Matrix stiffness and its influence on pancreatic diseases

Control of matrix stiffness promotes endodermal lineage specification by regulating SMAD2/3 via lncRNA LINC00458

(2020) Yu-Fan Chen et al.   Science Advances

Tissue stiffness contributes to YAP activation in bladder cancer patients undergoing transurethral resection

(2020) Hadi Ghasemi et al.   Annals of the New York Academy of Sciences

Pancreatic cancer stroma: an update on therapeutic targeting strategies

(2020) Abdel N. Hosein et al.   Nature Reviews Gastroenterology & Hepatology

Piezo1/2 mediate mechanotransduction essential for bone formation through concerted activation of NFAT-YAP1-ß-catenin

(2020) Taifeng Zhou et al.   eLife

Mechanically induced formation and maturation of 3D-matrix adhesions (3DMAs) in human mesenchymal stem cells

(2020) Li Chuen Wai et al.   BIOMATERIALS

Periostin and Matrix Stiffness Combine to Regulate Myofibroblast Differentiation and Fibronectin Synthesis During Palatal Healing

(2020) Georgia Nikoloudaki et al.   MATRIX BIOLOGY

Matrix stiffness-sensitive long noncoding RNA NEAT1 seeded paraspeckles in cancer cells

(2020) Vanja Todorovski et al.   MOLECULAR BIOLOGY OF THE CELL

Fibronectin synthesis, but not α-smooth muscle expression, is regulated by periostin in gingival healing through FAK/JNK signaling

(2019) Shawna S. Kim et al.   Scientific Reports

Integrin Signaling in Cancer: Mechanotransduction, Stemness, Epithelial Plasticity, and Therapeutic Resistance

(2019) Jonathan Cooper et al.   CANCER CELL

ROCK isoforms differentially modulate cancer cell motility by mechanosensing the substrate stiffness

(2019) Yueting Peng et al.   Acta Biomaterialia

Norcantharidin Suppresses YD-15 Cell Invasion Through Inhibition of FAK/Paxillin and F-Actin Reorganization

(2019) Kyoung-Ok Hong et al.   MOLECULES

Talin and Kindlin as Integrin-Activating Proteins: Focus on the Heart

(2019) Chao Chen et al.   PEDIATRIC CARDIOLOGY

The Small GTPase Rac1 Increases Cell Surface Stiffness and Enhances 3D Migration Into Extracellular Matrices

(2019) Tom Kunschmann et al.   Scientific Reports

Lysyl oxidases: from enzyme activity to extracellular matrix cross-links

(2019) Sylvain D. Vallet et al.   Essays in Biochemistry

Engineered chitosan for improved 3D tissue growth through Paxillin-FAK-ERK activation

(2019) Md Abdul Kafi et al.   Regenerative Biomaterials

Matrix stiffness regulates SMC functions via TGF-β signaling pathway

(2019) Baoxiang Tian et al.   BIOMATERIALS

Integrin diversity brings specificity in mechanotransduction

(2018) Shailaja Seetharaman et al.   BIOLOGY OF THE CELL

Matrix stiffening and EGFR cooperate to promote the collective invasion of cancer cells.

(2018) Eloise M Grasset et al.   CANCER RESEARCH

Multicellular spheroid based on a triple co-culture: A novel 3D model to mimic pancreatic tumor complexity

(2018) Gianpiero Lazzari et al.   Acta Biomaterialia

Matrix stiffness mediates stemness characteristics via activating the Yes-associated protein in colorectal cancer cells

(2018) Fengbo Tan et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

A tension-mediated glycocalyx–integrin feedback loop promotes mesenchymal-like glioblastoma

(2018) J. Matthew Barnes et al.   NATURE CELL BIOLOGY

TRPV4 regulates matrix stiffness and TGFβ1-induced epithelial-mesenchymal transition

(2018) Shweta Sharma et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Rigidity controls human desmoplastic matrix anisotropy to enable pancreatic cancer cell spread via extracellular signal-regulated kinase 2

(2018) R. Malik et al.   MATRIX BIOLOGY

Integrin activation by talin, kindlin and mechanical forces

(2018) Zhiqi Sun et al.   NATURE CELL BIOLOGY

A Feedforward Mechanism Mediated by Mechanosensitive Ion Channel PIEZO1 and Tissue Mechanics Promotes Glioma Aggression

