When healing turns into killing – the pathophysiology of pancreatic and hepatic fibrosis

CRISPR-Cas9 screen identifies oxidative phosphorylation as essential for cancer cell survival at low extracellular pH

(2022) Johanna Michl et al.   Cell Reports

Monocarboxylate Transporters Are Involved in Extracellular Matrix Remodelling in Pancreatic Ductal Adenocarcinoma

(2022) Ayşe Ufuk et al.   Cancers

Deletion of Mcpip1 in Mcpip1fl/flAlbCre mice recapitulates the phenotype of human primary biliary cholangitis

(2021) Jerzy Kotlinowski et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Hepatocyte-specific IL11 cis-signaling drives lipotoxicity and underlies the transition from NAFLD to NASH

(2021) Jinrui Dong et al.   Nature Communications

Fibroblast cells reveal their ancestry

(2021) Christopher D. Buckley   NATURE

The Roles of Calcium and ATP in the Physiology and Pathology of the Exocrine Pancreas

(2021) Ole H. Petersen et al.   PHYSIOLOGICAL REVIEWS

Cellular Mechanisms of Liver Fibrosis

(2021) Pragyan Acharya et al.   Frontiers in Pharmacology

Salidroside Inhibits CCl4-Induced Liver Fibrosis in Mice by Reducing Activation and Migration of HSC Induced by Liver Sinusoidal Endothelial Cell-Derived Exosomal SphK1

(2021) Qiannan Ye et al.   Frontiers in Pharmacology

Adipocyte Fatty Acid Binding Protein Promotes the Onset and Progression of Liver Fibrosis via Mediating the Crosstalk between Liver Sinusoidal Endothelial Cells and Hepatic Stellate Cells

(2021) Xiaoping Wu et al.   Advanced Science

Matrix stiffness and its influence on pancreatic diseases

(2021) Weifan Zhang et al.   BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER

Co-encapsulation of collagenase type I and silibinin in chondroitin sulfate coated multilayered nanoparticles for targeted treatment of liver fibrosis

(2021) Jingwen Luo et al.   CARBOHYDRATE POLYMERS

CYP2E1 in Alcoholic and Non-Alcoholic Liver Injury. Roles of ROS, Reactive Intermediates and Lipid Overload

(2021) Riina Harjumäki et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Pancreatic Cancer

(2021) Wungki Park et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Fasudil prevents liver fibrosis via activating natural killer cells and suppressing hepatic stellate cells

(2021) Qiu-Ju Han et al.   WORLD JOURNAL OF GASTROENTEROLOGY

Single-cell RNA-seq reveals fibroblast heterogeneity and increased mesenchymal fibroblasts in human fibrotic skin diseases

(2021) Cheng-Cheng Deng et al.   Nature Communications

Stromal hyaluronan accumulation is associated with low immune response and poor prognosis in pancreatic cancer

(2021) Kyösti Tahkola et al.   Scientific Reports

Tumor stiffening reversion through collagen crosslinking inhibition improves T cell migration and anti-PD-1 treatment

(2021) Alba Nicolas-Boluda et al.   eLife

Stiffness is associated with hepatic stellate cell heterogeneity during liver fibrosis

(2021) Enis Kostallari et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Nicotine facilitates pancreatic fibrosis by promoting activation of pancreatic stellate cells via α7nAChR-mediated JAK2/STAT3 signaling pathway in rats

(2021) Zhiren Li et al.   TOXICOLOGY LETTERS

Silymarin as Supportive Treatment in Liver Diseases: A Narrative Review

(2020) Anton Gillessen et al.   ADVANCES IN THERAPY

ROS in cancer therapy: the bright side of the moon

(2020) Bruno Perillo et al.   EXPERIMENTAL AND MOLECULAR MEDICINE

Mechanisms of Fibrosis Development in NASH

(2020) Robert F. Schwabe et al.   GASTROENTEROLOGY

Inflammation and fibrosis in chronic liver diseases including non-alcoholic fatty liver disease and hepatitis C

(2020) Sudeep Tanwar et al.   WORLD JOURNAL OF GASTROENTEROLOGY

Protonation of Piezo1 Impairs Cell-Matrix Interactions of Pancreatic Stellate Cells

(2020) Anna Kuntze et al.   Frontiers in Physiology

Signaling in the Physiology and Pathophysiology of Pancreatic Stellate Cells – a Brief Review of Recent Advances

(2020) Agnieszka A. Kusiak et al.   Frontiers in Physiology

Islet pericytes convert into profibrotic myofibroblasts in a mouse model of islet vascular fibrosis

(2020) Luciana Mateus Gonçalves et al.   DIABETOLOGIA

Evaluation of liver fibrosis in patients with Wilson’s disease

(2020) Adam Przybyłkowski et al.   EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY

Pancreatic Cancer and Its Microenvironment—Recent Advances and Current Controversies

