The antiviral enzyme viperin inhibits cholesterol biosynthesis

The Antiviral Enzyme, Viperin, Activates Protein Ubiquitination by the E3 Ubiquitin Ligase, TRAF6

(2021) Ayesha M. Patel et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Structural Basis of the Substrate Selectivity of Viperin

(2020) Michael K. Fenwick et al.   BIOCHEMISTRY

Interactions between Viperin, Vesicle-Associated Membrane Protein A, and Hepatitis C Virus Protein NS5A Modulate Viperin Activity and NS5A Degradation

(2020) Soumi Ghosh et al.   BIOCHEMISTRY

Viperin, through its radical‐SAM activity, depletes cellular nucleotide pools and interferes with mitochondrial metabolism to inhibit viral replication

(2020) Kourosh H. Ebrahimi et al.   FEBS LETTERS

Targeting viperin to the mitochondrion inhibits the thiolase activity of the trifunctional enzyme complex

(2020) Arti B. Dumbrepatil et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

ddhCTP produced by the radical‐SAM activity of RSAD2 (viperin) inhibits the NAD + ‐dependent activity of enzymes to modulate metabolism

(2020) Kourosh Honarmand Ebrahimi et al.   FEBS LETTERS

Viperin protein inhibits the replication of caprine parainfluenza virus 3 (CPIV 3) by interaction with viral N protein

(2020) Wenliang Li et al.   ANTIVIRAL RESEARCH

Viperin: an ancient radical-SAM enzyme finds its place in modern cellular metabolism and innate immunity

(2020) Soumi Ghosh et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structure and inhibition mechanism of the catalytic domain of human squalene epoxidase

(2019) Anil K. Padyana et al.   Nature Communications

Viperin interacts with the kinase IRAK1 and the E3 ubiquitin ligase TRAF6,  coupling innate immune signaling to antiviral ribonucleotide synthesis

(2019) Arti B. Dumbrepatil et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Viperin inhibits classical swine fever virus replication by interacting with viral nonstructural 5A protein

(2019) Chunmei Xu et al.   JOURNAL OF MEDICAL VIROLOGY

Targeting UBE4A Revives Viperin Protein in Epithelium to Enhance Host Antiviral Defense

(2019) Yukang Yuan et al.   MOLECULAR CELL

Human viperin catalyzes the modification of GPP and FPP potentially affecting cholesterol synthesis

(2018) Pavel Mikulecky et al.   FEBS LETTERS

Toll-like receptor agonist R848 blocks Zika virus replication by inducing the antiviral protein viperin

(2018) Bénédicte Vanwalscappel et al.   VIROLOGY

The antiviral protein Viperin suppresses T7 promoter dependent RNA synthesis–possible implications for its antiviral activity

(2018) Anna Dukhovny et al.   Scientific Reports

A naturally occurring antiviral ribonucleotide encoded by the human genome

(2018) Anthony S. Gizzi et al.   NATURE

The PRIDE database and related tools and resources in 2019: improving support for quantification data

(2018) Yasset Perez-Riverol et al.   NUCLEIC ACIDS RESEARCH

Cellular requirements for iron–sulfur cluster insertion into the antiviral radical SAM protein viperin

(2017) Arunkumar S. Upadhyay et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cholesterol is required for stability and infectivity of influenza A and respiratory syncytial viruses

(2017) Shringkhala Bajimaya et al.   VIROLOGY

Cholesterol reducing agents inhibit assembly of type I parainfluenza viruses

(2017) Shringkhala Bajimaya et al.   VIROLOGY

Systems Pharmacology Dissection of Cholesterol Regulation Reveals Determinants of Large Pharmacodynamic Variability between Cell Lines

(2017) Peter Blattmann et al.   Cell Systems

Viperin is an important host restriction factor in control of Zika virus infection

(2017) Kylie H. Van der Hoek et al.   Scientific Reports

Cholesterol Biosynthesis: A Mechanistic Overview

(2016) Nuno M. F. S. A. Cerqueira et al.   BIOCHEMISTRY

Does Viperin Function as a RadicalS-Adenosyl-l-methionine-dependent Enzyme in Regulating Farnesylpyrophosphate Synthase Expression and Activity?

