Intercellular Communication by Exosome-Derived microRNAs in Cancer

Exosomal Tumor MicroRNA Modulates Premetastatic Organ Cells

(2015) Sanyukta Rana et al.   NEOPLASIA

Characterization of human plasma-derived exosomal RNAs by deep sequencing

(2013) Xiaoyi Huang et al.   BMC GENOMICS

Serum microRNA expression profile: miR-1246 as a novel diagnostic and prognostic biomarker for oesophageal squamous cell carcinoma

(2013) N Takeshita et al.   BRITISH JOURNAL OF CANCER

Exosomes from triple-negative breast cancer cells can transfer phenotypic traits representing their cells of origin to secondary cells

(2013) Keith O’Brien et al.   EUROPEAN JOURNAL OF CANCER

Reciprocal interactions between endothelial cells and macrophages in angiogenic vascular niches

(2013) Caroline Baer et al.   EXPERIMENTAL CELL RESEARCH

Heparanase Regulates Secretion, Composition, and Function of Tumor Cell-derived Exosomes

(2013) Camilla A. Thompson et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Exosomes in the pathogenesis, diagnostics and therapeutics of liver diseases

(2013) Anatoliy I. Masyuk et al.   JOURNAL OF HEPATOLOGY

Exosomes reflect the hypoxic status of glioma cells and mediate hypoxia-dependent activation of vascular cells during tumor development

(2013) P. Kucharzewska et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Proteome profiling of exosomes derived from human primary and metastatic colorectal cancer cells reveal differential expression of key metastatic factors and signal transduction components

(2013) Hong Ji et al.   PROTEOMICS

Contribution of proteomics to understanding the role of tumor-derived exosomes in cancer progression: State of the art and new perspectives

(2013) Fontana Simona et al.   PROTEOMICS

Imaging exosome transfer from breast cancer cells to stroma at metastatic sites in orthotopic nude-mouse models

(2012) Atsushi Suetsugu et al.   ADVANCED DRUG DELIVERY REVIEWS

Profiling of microRNAs in exosomes released from PC-3 prostate cancer cells

(2012) Nina Pettersen Hessvik et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

Hypoxic enhancement of exosome release by breast cancer cells

(2012) Hamish W King et al.   BMC CANCER

Changes in circulating microRNA levels associated with prostate cancer

(2012) R J Bryant et al.   BRITISH JOURNAL OF CANCER

Accessories to the Crime: Functions of Cells Recruited to the Tumor Microenvironment

(2012) Douglas Hanahan et al.   CANCER CELL

Rab27a Supports Exosome-Dependent and -Independent Mechanisms That Modify the Tumor Microenvironment and Can Promote Tumor Progression

(2012) A. Bobrie et al.   CANCER RESEARCH

Exosomes Mediate Stromal Mobilization of Autocrine Wnt-PCP Signaling in Breast Cancer Cell Migration

(2012) Valbona Luga et al.   CELL

How apoptotic cells aid in the removal of their own cold dead bodies

(2012) G Wickman et al.   CELL DEATH AND DIFFERENTIATION

The ESCRT machinery

(2012) Oliver Schmidt et al.   CURRENT BIOLOGY

Defining a new role of GW182 in maintaining miRNA stability

(2012) Bing Yao et al.   EMBO REPORTS

Monitoring the Rab27 associated exosome pathway using nanoparticle tracking analysis

(2012) Ying Zheng et al.   EXPERIMENTAL CELL RESEARCH

Immune-related MicroRNAs are Abundant in Breast Milk Exosomes

(2012) Qi Zhou et al.   International Journal of Biological Sciences

Exosome removal as a therapeutic adjuvant in cancer

(2012) Annette M Marleau et al.   Journal of Translational Medicine

Comparison of ultracentrifugation, density gradient separation, and immunoaffinity capture methods for isolating human colon cancer cell line LIM1863-derived exosomes

(2012) Bow J. Tauro et al.   METHODS

Microparticle conferred microRNA profiles - implications in the transfer and dominance of cancer traits

(2012) Ritu Jaiswal et al.   Molecular Cancer

Importance of RNA isolation methods for analysis of exosomal RNA: Evaluation of different methods

(2012) Maria Eldh et al.   MOLECULAR IMMUNOLOGY

Systemically Injected Exosomes Targeted to EGFR Deliver Antitumor MicroRNA to Breast Cancer Cells

(2012) Shin-ichiro Ohno et al.   MOLECULAR THERAPY

Melanoma exosomes educate bone marrow progenitor cells toward a pro-metastatic phenotype through MET