(2020) Kinga B. Stopa et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

TGF-β1 secreted by pancreatic stellate cells promotes stemness and tumourigenicity in pancreatic cancer cells through L1CAM downregulation

(2020) Donatella Delle Cave et al.   ONCOGENE

Hepatocyte mitochondria-derived danger signals directly activate hepatic stellate cells and drive progression of liver fibrosis

(2020) Ping An et al.   Nature Communications

Liver Fibrosis: Mechanistic Concepts and Therapeutic Perspectives

(2020) Natascha Roehlen et al.   Cells

Human Pluripotent Stem Cell-Derived Organoids as Models of Liver Disease

(2020) Muhammad Nadzim Bin Ramli et al.   GASTROENTEROLOGY

Randomized Phase III Trial of Pegvorhyaluronidase Alfa With Nab-Paclitaxel Plus Gemcitabine for Patients With Hyaluronan-High Metastatic Pancreatic Adenocarcinoma

(2020) Eric Van Cutsem et al.   JOURNAL OF CLINICAL ONCOLOGY

Chronic pancreatitis

(2020) Georg Beyer et al.   LANCET

Liver regeneration: biological and pathological mechanisms and implications

(2020) George K. Michalopoulos et al.   Nature Reviews Gastroenterology & Hepatology

Single-cell analysis uncovers fibroblast heterogeneity and criteria for fibroblast and mural cell identification and discrimination

(2020) Lars Muhl et al.   Nature Communications

Electron paramagnetic resonance spectroscopy reveals alterations in the redox state of endogenous copper and iron complexes in photodynamic stress-induced ischemic mouse liver

(2020) Monika A. Jakubowska et al.   Redox Biology

Role of Exocrine and Endocrine Insufficiency in the Management of Patients with Chronic Pancreatitis

(2020) Carmelo Diéguez-Castillo et al.   Journal of Clinical Medicine

Cell Therapy for Advanced Liver Diseases: Repair or Rebuild

(2020) Benjamin J. Dwyer et al.   JOURNAL OF HEPATOLOGY

Acute pancreatitis

(2020) Lotte Boxhoorn et al.   LANCET

Persistent recovery of pancreatic function in patients with cystic fibrosis after ivacaftor

(2020) Danielle Munce et al.   PEDIATRIC PULMONOLOGY

Phase I clinical trial repurposing all-trans retinoic acid as a stromal targeting agent for pancreatic cancer

(2020) Hemant M. Kocher et al.   Nature Communications

Stroma-Targeting Therapy in Pancreatic Cancer: One Coin With Two Sides?

(2020) Bolun Jiang et al.   Frontiers in Oncology

Notch in mechanotransduction – from molecular mechanosensitivity to tissue mechanostasis

(2020) Oscar M. J. A. Stassen et al.   JOURNAL OF CELL SCIENCE

Fibrosis: from mechanisms to medicines

(2020) Neil C. Henderson et al.   NATURE

Experimental Acute Pancreatitis Models: History, Current Status, and Role in Translational Research

(2020) Xinmin Yang et al.   Frontiers in Physiology

Tumor-stromal crosstalk in pancreatic cancer and tissue fibrosis

(2019) Divya Thomas et al.   Molecular Cancer

The therapeutic potential of induced hepatocyte-like cells generated by direct reprogramming on hepatic fibrosis

(2019) Suhyun Park et al.   Stem Cell Research & Therapy

Interaction Mechanisms Between the NOX4/ROS and RhoA/ROCK1 Signaling Pathways as New Anti- fibrosis Targets of Ursolic Acid in Hepatic Stellate Cells

(2019) Chenkai Huang et al.   Frontiers in Pharmacology

ERK Pathway in Activated, Myofibroblast-Like, Hepatic Stellate Cells: A Critical Signaling Crossroad Sustaining Liver Fibrosis

(2019) Beatrice Foglia et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

siRNA- and miRNA-based therapeutics for liver fibrosis

(2019) Zhen Zhao et al.   Translational Research

Targeting TGF βR2‐mutant tumors exposes vulnerabilities to stromal TGF β blockade in pancreatic cancer

(2019) Huocong Huang et al.   EMBO Molecular Medicine

Mechanotransduction in Liver Diseases

(2019) Ningling Kang   SEMINARS IN LIVER DISEASE

A mechanism for the activation of the mechanosensitive Piezo1 channel by the small molecule Yoda1

(2019) Wesley M. Botello-Smith et al.   Nature Communications

Association between Smoking and Liver Fibrosis among Patients with Nonalcoholic Fatty Liver Disease

(2019) Hongjie Ou et al.   Canadian Journal of Gastroenterology and Hepatology

Mechanisms Underlying Hepatitis C Virus-Associated Hepatic Fibrosis

(2019) Mousumi Khatun et al.   Cells

TGF-β in Hepatic Stellate Cell Activation and Liver Fibrogenesis—Updated 2019

(2019) Dewidar et al.   Cells

Pancreatic stellate cells in the islets as a novel target to preserve the pancreatic β‐cell mass and function

