Biochemical role of the collagen-rich tumour microenvironment in pancreatic cancer progression

European cancer mortality predictions for the year 2011

(2011) M. Malvezzi et al.   ANNALS OF ONCOLOGY

Cancer statistics, 2011

(2011) Rebecca Siegel et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Global cancer statistics

(2011) Ahmedin Jemal et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Let-7 and miR-200 microRNAs: Guardians against pluripotency and cancer progression

(2011) Marcus E. Peter   CELL CYCLE

Pancreatic Cancer Cells Respond to Type I Collagen by Inducing Snail Expression to Promote Membrane Type 1 Matrix Metalloproteinase-dependent Collagen Invasion

(2011) Mario A. Shields et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Pancreatic cancer

(2011) Audrey Vincent et al.   LANCET

Hepatocyte-Derived Snail1 Propagates Liver Fibrosis Progression

(2011) R. G. Rowe et al.   MOLECULAR AND CELLULAR BIOLOGY

MT1-MMP Cooperates with KrasG12D to Promote Pancreatic Fibrosis through Increased TGF-  Signaling

(2011) S. B. Krantz et al.   MOLECULAR CANCER RESEARCH

HMGA proteins promote ATM expression and enhance cancer cell resistance to genotoxic agents

(2011) D Palmieri et al.   ONCOGENE

Snail1 transcription factor is a critical mediator of hepatic stellate cell activation following hepatic injury

(2010) Melania Scarpa et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Inhibition and Role of let-7d in Idiopathic Pulmonary Fibrosis

(2010) Kusum V. Pandit et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

MT1-MMP promotes cell growth and ERK activation through c-Src and paxillin in three-dimensional collagen matrix

(2010) Takahisa Takino et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

The role of the miR-200 family in epithelial-mesenchymal transition

(2010) Perry S. Mongroo et al.   CANCER BIOLOGY & THERAPY

Carcinomas Contain a Matrix Metalloproteinase–Resistant Isoform of Type I Collagen Exerting Selective Support to Invasion

(2010) Elena Makareeva et al.   CANCER RESEARCH

Three-Dimensional Collagen I Promotes Gemcitabine Resistance in Pancreatic Cancer through MT1-MMP-Mediated Expression of HMGA2

(2010) S. Dangi-Garimella et al.   CANCER RESEARCH

MicroRNAs and Metastasis: Little RNAs Go a Long Way

(2010) D. M. Dykxhoorn   CANCER RESEARCH

MicroRNA-21 in Pancreatic Cancer: Correlation with Clinical Outcome and Pharmacologic Aspects Underlying Its Role in the Modulation of Gemcitabine Activity

(2010) Elisa Giovannetti et al.   CANCER RESEARCH

Matrix Metalloproteinases: Regulators of the Tumor Microenvironment

(2010) Kai Kessenbrock et al.   CELL

Integrin–TGF-β crosstalk in fibrosis, cancer and wound healing

(2010) Coert Margadant et al.   EMBO REPORTS

Micro-RNA profiling reveals a role for miR-29 in human and murine liver fibrosis

(2010) Christoph Roderburg et al.   HEPATOLOGY

Alterations of microRNAs and their targets are associated with acquired resistance of MCF-7 breast cancer cells to cisplatin

(2010) Igor P. Pogribny et al.   INTERNATIONAL JOURNAL OF CANCER

Rho-ROCK-Myosin Signaling Meditates Membrane Type 1 Matrix Metalloproteinase-induced Cellular Aggregation of Keratinocytes

(2010) Surabhi Dangi-Garimella et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Molecular Mechanism of Type I Collagen Homotrimer Resistance to Mammalian Collagenases

(2010) Sejin Han et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Let-7g targets collagen type I α2 and inhibits cell migration in hepatocellular carcinoma

(2010) Junfang Ji et al.   JOURNAL OF HEPATOLOGY

miR-192 Mediates TGF- /Smad3-Driven Renal Fibrosis

(2010) A. C. K. Chung et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Pancreatic cancer: understanding and overcoming chemoresistance

(2010) Zhiwei Wang et al.   Nature Reviews Gastroenterology & Hepatology

MicroRNA control of signal transduction

(2010) Masafumi Inui et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Pancreatic Cancer

(2010) Manuel Hidalgo   NEW ENGLAND JOURNAL OF MEDICINE

Collagen regulation of let-7 in pancreatic cancer involves TGF-β1-mediated membrane type 1-matrix metalloproteinase expression

(2010) S Dangi-Garimella et al.   ONCOGENE

Extracellular matrix-induced transforming growth factor-β receptor signaling dynamics

(2010) N Garamszegi et al.   ONCOGENE

AP-1-Dependent miR-21 Expression Contributes to Chemoresistance in Cancer Stem Cell-Like SP Cells

(2010) Aya Misawa et al.   ONCOLOGY RESEARCH

miR-200b Precursor Can Ameliorate Renal Tubulointerstitial Fibrosis

(2010) Shigeyoshi Oba et al.   PLoS One

TGFβ: a sleeping giant awoken by integrins

(2010) John J. Worthington et al.   TRENDS IN BIOCHEMICAL SCIENCES

Integrin-Mediated Transforming Growth Factor-β Activation, a Potential Therapeutic Target in Fibrogenic Disorders