(2016) Caitlyn Makins et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Benzoyl chloride derivatization with liquid chromatography–mass spectrometry for targeted metabolomics of neurochemicals in biological samples

(2016) Jenny-Marie T Wong et al.   JOURNAL OF CHROMATOGRAPHY A

Identification of Interferon-Stimulated Gene Proteins That Inhibit Human Parainfluenza Virus Type 3

(2016) M. A. G. Rabbani et al.   JOURNAL OF VIROLOGY

Global, quantitative and dynamic mapping of protein subcellular localization

(2016) Daniel N Itzhak et al.   eLife

Viperin protein expression inhibits the late stage of respiratory syncytial virus morphogenesis

(2015) Muhammad Raihan Jumat et al.   ANTIVIRAL RESEARCH

The Regulatory Domain of Squalene Monooxygenase Contains a Re-entrant Loop and Senses Cholesterol via a Conformational Change

(2015) Vicky Howe et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The E3 Ubiquitin Ligase MARCH6 Degrades Squalene Monooxygenase and Affects 3-Hydroxy-3-Methyl-Glutaryl Coenzyme A Reductase and the Cholesterol Synthesis Pathway

(2014) N. Zelcer et al.   MOLECULAR AND CELLULAR BIOLOGY

The Role of Viperin in the Innate Antiviral Response

(2013) Karla J. Helbig et al.   JOURNAL OF MOLECULAR BIOLOGY

The CRAPome: a contaminant repository for affinity purification–mass spectrometry data

(2013) Dattatreya Mellacheruvu et al.   NATURE METHODS

Viperin Is Induced following Dengue Virus Type-2 (DENV-2) Infection and Has Anti-viral Actions Requiring the C-terminal End of Viperin

(2013) Karla J. Helbig et al.   PLoS Neglected Tropical Diseases

Viperin Regulates Cellular Lipid Metabolism during Human Cytomegalovirus Infection

(2013) Jun-Young Seo et al.   PLoS Pathogens

HIV-1 infection of human macrophages directly induces viperin which inhibits viral production

(2012) N. Nasr et al.   BLOOD

Replication of Respiratory Syncytial Virus Is Inhibited by the Host Defense Molecule Viperin

(2012) Glen McGillivary et al.   Journal of Innate Immunity

The Presence of the Iron-Sulfur Motif Is Important for the Conformational Stability of the Antiviral Protein, Viperin

(2012) Shubhasis Haldar et al.   PLoS One

Viperin: A Multifunctional, Interferon-Inducible Protein that Regulates Virus Replication

(2011) Jun-Young Seo et al.   Cell Host & Microbe

Cholesterol-Dependent Degradation of Squalene Monooxygenase, a Control Point in Cholesterol Synthesis beyond HMG-CoA Reductase

(2011) Saloni Gill et al.   Cell Metabolism

The antiviral protein viperin inhibits hepatitis C virus replication via interaction with nonstructural protein 5A

(2011) Karla J. Helbig et al.   HEPATOLOGY

Viperin Links Lipid Bodies to Immune Defense

(2011) Xiaomo Jiang et al.   IMMUNITY

Antiviral Protein Viperin Promotes Toll-like Receptor 7- and Toll-like Receptor 9-Mediated Type I Interferon Production in Plasmacytoid Dendritic Cells

(2011) Tatsuya Saitoh et al.   IMMUNITY

Viperin inhibits hepatitis C virus replication by interfering with binding of NS5A to host protein hVAP-33

(2011) S. Wang et al.   JOURNAL OF GENERAL VIROLOGY

Viperin, a key player in the antiviral response

(2011) Sandy Mattijssen et al.   MICROBES AND INFECTION

Human Cytomegalovirus Directly Induces the Antiviral Protein Viperin to Enhance Infectivity

(2011) J.-Y. Seo et al.   SCIENCE

The antiviral protein viperin is a radical SAM enzyme

(2010) Kaitlin S. Duschene et al.   FEBS LETTERS

The Interferon Inducible Gene: Viperin

(2010) Katherine A. Fitzgerald   JOURNAL OF INTERFERON AND CYTOKINE RESEARCH

All Three Domains of the Hepatitis C Virus Nonstructural NS5A Protein Contribute to RNA Binding

(2010) T. L. Foster et al.   JOURNAL OF VIROLOGY

Identification of Five Interferon-Induced Cellular Proteins That Inhibit West Nile Virus and Dengue Virus Infections

(2010) D. Jiang et al.   JOURNAL OF VIROLOGY

SAINT: probabilistic scoring of affinity purification–mass spectrometry data

(2010) Hyungwon Choi et al.   NATURE METHODS

Structural characterization reveals that viperin is a radical S-adenosyl-l-methionine (SAM) enzyme

(2009) Goyal Shaveta et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

The antiviral protein, viperin, localizes to lipid droplets via its N-terminal amphipathic  -helix

(2009) E. R. Hinson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The N-terminal Amphipathic α-Helix of Viperin Mediates Localization to the Cytosolic Face of the Endoplasmic Reticulum and Inhibits Protein Secretion

(2008) Ella R. Hinson et al.   JOURNAL OF BIOLOGICAL CHEMISTRY