The mRNA-binding protein HuR promotes hypoxia-induced chemoresistance through posttranscriptional regulation of the proto-oncogene PIM1 in pancreatic cancer cells

Identification and Validation of Novel Small Molecule Disruptors of HuR-mRNA Interaction

(2015) Xiaoqing Wu et al.   ACS Chemical Biology

HuR Suppresses Fas Expression and Correlates with Patient Outcome in Liver Cancer

(2015) H. Zhu et al.   MOLECULAR CANCER RESEARCH

Pim-1 Kinase Expression Predicts Radiation Response in Squamocellular Carcinoma of Head and Neck and Is under the Control of Epidermal Growth Factor Receptor

(2015) Katriina Peltola et al.   NEOPLASIA

Projecting Cancer Incidence and Deaths to 2030: The Unexpected Burden of Thyroid, Liver, and Pancreas Cancers in the United States

(2014) L. Rahib et al.   CANCER RESEARCH

HuR Posttranscriptionally Regulates WEE1: Implications for the DNA Damage Response in Pancreatic Cancer Cells

(2014) S. Lal et al.   CANCER RESEARCH

RNA-binding protein HuR promotes growth of small intestinal mucosa by activating the Wnt signaling pathway

(2014) Lan Liu et al.   MOLECULAR BIOLOGY OF THE CELL

MUC1 Promoter–Driven DTA as a Targeted Therapeutic Strategy against Pancreatic Cancer

(2014) Renee M. Tholey et al.   MOLECULAR CANCER RESEARCH

Notch1 is required for hypoxia-induced proliferation, invasion and chemoresistance of T-cell acute lymphoblastic leukemia cells

(2013) Jie Zou et al.   Journal of Hematology & Oncology

Transforming Growth Factor   Regulates P-Body Formation through Induction of the mRNA Decay Factor Tristetraprolin

(2013) F. F. Blanco et al.   MOLECULAR AND CELLULAR BIOLOGY

Systems Analysis of the NCI-60 Cancer Cell Lines by Alignment of Protein Pathway Activation Modules with “-OMIC” Data Fields and Therapeutic Response Signatures

(2013) Giulia Federici et al.   MOLECULAR CANCER RESEARCH

Increased Survival in Pancreatic Cancer with nab-Paclitaxel plus Gemcitabine

(2013) Daniel D. Von Hoff et al.   NEW ENGLAND JOURNAL OF MEDICINE

High Expression of HuR in Cytoplasm, but Not Nuclei, Is Associated with Malignant Aggressiveness and Prognosis in Bladder Cancer

(2013) Yasuyoshi Miyata et al.   PLoS One

HuR is a post-transcriptional regulator of core metabolic enzymes in pancreatic cancer

(2013) Richard A Burkhart et al.   RNA Biology

TMEM45A is essential for hypoxia-induced chemoresistance in breast and liver cancer cells

(2012) Lionel Flamant et al.   BMC CANCER

HuR’s post-transcriptional regulation of death receptor 5 in pancreatic cancer cells

(2012) Danielle M. Pineda et al.   CANCER BIOLOGY & THERAPY

Tumor cycling hypoxia induces chemoresistance in glioblastoma multiforme by upregulating the expression and function of ABCB1

(2012) Chii-Wen Chou et al.   NEURO-ONCOLOGY

HuR keeps an angiogenic switch on by stabilising mRNA of VEGF and COX-2 in tumour endothelium

(2011) T Kurosu et al.   BRITISH JOURNAL OF CANCER

Hypoxia Predicts Aggressive Growth and Spontaneous Metastasis Formation from Orthotopically Grown Primary Xenografts of Human Pancreatic Cancer

(2011) Q. Chang et al.   CANCER RESEARCH

The oncogenic kinase Pim-1 is modulated by K-Ras signaling and mediates transformed growth and radioresistance in human pancreatic ductal adenocarcinoma cells

(2011) D. Xu et al.   CARCINOGENESIS

The RNA-binding Protein HuR Stabilizes Cytosolic Phospholipase A2α mRNA under Interleukin-1β Treatment in Non-small Cell Lung Cancer A549 Cells

(2011) Wan-Lin Liao et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Myeloid cell expression of the RNA-binding protein HuR protects mice from pathologic inflammation and colorectal carcinogenesis

(2011) Anthie Yiakouvaki et al.   JOURNAL OF CLINICAL INVESTIGATION

Protein Pathway Activation Mapping of Brain Metastasis from Lung and Breast Cancers Reveals Organ Type Specific Drug Target Activation

(2011) Giuseppina Improta et al.   JOURNAL OF PROTEOME RESEARCH

The mRNA Stability Factor HuR Inhibits MicroRNA-16 Targeting of COX-2

(2011) L. E. Young et al.   MOLECULAR CANCER RESEARCH

Integrative Regulatory Mapping Indicates that the RNA-Binding Protein HuR Couples Pre-mRNA Processing and mRNA Stability

(2011) Neelanjan Mukherjee et al.   MOLECULAR CELL

A quantitative analysis of CLIP methods for identifying binding sites of RNA-binding proteins

(2011) Shivendra Kishore et al.   NATURE METHODS

FOLFIRINOX versus Gemcitabine for Metastatic Pancreatic Cancer

(2011) Thierry Conroy et al.   NEW ENGLAND JOURNAL OF MEDICINE

The RNA binding protein HuR differentially regulates unique subsets of mRNAs in estrogen receptor negative and estrogen receptor positive breast cancer

(2010) Robert Calaluce et al.   BMC CANCER

Hypoxia-inducible proto-oncogene Pim-1 is a prognostic marker in pancreatic ductal adenocarcinoma

(2010) Carolin Reiser-Erkan et al.   CANCER BIOLOGY & THERAPY

Models of carcinogenesis: an overview

(2010) P. Vineis et al.   CARCINOGENESIS

Why target PIM1 for cancer diagnosis and treatment?

(2010) Nancy S Magnuson et al.   Future Oncology

Post-transcriptional regulation of the DUSP6/MKP-3 phosphatase by MEK/ERK signaling and hypoxia

(2010) Olga Bermudez et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Pim-1 is up-regulated by shear stress and is involved in shear stress-induced proliferation of rat mesenchymal stem cells

(2010) Ming-Li Tu et al.   LIFE SCIENCES

Pim1 kinase synergizes with c-MYC to induce advanced prostate carcinoma

(2010) J Wang et al.   ONCOGENE

HuR's role in gemcitabine efficacy: an exception or opportunity?

(2010) Jonathan R. Brody et al.   Wiley Interdisciplinary Reviews-RNA

Posttranscriptional regulation of cancer traits by HuR

(2010) Kotb Abdelmohsen et al.   Wiley Interdisciplinary Reviews-RNA

Activation of the Wnt Pathway Plays a Pathogenic Role in Diabetic Retinopathy in Humans and Animal Models

(2009) Ying Chen et al.   AMERICAN JOURNAL OF PATHOLOGY

Post-transcriptional regulation of MEK-1 by polyamines through the RNA-binding protein HuR modulating intestinal epithelial apoptosis

(2009) Peng-Yuan Wang et al.   BIOCHEMICAL JOURNAL

Pim kinase inhibitor, SGI-1776, induces apoptosis in chronic lymphocytic leukemia cells

(2009) L. S. Chen et al.   BLOOD

Protein synthesis is resistant to rapamycin and constitutes a promising therapeutic target in acute myeloid leukemia

(2009) J. Tamburini et al.   BLOOD

The Role of HuR in Gemcitabine Efficacy in Pancreatic Cancer: HuR Up-regulates the Expression of the Gemcitabine Metabolizing Enzyme Deoxycytidine Kinase

(2009) C. L. Costantino et al.   CANCER RESEARCH

The mRNA Binding Proteins HuR and Tristetraprolin Regulate Cyclooxygenase 2 Expression During Colon Carcinogenesis

(2009) Lisa E. Young et al.   GASTROENTEROLOGY

Hypoxia induces chemoresistance in ovarian cancer cells by activation of signal transducer and activator of transcription 3

(2009) Karuppaiyah Selvendiran et al.   INTERNATIONAL JOURNAL OF CANCER

Essential role of the RNA-binding protein HuR in progenitor cell survival in mice

(2009) Mallika Ghosh et al.   JOURNAL OF CLINICAL INVESTIGATION

Pim-1 plays a pivotal role in hypoxia-induced chemoresistance

(2009) J Chen et al.   ONCOGENE

Severe hypoxia induces chemo-resistance in clinical cervical tumors through MVP over-expression

(2009) Pedro C Lara et al.   Radiation Oncology

Primary mediastinal large B-cell lymphoma

(2008) Maurizio Martelli et al.   CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY

Ki67 and PIM1 expression predict outcome in mantle cell lymphoma treated with high dose therapy, stem cell transplantation and rituximab: a Cancer and Leukemia Group B 59909 correlative science study

(2008) Eric D. Hsi et al.   LEUKEMIA & LYMPHOMA

Hypoxia-induced resistance to anticancer drugs is associated with decreased senescence and requires hypoxia-inducible factor-1 activity

(2008) R. Sullivan et al.   MOLECULAR CANCER THERAPEUTICS

Core Signaling Pathways in Human Pancreatic Cancers Revealed by Global Genomic Analyses

(2008) S. Jones et al.   SCIENCE