Inflammation and fibrosis in chronic liver diseases including non-alcoholic fatty liver disease and hepatitis C

Interferon-alpha 2 but not Interferon-gamma serum levels are associated with intramuscular fat in obese patients with nonalcoholic fatty liver disease

(2019) Giovanni Tarantino et al.   Journal of Translational Medicine

Characterization of fibrosis changes in chronic hepatitis C patients after virological cure: A systematic review with meta-analysis

(2017) Zhipeng Liu et al.   JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY

EASL Recommendations on Treatment of Hepatitis C 2016

(2017)   JOURNAL OF HEPATOLOGY

Clinical and Metabolic Characterization of Lean Caucasian Subjects With Non-alcoholic Fatty Liver

(2016) Alexandra Feldman et al.   AMERICAN JOURNAL OF GASTROENTEROLOGY

Vascular assessment of liver disease—towards a new frontier in MRI

(2016) Manil D Chouhan et al.   BRITISH JOURNAL OF RADIOLOGY

Free fatty acids, not triglycerides, are associated with non-alcoholic liver injury progression in high fat diet induced obese rats

(2016) Jiali Liu et al.   Lipids in Health and Disease

Hepatic TLR4 signaling in obese NAFLD

(2015) Torfay Sharifnia et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Endothelial Dysfunction in Advanced Liver Disease

(2015) Don C. Rockey   AMERICAN JOURNAL OF THE MEDICAL SCIENCES

Programmed Necrosis in the Cross Talk of Cell Death and Inflammation

(2015) Francis Ka-Ming Chan et al.   Annual Review of Immunology

Platelets in leucocyte recruitment and function

(2015) Jan Rossaint et al.   CARDIOVASCULAR RESEARCH

Weight Loss Through Lifestyle Modification Significantly Reduces Features of Nonalcoholic Steatohepatitis

(2015) Eduardo Vilar-Gomez et al.   GASTROENTEROLOGY

A dynamic spectrum of monocytes arising from the in situ reprogramming of CCR2+monocytes at a site of sterile injury

(2015) Daniela Dal-Secco et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Incretin-based therapies for the treatment of non-alcoholic fatty liver disease: A systematic review and meta-analysis

(2015) Laura J Carbone et al.   JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY

Statin use and non-alcoholic steatohepatitis in at risk individuals

(2015) Paola Dongiovanni et al.   JOURNAL OF HEPATOLOGY

Hepatic fibrosis: Concept to treatment

(2015) Christian Trautwein et al.   JOURNAL OF HEPATOLOGY

Farnesoid X nuclear receptor ligand obeticholic acid for non-cirrhotic, non-alcoholic steatohepatitis (FLINT): a multicentre, randomised, placebo-controlled trial

(2015) Brent A Neuschwander-Tetri et al.   LANCET

The interplay of the Notch signaling in hepatic stellate cells and macrophages determines the fate of liver fibrogenesis

(2015) Ruchi Bansal et al.   Scientific Reports

Association Between Patatin-Like Phospholipase Domain Containing 3 Gene (PNPLA3) Polymorphisms and Nonalcoholic Fatty Liver Disease: A HuGE Review and Meta-Analysis

(2015) Renfan Xu et al.   Scientific Reports

In Vivo Gene-Silencing in Fibrotic Liver by siRNA-Loaded Cationic Nanohydrogel Particles

(2015) Leonard Kaps et al.   Advanced Healthcare Materials

The role of neutrophils in the development of liver diseases

(2014) Ruonan Xu et al.   Cellular & Molecular Immunology

The Fatty Acid–Bile Acid Conjugate Aramchol Reduces Liver Fat Content in Patients With Nonalcoholic Fatty Liver Disease

(2014) Rifaat Safadi et al.   Clinical Gastroenterology and Hepatology

Biomarkers of liver cell death

(2014) Akiko Eguchi et al.   JOURNAL OF HEPATOLOGY

An Important Role for Type III Interferon (IFN- /IL-28) in TLR-Induced Antiviral Activity

(2014) N. Ank et al.   JOURNAL OF IMMUNOLOGY

NLRP3 inflammasome activation is required for fibrosis development in NAFLD

(2014) Alexander Wree et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Is serum Interleukin-17 associated with early atherosclerosis in obese patients?