(2019) Yeoree Yang et al.   Journal of Diabetes Investigation

Yes-Associated Protein 1 Plays Major Roles in Pancreatic Stellate Cell Activation and Fibroinflammatory Responses

(2019) Cheng Hu et al.   Frontiers in Physiology

Activin-A causes Hepatic stellate cell activation via the induction of TNFα and TGFβ in Kupffer cells

(2018) Foteini Kiagiadaki et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Generation of Hepatic Stellate Cells from Human Pluripotent Stem Cells Enables In Vitro Modeling of Liver Fibrosis

(2018) Mar Coll et al.   Cell Stem Cell

HMGB1-induced autophagy facilitates hepatic stellate cells activation: a new pathway in liver fibrosis

(2018) Jing Li et al.   CLINICAL SCIENCE

A novel flow cytometry tool for fibrosis scoring through hepatic stellate cell differentiation

(2018) Johnny Amer et al.   CYTOMETRY PART A

Acute Pancreatitis and Pancreatic Cancer Risk: A Nationwide Matched-Cohort Study in Denmark

(2018) Jakob Kirkegård et al.   GASTROENTEROLOGY

Mechanosensing and fibrosis

(2018) Daniel J. Tschumperlin et al.   JOURNAL OF CLINICAL INVESTIGATION

Resveratrol Inhibits ROS-Promoted Activation and Glycolysis of Pancreatic Stellate Cells via Suppression of miR-21

(2018) Bin Yan et al.   Oxidative Medicine and Cellular Longevity

Pathogenesis of non-alcoholic fatty liver disease in children and adolescence: From “two hit theory” to “multiple hit model”

(2018) Yan-Lan Fang et al.   WORLD JOURNAL OF GASTROENTEROLOGY

Fibroblast-to-myofibroblast transition in bronchial asthma

(2018) Marta Michalik et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

CXCL6-EGFR-induced Kupffer cells secrete TGF-β1 promoting hepatic stellate cell activation via the SMAD2/BRD4/C-MYC/EZH2 pathway in liver fibrosis

(2018) Xiaobo Cai et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

IVACAFTOR restores FGF19 regulated bile acid homeostasis in cystic fibrosis patients with an S1251N or a G551D gating mutation

(2018) Ivo P. van de Peppel et al.   Journal of Cystic Fibrosis

Alcoholic liver disease

(2018) Helmut K. Seitz et al.   Nature Reviews Disease Primers

Carvedilol attenuates liver fibrosis by suppressing autophagy and promoting apoptosis in hepatic stellate cells

(2018) Dongxiao Meng et al.   BIOMEDICINE & PHARMACOTHERAPY

The renin-angiotensin system as a target to solve the riddle of endocrine pancreas homeostasis

(2018) Francielle Graus-Nunes et al.   BIOMEDICINE & PHARMACOTHERAPY

GPER is a mechanoregulator of pancreatic stellate cells and the tumor microenvironment

(2018) Ernesto Cortes et al.   EMBO REPORTS

Substance P Promotes Liver Sinusoidal Endothelium-Mediated Hepatic Regeneration by NO/HGF Regulation

(2018) Jiyuan Piao et al.   JOURNAL OF INTERFERON AND CYTOKINE RESEARCH

Wound Healing: A Cellular Perspective

(2018) Melanie Rodrigues et al.   PHYSIOLOGICAL REVIEWS

Cystic Fibrosis of the Pancreas: The Role of CFTR Channel in the Regulation of Intracellular Ca2+ Signaling and Mitochondrial Function in the Exocrine Pancreas

(2018) Tamara Madácsy et al.   Frontiers in Physiology

Methyl ferulic acid attenuates liver fibrosis and hepatic stellate cell activation through the TGF-β1/Smad and NOX4/ROS pathways

(2018) Qi Cheng et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Hepatitis C virus-induced CCL5 secretion from macrophages activates hepatic stellate cells

(2017) Reina Sasaki et al.   HEPATOLOGY

Nanoparticles for the treatment of liver fibrosis

(2017) Suchithra Poilil Surendran et al.   International Journal of Nanomedicine

Brazilian guidelines for the diagnosis and treatment of cystic fibrosis

(2017) Rodrigo Abensur Athanazio et al.   Jornal Brasileiro de Pneumologia

Metabolic syndrome and severity of fibrosis in nonalcoholic fatty liver disease: An age-dependent risk profiling study

(2017) Salvatore Petta et al.   LIVER INTERNATIONAL

Role and regulation of autophagy and apoptosis by nitric oxide in hepatic stellate cells during acute liver failure

(2017) Li Jin et al.   LIVER INTERNATIONAL

Human hepatocyte transplantation for liver disease: current status and future perspectives

(2017) V Iansante et al.   PEDIATRIC RESEARCH

Biology of pancreatic stellate cells—more than just pancreatic cancer

(2017) Pawel E. Ferdek et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

TRPC6 channels modulate the response of pancreatic stellate cells to hypoxia

(2017) Nikolaj Nielsen et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

The Impact of Renin-Angiotensin System Blockade on Renal Outcomes and Mortality in Pre-Dialysis Patients with Advanced Chronic Kidney Disease

(2017) Yun Jung Oh et al.   PLoS One

Roles of pH and the Na + /H + exchanger NHE1 in cancer: From cell biology and animal models to an emerging translational perspective?

