Lipid Droplets and Cellular Lipid Metabolism

Cardiac dysfunction in adipose triglyceride lipase deficiency: treatment with a PPARα agonist

(2011) G Wölkart et al.   BRITISH JOURNAL OF PHARMACOLOGY

Phosphatidylcholine Synthesis for Lipid Droplet Expansion Is Mediated by Localized Activation of CTP:Phosphocholine Cytidylyltransferase

(2011) Natalie Krahmer et al.   Cell Metabolism

Autophagy Regulates Cholesterol Efflux from Macrophage Foam Cells via Lysosomal Acid Lipase

(2011) Mireille Ouimet et al.   Cell Metabolism

Human Lysophosphatidylcholine Acyltransferases 1 and 2 Are Located in Lipid Droplets Where They Catalyze the Formation of Phosphatidylcholine

(2011) Christine Moessinger et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Unique Regulation of Adipose Triglyceride Lipase (ATGL) by Perilipin 5, a Lipid Droplet-associated Protein

(2011) Hong Wang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Monoglyceride Lipase Deficiency in Mice Impairs Lipolysis and Attenuates Diet-induced Insulin Resistance

(2011) Ulrike Taschler et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Dual Role of Ancient Ubiquitous Protein 1 (AUP1) in Lipid Droplet Accumulation and Endoplasmic Reticulum (ER) Protein Quality Control

(2011) Elizabeth J. Klemm et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Lipid Droplet Formation Is Dispensable for Endoplasmic Reticulum-associated Degradation

(2011) James A. Olzmann et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Retinyl Ester Storage Particles (Retinosomes) from the Retinal Pigmented Epithelium Resemble Lipid Droplets in Other Tissues

(2011) Tivadar Orban et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Fsp27 promotes lipid droplet growth by lipid exchange and transfer at lipid droplet contact sites

(2011) Jingyi Gong et al.   JOURNAL OF CELL BIOLOGY

Lipid droplets are functionally connected to the endoplasmic reticulum in Saccharomyces cerevisiae

(2011) N. Jacquier et al.   JOURNAL OF CELL SCIENCE

The role of lipid droplets in metabolic disease in rodents and humans

(2011) Andrew S. Greenberg et al.   JOURNAL OF CLINICAL INVESTIGATION

FSP27 Promotes Lipid Droplet Clustering and Then Fusion to Regulate Triglyceride Accumulation

(2011) Srikarthika Jambunathan et al.   PLoS One

Unique ties between hepatitis C virus replication and intracellular lipids

(2011) Eva Herker et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Not Just Fat: The Structure and Function of the Lipid Droplet

(2011) T. Fujimoto et al.   Cold Spring Harbor Perspectives in Biology

A Role for Phosphatidic Acid in the Formation of “Supersized” Lipid Droplets

(2011) Weihua Fei et al.   PLoS Genetics

A New Wave of Cellular Imaging

(2010) Derek Toomre et al.   Annual Review of Cell and Developmental Biology

Seipin Is a Discrete Homooligomer

(2010) Derk Binns et al.   BIOCHEMISTRY

Spartin activates atrophin-1-interacting protein 4 (AIP4) E3 ubiquitin ligase and promotes ubiquitination of adipophilin on lipid droplets

(2010) Christopher Hooper et al.   BMC BIOLOGY

Drosophila Genome-wide Obesity Screen Reveals Hedgehog as a Determinant of Brown versus White Adipose Cell Fate

(2010) J. Andrew Pospisilik et al.   CELL

PERILIPIN-Dependent Control of Lipid Droplet Structure and Fat Storage in Drosophila

(2010) Mathias Beller et al.   Cell Metabolism

The G0/G1 Switch Gene 2 Regulates Adipose Lipolysis through Association with Adipose Triglyceride Lipase

(2010) Xingyuan Yang et al.   Cell Metabolism

Patatin-like phospholipase domain-containing 3/adiponutrin deficiency in mice is not associated with fatty liver disease

(2010) Weiqin Chen et al.   HEPATOLOGY

Interactions of Perilipin-5 (Plin5) with Adipose Triglyceride Lipase

(2010) James G. Granneman et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Fat-specific Protein 27 Undergoes Ubiquitin-dependent Degradation Regulated by Triacylglycerol Synthesis and Lipid Droplet Formation

(2010) Zongqian Nian et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The N-terminal Region of Comparative Gene Identification-58 (CGI-58) Is Important for Lipid Droplet Binding and Activation of Adipose Triglyceride Lipase