(2014) Giovanni Tarantino et al.   Journal of Translational Medicine

Cirrhosis regression in hepatitis C patients with sustained virological response after antiviral therapy: a meta-analysis

(2014) Ehsaan Akhtar et al.   LIVER INTERNATIONAL

Susceptibility of Nrf2-Null Mice to Steatohepatitis and Cirrhosis upon Consumption of a High-Fat Diet Is Associated with Oxidative Stress, Perturbation of the Unfolded Protein Response, and Disturbance in the Expression of Metabolic Enzymes but Not with Insulin Resistance

(2014) P. J. Meakin et al.   MOLECULAR AND CELLULAR BIOLOGY

Role of endoplasmic reticulum stress in the pathogenesis of nonalcoholic fatty liver disease

(2014) Xue-Qun Zhang   WORLD JOURNAL OF GASTROENTEROLOGY

From Monocytes to M1/M2 Macrophages: Phenotypical vs. Functional Differentiation

(2014) Paola Italiani et al.   Frontiers in Immunology

B Lymphocytes in obesity-related adipose tissue inflammation and insulin resistance

(2013) Daniel A. Winer et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Analytical Solutions for the Mathematical Model Describing the Formation of Liver Zones via Adomian’s Method

(2013) Abdelhalim Ebaid   Computational and Mathematical Methods in Medicine

Dual Peroxisome Proliferator-Activated Receptor  /  Agonist GFT505 Improves Hepatic and Peripheral Insulin Sensitivity in Abdominally Obese Subjects

(2013) B. Cariou et al.   DIABETES CARE

Intestinal microbiota in patients with nonalcoholic fatty liver disease

(2013) Marialena Mouzaki et al.   HEPATOLOGY

M2 Kupffer cells promote M1 Kupffer cell apoptosis: A protective mechanism against alcoholic and nonalcoholic fatty liver disease

(2013) Jinghong Wan et al.   HEPATOLOGY

Adaptive immune responses triggered by oxidative stress contribute to hepatic inflammation in NASH

(2013) Salvatore Sutti et al.   HEPATOLOGY

IL-17 signaling accelerates the progression of nonalcoholic fatty liver disease in mice

(2013) Isaac T.W. Harley et al.   HEPATOLOGY

The portal inflammatory infiltrate and ductular reaction in human nonalcoholic fatty liver disease

(2013) Victoria L. Gadd et al.   HEPATOLOGY

Immunological Mechanisms in the Pathophysiology of Non-Alcoholic Steatohepatitis

(2013) Luisa Vonghia et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

1 and 5 year survival estimates for people with cirrhosis of the liver in England, 1998–2009: A large population study

(2013) Sonia Ratib et al.   JOURNAL OF HEPATOLOGY

Transgenic expression of human neutrophil peptide-1 enhances hepatic fibrosis in mice fed a choline-deficient, L-amino acid-defined diet

(2013) Rie Ibusuki et al.   LIVER INTERNATIONAL

Convergent pathways that cause hepatic fibrosis in NASH

(2013) Scott L. Friedman   Nature Reviews Gastroenterology & Hepatology

The Adaptive Endoplasmic Reticulum Stress Response to Lipotoxicity in Progressive Human Nonalcoholic Fatty Liver Disease

(2013) April D. Lake et al.   TOXICOLOGICAL SCIENCES

Deactivation of Hepatic Stellate Cells During Liver Fibrosis Resolution in Mice

(2012) Juliane S. Troeger et al.   GASTROENTEROLOGY

Specific immunization strategies against oxidized low-density lipoprotein: A novel way to reduce nonalcoholic steatohepatitis in mice

(2012) Veerle Bieghs et al.   HEPATOLOGY

Chemokine Cxcl9 attenuates liver fibrosis-associated angiogenesis in mice

(2012) Hacer Sahin et al.   HEPATOLOGY

Pentoxifylline decreases oxidized lipid products in nonalcoholic steatohepatitis: New evidence on the potential therapeutic mechanism

(2012) Claudia O. Zein et al.   HEPATOLOGY

Characterization of gut microbiomes in nonalcoholic steatohepatitis (NASH) patients: A connection between endogenous alcohol and NASH

(2012) Lixin Zhu et al.   HEPATOLOGY

HSC-specific inhibition of Rho-kinase reduces portal pressure in cirrhotic rats without major systemic effects

(2012) Sabine Klein et al.   JOURNAL OF HEPATOLOGY

Inflammasomes in liver diseases

(2012) Gyongyi Szabo et al.   JOURNAL OF HEPATOLOGY

Non-alcoholic steatohepatitis: The role of oxidized low-density lipoproteins

(2012) Sofie M.A. Walenbergh et al.   JOURNAL OF HEPATOLOGY

Bile acid receptors as targets for the treatment of dyslipidemia and cardiovascular disease

(2012) Geoffrey Porez et al.   JOURNAL OF LIPID RESEARCH

Increased Th17 cells contribute to disease progression in patients with HBV-associated liver cirrhosis

(2012) H. Q. Sun et al.   JOURNAL OF VIRAL HEPATITIS

Caspase-1-mediated regulation of fibrogenesis in diet-induced steatohepatitis

(2012) Laura J Dixon et al.   LABORATORY INVESTIGATION

Inflammasome-mediated dysbiosis regulates progression of NAFLD and obesity

(2012) Jorge Henao-Mejia et al.   NATURE

Neutrophils mediate insulin resistance in mice fed a high-fat diet through secreted elastase

