HuR up-regulates cell surface PD-L1 via stabilizing CMTM6 transcript in cancer

Anti-cancer effects of the HuR inhibitor, MS-444, in malignant glioma cells

(2019) Jiping Wang et al.   CANCER BIOLOGY & THERAPY

Suppression of Exosomal PD-L1 Induces Systemic Anti-tumor Immunity and Memory

(2019) Mauro Poggio et al.   CELL

UDP-glucose accelerates SNAI1 mRNA decay and impairs lung cancer metastasis

(2019) Xiongjun Wang et al.   NATURE

The HuR CMLD-2 inhibitor exhibits antitumor effects via MAD2 downregulation in thyroid cancer cells

(2019) Lorenzo Allegri et al.   Scientific Reports

Regulation and Function of the PD-L1 Checkpoint

(2018) Chong Sun et al.   IMMUNITY

Exosomal PD-L1 contributes to immunosuppression and is associated with anti-PD-1 response

(2018) Gang Chen et al.   NATURE

CMTM6 overexpression is associated with molecular and clinical characteristics of malignancy and predicts poor prognosis in gliomas

(2018) Xiudong Guan et al.   EBioMedicine

Stearoyl-CoA Desaturase Promotes Liver Fibrosis and Tumor Development in Mice via a Wnt Positive-Signaling Loop by Stabilization of Low-Density Lipoprotein-Receptor-Related Proteins 5 and 6

(2017) Keane K.Y. Lai et al.   GASTROENTEROLOGY

Oncogenic RAS Signaling Promotes Tumor Immunoresistance by Stabilizing PD-L1 mRNA

(2017) Matthew A. Coelho et al.   IMMUNITY

CRISPR Knockout of the HuR Gene Causes a Xenograft Lethal Phenotype

(2017) Shruti Lal et al.   MOLECULAR CANCER RESEARCH

Identification of CMTM6 and CMTM4 as PD-L1 protein regulators

(2017) Riccardo Mezzadra et al.   NATURE

CMTM6 maintains the expression of PD-L1 and regulates anti-tumour immunity

(2017) Marian L. Burr et al.   NATURE

GEPIA: a web server for cancer and normal gene expression profiling and interactive analyses

(2017) Zefang Tang et al.   NUCLEIC ACIDS RESEARCH

HuR-targeted small molecule inhibitor exhibits cytotoxicity towards human lung cancer cells

(2017) Ranganayaki Muralidharan et al.   Scientific Reports

Aberrant PD-L1 expression through 3′-UTR disruption in multiple cancers

(2016) Keisuke Kataoka et al.   NATURE

MYC regulates the antitumor immune response through CD47 and PD-L1

(2016) S. C. Casey et al.   SCIENCE

Impact of HuR inhibition by the small molecule MS-444 on colorectal cancer cell tumorigenesis

(2016) Fernando F. Blanco et al.   Oncotarget

Identification and Validation of Novel Small Molecule Disruptors of HuR-mRNA Interaction

(2015) Xiaoqing Wu et al.   ACS Chemical Biology

The future of immune checkpoint therapy

(2015) P. Sharma et al.   SCIENCE

Identification of Small-Molecule Inhibitors of the HuR/RNA Interaction Using a Fluorescence Polarization Screening Assay Followed by NMR Validation

(2015) Zhonghua Wang et al.   PLoS One

Genomic rearrangements involving programmed death ligands are recurrent in primary mediastinal large B-cell lymphoma

(2014) David D. W. Twa et al.   BLOOD

PD-L1 is a novel direct target of HIF-1α, and its blockade under hypoxia enhanced MDSC-mediated T cell activation

(2014) Muhammad Zaeem Noman et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Metastasis is regulated via microRNA-200/ZEB1 axis control of tumour cell PD-L1 expression and intratumoral immunosuppression

(2014) Limo Chen et al.   Nature Communications

The RNA-Binding Protein HuR Promotes Glioma Growth and Treatment Resistance

(2011) N. Filippova et al.   MOLECULAR CANCER RESEARCH

Integrative analysis reveals selective 9p24.1 amplification, increased PD-1 ligand expression, and further induction via JAK2 in nodular sclerosing Hodgkin lymphoma and primary mediastinal large B-cell lymphoma

(2010) M. R. Green et al.   BLOOD

The mRNA-Destabilizing Protein Tristetraprolin Is Suppressed in Many Cancers, Altering Tumorigenic Phenotypes and Patient Prognosis

(2009) S. E. Brennan et al.   CANCER RESEARCH

The mRNA Binding Proteins HuR and Tristetraprolin Regulate Cyclooxygenase 2 Expression During Colon Carcinogenesis

(2009) Lisa E. Young et al.   GASTROENTEROLOGY

NF-κB Activates Transcription of the RNA-Binding Factor HuR, via PI3K-AKT Signaling, to Promote Gastric Tumorigenesis

(2008) Min–Ju Kang et al.   GASTROENTEROLOGY