(2018) Xin Chen et al.   NEURON

The Strain Ratio as Obtained by Endoscopic Ultrasonography Elastography Correlates With the Stroma Proportion and the Prognosis of Local Pancreatic Cancer

(2018) Si Shi et al.   ANNALS OF SURGERY

Hyaluronan content governs tissue stiffness in pancreatic islet inflammation

(2017) Nadine Nagy et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Force-dependent breaching of the basement membrane

(2017) Tammy T. Chang et al.   MATRIX BIOLOGY

Matrix stiffness induces epithelial–mesenchymal transition and promotes chemoresistance in pancreatic cancer cells

(2017) A J Rice et al.   Oncogenesis

Softening Substrates Promote Chondrocytes Phenotype via RhoA/ROCK Pathway

(2016) Tao Zhang et al.   ACS Applied Materials & Interfaces

Extracellular matrix component signaling in cancer

(2016) Hinke A.B. Multhaupt et al.   ADVANCED DRUG DELIVERY REVIEWS

Extracellular matrix structure

(2016) Achilleas D. Theocharis et al.   ADVANCED DRUG DELIVERY REVIEWS

A Computational Model of YAP/TAZ Mechanosensing

(2016) Meng Sun et al.   BIOPHYSICAL JOURNAL

Stiffness of pancreatic cancer cells is associated with increased invasive potential

(2016) Angelyn V. Nguyen et al.   Integrative Biology

P-selectin-mediated LOX expression promotes insulinoma growth in Rip1-Tag2 mice by increasing tissue stiffness

(2016) Cuiling Qi et al.   International Journal of Biological Sciences

Extracellular matrix stiffness dictates Wnt expression through integrin pathway

(2016) Jing Du et al.   Scientific Reports

Matrix stiffness drives epithelial–mesenchymal transition and tumour metastasis through a TWIST1–G3BP2 mechanotransduction pathway

(2015) Spencer C. Wei et al.   NATURE CELL BIOLOGY

Mechanical sensitivity of Piezo1 ion channels can be tuned by cellular membrane tension

(2015) Amanda H Lewis et al.   eLife

Laminins: Roles and Utility in Wound Repair

(2015) Valentina Iorio et al.   Advances in Wound Care

Matrix rigidity regulates spatiotemporal dynamics of Cdc42 activity and vacuole formation kinetics of endothelial colony forming cells

(2014) Seung Joon Kim et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Matrix Elasticity Regulates Lamin-A,C Phosphorylation and Turnover with Feedback to Actomyosin

(2014) Amnon Buxboim et al.   CURRENT BIOLOGY

Cellular contractility and extracellular matrix stiffness regulate matrix metalloproteinase activity in pancreatic cancer cells

(2014) Amanda Haage et al.   FASEB JOURNAL

Stretch-activated ion channel Piezo1 directs lineage choice in human neural stem cells

(2014) Medha M. Pathak et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cellular biophysical dynamics and ion channel activities detected by AFM-based nanorobotic manipulator in insulinoma β-cells

(2012) Ruiguo Yang et al.   Nanomedicine-Nanotechnology Biology and Medicine

Hippo pathway regulation by cell morphology and stress fibers

(2011) K.-I. Wada et al.   DEVELOPMENT

The Rho GEFs LARG and GEF-H1 regulate the mechanical response to force on integrins

(2011) Christophe Guilluy et al.   NATURE CELL BIOLOGY

Overview of the Matrisome--An Inventory of Extracellular Matrix Constituents and Functions

(2011) R. O. Hynes et al.   Cold Spring Harbor Perspectives in Biology

The Collagen Family

(2010) S. Ricard-Blum   Cold Spring Harbor Perspectives in Biology

Regulation of cancer invasiveness by the physical extracellular matrix environment

(2010) Aron Parekh et al.   Cell Adhesion & Migration

Integrin α8β1 regulates adhesion, migration and proliferation of human intestinal crypt cells via a predominant RhoA/ROCK-dependent mechanism

(2009) Yannick D. Benoit et al.   BIOLOGY OF THE CELL

Mechanically Activated Integrin Switch Controls  5 1 Function

(2009) J. C. Friedland et al.   SCIENCE