(2009) Stephen L. Nishimura   AMERICAN JOURNAL OF PATHOLOGY

Suppression of type I collagen production by microRNA-29b in cultured human stellate cells

(2009) Tomohiro Ogawa et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

MicroRNA in pancreatic cancer: Pathological, diagnostic and therapeutic implications

(2009) Satyanarayana Rachagani et al.   CANCER LETTERS

Selective Inhibition of Matrix Metalloproteinase-14 Blocks Tumor Growth, Invasion, and Angiogenesis

(2009) Laetitia Devy et al.   CANCER RESEARCH

Phosphorylation of the Human MicroRNA-Generating Complex Mediates MAPK/Erk Signaling

(2009) Zain Paroo et al.   CELL

Matrix Crosslinking Forces Tumor Progression by Enhancing Integrin Signaling

(2009) Kandice R. Levental et al.   CELL

Cardiac-Restricted Overexpression of Membrane Type-1 Matrix Metalloproteinase in Mice

(2009) Francis G. Spinale et al.   Circulation-Heart Failure

MicroRNA dynamics in the stages of tumorigenesis correlate with hallmark capabilities of cancer

(2009) P. Olson et al.   GENES & DEVELOPMENT

let-7 MicroRNA Transfer in Pancreatic Cancer-Derived Cells Inhibits In Vitro Cell Proliferation but Fails to Alter Tumor Progression

(2009) Jérôme Torrisani et al.   HUMAN GENE THERAPY

Mesenchymal cells reactivate Snail1 expression to drive three-dimensional invasion programs

(2009) R. Grant Rowe et al.   JOURNAL OF CELL BIOLOGY

Type I collagen promotes epithelial–mesenchymal transition through ILK-dependent activation of NF-κB and LEF-1

(2009) Damian Medici et al.   MATRIX BIOLOGY

MicroRNA-21 modulates biological functions of pancreatic cancer cells including their proliferation, invasion, and chemoresistance

(2009) T. Moriyama et al.   MOLECULAR CANCER THERAPEUTICS

HMGA2 exhibits dRP/AP site cleavage activity and protects cancer cells from DNA-damage-induced cytotoxicity during chemotherapy

(2009) Heike Summer et al.   NUCLEIC ACIDS RESEARCH

Induction of a MT1-MMP and MT2-MMP-dependent basement membrane transmigration program in cancer cells by Snail1

(2009) I. Ota et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Breaching the Cancer Fortress

(2009) P. Olson et al.   SCIENCE

Inhibition of Hedgehog Signaling Enhances Delivery of Chemotherapy in a Mouse Model of Pancreatic Cancer

(2009) K. P. Olive et al.   SCIENCE

The High Mobility Group Protein HMGA2: A Co-Regulator of Chromatin Structure and Pluripotency in Stem Cells?

(2009) Kurt Pfannkuche et al.   Stem Cell Reviews and Reports

Pancreatic Cancer

(2008) Anirban Maitra et al.   Annual Review of Pathology-Mechanisms of Disease

Interruption of the Ras/MEK/ERK signaling cascade enhances Chk1 inhibitor-induced DNA damage in vitro and in vivo in human multiple myeloma cells

(2008) Y. Dai et al.   BLOOD

Identification of Let-7-Regulated Oncofetal Genes

(2008) B. Boyerinas et al.   CANCER RESEARCH

Cancer-Associated Stromal Fibroblasts Promote Pancreatic Tumor Progression

(2008) R. F. Hwang et al.   CANCER RESEARCH

HMGA2, MicroRNAs, and Stem Cell Aging

(2008) Scott M. Hammond et al.   CELL

HMGA1 Is a Molecular Determinant of Chemoresistance to Gemcitabine in Pancreatic Adenocarcinoma

(2008) S.-S. Liau et al.   CLINICAL CANCER RESEARCH

The Activated Stroma Index Is a Novel and Independent Prognostic Marker in Pancreatic Ductal Adenocarcinoma

(2008) Mert Erkan et al.   Clinical Gastroenterology and Hepatology

MT1-MMP releases latent TGF-β1 from endothelial cell extracellular matrix via proteolytic processing of LTBP-1

(2008) O TATTI et al.   EXPERIMENTAL CELL RESEARCH

Role of Ras Signaling in the Induction of Snail by Transforming Growth Factor-β

(2008) Kana Horiguchi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cancer Stem Cells: A Step Toward the Cure

(2008) Bruce M. Boman et al.   JOURNAL OF CLINICAL ONCOLOGY

MicroRNA-21 is Overexpressed in Pancreatic Cancer and a Potential Predictor of Survival

(2008) Mary Dillhoff et al.   JOURNAL OF GASTROINTESTINAL SURGERY

Transforming Growth Factor- 1 Promotes Matrix Metalloproteinase-9-Mediated Oral Cancer Invasion through Snail Expression

(2008) L. Sun et al.   MOLECULAR CANCER RESEARCH

Endogenous human microRNAs that suppress breast cancer metastasis

(2008) Sohail F. Tavazoie et al.   NATURE

Suppression of non-small cell lung tumor development by the let-7 microRNA family

(2008) M. S. Kumar et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA