Spontaneously Engages Type I IFN Signaling
- (2015) Autumn G. York et al. CELL
- Metabolic reprogramming in macrophages and dendritic cells in innate immunity
- (2015) Beth Kelly et al. CELL RESEARCH
- Lipid droplet dynamics at early stages ofMycobacterium marinuminfection inDictyostelium
- (2015) Caroline Barisch et al. CELLULAR MICROBIOLOGY
- Protein Crowding Is a Determinant of Lipid Droplet Protein Composition
- (2015) Nora Kory et al. DEVELOPMENTAL CELL
- Fatty Acid Trafficking in Starved Cells: Regulation by Lipid Droplet Lipolysis, Autophagy, and Mitochondrial Fusion Dynamics
- (2015) Angelika S. Rambold et al. DEVELOPMENTAL CELL
- ATGL-Catalyzed Lipolysis Regulates SIRT1 to Control PGC-1α/PPAR-α Signaling
- (2015) Salmaan Ahmed Khan et al. DIABETES
- Intercellular interplay between Sirt1 signalling and cell metabolism in immune cell biology
- (2015) Xi Chen et al. IMMUNOLOGY
- Chlamydia trachomatisScavenges Host Fatty Acids for Phospholipid Synthesis via an Acyl-Acyl Carrier Protein Synthetase
- (2015) Jiangwei Yao et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Degradation of lipid droplet-associated proteins by chaperone-mediated autophagy facilitates lipolysis
- (2015) Susmita Kaushik et al. NATURE CELL BIOLOGY
- Chlamydia trachomatis Infection Leads to Defined Alterations to the Lipid Droplet Proteome in Epithelial Cells
- (2015) Hector Alex Saka et al. PLoS One
- Dermal adipocytes protect against invasive Staphylococcus aureus skin infection
- (2015) L.-j. Zhang et al. SCIENCE
- Viral activation of cellular metabolism
- (2015) Erica L. Sanchez et al. VIROLOGY
- AMPK activation promotes lipid droplet dispersion on detyrosinated microtubules to increase mitochondrial fatty acid oxidation
- (2015) Albert Herms et al. Nature Communications
- Chlamydia trachomatis growth depends on eukaryotic cholesterol esterification and is affected by Acyl-CoA:cholesterol acyltransferase inhibition
- (2015) Jan Peters et al. Pathogens and Disease
- Remodeling of host phosphatidylcholine byChlamydiaacyltransferase is regulated by acyl-CoA binding protein ACBD6 associated with lipid droplets
- (2015) Eric Soupene et al. MicrobiologyOpen
- The Broad-Spectrum Antiviral Compound ST-669 Restricts Chlamydial Inclusion Development and Bacterial Growth and Localizes to Host Cell Lipid Droplets within Treated Cells
- (2014) Kelsi M. Sandoz et al. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
- Neutral Lipid Stores and Lipase PNPLA5 Contribute to Autophagosome Biogenesis
- (2014) Nicolas Dupont et al. CURRENT BIOLOGY
- Biogenesis of the multifunctional lipid droplet: Lipids, proteins, and sites
- (2014) Albert Pol et al. JOURNAL OF CELL BIOLOGY
- Chlamydia pneumoniae-Induced Foam Cell Formation Requires MyD88-Dependent and -Independent Signaling and Is Reciprocally Modulated by Liver X Receptor Activation
- (2014) S. Chen et al. JOURNAL OF IMMUNOLOGY
- Adipose triglyceride lipase regulates eicosanoid production in activated human mast cells
- (2014) Andrea Dichlberger et al. JOURNAL OF LIPID RESEARCH
- Rab18 Facilitates Dengue Virus Infection by Targeting Fatty Acid Synthase to Sites of Viral Replication
- (2014) W.-C. Tang et al. JOURNAL OF VIROLOGY
- Cell-to-Cell Heterogeneity in Lipid Droplets Suggests a Mechanism to Reduce Lipotoxicity
- (2013) Albert Herms et al. CURRENT BIOLOGY
- Diacylglycerol Acyltransferase-1 Localizes Hepatitis C Virus NS5A Protein to Lipid Droplets and Enhances NS5A Interaction with the Viral Capsid Core
- (2013) Gregory Camus et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Acyl-CoA synthetase 3 promotes lipid droplet biogenesis in ER microdomains
- (2013) Adam Kassan et al. JOURNAL OF CELL BIOLOGY
- Dengue virus capsid protein interacts specifically with very low-density lipoproteins
- (2013) André F. Faustino et al. Nanomedicine-Nanotechnology Biology and Medicine
- Lipid Droplet-Binding Protein TIP47 Regulates Hepatitis C Virus RNA Replication through Interaction with the Viral NS5A Protein
- (2013) Dorothee A. Vogt et al. PLoS Pathogens
- Rab18 Binds to Hepatitis C Virus NS5A and Promotes Interaction between Sites of Viral Replication and Lipid Droplets
- (2013) Shadi Salloum et al. PLoS Pathogens
- Metabolic host responses to infection by intracellular bacterial pathogens
- (2013) Wolfgang Eisenreich et al. Frontiers in Cellular and Infection Microbiology
- Lipid Droplets and Cellular Lipid Metabolism
