标题
The RNA-binding protein HuR in human cancer: A friend or foe?
作者
关键词
RNA-binding protein, HuR, Cancer, Small molecules, Drug discovery, Drug development, Companion assay, Molecular therapy, Drug resistance
出版物
ADVANCED DRUG DELIVERY REVIEWS
Volume 184, Issue -, Pages 114179
出版商
Elsevier BV
发表日期
2022-03-04
DOI
10.1016/j.addr.2022.114179
参考文献
相关参考文献
注意：仅列出部分参考文献，下载原文获取全部文献信息。- Hallmarks of Cancer: New Dimensions
- (2022) Douglas Hanahan Cancer Discovery
- Targeting the HuR oncogenic role with a new class of cytoplasmic dimerization inhibitors
- (2021) Natalia Filippova et al. CANCER RESEARCH
- HuR up-regulates cell surface PD-L1 via stabilizing CMTM6 transcript in cancer
- (2021) Yanbin Liu et al. ONCOGENE
- Adipocyte-specific deletion of HuR induces spontaneous cardiac hypertrophy and fibrosis
- (2021) Adrienne R. Guarnieri et al. AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
- The RNA-binding protein HuR is a novel target of Pirh2 E3 ubiquitin ligase
- (2021) Alexandra Daks et al. Cell Death & Disease
- Identification of N,N-arylalkyl-picolinamide derivatives targeting the RNA-binding protein HuR, by combining biophysical fragment-screening and molecular hybridization
- (2021) S. Della Volpe et al. BIOORGANIC CHEMISTRY
- Novel indole derivatives targeting HuR-mRNA complex to counteract high glucose damage in retinal endothelial cells
- (2020) Chiara Bianca Maria Platania et al. BIOCHEMICAL PHARMACOLOGY
- Inhibition of RNA-binding protein HuR reduces glomerulosclerosis in experimental nephritis
- (2020) Simeng Liu et al. CLINICAL SCIENCE
- Poly(ADP-ribosyl)ation enhances HuR oligomerization and contributes to pro-inflammatory gene mRNA stabilization
- (2020) Yueshuang Ke et al. CELLULAR AND MOLECULAR LIFE SCIENCES
- Molecular and functional extracellular vesicle analysis using nanopatterned microchips monitors tumor progression and metastasis
- (2020) Peng Zhang et al. Science Translational Medicine
- Targeting the interaction between RNA-binding protein HuR and FOXQ1 suppresses breast cancer invasion and metastasis
- (2020) Xiaoqing Wu et al. Communications Biology
- An RNA-Binding Protein, Hu-antigen R, in Pancreatic Cancer Epithelial to Mesenchymal Transition, Metastasis, and Cancer Stem Cells
- (2020) Ruochen Dong et al. MOLECULAR CANCER THERAPEUTICS
- Molecular basis for AU-rich element recognition and dimerization by the HuR C-terminal RRM
- (2019) Nina Ripin et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Adipose HuR protects against diet-induced obesity and insulin resistance
- (2019) Jingyuan Li et al. Nature Communications
- The HuR CMLD-2 inhibitor exhibits antitumor effects via MAD2 downregulation in thyroid cancer cells
- (2019) Lorenzo Allegri et al. Scientific Reports
- HuR regulates phospholamban expression in isoproterenol-induced cardiac remodelling
- (2019) Han Hu et al. CARDIOVASCULAR RESEARCH
- Depletion of HuR in murine skeletal muscle enhances exercise endurance and prevents cancer-induced muscle atrophy
- (2019) Brenda Janice Sánchez et al. Nature Communications
- HuR Reduces Radiation-Induced DNA Damage by Enhancing Expression of ARID1A
- (2019) Daniel Andrade et al. Cancers
- Are liquid biopsies a surrogate for tissue EGFR testing?