(2017) Christian Stock et al.   SEMINARS IN CANCER BIOLOGY

Cardiovascular consequences of metabolic syndrome

(2017) Johnathan D. Tune et al.   Translational Research

Efficacy and safety of pancreatic enzyme replacement therapy on exocrine pancreatic insufficiency: a meta-analysis

(2017) Can Gan et al.   Oncotarget

Inhibition of Jak/STAT signaling reduces the activation of pancreatic stellate cells in vitro and limits caerulein-induced chronic pancreatitis in vivo

(2017) Hannah M. Komar et al.   Scientific Reports

Substrate Rigidity Controls Activation and Durotaxis in Pancreatic Stellate Cells

(2017) Dariusz Lachowski et al.   Scientific Reports

Calcium signalling in pancreatic stellate cells: Mechanisms and potential roles

(2016) Oleksiy Gryshchenko et al.   CELL CALCIUM

Medical and Surgical Treatment Options for Nonalcoholic Steatohepatitis

(2016) Kathleen E. Corey et al.   DIGESTIVE DISEASES AND SCIENCES

Role of TRPC1 channels in pressure-mediated activation of murine pancreatic stellate cells

(2016) Benedikt Fels et al.   EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS

Beyond pancreatic insufficiency and liver disease in cystic fibrosis

(2016) Stephanie Demeyer et al.   EUROPEAN JOURNAL OF PEDIATRICS

Isolation and characterization of human islet stellate cells

(2016) Min Zha et al.   EXPERIMENTAL CELL RESEARCH

Targeting the renin–angiotensin system in liver fibrosis

(2016) Pau Sancho-Bru et al.   Hepatology International

Hepatic expression of Sonic Hedgehog induces liver fibrosis and promotes hepatocarcinogenesis in a transgenic mouse model

(2016) Sook In Chung et al.   JOURNAL OF HEPATOLOGY

Transplantation of a human iPSC-derived hepatocyte sheet increases survival in mice with acute liver failure

(2016) Yasuhito Nagamoto et al.   JOURNAL OF HEPATOLOGY

Bile acids induce necrosis in pancreatic stellate cells dependent on calcium entry and sodium-driven bile uptake

(2016) Pawel E. Ferdek et al.   JOURNAL OF PHYSIOLOGY-LONDON

Bile as a key aetiological factor of acute but not chronic pancreatitis: a possible theory revealed

(2016) Péter Hegyi   JOURNAL OF PHYSIOLOGY-LONDON

Clinical Advancements in the Targeted Therapies against Liver Fibrosis

(2016) Ruchi Bansal et al.   MEDIATORS OF INFLAMMATION

The multiple-hit pathogenesis of non-alcoholic fatty liver disease (NAFLD)

(2016) Elena Buzzetti et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Diabetes Mellitus Is Associated With an Exocrine Pancreatopathy

(2016) Sonmoon Mohapatra et al.   PANCREAS

Pancreatic stellate cells regulate blood vessel density in the stroma of pancreatic ductal adenocarcinoma

(2016) Francesco Di Maggio et al.   PANCREATOLOGY

Oriented collagen fibers direct tumor cell intravasation

(2016) Weijing Han et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Anti-viral role of toll like receptor 4 in hepatitis B virus infection: An in vitro study

(2016) Dipanwita Das et al.   WORLD JOURNAL OF GASTROENTEROLOGY

Metabolic alterations and hepatitis C: From bench to bedside

(2016) Ming-Ling Chang   WORLD JOURNAL OF GASTROENTEROLOGY

MicroRNA-378 limits activation of hepatic stellate cells and liver fibrosis by suppressing Gli3 expression

(2016) Jeongeun Hyun et al.   Nature Communications

ATRA mechanically reprograms pancreatic stellate cells to suppress matrix remodelling and inhibit cancer cell invasion

(2016) Antonios Chronopoulos et al.   Nature Communications

IFN  and CCL2 Cooperate to Redirect Tumor-Infiltrating Monocytes to Degrade Fibrosis and Enhance Chemotherapy Efficacy in Pancreatic Carcinoma

(2016) K. B. Long et al.   Cancer Discovery

HCV derived from sera of HCV-infected patients induces pro-fibrotic effects in human primary fibroblasts by activating GLI2

