Triacylglycerol synthesis enhances macrophage inflammatory function

Inflammatory macrophage dependence on NAD+ salvage is a consequence of reactive oxygen species–mediated DNA damage

(2019) Alanna M. Cameron et al.   NATURE IMMUNOLOGY

Probing the Global Cellular Responses to Lipotoxicity Caused by Saturated Fatty Acids

(2019) Manuele Piccolis et al.   MOLECULAR CELL

Macrophage fatty acid oxidation inhibits atherosclerosis progression

(2019) Mitsunori Nomura et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

snakePipes: facilitating flexible, scalable and integrative epigenomic analysis

(2019) Vivek Bhardwaj et al.   BIOINFORMATICS

Quantitative 1H NMR Metabolomics Reveal Distinct Metabolic Adaptations in Human Macrophages Following Differential Activation

(2019) Amanda L. Fuchs et al.   Metabolites

Foam Cells: One Size Doesn’t Fit All

(2019) Valentina Guerrini et al.   TRENDS IN IMMUNOLOGY

The assembly of lipid droplets and their roles in challenged cells

(2018) W Mike Henne et al.   EMBO JOURNAL

Lipid droplet formation in Mycobacterium tuberculosis infected macrophages requires IFN-γ/HIF-1α signaling and supports host defense

(2018) Matthew Knight et al.   PLoS Pathogens

A Role for the Krebs Cycle Intermediate Citrate in Metabolic Reprogramming in Innate Immunity and Inflammation

(2018) Niamh C. Williams et al.   Frontiers in Immunology

Necrosis Driven Triglyceride Synthesis Primes Macrophages for Inflammation During Mycobacterium tuberculosis Infection

(2018) Neetika Jaisinghani et al.   Frontiers in Immunology

Triglycerides Promote Lipid Homeostasis during Hypoxic Stress by Balancing Fatty Acid Saturation

(2018) Daniel Ackerman et al.   Cell Reports

Transcriptome Analysis Reveals Nonfoamy Rather Than Foamy Plaque Macrophages Are Proinflammatory in Atherosclerotic Murine Models

(2018) Kyeongdae Kim et al.   CIRCULATION RESEARCH

The Induction of Pro–IL-1β by Lipopolysaccharide Requires Endogenous Prostaglandin E2Production

(2017) Zbigniew Zasłona et al.   JOURNAL OF IMMUNOLOGY

Effect of interleukin-1β inhibition with canakinumab on incident lung cancer in patients with atherosclerosis: exploratory results from a randomised, double-blind, placebo-controlled trial

(2017) Paul M Ridker et al.   LANCET

Antiinflammatory Therapy with Canakinumab for Atherosclerotic Disease

(2017) Paul M Ridker et al.   NEW ENGLAND JOURNAL OF MEDICINE

Long-chain acylcarnitines determine ischaemia/reperfusion-induced damage in heart mitochondria

(2016) E. Liepinsh et al.   BIOCHEMICAL JOURNAL

Mitochondrial Dynamics Controls T Cell Fate through Metabolic Programming

(2016) Michael D. Buck et al.   CELL

Lipid droplets in leukocytes: Organelles linked to inflammatory responses

(2016) Rossana C.N. Melo et al.   EXPERIMENTAL CELL RESEARCH

Danger-associated molecular patterns in Alzheimer’s disease

(2016) Carmen Venegas et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Senescent intimal foam cells are deleterious at all stages of atherosclerosis

(2016) B. G. Childs et al.   SCIENCE

Enhanced fatty acid oxidation in adipocytes and macrophages reduces lipid-induced triglyceride accumulation and inflammation

(2015) Maria Ida Malandrino et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

A roadmap for interpreting 13 C metabolite labeling patterns from cells

(2015) Joerg M Buescher et al.   CURRENT OPINION IN BIOTECHNOLOGY

Network Integration of Parallel Metabolic and Transcriptional Data Reveals Metabolic Modules that Regulate Macrophage Polarization

(2015) Abhishek K. Jha et al.   IMMUNITY

Immunometabolism governs dendritic cell and macrophage function

(2015) Luke A.J. O’Neill et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Pathophysiological Roles of Cyclooxygenases and Prostaglandins in the Central Nervous System

(2015) Tatsurou Yagami et al.   MOLECULAR NEUROBIOLOGY

Acylcarnitines activate proinflammatory signaling pathways

(2014) Jennifer M. Rutkowsky et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Cell-intrinsic lysosomal lipolysis is essential for alternative activation of macrophages

(2014) Stanley Ching-Cheng Huang et al.   NATURE IMMUNOLOGY

TLR-driven early glycolytic reprogramming via the kinases TBK1-IKKɛ supports the anabolic demands of dendritic cell activation

(2014) Bart Everts et al.   NATURE IMMUNOLOGY

Mitochondrial Cristae Shape Determines Respiratory Chain Supercomplexes Assembly and Respiratory Efficiency

(2013) Sara Cogliati et al.   CELL

Carnitine palmitoyltransferase 2 and carnitine/acylcarnitine translocase are involved in the mitochondrial synthesis and export of acylcarnitines

(2013) Sara Violante et al.   FASEB JOURNAL

Toll-like Receptor Agonists Promote Prolonged Triglyceride Storage in Macrophages

(2013) Ying-ling Huang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Fatty acid–induced mitochondrial uncoupling elicits inflammasome-independent IL-1α and sterile vascular inflammation in atherosclerosis

(2013) Stefan Freigang et al.   NATURE IMMUNOLOGY

The biophysics and cell biology of lipid droplets

(2013) Abdou Rachid Thiam et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

PTENHaploinsufficiency, Obesity, and Insulin Sensitivity

(2012)   NEW ENGLAND JOURNAL OF MEDICINE

Interleukin-1 in the pathogenesis and treatment of inflammatory diseases

(2011) C. A. Dinarello   BLOOD

A clinical perspective of IL-1β as the gatekeeper of inflammation

(2011) Charles A. Dinarello   EUROPEAN JOURNAL OF IMMUNOLOGY

Targeting Acyl-CoA:Diacylglycerol Acyltransferase 1 (DGAT1) with Small Molecule Inhibitors for the Treatment of Metabolic Diseases

(2011) Jingsong Cao et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Mouse Macrophage Lipidome

(2010) Edward A. Dennis et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Efficient Phagocytosis Requires Triacylglycerol Hydrolysis by Adipose Triglyceride Lipase

(2010) Prakash G. Chandak et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mycobacterium tuberculosis evades macrophage defenses by inhibiting plasma membrane repair

(2009) Maziar Divangahi et al.   NATURE IMMUNOLOGY

Use of Canakinumab in the Cryopyrin-Associated Periodic Syndrome

(2009) Helen J. Lachmann et al.   NEW ENGLAND JOURNAL OF MEDICINE

Lipid mediators in innate immunity against tuberculosis: opposing roles of PGE2and LXA4in the induction of macrophage death

(2008) Minjian Chen et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Thematic Review Series: Glycerolipids.DGAT enzymes and triacylglycerol biosynthesis

(2008) Chi-Liang Eric Yen et al.   JOURNAL OF LIPID RESEARCH

Lipid extraction by methyl-tert-butyl ether for high-throughput lipidomics

(2008) Vitali Matyash et al.   JOURNAL OF LIPID RESEARCH