- (2018) J W Goldman et al. ANNALS OF ONCOLOGY
- Cytoplasmic HuR Status Predicts Disease-free Survival in Resected Pancreatic Cancer
- (2018) Talar Tatarian et al. ANNALS OF SURGERY
- Interfering with HuR–RNA Interaction: Design, Synthesis and Biological Characterization of Tanshinone Mimics as Novel, Effective HuR Inhibitors
- (2018) Leonardo Manzoni et al. JOURNAL OF MEDICINAL CHEMISTRY
- The Jun/miR-22/HuR regulatory axis contributes to tumourigenesis in colorectal cancer
- (2018) Yanqing Liu et al. Molecular Cancer
- Chemo-biologic combinatorial drug delivery using folate receptor-targeted dendrimer nanoparticles for lung cancer treatment
- (2018) Narsireddy Amreddy et al. Nanomedicine-Nanotechnology Biology and Medicine
- Shedding light on the cell biology of extracellular vesicles
- (2018) Guillaume van Niel et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- Complex HuR function in pancreatic cancer cells
- (2018) Jonathan R. Brody et al. Wiley Interdisciplinary Reviews-RNA
- Exosomal PD-L1 contributes to immunosuppression and is associated with anti-PD-1 response
- (2018) Gang Chen et al. NATURE
- HuR biological function involves RRM3-mediated dimerization and RNA binding by all three RRMs
- (2018) Marta Pabis et al. NUCLEIC ACIDS RESEARCH
- CRISPR Knockout of the HuR Gene Causes a Xenograft Lethal Phenotype
- (2017) Shruti Lal et al. MOLECULAR CANCER RESEARCH
- Tumor-targeted Nanoparticle Delivery of HuR siRNA Inhibits Lung Tumor Growth In Vitro and In Vivo By Disrupting the Oncogenic Activity of the RNA-binding Protein HuR
- (2017) Ranganayaki Muralidharan et al. MOLECULAR CANCER THERAPEUTICS
- Integrating liquid biopsies into the management of cancer
- (2017) Giulia Siravegna et al. Nature Reviews Clinical Oncology
- Regulation of HuR structure and function by dihydrotanshinone-I
- (2017) Preet Lal et al. NUCLEIC ACIDS RESEARCH
- PARP1 promotes gene expression at the post-transcriptiona level by modulating the RNA-binding protein HuR
- (2017) Yueshuang Ke et al. Nature Communications
- The fungal natural product azaphilone-9 binds to HuR and inhibits HuR-RNA interaction in vitro
- (2017) Kawaljit Kaur et al. PLoS One
- HuR-targeted small molecule inhibitor exhibits cytotoxicity towards human lung cancer cells
- (2017) Ranganayaki Muralidharan et al. Scientific Reports
- Delivery of Therapeutics Targeting the mRNA-Binding Protein HuR Using 3DNA Nanocarriers Suppresses Ovarian Tumor Growth
- (2016) Yu-Hung Huang et al. CANCER RESEARCH
- Human antigen R is positively associated with malignant aggressiveness via upregulation of cell proliferation, migration, and vascular endothelial growth factors and cyclooxygenase-2 in prostate cancer
- (2016) Kensuke Mitsunari et al. Translational Research
- Impact of HuR inhibition by the small molecule MS-444 on colorectal cancer cell tumorigenesis
- (2016) Fernando F. Blanco et al. Oncotarget
- Posttranslational control of HuR function
- (2016) Ioannis Grammatikakis et al. Wiley Interdisciplinary Reviews-RNA
- Identification and Validation of Novel Small Molecule Disruptors of HuR-mRNA Interaction
- (2015) Xiaoqing Wu et al. ACS Chemical Biology
- Prognostic effect of hENT1, dCK and HuR expression by morphological type in periampullary adenocarcinoma, including pancreatic cancer
- (2015) Jacob Elebro et al. ACTA ONCOLOGICA
- The cytoskeletal inhibitors latrunculin A and blebbistatin exert antitumorigenic properties in human hepatocellular carcinoma cells by interfering with intracellular HuR trafficking
- (2015) Anke Doller et al. EXPERIMENTAL CELL RESEARCH
- Methyl(R217)HuR and MCM6 are inversely correlated and are prognostic markers in non small cell lung carcinoma
- (2015) Charlène Vigouroux et al. LUNG CANCER