(2012) Saswata Talukdar et al.   NATURE MEDICINE

Myofibroblasts revert to an inactive phenotype during regression of liver fibrosis

(2012) T. Kisseleva et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Differential Ly-6C expression identifies the recruited macrophage phenotype, which orchestrates the regression of murine liver fibrosis

(2012) P. Ramachandran et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Pathogenesis of Liver Fibrosis

(2011) Virginia Hernandez-Gea et al.   Annual Review of Pathology-Mechanisms of Disease

Interleukin-17 exacerbates hepatic steatosis and inflammation in non-alcoholic fatty liver disease

(2011) Y. Tang et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Correlation Analysis Between Gene Expression Profile of Rat Liver Tissues and High-Fat Emulsion-Induced Nonalcoholic Fatty Liver

(2011) Cunshuan Xu et al.   DIGESTIVE DISEASES AND SCIENCES

Prediction of Significant Fibrosis in Chronic Hepatitis C Patients with Normal ALT

(2011) Jae Jun Park et al.   HEPATO-GASTROENTEROLOGY

Complementary vascular and matrix regulatory pathways underlie the beneficial mechanism of action of sorafenib in liver fibrosis

(2011) Dominique Thabut et al.   HEPATOLOGY

Protease profiling of liver fibrosis reveals the ADAM metallopeptidase with thrombospondin type 1 motif, 1 as a central activator of transforming growth factor beta

(2011) Katia Bourd-Boittin et al.   HEPATOLOGY

Fatty acid and endotoxin activate inflammasomes in mouse hepatocytes that release danger signals to stimulate immune cells

(2011) Timea Csak et al.   HEPATOLOGY

Hedgehog pathway activation parallels histologic severity of injury and fibrosis in human nonalcoholic fatty liver disease

(2011) Cynthia D. Guy et al.   HEPATOLOGY

Effect of Vitamin E or Metformin for Treatment of Nonalcoholic Fatty Liver Disease in Children and Adolescents

(2011) Joel E. Lavine   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Lack of interleukin-1α or interleukin-1β inhibits transformation of steatosis to steatohepatitis and liver fibrosis in hypercholesterolemic mice

(2011) Yehuda Kamari et al.   JOURNAL OF HEPATOLOGY

Should we treat HCV carriers with normal ALT levels? The ‘5Ws’ dilemma

(2011) C. Puoti et al.   JOURNAL OF VIRAL HEPATITIS

Hepatitis C virus core protein induces fibrogenic actions of hepatic stellate cells via toll-like receptor 2

(2011) Martin Coenen et al.   LABORATORY INVESTIGATION

Neutrophil to lymphocyte ratio: a new marker for predicting steatohepatitis and fibrosis in patients with nonalcoholic fatty liver disease

(2011) Naim Alkhouri et al.   LIVER INTERNATIONAL

B cells promote insulin resistance through modulation of T cells and production of pathogenic IgG antibodies

(2011) Daniel A Winer et al.   NATURE MEDICINE

Hedgehog Signaling Antagonist Promotes Regression of Both Liver Fibrosis and Hepatocellular Carcinoma in a Murine Model of Primary Liver Cancer

(2011) George M. Philips et al.   PLoS One

Genome-Wide Association Analysis Identifies Variants Associated with Nonalcoholic Fatty Liver Disease That Have Distinct Effects on Metabolic Traits

(2011) Elizabeth K. Speliotes et al.   PLoS Genetics

The rate of decompensation and clinical progression of disease in people with cirrhosis: a cohort study

(2010) K. M. Fleming et al.   ALIMENTARY PHARMACOLOGY & THERAPEUTICS

Lipid accumulation impairs adiponectin-mediated induction of activin A by increasing TGFbeta in primary human hepatocytes

(2010) Josef Wanninger et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Monocytes: Protagonists of Infarct Inflammation and Repair After Myocardial Infarction

(2010) Matthias Nahrendorf et al.   CIRCULATION

Modulation of programmed cell death pathways by the hepatitis C virus

(2010) Jude Juventus Aweya   Frontiers in Bioscience-Landmark

Hepatitis C Virus Regulates Transforming Growth Factor β1 Production Through the Generation of Reactive Oxygen Species in a Nuclear Factor κB–Dependent Manner

(2010) Wenyu Lin et al.   GASTROENTEROLOGY

Histologic outcomes in hepatitis C-infected patients with varying degrees of virologic response to interferon-based treatments

(2010) Paul J. Pockros et al.   HEPATOLOGY

The fractalkine receptor CX3CR1 protects against liver fibrosis by controlling differentiation and survival of infiltrating hepatic monocytes

