The RNA-binding protein HuR in human cancer: A friend or foe?

Hallmarks of Cancer: New Dimensions

(2022) Douglas Hanahan   Cancer Discovery

Targeting the HuR oncogenic role with a new class of cytoplasmic dimerization inhibitors

(2021) Natalia Filippova et al.   CANCER RESEARCH

HuR up-regulates cell surface PD-L1 via stabilizing CMTM6 transcript in cancer

(2021) Yanbin Liu et al.   ONCOGENE

Adipocyte-specific deletion of HuR induces spontaneous cardiac hypertrophy and fibrosis

(2021) Adrienne R. Guarnieri et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

The RNA-binding protein HuR is a novel target of Pirh2 E3 ubiquitin ligase

(2021) Alexandra Daks et al.   Cell Death & Disease

Identification of N,N-arylalkyl-picolinamide derivatives targeting the RNA-binding protein HuR, by combining biophysical fragment-screening and molecular hybridization

(2021) S. Della Volpe et al.   BIOORGANIC CHEMISTRY

Novel indole derivatives targeting HuR-mRNA complex to counteract high glucose damage in retinal endothelial cells

(2020) Chiara Bianca Maria Platania et al.   BIOCHEMICAL PHARMACOLOGY

Inhibition of RNA-binding protein HuR reduces glomerulosclerosis in experimental nephritis

(2020) Simeng Liu et al.   CLINICAL SCIENCE

Poly(ADP-ribosyl)ation enhances HuR oligomerization and contributes to pro-inflammatory gene mRNA stabilization

(2020) Yueshuang Ke et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Molecular and functional extracellular vesicle analysis using nanopatterned microchips monitors tumor progression and metastasis

(2020) Peng Zhang et al.   Science Translational Medicine

Targeting the interaction between RNA-binding protein HuR and FOXQ1 suppresses breast cancer invasion and metastasis

(2020) Xiaoqing Wu et al.   Communications Biology

An RNA-Binding Protein, Hu-antigen R, in Pancreatic Cancer Epithelial to Mesenchymal Transition, Metastasis, and Cancer Stem Cells

(2020) Ruochen Dong et al.   MOLECULAR CANCER THERAPEUTICS

Molecular basis for AU-rich element recognition and dimerization by the HuR C-terminal RRM

(2019) Nina Ripin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Adipose HuR protects against diet-induced obesity and insulin resistance

(2019) Jingyuan Li et al.   Nature Communications

The HuR CMLD-2 inhibitor exhibits antitumor effects via MAD2 downregulation in thyroid cancer cells

(2019) Lorenzo Allegri et al.   Scientific Reports

HuR regulates phospholamban expression in isoproterenol-induced cardiac remodelling

(2019) Han Hu et al.   CARDIOVASCULAR RESEARCH

Depletion of HuR in murine skeletal muscle enhances exercise endurance and prevents cancer-induced muscle atrophy

(2019) Brenda Janice Sánchez et al.   Nature Communications

HuR Reduces Radiation-Induced DNA Damage by Enhancing Expression of ARID1A

(2019) Daniel Andrade et al.   Cancers

Are liquid biopsies a surrogate for tissue EGFR testing?

(2018) J W Goldman et al.   ANNALS OF ONCOLOGY

Cytoplasmic HuR Status Predicts Disease-free Survival in Resected Pancreatic Cancer

(2018) Talar Tatarian et al.   ANNALS OF SURGERY

Interfering with HuR–RNA Interaction: Design, Synthesis and Biological Characterization of Tanshinone Mimics as Novel, Effective HuR Inhibitors

(2018) Leonardo Manzoni et al.   JOURNAL OF MEDICINAL CHEMISTRY

The Jun/miR-22/HuR regulatory axis contributes to tumourigenesis in colorectal cancer

(2018) Yanqing Liu et al.   Molecular Cancer

Chemo-biologic combinatorial drug delivery using folate receptor-targeted dendrimer nanoparticles for lung cancer treatment

(2018) Narsireddy Amreddy et al.   Nanomedicine-Nanotechnology Biology and Medicine

Shedding light on the cell biology of extracellular vesicles

(2018) Guillaume van Niel et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Complex HuR function in pancreatic cancer cells

(2018) Jonathan R. Brody et al.   Wiley Interdisciplinary Reviews-RNA

Exosomal PD-L1 contributes to immunosuppression and is associated with anti-PD-1 response

(2018) Gang Chen et al.   NATURE

HuR biological function involves RRM3-mediated dimerization and RNA binding by all three RRMs

(2018) Marta Pabis et al.   NUCLEIC ACIDS RESEARCH

CRISPR Knockout of the HuR Gene Causes a Xenograft Lethal Phenotype

(2017) Shruti Lal et al.   MOLECULAR CANCER RESEARCH

Tumor-targeted Nanoparticle Delivery of HuR siRNA Inhibits Lung Tumor Growth In Vitro and In Vivo By Disrupting the Oncogenic Activity of the RNA-binding Protein HuR

(2017) Ranganayaki Muralidharan et al.   MOLECULAR CANCER THERAPEUTICS

Integrating liquid biopsies into the management of cancer

(2017) Giulia Siravegna et al.   Nature Reviews Clinical Oncology

Regulation of HuR structure and function by dihydrotanshinone-I

(2017) Preet Lal et al.   NUCLEIC ACIDS RESEARCH

PARP1 promotes gene expression at the post-transcriptiona level by modulating the RNA-binding protein HuR

(2017) Yueshuang Ke et al.   Nature Communications

The fungal natural product azaphilone-9 binds to HuR and inhibits HuR-RNA interaction in vitro

(2017) Kawaljit Kaur et al.   PLoS One

HuR-targeted small molecule inhibitor exhibits cytotoxicity towards human lung cancer cells

(2017) Ranganayaki Muralidharan et al.   Scientific Reports

Delivery of Therapeutics Targeting the mRNA-Binding Protein HuR Using 3DNA Nanocarriers Suppresses Ovarian Tumor Growth

(2016) Yu-Hung Huang et al.   CANCER RESEARCH

Human antigen R is positively associated with malignant aggressiveness via upregulation of cell proliferation, migration, and vascular endothelial growth factors and cyclooxygenase-2 in prostate cancer

(2016) Kensuke Mitsunari et al.   Translational Research

Impact of HuR inhibition by the small molecule MS-444 on colorectal cancer cell tumorigenesis

(2016) Fernando F. Blanco et al.   Oncotarget

Posttranslational control of HuR function

(2016) Ioannis Grammatikakis et al.   Wiley Interdisciplinary Reviews-RNA

Identification and Validation of Novel Small Molecule Disruptors of HuR-mRNA Interaction

(2015) Xiaoqing Wu et al.   ACS Chemical Biology

Prognostic effect of hENT1, dCK and HuR expression by morphological type in periampullary adenocarcinoma, including pancreatic cancer

(2015) Jacob Elebro et al.   ACTA ONCOLOGICA

The cytoskeletal inhibitors latrunculin A and blebbistatin exert antitumorigenic properties in human hepatocellular carcinoma cells by interfering with intracellular HuR trafficking

(2015) Anke Doller et al.   EXPERIMENTAL CELL RESEARCH

Methyl(R217)HuR and MCM6 are inversely correlated and are prognostic markers in non small cell lung carcinoma

(2015) Charlène Vigouroux et al.   LUNG CANCER

Negative regulation of RNA-binding protein HuR by tumor-suppressor ECRG2

(2015) C Lucchesi et al.   ONCOGENE

The mRNA-binding protein HuR promotes hypoxia-induced chemoresistance through posttranscriptional regulation of the proto-oncogene PIM1 in pancreatic cancer cells

(2015) F F Blanco et al.   ONCOGENE

Cytoplasmic accumulation of ELAVL1 is an independent predictor of biochemical recurrence associated with genomic instability in prostate cancer