(2016) M. Granato et al.   Scientific Reports

Skin fibrosis: Models and mechanisms

(2016) N.N. Do et al.   Current Research in Translational Medicine

Characterization of the MMP/TIMP Imbalance and Collagen Production Induced by IL-1β or TNF-α Release from Human Hepatic Stellate Cells

(2016) Sacha Robert et al.   PLoS One

Suppression of ROS Production by Exendin-4 in PSC Attenuates the High Glucose-Induced Islet Fibrosis

(2016) Ji-Won Kim et al.   PLoS One

Involvement of Pancreatic Stellate Cells in Regeneration of Remnant Pancreas after Partial Pancreatectomy

(2016) Shigenori Ota et al.   PLoS One

Stiffening hydrogels for investigating the dynamics of hepatic stellate cell mechanotransduction during myofibroblast activation

(2016) Steven R. Caliari et al.   Scientific Reports

Experimental models of liver fibrosis

(2015) Sara Crespo Yanguas et al.   ARCHIVES OF TOXICOLOGY

Desmoplasia in Primary Tumors and Metastatic Lesions of Pancreatic Cancer

(2015) C. J. Whatcott et al.   CLINICAL CANCER RESEARCH

Antioxidant therapy for patients with chronic pancreatitis: A systematic review and meta-analysis

(2015) Dongkai Zhou et al.   CLINICAL NUTRITION

Pancreatic stellate cell

(2015) Minote Apte et al.   CURRENT OPINION IN GASTROENTEROLOGY

Frequency of Progression From Acute to Chronic Pancreatitis and Risk Factors: A Meta-analysis

(2015) Sharanya J. Sankaran et al.   GASTROENTEROLOGY

Liver fibrosis occurs through dysregulation of MyD88-dependent innate B-cell activity

(2015) Manoj Thapa et al.   HEPATOLOGY

Metabolic Reprogramming Is Required for Myofibroblast Contractility and Differentiation

(2015) Karen Bernard et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structural and functional hepatocyte polarity and liver disease

(2015) Paul Gissen et al.   JOURNAL OF HEPATOLOGY

Kupffer Cells Support Hepatitis B Virus–Mediated CD8+T Cell Exhaustion via Hepatitis B Core Antigen–TLR2 Interactions in Mice

(2015) Min Li et al.   JOURNAL OF IMMUNOLOGY

Pancreatic pathophysiology in cystic fibrosis

(2015) Katherine N Gibson-Corley et al.   JOURNAL OF PATHOLOGY

Ca2+signals mediated by bradykinin type 2 receptors in normal pancreatic stellate cells can be inhibited by specific Ca2+channel blockade

(2015) Oleksiy Gryshchenko et al.   JOURNAL OF PHYSIOLOGY-LONDON

Functions of Coenzyme Q10 Supplementation on Liver Enzymes, Markers of Systemic Inflammation, and Adipokines in Patients Affected by Nonalcoholic Fatty Liver Disease: A Double-Blind, Placebo-Controlled, Randomized Clinical Trial

(2015) Farnaz Farsi et al.   JOURNAL OF THE AMERICAN COLLEGE OF NUTRITION

Periductal stromal collagen topology of pancreatic ductal adenocarcinoma differs from that of normal and chronic pancreatitis

(2015) Cole R Drifka et al.   MODERN PATHOLOGY

Inhibition of liver fibrosis using vitamin A-coupled liposomes to deliver matrix metalloproteinase-2 siRNA in vitro

(2015) YIPING LI et al.   Molecular Medicine Reports

The role of fat and alcohol in acute pancreatitis: A dangerous liaison

(2015) David N. Criddle   PANCREATOLOGY

Non-Canonical Wnt Predominates in Activated Rat Hepatic Stellate Cells, Influencing HSC Survival and Paracrine Stimulation of Kupffer Cells

(2015) Laura Corbett et al.   PLoS One

The Use of Nanoparticles to Deliver Nitric Oxide to Hepatic Stellate Cells for Treating Liver Fibrosis and Portal Hypertension

(2015) Hien T. T. Duong et al.   Small

Inhibition of IRS-1 by hepatitis C virus infection leads to insulin resistance in a PTEN-dependent manner

(2015) Ting-ting Gao et al.   Virology Journal

Tumors: Wounds That Do Not Heal--Redux

(2015) H. F. Dvorak   Cancer Immunology Research

Cancer-Stellate Cell Interactions Perpetuate the Hypoxia-Fibrosis Cycle in Pancreatic Ductal Adenocarcinoma

(2015) Mert Erkan et al.   NEOPLASIA

Oral Coenzyme Q10 Supplementation in Patients with Nonalcoholic Fatty Liver Disease: Effects on Serum Vaspin, Chemerin, Pentraxin 3, Insulin Resistance and Oxidative Stress

(2014) Mahdieh Abbasalizad Farhangi et al.   ARCHIVES OF MEDICAL RESEARCH

Acid-base transport in pancreatic cancer: Molecular mechanisms and clinical potential

(2014) Su Chii Kong et al.   Biochemistry and Cell Biology

Depletion of Carcinoma-Associated Fibroblasts and Fibrosis Induces Immunosuppression and Accelerates Pancreas Cancer with Reduced Survival

(2014) Berna C. Özdemir et al.   CANCER CELL

Stromal Elements Act to Restrain, Rather Than Support, Pancreatic Ductal Adenocarcinoma

(2014) Andrew D. Rhim et al.   CANCER CELL

Neutralizing Murine TGF R2 Promotes a Differentiated Tumor Cell Phenotype and Inhibits Pancreatic Cancer Metastasis

(2014) K. T. Ostapoff et al.   CANCER RESEARCH

Crosstalk between fibroblasts and inflammatory cells

(2014) S. Van Linthout et al.   CARDIOVASCULAR RESEARCH

Vitamin D Receptor-Mediated Stromal Reprogramming Suppresses Pancreatitis and Enhances Pancreatic Cancer Therapy

(2014) Mara H. Sherman et al.   CELL

Calcium signalling and secretory epithelia

(2014) O.H. Petersen   CELL CALCIUM

Sonic Hedgehog Paracrine Signaling Activates Stromal Cells to Promote Perineural Invasion in Pancreatic Cancer

(2014) X. Li et al.   CLINICAL CANCER RESEARCH

Prevailing Role of Contact Guidance in Intrastromal T-cell Trapping in Human Pancreatic Cancer

(2014) N. Hartmann et al.   CLINICAL CANCER RESEARCH

High Mobility Group Box-1 (HMGB1) Participates in the Pathogenesis of Alcoholic Liver Disease (ALD)

(2014) Xiaodong Ge et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The chemistry, physiology and pathology of pH in cancer

(2014) P. Swietach et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Dimethyl Fumarate Protects Pancreatic Islet Cells and Non-Endocrine Tissue in L-Arginine-Induced Chronic Pancreatitis

(2014) Lourdes Robles et al.   PLoS One

Hepatocyte Produced Matrix Metalloproteinases Are Regulated by CD147 in Liver Fibrogenesis

(2014) Sarah R. Calabro et al.   PLoS One

Chronic hepatitis C and liver fibrosis

(2014) Giada Sebastiani   WORLD JOURNAL OF GASTROENTEROLOGY

Isolation and characterization of islet stellate cells in rat

(2014) Min Zha et al.   Islets

Silymarin coated gold nanoparticles ameliorates CCl4-induced hepatic injury and cirrhosis through down regulation of hepatic stellate cells and attenuation of Kupffer cells

(2014) Nurul Kabir et al.   RSC Advances

Fibroblasts in fibrosis: novel roles and mediators

(2014) Ryan T. Kendall et al.   Frontiers in Pharmacology

Prolonged high fat/alcohol exposure increases TRPV4 and its functional responses in pancreatic stellate cells

(2013) L. P. Zhang et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

Pancreas Organogenesis: From Lineage Determination to Morphogenesis

(2013) Hung Ping Shih et al.   Annual Review of Cell and Developmental Biology

Reactive Oxygen Species in Inflammation and Tissue Injury

(2013) Manish Mittal et al.   ANTIOXIDANTS & REDOX SIGNALING

Hepatitis C virus nonstructural protein 5A favors upregulation of gluconeogenic and lipogenic gene expression leading towards insulin resistance: a metabolic syndrome

(2013) Fahed Parvaiz et al.   ARCHIVES OF VIROLOGY

Oxidative stress plays a role in high glucose-induced activation of pancreatic stellate cells

(2013) Gyeong Ryul Ryu et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

The pathogenesis of cardiac fibrosis

(2013) Ping Kong et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Newly diagnosed diabetes mellitus after acute pancreatitis: a systematic review and meta-analysis

(2013) Stephanie L M Das et al.   GUT

Macrophage-secreted cytokines drive pancreatic acinar-to-ductal metaplasia through NF-κB and MMPs

(2013) Geou-Yarh Liou et al.   JOURNAL OF CELL BIOLOGY

IFN-γ inhibits liver progenitor cell proliferation in HBV-infected patients and in 3,5-diethoxycarbonyl-1,4-dihydrocollidine diet-fed mice

(2013) Hong-lei Weng et al.   JOURNAL OF HEPATOLOGY

Cytokine and Chemokine Responses in the Acute Phase of Hepatitis B Virus Replication in Naive and Previously Vaccinated Blood and Plasma Donors

(2013) S. M. Keating et al.   JOURNAL OF INFECTIOUS DISEASES

Differential Serum Levels of Eosinophilic Eotaxins in Primary Sclerosing Cholangitis, Primary Biliary Cirrhosis, and Autoimmune Hepatitis

(2013) Abdolamir Landi et al.   JOURNAL OF INTERFERON AND CYTOKINE RESEARCH

Hepatitis C Virus Induces Interleukin-1  (IL-1 )/IL-18 in Circulatory and Resident Liver Macrophages

(2013) S. Shrivastava et al.   JOURNAL OF VIROLOGY

The role of protein synthesis and digestive enzymes in acinar cell injury

(2013) Craig D. Logsdon et al.   Nature Reviews Gastroenterology & Hepatology

STING-IRF3 pathway links endoplasmic reticulum stress with hepatocyte apoptosis in early alcoholic liver disease

(2013) J. Petrasek et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Epithelial-to-mesenchymal transition predicts prognosis of pancreatic cancer

(2013) Suguru Yamada et al.   SURGERY

Emerging concepts in pancreatic cancer medicine: targeting the tumor stroma

(2013) Albrecht Neesse et al.   OncoTargets and Therapy

The Cystic Fibrosis of Exocrine Pancreas

(2013) M. Wilschanski et al.   Cold Spring Harbor Perspectives in Medicine

Mass Spectrometry-based Quantitative Proteomic Profiling of Human Pancreatic and Hepatic Stellate Cell Lines

(2013) Joao A. Paulo et al.   GENOMICS PROTEOMICS & BIOINFORMATICS

Ursodeoxycholic acid therapy in cystic fibrosis liver disease - a retrospective long-term follow-up case-control study

(2012) M. Kappler et al.   ALIMENTARY PHARMACOLOGY & THERAPEUTICS

Extracellular matrix degradation in liver fibrosis: Biochemistry and regulation

(2012) John P. Iredale et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Enzymatic Targeting of the Stroma Ablates Physical Barriers to Treatment of Pancreatic Ductal Adenocarcinoma

(2012) Paolo P. Provenzano et al.   CANCER CELL

TGF-  and  v 6 Integrin Act in a Common Pathway to Suppress Pancreatic Cancer Progression

(2012) A. F. Hezel et al.   CANCER RESEARCH

Liver fibrosis and hepatocyte apoptosis are attenuated by GKT137831, a novel NOX4/NOX1 inhibitor in vivo

(2012) Joy X. Jiang et al.   FREE RADICAL BIOLOGY AND MEDICINE

β1 integrin–extracellular matrix interactions are essential for maintaining exocrine pancreas architecture and function

(2012) Matthew M Riopel et al.   LABORATORY INVESTIGATION

Toxic hepatitis in occupational exposure to solvents

(2012) Giulia Malaguarnera   WORLD JOURNAL OF GASTROENTEROLOGY

Smoking Is Related to Pancreatic Fibrosis in Humans

(2011) Erwin J M van Geenen et al.   AMERICAN JOURNAL OF GASTROENTEROLOGY

Increased contractility of hepatic stellate cells in cirrhosis is mediated by enhanced Ca2+-dependent and Ca2+-sensitization pathways

(2011) Masateru Iizuka et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Mechanisms of hepatic fibrogenesis

(2011) Ursula E. Lee et al.   BEST PRACTICE & RESEARCH IN CLINICAL GASTROENTEROLOGY

Biochemical role of the collagen-rich tumour microenvironment in pancreatic cancer progression

(2011) Mario A. Shields et al.   BIOCHEMICAL JOURNAL

Duct Cells Contribute to Regeneration of Endocrine and Acinar Cells Following Pancreatic Damage in Adult Mice

(2011) Angela Criscimanna et al.   GASTROENTEROLOGY

Pancreatic Cancer Cells Respond to Type I Collagen by Inducing Snail Expression to Promote Membrane Type 1 Matrix Metalloproteinase-dependent Collagen Invasion

(2011) Mario A. Shields et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Th2 signals induce epithelial injury in mice and are compatible with the biliary atresia phenotype

(2011) Jun Li et al.   JOURNAL OF CLINICAL INVESTIGATION

Best practice guidance for the diagnosis and management of cystic fibrosis-associated liver disease

(2011) Dominique Debray et al.   Journal of Cystic Fibrosis

Chronic pancreatitis

(2011) Joan M Braganza et al.   LANCET

Molecular Basis of P2-Receptor-Mediated Calcium Signaling in Activated Pancreatic Stellate Cells

(2011) Jan K. Hennigs et al.   PANCREAS

Recruitment and Activation of Pancreatic Stellate Cells from the Bone Marrow in Pancreatic Cancer: A Model of Tumor-Host Interaction

(2011) Christopher J. Scarlett et al.   PLoS One

Toll-Like Receptors Signaling Contributes to Immunopathogenesis of HBV Infection

(2011) Yasuteru Kondo et al.   Gastroenterology Research and Practice

Pathology of Gastrointestinal Organs in a Porcine Model of Cystic Fibrosis

(2010) David K. Meyerholz et al.   AMERICAN JOURNAL OF PATHOLOGY

Hepatic Fibrosis and the Renin-Angiotensin System

(2010) Ghulam Abbas et al.   AMERICAN JOURNAL OF THERAPEUTICS

Three-Dimensional Collagen I Promotes Gemcitabine Resistance in Pancreatic Cancer through MT1-MMP-Mediated Expression of HMGA2