(2010) Karlin Raja Karlmark et al.   HEPATOLOGY

A common variant in the patatin-like phospholipase 3 gene (PNPLA3) is associated with fatty liver disease in obese children and adolescents

(2010) Nicola Santoro et al.   HEPATOLOGY

Evolution of inflammation in nonalcoholic fatty liver disease: The multiple parallel hits hypothesis

(2010) Herbert Tilg et al.   HEPATOLOGY

Nonalcoholic fatty liver disease (NAFLD) activity score and the histopathologic diagnosis in NAFLD: distinct clinicopathologic meanings

(2010) Elizabeth M. Brunt et al.   HEPATOLOGY

Oxidative stress parameters in paediatric non-alcoholic fatty liver disease

(2010) Nobili   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Intrahepatic angiogenesis and sinusoidal remodeling in chronic liver disease: New targets for the treatment of portal hypertension?

(2010) Dominique Thabut et al.   JOURNAL OF HEPATOLOGY

Allosteric inhibition of lysyl oxidase–like-2 impedes the development of a pathologic microenvironment

(2010) Vivian Barry-Hamilton et al.   NATURE MEDICINE

Pathology of nonalcoholic fatty liver disease

(2010) Elizabeth M. Brunt   Nature Reviews Gastroenterology & Hepatology

Pioglitazone, Vitamin E, or Placebo for Nonalcoholic Steatohepatitis

(2010) Arun J. Sanyal et al.   NEW ENGLAND JOURNAL OF MEDICINE

Development of Monocytes, Macrophages, and Dendritic Cells

(2010) F. Geissmann et al.   SCIENCE

Intravascular Danger Signals Guide Neutrophils to Sites of Sterile Inflammation

(2010) B. McDonald et al.   SCIENCE

Increased Hepatic Myeloperoxidase Activity in Obese Subjects with Nonalcoholic Steatohepatitis

(2009) Sander S. Rensen et al.   AMERICAN JOURNAL OF PATHOLOGY

The Liver as a Lymphoid Organ

(2009) Ian Nicholas Crispe   Annual Review of Immunology

Depletion of Liver Kupffer Cells Prevents the Development of Diet-Induced Hepatic Steatosis and Insulin Resistance

(2009) W. Huang et al.   DIABETES

Randomized controlled trial testing the effects of weight loss on nonalcoholic steatohepatitis

(2009) Kittichai Promrat et al.   HEPATOLOGY

Hepatic Lipid Partitioning and Liver Damage in Nonalcoholic Fatty Liver Disease

(2009) Zheng Zheng Li et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Angiogenesis in liver disease

(2009) Mercedes Fernández et al.   JOURNAL OF HEPATOLOGY

Toll-Like Receptor 3 Mediates Establishment of an Antiviral State against Hepatitis C Virus in Hepatoma Cells

(2009) N. Wang et al.   JOURNAL OF VIROLOGY

AIM2 activates the inflammasome and cell death in response to cytoplasmic DNA

(2009) Teresa Fernandes-Alnemri et al.   NATURE

Inhibition of Integrin αvβ6 on Cholangiocytes Blocks Transforming Growth Factor-β Activation and Retards Biliary Fibrosis Progression

(2008) Eleonora Patsenker et al.   GASTROENTEROLOGY

Mechanisms of Hepatic Fibrogenesis

(2008) Scott L. Friedman   GASTROENTEROLOGY

Orlistat for overweight subjects with nonalcoholic steatohepatitis: A randomized, prospective trial

(2008) Stephen A. Harrison et al.   HEPATOLOGY

Liver biopsy

(2008) Don C. Rockey et al.   HEPATOLOGY

The Biological Functions of T Helper 17 Cell Effector Cytokines in Inflammation

(2008) Wenjun Ouyang et al.   IMMUNITY

Increased activity of interleukin-23/interleukin-17 proinflammatory axis in obese women

(2008) M Sumarac-Dumanovic et al.   INTERNATIONAL JOURNAL OF OBESITY

Hedgehog signaling regulates epithelial-mesenchymal transition during biliary fibrosis in rodents and humans

(2008) Alessia Omenetti et al.   JOURNAL OF CLINICAL INVESTIGATION

3 COLCHICINE VERSUS PEG-INTERFERON ALFA 2B LONG TERM THERAPY: RESULTS OF THE 4 YEAR COPILOT TRIAL

(2008) N.H. Afdhal et al.   JOURNAL OF HEPATOLOGY

Liver cirrhosis

(2008) Detlef Schuppan et al.   LANCET

Prolonged Therapy of Advanced Chronic Hepatitis C with Low-Dose Peginterferon

(2008) Adrian M. Di Bisceglie et al.   NEW ENGLAND JOURNAL OF MEDICINE

Hepatic Stellate Cells: Protean, Multifunctional, and Enigmatic Cells of the Liver

(2008) Scott L. Friedman   PHYSIOLOGICAL REVIEWS