ATRA mechanically reprograms pancreatic stellate cells to suppress matrix remodelling and inhibit cancer cell invasion

Genotype tunes pancreatic ductal adenocarcinoma tissue tension to induce matricellular fibrosis and tumor progression

(2016) Hanane Laklai et al.   NATURE MEDICINE

A biomechanical perspective on stress fiber structure and function

(2015) Elena Kassianidou et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Retinoic Acid Ameliorates Pancreatic Fibrosis and Inhibits the Activation of Pancreatic Stellate Cells in Mice with Experimental Chronic Pancreatitis via Suppressing the Wnt/β-Catenin Signaling Pathway

(2015) Wenqin Xiao et al.   PLoS One

Depletion of Carcinoma-Associated Fibroblasts and Fibrosis Induces Immunosuppression and Accelerates Pancreas Cancer with Reduced Survival

(2014) Berna C. Özdemir et al.   CANCER CELL

Stromal Elements Act to Restrain, Rather Than Support, Pancreatic Ductal Adenocarcinoma

(2014) Andrew D. Rhim et al.   CANCER CELL

Vitamin D Receptor-Mediated Stromal Reprogramming Suppresses Pancreatitis and Enhances Pancreatic Cancer Therapy

(2014) Mara H. Sherman et al.   CELL

Stressing the limits of focal adhesion mechanosensitivity

(2014) Patrick W Oakes et al.   CURRENT OPINION IN CELL BIOLOGY

Diverse functions of matrix metalloproteinases during fibrosis

(2014) M. Giannandrea et al.   Disease Models & Mechanisms

Roles for Chemokines in Liver Disease

(2014) Fabio Marra et al.   GASTROENTEROLOGY

Hepatic stellate cells and extracellular matrix in hepatocellular carcinoma: more complicated than ever

(2014) Vinicio Carloni et al.   LIVER INTERNATIONAL

Reduced retinoids and retinoid receptors' expression in pancreatic cancer: A link to patient survival

(2014) Tim Bleul et al.   MOLECULAR CARCINOGENESIS

Fibrosis—a lethal component of systemic sclerosis

(2014) Yuen Yee Ho et al.   Nature Reviews Rheumatology

Stromal response to Hedgehog signaling restrains pancreatic cancer progression

(2014) J. J. Lee et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Stars and stripes in pancreatic cancer: role of stellate cells and stroma in cancer progression

(2014) Jeremy S. Wilson et al.   Frontiers in Physiology

Mechanotransduction and YAP-dependent matrix remodelling is required for the generation and maintenance of cancer-associated fibroblasts

(2013) Fernando Calvo et al.   NATURE CELL BIOLOGY

Myosin II-Mediated Focal Adhesion Maturation Is Tension Insensitive

(2013) Jonathan Stricker et al.   PLoS One

Emerging concepts in pancreatic cancer medicine: targeting the tumor stroma

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Persistent activation of pancreatic stellate cells creates a microenvironment favorable for the malignant behavior of pancreatic ductal adenocarcinoma

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Tension is required but not sufficient for focal adhesion maturation without a stress fiber template

(2012) Patrick W. Oakes et al.   JOURNAL OF CELL BIOLOGY

Assembly of non-contractile dorsal stress fibers requires α-actinin-1 and Rac1 in migrating and spreading cells

(2012) Bianca Kovac et al.   JOURNAL OF CELL SCIENCE

The potential mechanism for the different expressions of gelatinases induced by all-trans retinoic acid in different cells

(2012) Tian-Biao Zhou et al.   JOURNAL OF RECEPTORS AND SIGNAL TRANSDUCTION

The role of stroma in pancreatic cancer: diagnostic and therapeutic implications

(2012) Mert Erkan et al.   Nature Reviews Gastroenterology & Hepatology

The role of the myofibroblast in tumor stroma remodeling

(2012) Marcela Otranto et al.   Cell Adhesion & Migration

Hepatic stellate cells require a stiff environment for myofibroblastic differentiation

(2011) Abby L. Olsen et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Survival after Resection of Pancreatic Adenocarcinoma: Results from a Single Institution over Three Decades

(2011) Jordan M. Winter et al.   ANNALS OF SURGICAL ONCOLOGY

Actomyosin-Mediated Cellular Tension Drives Increased Tissue Stiffness and β-Catenin Activation to Induce Epidermal Hyperplasia and Tumor Growth

(2011) Michael S. Samuel et al.   CANCER CELL

Biomechanical Remodeling of the Microenvironment by Stromal Caveolin-1 Favors Tumor Invasion and Metastasis

(2011) Jacky G. Goetz et al.   CELL

Retinoic Acid–Induced Pancreatic Stellate Cell Quiescence Reduces Paracrine Wnt–β-Catenin Signaling to Slow Tumor Progression

(2011) Fieke E.M. Froeling et al.   GASTROENTEROLOGY

The Rho GEFs LARG and GEF-H1 regulate the mechanical response to force on integrins

(2011) Christophe Guilluy et al.   NATURE CELL BIOLOGY

Balancing forces: architectural control of mechanotransduction

(2011) Christopher C. DuFort et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Fibrogenic signalling in hepatic stellate cells

(2010) Derek A. Mann et al.   JOURNAL OF HEPATOLOGY

Vitamin A Upregulates Matrix Metalloproteinase-9 Activity by Murine Myeloid Dendritic Cells through a Nonclassical Transcriptional Mechanism

(2010) Denise E. Lackey et al.   JOURNAL OF NUTRITION

Forcing form and function: biomechanical regulation of tumor evolution

(2010) Hongmei Yu et al.   TRENDS IN CELL BIOLOGY

All-trans retinoic acid is capable of inducing folate receptor β expression in KG-1 cells

(2010) Ying Xu et al.   TUMOR BIOLOGY

All-trans retinoic acid (ATRA) downregulated MMP-9 by modulating its regulatory molecules

(2010) Anindita Dutta et al.   Cell Adhesion & Migration

Blebbistatin inhibits contraction and accelerates migration in mouse hepatic stellate cells

(2009) Zhenan Liu et al.   BRITISH JOURNAL OF PHARMACOLOGY

Mechanism of Regulation and Suppression of Melanoma Invasiveness by Novel Retinoic Acid Receptor-  Target Gene Carbohydrate Sulfotransferase 10

(2009) X. Zhao et al.   CANCER RESEARCH

Matrix Crosslinking Forces Tumor Progression by Enhancing Integrin Signaling

(2009) Kandice R. Levental et al.   CELL

The mechanical integrin cycle

(2009) E. Puklin-Faucher et al.   JOURNAL OF CELL SCIENCE

Inhibition of Hedgehog Signaling Enhances Delivery of Chemotherapy in a Mouse Model of Pancreatic Cancer

(2009) K. P. Olive et al.   SCIENCE

The Retinoic Acid Receptor-α mediates human T-cell activation and Th2 cytokine and chemokine production

(2008) Harry D Dawson et al.   BMC IMMUNOLOGY

Pancreatic Stellate Cells: Partners in Crime with Pancreatic Cancer Cells

(2008) A. Vonlaufen et al.   CANCER RESEARCH

Cancer-Associated Stromal Fibroblasts Promote Pancreatic Tumor Progression

(2008) R. F. Hwang et al.   CANCER RESEARCH