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Title
The pathogenesis of cardiac fibrosis
Authors
Keywords
Myofibroblast, Cardiac remodeling, Macrophage, Mast cell, Chemokine, TGF-β, Angiotensin, Extracellular matrix
Journal
CELLULAR AND MOLECULAR LIFE SCIENCES
Volume 71, Issue 4, Pages 549-574
Publisher
Springer Nature
Online
2013-05-06
DOI
10.1007/s00018-013-1349-6
References
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- (2010) Sergio Carracedo et al. JOURNAL OF BIOLOGICAL CHEMISTRY
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