(2015) Nathaniel Melling et al.   PROSTATE

Dihydrotanshinone-I interferes with the RNA-binding activity of HuR affecting its post-transcriptional function

(2015) Vito Giuseppe D’Agostino et al.   Scientific Reports

The C-terminal RNA binding motif of HuR is a multi-functional domain leading to HuR oligomerization and binding to U-rich RNA targets

(2015) Rafael M Scheiba et al.   RNA Biology

dCK expression correlates with 5-fluorouracil efficacy and HuR cytoplasmic expression in pancreatic cancer

(2014) Florencia McAllister et al.   CANCER BIOLOGY & THERAPY

MiRNA in melanoma-derived exosomes

(2014) Anna Gajos-Michniewicz et al.   CANCER LETTERS

HuR Posttranscriptionally Regulates WEE1: Implications for the DNA Damage Response in Pancreatic Cancer Cells

(2014) S. Lal et al.   CANCER RESEARCH

Predictive and prognostic significance of cytoplasmic expression of ELAV-like protein HuR in invasive breast cancer treated with neoadjuvant chemotherapy

(2013) Jun Wang et al.   BREAST CANCER RESEARCH AND TREATMENT

Real-time Liquid Biopsy in Cancer Patients: Fact or Fiction?

(2013) K. Pantel et al.   CANCER RESEARCH

Intercellular Communication by Exosome-Derived microRNAs in Cancer

(2013) Bethany Hannafon et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

MPT0B098, a Novel Microtubule Inhibitor That Destabilizes the Hypoxia-Inducible Factor-1  mRNA through Decreasing Nuclear-Cytoplasmic Translocation of RNA-Binding Protein HuR

(2013) Y.-C. Cheng et al.   MOLECULAR CANCER THERAPEUTICS

Liquid biopsy: monitoring cancer-genetics in the blood

(2013) Emily Crowley et al.   Nature Reviews Clinical Oncology

Apoptotic-induced cleavage shifts HuR from being a promoter of survival to an activator of caspase-mediated apoptosis

(2012) C von Roretz et al.   CELL DEATH AND DIFFERENTIATION

The RNA-binding Protein RNPC1 Stabilizes the mRNA Encoding the RNA-binding Protein HuR and Cooperates with HuR to Suppress Cell Proliferation

(2012) Seong-Jun Cho et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Phosphoregulation of the RNA-binding Protein Hu Antigen R (HuR) by Cdk5 Affects Centrosome Function

(2012) Natalia Filippova et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Downregulation of HuR as a new mechanism of doxorubicin resistance in breast cancer cells

(2012) Elisa Latorre et al.   Molecular Cancer

HuR function in disease

(2011) Subramanya Srikantan   Frontiers in Bioscience-Landmark

Murine double minute 2 regulates Hu antigen R stability in human liver and colon cancer through NEDDylation

(2011) Nieves Embade et al.   HEPATOLOGY

mRNA stability alterations mediated by HuR are necessary to sustain the fast growth of glioma cells

(2011) Federico Bolognani et al.   JOURNAL OF NEURO-ONCOLOGY

Role of RNA binding protein HuR in ductal carcinoma in situ of the breast

(2011) Mira Heinonen et al.   JOURNAL OF PATHOLOGY

The RNA-binding protein ELAVL1/HuR is essential for mouse spermatogenesis, acting both at meiotic and postmeiotic stages

(2011) Mai Nguyen Chi et al.   MOLECULAR BIOLOGY OF THE CELL

The RNA-Binding Protein HuR Promotes Glioma Growth and Treatment Resistance

(2011) N. Filippova et al.   MOLECULAR CANCER RESEARCH

UneCLIPsing HuR Nuclear Function

(2011) Subramanya Srikantan et al.   MOLECULAR CELL

RNA-binding protein HuR autoregulates its expression by promoting alternative polyadenylation site usage

(2011) Weijun Dai et al.   NUCLEIC ACIDS RESEARCH

Cytoplasmic accumulation of the RNA binding protein HuR is central to tamoxifen resistance in estrogen receptor positive breast cancer cells