- Negative regulation of RNA-binding protein HuR by tumor-suppressor ECRG2
- (2015) C Lucchesi et al. ONCOGENE
- The mRNA-binding protein HuR promotes hypoxia-induced chemoresistance through posttranscriptional regulation of the proto-oncogene PIM1 in pancreatic cancer cells
- (2015) F F Blanco et al. ONCOGENE
- Cytoplasmic accumulation of ELAVL1 is an independent predictor of biochemical recurrence associated with genomic instability in prostate cancer
- (2015) Nathaniel Melling et al. PROSTATE
- Dihydrotanshinone-I interferes with the RNA-binding activity of HuR affecting its post-transcriptional function
- (2015) Vito Giuseppe D’Agostino et al. Scientific Reports
- The C-terminal RNA binding motif of HuR is a multi-functional domain leading to HuR oligomerization and binding to U-rich RNA targets
- (2015) Rafael M Scheiba et al. RNA Biology
- dCK expression correlates with 5-fluorouracil efficacy and HuR cytoplasmic expression in pancreatic cancer
- (2014) Florencia McAllister et al. CANCER BIOLOGY & THERAPY
- MiRNA in melanoma-derived exosomes
- (2014) Anna Gajos-Michniewicz et al. CANCER LETTERS
- HuR Posttranscriptionally Regulates WEE1: Implications for the DNA Damage Response in Pancreatic Cancer Cells
- (2014) S. Lal et al. CANCER RESEARCH
- Predictive and prognostic significance of cytoplasmic expression of ELAV-like protein HuR in invasive breast cancer treated with neoadjuvant chemotherapy
- (2013) Jun Wang et al. BREAST CANCER RESEARCH AND TREATMENT
- Real-time Liquid Biopsy in Cancer Patients: Fact or Fiction?
- (2013) K. Pantel et al. CANCER RESEARCH
- Intercellular Communication by Exosome-Derived microRNAs in Cancer
- (2013) Bethany Hannafon et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- MPT0B098, a Novel Microtubule Inhibitor That Destabilizes the Hypoxia-Inducible Factor-1 mRNA through Decreasing Nuclear-Cytoplasmic Translocation of RNA-Binding Protein HuR
- (2013) Y.-C. Cheng et al. MOLECULAR CANCER THERAPEUTICS
- Liquid biopsy: monitoring cancer-genetics in the blood
- (2013) Emily Crowley et al. Nature Reviews Clinical Oncology
- Apoptotic-induced cleavage shifts HuR from being a promoter of survival to an activator of caspase-mediated apoptosis
- (2012) C von Roretz et al. CELL DEATH AND DIFFERENTIATION
- The RNA-binding Protein RNPC1 Stabilizes the mRNA Encoding the RNA-binding Protein HuR and Cooperates with HuR to Suppress Cell Proliferation
- (2012) Seong-Jun Cho et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Phosphoregulation of the RNA-binding Protein Hu Antigen R (HuR) by Cdk5 Affects Centrosome Function
- (2012) Natalia Filippova et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Downregulation of HuR as a new mechanism of doxorubicin resistance in breast cancer cells
- (2012) Elisa Latorre et al. Molecular Cancer
- HuR function in disease
- (2011) Subramanya Srikantan Frontiers in Bioscience-Landmark
- Murine double minute 2 regulates Hu antigen R stability in human liver and colon cancer through NEDDylation
- (2011) Nieves Embade et al. HEPATOLOGY
- mRNA stability alterations mediated by HuR are necessary to sustain the fast growth of glioma cells
- (2011) Federico Bolognani et al. JOURNAL OF NEURO-ONCOLOGY
- Role of RNA binding protein HuR in ductal carcinoma in situ of the breast
- (2011) Mira Heinonen et al. JOURNAL OF PATHOLOGY
- The RNA-binding protein ELAVL1/HuR is essential for mouse spermatogenesis, acting both at meiotic and postmeiotic stages
- (2011) Mai Nguyen Chi et al. MOLECULAR BIOLOGY OF THE CELL
- The RNA-Binding Protein HuR Promotes Glioma Growth and Treatment Resistance
- (2011) N. Filippova et al. MOLECULAR CANCER RESEARCH
- UneCLIPsing HuR Nuclear Function
- (2011) Subramanya Srikantan et al. MOLECULAR CELL
- RNA-binding protein HuR autoregulates its expression by promoting alternative polyadenylation site usage
- (2011) Weijun Dai et al. NUCLEIC ACIDS RESEARCH
- Cytoplasmic accumulation of the RNA binding protein HuR is central to tamoxifen resistance in estrogen receptor positive breast cancer cells
- (2010) Christine Hostetter et al. CANCER BIOLOGY & THERAPY
- Role of the RNA-binding protein HuR in human renal cell carcinoma
- (2010) Sabrina Danilin et al. CARCINOGENESIS
- Loss of Repression of HuR Translation by miR-16 May Be Responsible for the Elevation of HuR in Human Breast Carcinoma
- (2010) Fang Xu et al. JOURNAL OF CELLULAR BIOCHEMISTRY
- Cytoplasmic HuR expression correlates with angiogenesis, lymphangiogenesis, and poor outcome in lung cancer
- (2010) Jun Wang et al. MEDICAL ONCOLOGY
- Tandem Phosphorylation of Serines 221 and 318 by Protein Kinase C Coordinates mRNA Binding and Nucleocytoplasmic Shuttling of HuR
- (2010) A. Doller et al. MOLECULAR AND CELLULAR BIOLOGY
- MicroRNA-125a represses cell growth by targeting HuR in breast cancer
- (2010) Xun Guo et al. RNA Biology
- HuR expression in the nucleus correlates with high histological grade and poor disease-free survival in ovarian cancer
- (2009) Xiaofang YI et al. AUSTRALIAN & NEW ZEALAND JOURNAL OF OBSTETRICS & GYNAECOLOGY
- The Role of HuR in Gemcitabine Efficacy in Pancreatic Cancer: HuR Up-regulates the Expression of the Gemcitabine Metabolizing Enzyme Deoxycytidine Kinase
- (2009) C. L. Costantino et al. CANCER RESEARCH
- Chemical inhibitors destabilize HuR binding to the AU-rich element of TNF-α mRNA
- (2009) Min-Ju Chae et al. EXPERIMENTAL AND MOLECULAR MEDICINE
- Transcriptional Control of Human Antigen R by Bone Morphogenetic Protein
- (2009) Selvi C. Jeyaraj et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Essential role of the RNA-binding protein HuR in progenitor cell survival in mice
- (2009) Mallika Ghosh et al. JOURNAL OF CLINICAL INVESTIGATION
- The RNA-Binding Protein Elavl1/HuR Is Essential for Placental Branching Morphogenesis and Embryonic Development
- (2009) V. Katsanou et al. MOLECULAR AND CELLULAR BIOLOGY
- Alternative polyadenylation variants of the RNA binding protein, HuR: abundance, role of AU-rich elements and auto-Regulation
- (2009) Wijdan Al-Ahmadi et al. NUCLEIC ACIDS RESEARCH
- The Expression of RNA-Binding Protein HuR in Non-Small Cell Lung Cancer Correlates with Vascular Endothelial Growth Factor-C Expression and Lymph Node Metastasis
- (2009) Jun Wang et al. ONCOLOGY
- Cytoplasmic Expression of HuR is Related to Cyclooxygenase-2 Expression in Colon Cancer
- (2009) Sung-Jig Lim et al. Cancer Research and Treatment
- Diverse molecular functions of Hu proteins
- (2008) M. N. Hinman et al. CELLULAR AND MOLECULAR LIFE SCIENCES
- Signalling pathways regulating nucleo-cytoplasmic shuttling of the mRNA-binding protein HuR
- (2008) Anke Doller et al. CELLULAR SIGNALLING
- RNA-binding proteins and post-transcriptional gene regulation
- (2008) Tina Glisovic et al. FEBS LETTERS
- NF-κB Activates Transcription of the RNA-Binding Factor HuR, via PI3K-AKT Signaling, to Promote Gastric Tumorigenesis
- (2008) Min–Ju Kang et al. GASTROENTEROLOGY
- Nuclear HuR accumulation through phosphorylation by Cdk1
- (2008) H. H. Kim et al. GENES & DEVELOPMENT
- Glioblastoma microvesicles transport RNA and proteins that promote tumour growth and provide diagnostic biomarkers
- (2008) Johan Skog et al. NATURE CELL BIOLOGY
- miR-519 reduces cell proliferation by lowering RNA-binding protein HuR levels
- (2008) K. Abdelmohsen et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
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