(2010) Astrid Gruber et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Ancient Ubiquitous Protein 1 (AUP1) Localizes to Lipid Droplets and Binds the E2 Ubiquitin Conjugase G2 (Ube2g2) via Its G2 Binding Region

(2010) Johanna Spandl et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Sterol-induced Dislocation of 3-Hydroxy-3-methylglutaryl Coenzyme A Reductase from Endoplasmic Reticulum Membranes into the Cytosol through a Subcellular Compartment Resembling Lipid Droplets

(2010) Isamu Z. Hartman et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

DGAT1-dependent triacylglycerol storage by macrophages protects mice from diet-induced insulin resistance and inflammation

(2010) Suneil K. Koliwad et al.   JOURNAL OF CLINICAL INVESTIGATION

Pnpla3/Adiponutrin deficiency in mice does not contribute to fatty liver disease or metabolic syndrome

(2010) Mahesh K. Basantani et al.   JOURNAL OF LIPID RESEARCH

Induction of Liver Steatosis and Lipid Droplet Formation in ATF6α-Knockout Mice Burdened with Pharmacological Endoplasmic Reticulum Stress

(2010) Keisuke Yamamoto et al.   MOLECULAR BIOLOGY OF THE CELL

Efficient hepatitis C virus particle formation requires diacylglycerol acyltransferase-1

(2010) Eva Herker et al.   NATURE MEDICINE

Structural Insights into Triglyceride Storage Mediated by Fat Storage-Inducing Transmembrane (FIT) Protein 2

(2010) David A. Gross et al.   PLoS One

Quantitative Analysis of Lipid Droplet Fusion: Inefficient Steady State Fusion but Rapid Stimulation by Chemical Fusogens

(2010) Samantha Murphy et al.   PLoS One

Physiological and developmental regulation of seed oil production

(2010) Sébastien Baud et al.   PROGRESS IN LIPID RESEARCH

Lipid droplets in inflammation and cancer

(2010) Patricia T. Bozza et al.   PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS

Leptin at 14 y of age: an ongoing story

(2009) Jeffrey M Friedman   AMERICAN JOURNAL OF CLINICAL NUTRITION

Endogenous spartin (SPG20) is recruited to endosomes and lipid droplets and interacts with the ubiquitin E3 ligases AIP4 and AIP5

(2009) Thomas L. Edwards et al.   BIOCHEMICAL JOURNAL

Conditions of endoplasmic reticulum stress stimulate lipid droplet formation inSaccharomyces cerevisiae

(2009) Weihua Fei et al.   BIOCHEMICAL JOURNAL

Lipodystrophies: Disorders of adipose tissue biology

(2009) Abhimanyu Garg et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Lipid Droplets Finally Get a Little R-E-S-P-E-C-T

(2009) Robert V. Farese et al.   CELL

Cideb, an ER- and Lipid Droplet-Associated Protein, Mediates VLDL Lipidation and Maturation by Interacting with Apolipoprotein B

(2009) Jing Ye et al.   Cell Metabolism

Lipid Droplet Biogenesis Induced by Stress Involves Triacylglycerol Synthesis That Depends on Group VIA Phospholipase A2

(2009) Albert Gubern et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Sequence Variation (I148M) in PNPLA3 Associated with Nonalcoholic Fatty Liver Disease Disrupts Triglyceride Hydrolysis

(2009) Shaoqing He et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

DGAT1 Expression Increases Heart Triglyceride Content but Ameliorates Lipotoxicity

(2009) Li Liu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Lipid Droplets Are Novel Sites ofN-Acylethanolamine Inactivation by Fatty Acid Amide Hydrolase-2

(2009) Martin Kaczocha et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Activation of Hormone-sensitive Lipase Requires Two Steps, Protein Phosphorylation and Binding to the PAT-1 Domain of Lipid Droplet Coat Proteins

(2009) Hong Wang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Diacylglycerol Enrichment of Endoplasmic Reticulum or Lipid Droplets Recruits Perilipin 3/TIP47 during Lipid Storage and Mobilization

(2009) James R. Skinner et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A role for ubiquitin ligases and Spartin/SPG20 in lipid droplet turnover

(2009) Scott W. Eastman et al.   JOURNAL OF CELL BIOLOGY

TIP47 functions in the biogenesis of lipid droplets

(2009) Anna V. Bulankina et al.   JOURNAL OF CELL BIOLOGY

Coatomer-dependent protein delivery to lipid droplets

(2009) K. G. Soni et al.   JOURNAL OF CELL SCIENCE

A dynamic, cytoplasmic triacylglycerol pool in enterocytes revealed by ex vivo and in vivo coherent anti-Stokes Raman scattering imaging

(2009) Jiabin Zhu et al.   JOURNAL OF LIPID RESEARCH

OSBP-related protein 2 is a sterol receptor on lipid droplets that regulates the metabolism of neutral lipids

(2009) Riikka Hynynen et al.   JOURNAL OF LIPID RESEARCH

Cdk1/Cdc28-Dependent Activation of the Major Triacylglycerol Lipase Tgl4 in Yeast Links Lipolysis to Cell-Cycle Progression

(2009) Christoph F. Kurat et al.   MOLECULAR CELL

Autophagy regulates lipid metabolism

(2009) Rajat Singh et al.   NATURE

Tobacco as a production platform for biofuel: overexpression ofArabidopsis DGATandLEC2genes increases accumulation and shifts the composition of lipids in green biomass

(2009) Vyacheslav Andrianov et al.   PLANT BIOTECHNOLOGY JOURNAL

The antiviral protein, viperin, localizes to lipid droplets via its N-terminal amphipathic  -helix

(2009) E. R. Hinson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Seed Storage Oil Mobilization

(2008) Ian A. Graham   Annual Review of Plant Biology

The life of lipid droplets

(2008) Tobias C. Walther et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Hepatic stellate cell lipid droplets: A specialized lipid droplet for retinoid storage

(2008) William S. Blaner et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Consequences of Motor Copy Number on the Intracellular Transport of Kinesin-1-Driven Lipid Droplets

(2008) George T. Shubeita et al.   CELL

Cell biology of lipid droplets

(2008) Christoph Thiele et al.   CURRENT OPINION IN CELL BIOLOGY

The C-terminal Region of Human Adipose Triglyceride Lipase Affects Enzyme Activity and Lipid Droplet Binding

(2008) Martina Schweiger et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Endoplasmic Reticulum Enzyme DGAT2 Is Found in Mitochondria-associated Membranes and Has a Mitochondrial Targeting Signal That Promotes Its Association with Mitochondria

(2008) Scot J. Stone et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Fat-specific Protein 27 Regulates Storage of Triacylglycerol

(2008) Pernille Keller et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structural and Biochemical Properties of Lipid Particles from the YeastSaccharomyces cerevisiae

(2008) Tibor Czabany et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Fld1p, a functional homologue of human seipin, regulates the size of lipid droplets in yeast

(2008) Weihua Fei et al.   JOURNAL OF CELL BIOLOGY

Identification of a novel N-terminal hydrophobic sequence that targets proteins to lipid droplets

(2008) J. K. Zehmer et al.   JOURNAL OF CELL SCIENCE

Lipid droplets are arrested in the ER membrane by tight binding of lipidated apolipoprotein B-100

(2008) Y. Ohsaki et al.   JOURNAL OF CELL SCIENCE

Hepatic triacylglycerol accumulation and insulin resistance

(2008) Cynthia A. Nagle et al.   JOURNAL OF LIPID RESEARCH

Suppression of Soybean Oleosin Produces Micro-Oil Bodies that Aggregate into Oil Body/ER Complexes

(2008) Monica A. Schmidt et al.   Molecular Plant

Functional genomic screen reveals genes involved in lipid-droplet formation and utilization

(2008) Yi Guo et al.   NATURE

A phenylalanine in DGAT is a key determinant of oil content and composition in maize

(2008) Peizhong Zheng et al.   NATURE GENETICS

Ser649 and Ser650 Are the Major Determinants of Protein Kinase A-Mediated Activation of Human Hormone-Sensitive Lipase against Lipid Substrates

(2008) Christian Krintel et al.   PLoS One

Hepatitis C Virus Core Protein Induces Lipid Droplet Redistribution in a Microtubule- and Dynein-Dependent Manner

(2008) Steeve Boulant et al.   TRAFFIC

Imaging of Lipid Biosynthesis: How a Neutral Lipid Enters Lipid Droplets

(2008) Lars Kuerschner et al.   TRAFFIC

COPI Complex Is a Regulator of Lipid Homeostasis

(2008) Mathias Beller et al.   PLOS BIOLOGY