(2010) Christine Hostetter et al.   CANCER BIOLOGY & THERAPY

Role of the RNA-binding protein HuR in human renal cell carcinoma

(2010) Sabrina Danilin et al.   CARCINOGENESIS

Loss of Repression of HuR Translation by miR-16 May Be Responsible for the Elevation of HuR in Human Breast Carcinoma

(2010) Fang Xu et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Cytoplasmic HuR expression correlates with angiogenesis, lymphangiogenesis, and poor outcome in lung cancer

(2010) Jun Wang et al.   MEDICAL ONCOLOGY

Tandem Phosphorylation of Serines 221 and 318 by Protein Kinase C  Coordinates mRNA Binding and Nucleocytoplasmic Shuttling of HuR

(2010) A. Doller et al.   MOLECULAR AND CELLULAR BIOLOGY

MicroRNA-125a represses cell growth by targeting HuR in breast cancer

(2010) Xun Guo et al.   RNA Biology

HuR expression in the nucleus correlates with high histological grade and poor disease-free survival in ovarian cancer

(2009) Xiaofang YI et al.   AUSTRALIAN & NEW ZEALAND JOURNAL OF OBSTETRICS & GYNAECOLOGY

The Role of HuR in Gemcitabine Efficacy in Pancreatic Cancer: HuR Up-regulates the Expression of the Gemcitabine Metabolizing Enzyme Deoxycytidine Kinase

(2009) C. L. Costantino et al.   CANCER RESEARCH

Chemical inhibitors destabilize HuR binding to the AU-rich element of TNF-α mRNA

(2009) Min-Ju Chae et al.   EXPERIMENTAL AND MOLECULAR MEDICINE

Transcriptional Control of Human Antigen R by Bone Morphogenetic Protein

(2009) Selvi C. Jeyaraj et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Essential role of the RNA-binding protein HuR in progenitor cell survival in mice

(2009) Mallika Ghosh et al.   JOURNAL OF CLINICAL INVESTIGATION

The RNA-Binding Protein Elavl1/HuR Is Essential for Placental Branching Morphogenesis and Embryonic Development

(2009) V. Katsanou et al.   MOLECULAR AND CELLULAR BIOLOGY

Alternative polyadenylation variants of the RNA binding protein, HuR: abundance, role of AU-rich elements and auto-Regulation

(2009) Wijdan Al-Ahmadi et al.   NUCLEIC ACIDS RESEARCH

The Expression of RNA-Binding Protein HuR in Non-Small Cell Lung Cancer Correlates with Vascular Endothelial Growth Factor-C Expression and Lymph Node Metastasis

(2009) Jun Wang et al.   ONCOLOGY

Cytoplasmic Expression of HuR is Related to Cyclooxygenase-2 Expression in Colon Cancer

(2009) Sung-Jig Lim et al.   Cancer Research and Treatment

Diverse molecular functions of Hu proteins

(2008) M. N. Hinman et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Signalling pathways regulating nucleo-cytoplasmic shuttling of the mRNA-binding protein HuR

(2008) Anke Doller et al.   CELLULAR SIGNALLING

RNA-binding proteins and post-transcriptional gene regulation

(2008) Tina Glisovic et al.   FEBS LETTERS

NF-κB Activates Transcription of the RNA-Binding Factor HuR, via PI3K-AKT Signaling, to Promote Gastric Tumorigenesis

(2008) Min–Ju Kang et al.   GASTROENTEROLOGY

Nuclear HuR accumulation through phosphorylation by Cdk1

(2008) H. H. Kim et al.   GENES & DEVELOPMENT

Glioblastoma microvesicles transport RNA and proteins that promote tumour growth and provide diagnostic biomarkers

(2008) Johan Skog et al.   NATURE CELL BIOLOGY

miR-519 reduces cell proliferation by lowering RNA-binding protein HuR levels

(2008) K. Abdelmohsen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA