Subcellular antibiotic visualization reveals a dynamic drug reservoir in infected macrophages

Verapamil Targets Membrane Energetics in Mycobacterium tuberculosis

(2018) Chao Chen et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Characterization of a secretory hydrolase fromMycobacterium tuberculosissheds critical insight into host lipid utilization byM. tuberculosis

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Mycobacterium tuberculosisreplicates within necrotic human macrophages

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6-Cyano Analogues of Bedaquiline as Less Lipophilic and Potentially Safer Diarylquinolines for Tuberculosis

(2017) Amy S. T. Tong et al.   ACS Medicinal Chemistry Letters

Mycobacterium marinum Degrades Both Triacylglycerols and Phospholipids from Its Dictyostelium Host to Synthesise Its Own Triacylglycerols and Generate Lipid Inclusions

(2017) Caroline Barisch et al.   PLoS Pathogens

Bedaquiline, an FDA-approved antibiotic, inhibits mitochondrial function and potently blocks the proliferative expansion of stem-like cancer cells (CSCs)

(2016) Marco Fiorillo et al.   Aging-US

3D correlative light and electron microscopy of cultured cells using serial blockface scanning electron microscopy

(2016) Matthew R. G. Russell et al.   JOURNAL OF CELL SCIENCE

Lymphatic endothelial cells are a replicative niche for Mycobacterium tuberculosis

(2016) Thomas R. Lerner et al.   JOURNAL OF CLINICAL INVESTIGATION

Apicoplast-Localized Lysophosphatidic Acid Precursor Assembly Is Required for Bulk Phospholipid Synthesis in Toxoplasma gondii and Relies on an Algal/Plant-Like Glycerol 3-Phosphate Acyltransferase

(2016) Souad Amiar et al.   PLoS Pathogens

Bedaquiline and Pyrazinamide Treatment Responses Are Affected by Pulmonary Lesion Heterogeneity in Mycobacterium tuberculosis Infected C3HeB/FeJ Mice

(2016) Scott M. Irwin et al.   ACS Infectious Diseases

Determination of Bedaquiline in Human Serum Using Liquid Chromatography-Tandem Mass Spectrometry

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Lipid droplet dynamics at early stages ofMycobacterium marinuminfection inDictyostelium

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The association between sterilizing activity and drug distribution into tuberculosis lesions

(2015) Brendan Prideaux et al.   NATURE MEDICINE

Bedaquiline: a review of human pharmacokinetics and drug-drug interactions

(2014) R. P. G. van Heeswijk et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Verapamil, and Its Metabolite Norverapamil, Inhibit Macrophage-induced, Bacterial Efflux Pump-mediated Tolerance to Multiple Anti-tubercular Drugs

(2014) Kristin N. Adams et al.   JOURNAL OF INFECTIOUS DISEASES

Stable isotope imaging of biological samples with high resolution secondary ion mass spectrometry and complementary techniques

(2014) H. Jiang et al.   METHODS

Mycobacterium tuberculosis Modulates Macrophage Lipid-Sensing Nuclear Receptors PPAR  and TR4 for Survival

(2012) S. Mahajan et al.   JOURNAL OF IMMUNOLOGY

Lipid Body–Phagosome Interaction in Macrophages during Infectious Diseases: Host Defense or Pathogen Survival Strategy?

(2012) Rossana C. N. Melo et al.   PLoS Pathogens

Conserved Pro-Glu (PE) and Pro-Pro-Glu (PPE) Protein Domains Target LipY Lipases of Pathogenic Mycobacteria to the Cell Surface via the ESX-5 Pathway

(2011) Maria H. Daleke et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mycobacterium tuberculosis Uses Host Triacylglycerol to Accumulate Lipid Droplets and Acquires a Dormancy-Like Phenotype in Lipid-Loaded Macrophages

(2011) Jaiyanth Daniel et al.   PLoS Pathogens

Lipophilicity in drug discovery

(2010) Michael J Waring   Expert Opinion on Drug Discovery

Gluconeogenic carbon flow of tricarboxylic acid cycle intermediates is critical for Mycobacterium tuberculosis to establish and maintain infection

(2010) J. Marrero et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Foamy macrophages and the progression of the human tuberculosis granuloma

(2009) David G Russell et al.   NATURE IMMUNOLOGY

Foamy Macrophages from Tuberculous Patients' Granulomas Constitute a Nutrient-Rich Reservoir for M. tuberculosis Persistence

(2008) Pascale Peyron et al.   PLoS Pathogens