- (2012) Tobias C. Walther et al. Annual Review of Biochemistry
- Lipid Droplets Control the Maternal Histone Supply of Drosophila Embryos
- (2012) Zhihuan Li et al. CURRENT BIOLOGY
- Fat-specific protein 27 modulates nuclear factor of activated T cells 5 and the cellular response to stress
- (2012) Masami Ueno et al. JOURNAL OF LIPID RESEARCH
- Transcriptomic Signature of Leishmania Infected Mice Macrophages: A Metabolic Point of View
- (2012) Imen Rabhi et al. PLoS Neglected Tropical Diseases
- A novel role for lipid droplets in the organismal antibacterial response
- (2012) Preetha Anand et al. eLife
- Emerging Roles for Lipid Droplets in Immunity and Host-Pathogen Interactions
- (2011) Hector Alex Saka et al. Annual Review of Cell and Developmental Biology
- The antiviral protein viperin inhibits hepatitis C virus replication via interaction with nonstructural protein 5A
- (2011) Karla J. Helbig et al. HEPATOLOGY
- Antiviral Protein Viperin Promotes Toll-like Receptor 7- and Toll-like Receptor 9-Mediated Type I Interferon Production in Plasmacytoid Dendritic Cells
- (2011) Tatsuya Saitoh et al. IMMUNITY
- Diverse Bacteria Promote Macrophage Foam Cell Formation Via Toll-Like Receptor-Dependent Lipid Body Biosynthesis
- (2011) Giovanna Nicolaou et al. Journal of Atherosclerosis and Thrombosis
- Extracellular Histones Are Mediators of Death through TLR2 and TLR4 in Mouse Fatal Liver Injury
- (2011) J. Xu et al. JOURNAL OF IMMUNOLOGY
- SIRT1 controls lipolysis in adipocytes via FOXO1-mediated expression of ATGL
- (2011) Partha Chakrabarti et al. JOURNAL OF LIPID RESEARCH
- ATGL-mediated fat catabolism regulates cardiac mitochondrial function via PPAR-α and PGC-1
- (2011) Guenter Haemmerle et al. NATURE MEDICINE
- Lipid body function in eicosanoid synthesis: An update
- (2011) Patricia T. Bozza et al. PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS
- Endocannabinoid Hydrolysis Generates Brain Prostaglandins That Promote Neuroinflammation
- (2011) D. K. Nomura et al. SCIENCE
- Mycobacterium tuberculosis Uses Host Triacylglycerol to Accumulate Lipid Droplets and Acquires a Dormancy-Like Phenotype in Lipid-Loaded Macrophages
- (2011) Jaiyanth Daniel et al. PLoS Pathogens
- Dengue Virus-Induced Autophagy Regulates Lipid Metabolism
- (2010) Nicholas S. Heaton et al. Cell Host & Microbe
- Modulation of lipid droplets by Mycobacterium leprae in Schwann cells: a putative mechanism for host lipid acquisition and bacterial survival in phagosomes
- (2010) Katherine A. Mattos et al. CELLULAR MICROBIOLOGY
- Caseation of human tuberculosis granulomas correlates with elevated host lipid metabolism
- (2010) Mi-Jeong Kim et al. EMBO Molecular Medicine
- Dengue virus nonstructural protein 3 redistributes fatty acid synthase to sites of viral replication and increases cellular fatty acid synthesis
- (2010) N. S. Heaton et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Acyl-coenzyme A:cholesterol acyltransferases
- (2009) Ta-Yuan Chang et al. AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
- Lipid Droplets Finally Get a Little R-E-S-P-E-C-T
- (2009) Robert V. Farese et al. CELL
- A Role for Lipid Bodies in the Cross-presentation of Phagocytosed Antigens by MHC Class I in Dendritic Cells
- (2009) Laurence Bougnères et al. IMMUNITY
- SIRT1 Suppresses Activator Protein-1 Transcriptional Activity and Cyclooxygenase-2 Expression in Macrophages
- (2009) Ran Zhang et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Autophagy regulates lipid metabolism
- (2009) Rajat Singh et al. NATURE
- The N-terminal Amphipathic α-Helix of Viperin Mediates Localization to the Cytosolic Face of the Endoplasmic Reticulum and Inhibits Protein Secretion
- (2008) Ella R. Hinson et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Cytoplasmic lipid droplets are translocated into the lumen of the Chlamydia trachomatis parasitophorous vacuole
- (2008) J. L. Cocchiaro et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Foamy Macrophages from Tuberculous Patients' Granulomas Constitute a Nutrient-Rich Reservoir for M. tuberculosis Persistence
- (2008) Pascale Peyron et al. PLoS Pathogens
Create your own webinar
Interested in hosting your own webinar? Check the schedule and propose your idea to the Peeref Content Team.
Create NowAsk a Question. Answer a Question.
Quickly pose questions to the entire community. Debate answers and get clarity on the most important issues facing researchers.
Get Started