(2010) S. Dangi-Garimella et al.   CANCER RESEARCH

Bone marrow-derived pancreatic stellate cells in rats

(2010) Gisela Sparmann et al.   CELL RESEARCH

Effect of indole-3-carbinol on ethanol-induced liver injury and acetaldehyde-stimulated hepatic stellate cells activation using precision-cut rat liver slices

(2010) Yu Guo et al.   CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY

Organogenesis and Development of the Liver

(2010) Karim Si-Tayeb et al.   DEVELOPMENTAL CELL

Suppressive and pro-inflammatory roles for IL-4 in the pathogenesis of experimental drug-induced liver injury: a review

(2010) Dolores B Njoku   Expert Opinion on Drug Metabolism & Toxicology

Withdrawal of alcohol promotes regression while continued alcohol intake promotes persistence of LPS-induced pancreatic injury in alcohol-fed rats

(2010) A. Vonlaufen et al.   GUT

Septum transversum-derived mesothelium gives rise to hepatic stellate cells and perivascular mesenchymal cells in developing mouse liver

(2010) Kinji Asahina et al.   HEPATOLOGY

Hepatitis B Virus Protein X-induced Expression of the CXC Chemokine IP-10 Is Mediated through Activation of NF-κB and Increases Migration of Leukocytes

(2010) Yu Zhou et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Smoking and severity of hepatic fibrosis in nonalcoholic fatty liver disease

(2010) Claudia O. Zein et al.   JOURNAL OF HEPATOLOGY

Viral factors induce Hedgehog pathway activation in humans with viral hepatitis, cirrhosis and hepatocellular carcinoma

(2010) Thiago de Almeida Pereira et al.   LABORATORY INVESTIGATION

Phenotypic changes in mouse pancreatic stellate cell Ca2+ signaling events following activation in culture and in a disease model of pancreatitis

(2010) Jong Hak Won et al.   MOLECULAR BIOLOGY OF THE CELL

Pioglitazone, Vitamin E, or Placebo for Nonalcoholic Steatohepatitis

(2010) Arun J. Sanyal et al.   NEW ENGLAND JOURNAL OF MEDICINE

Lipid accumulation in hepatocytes induces fibrogenic activation of hepatic stellate cells

(2009) Hella Wobser et al.   CELL RESEARCH

Age-Dependent Decline in  -Cell Proliferation Restricts the Capacity of  -Cell Regeneration in Mice

(2009) S.-I. Tschen et al.   DIABETES

Adaptive  -Cell Proliferation Is Severely Restricted With Advanced Age

(2009) M. M. Rankin et al.   DIABETES

Hepatic recruitment of the inflammatory Gr1+monocyte subset upon liver injury promotes hepatic fibrosis

(2009) Karlin Raja Karlmark et al.   HEPATOLOGY

Signal transduction in pancreatic stellate cells

(2009) Atsushi Masamune et al.   JOURNAL OF GASTROENTEROLOGY

Therapeutic targeting of the PDGF and TGF-β-signaling pathways in hepatic stellate cells by PTK787/ZK22258

(2009) Yuqing Liu et al.   LABORATORY INVESTIGATION

The effect of angiotensin-blocking agents on liver fibrosis in patients with hepatitis C

(2009) Kathleen E. Corey et al.   LIVER INTERNATIONAL

Inhibition of Transforming Growth Factor β Signaling by Halofuginone as a Modality for Pancreas Fibrosis Prevention

(2009) Orit Zion et al.   PANCREAS

Pancreatic protease activation by alcohol metabolite depends on Ca2+ release via acid store IP3 receptors

(2009) J. V. Gerasimenko et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Inhibition of liver fibrosis by solubilized coenzyme Q10: Role of Nrf2 activation in inhibiting transforming growth factor-β1 expression

(2009) Hoo-Kyun Choi et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Hypoxia stimulates pancreatic stellate cells to induce fibrosis and angiogenesis in pancreatic cancer

(2008) Atsushi Masamune et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Loss of beta-cells with fibrotic islet destruction in type 2 diabetes mellitus

(2008) Ji-Won Kim   Frontiers in Bioscience-Landmark

Role of bone marrow-derived cells in experimental chronic pancreatitis

(2008) F Marrache et al.   GUT

Sinusoidal endothelial cells prevent rat stellate cell activation and promote reversion to quiescence

(2008) Laurie D. DeLeve et al.   HEPATOLOGY

Molecular mechanism of hepatic stellate cell activation and antifibrotic therapeutic strategies

(2008) Jing-Ting Li et al.   JOURNAL OF GASTROENTEROLOGY

Hepatic Stellate Cells: Protean, Multifunctional, and Enigmatic Cells of the Liver

(2008) Scott L. Friedman   PHYSIOLOGICAL REVIEWS