(2012) Héctor Peinado et al.   NATURE MEDICINE

MicroRNAs are exported from malignant cells in customized particles

(2012) Jaime Palma et al.   NUCLEIC ACIDS RESEARCH

Small RNA deep sequencing reveals a distinct miRNA signature released in exosomes from prion-infected neuronal cells

(2012) Shayne A. Bellingham et al.   NUCLEIC ACIDS RESEARCH

Leukemia cell to endothelial cell communication via exosomal miRNAs

(2012) T Umezu et al.   ONCOGENE

Breastfeeding and the Use of Human Milk

(2012)   PEDIATRICS

The Majority of MicroRNAs Detectable in Serum and Saliva Is Concentrated in Exosomes

(2012) Alessia Gallo et al.   PLoS One

N-3 Poly-Unsaturated Fatty Acids Shift Estrogen Signaling to Inhibit Human Breast Cancer Cell Growth

(2012) WenQing Cao et al.   PLoS One

miRandola: Extracellular Circulating MicroRNAs Database

(2012) Francesco Russo et al.   PLoS One

Identifying mRNA, MicroRNA and Protein Profiles of Melanoma Exosomes

(2012) Deyi Xiao et al.   PLoS One

MicroRNAs bind to Toll-like receptors to induce prometastatic inflammatory response

(2012) M. Fabbri et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Exosomes released by K562 chronic myeloid leukemia cells promote angiogenesis in a src-dependent fashion

(2011) Marco Mineo et al.   ANGIOGENESIS

Multivesicular Body Morphogenesis

(2011) Phyllis I. Hanson et al.   Annual Review of Cell and Developmental Biology

Mechanism of transfer of functional microRNAs between mouse dendritic cells via exosomes

(2011) A. Montecalvo et al.   BLOOD

Exosomes derived from human bone marrow mesenchymal stem cells promote tumor growth in vivo

(2011) Wei Zhu et al.   CANCER LETTERS

Microvesicles Released from Human Renal Cancer Stem Cells Stimulate Angiogenesis and Formation of Lung Premetastatic Niche

(2011) C. Grange et al.   CANCER RESEARCH

MicroRNA regulation of innate immune responses in epithelial cells

(2011) Rui Zhou et al.   Cellular & Molecular Immunology

Amphiregulin Exosomes Increase Cancer Cell Invasion

(2011) James N. Higginbotham et al.   CURRENT BIOLOGY

The Tetraspanin CD63 Regulates ESCRT-Independent and -Dependent Endosomal Sorting during Melanogenesis

(2011) Guillaume van Niel et al.   DEVELOPMENTAL CELL

Exosomes from ovarian cancer cells induce adipose tissue-derived mesenchymal stem cells to acquire the physical and functional characteristics of tumor-supporting myofibroblasts

(2011) Jung Ah Cho et al.   GYNECOLOGIC ONCOLOGY

Intercellular nanovesicle-mediated microRNA transfer: A mechanism of environmental modulation of hepatocellular cancer cell growth

(2011) Takayuki Kogure et al.   HEPATOLOGY

Exosome-associated Tau Is Secreted in Tauopathy Models and Is Selectively Phosphorylated in Cerebrospinal Fluid in Early Alzheimer Disease

(2011) Sudad Saman et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Potential role of HER2-overexpressing exosomes in countering trastuzumab-based therapy

(2011) Valentina Ciravolo et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Chemokine-Containing Exosomes Are Released from Heat-Stressed Tumor Cells via Lipid Raft-Dependent Pathway and Act as Efficient Tumor Vaccine

(2011) T. Chen et al.   JOURNAL OF IMMUNOLOGY

Microvesicles secreted by macrophages shuttle invasion-potentiating microRNAs into breast cancer cells

(2011) Mei Yang et al.   Molecular Cancer

ExoCarta 2012: database of exosomal proteins, RNA and lipids

(2011) S. Mathivanan et al.   NUCLEIC ACIDS RESEARCH

Role of Rab GTPases in Membrane Traffic and Cell Physiology

(2011) Alex H. Hutagalung et al.   PHYSIOLOGICAL REVIEWS

Detachment of Breast Tumor Cells Induces Rapid Secretion of Exosomes Which Subsequently Mediate Cellular Adhesion and Spreading

(2011) Rainelli B. Koumangoye et al.   PLoS One

Exosome Secretion: Molecular Mechanisms and Roles in Immune Responses

(2011) Angélique Bobrie et al.   TRAFFIC

Unidirectional transfer of microRNA-loaded exosomes from T cells to antigen-presenting cells

(2011) María Mittelbrunn et al.   Nature Communications

Cellular phenotype switching and microvesicles

(2010) Peter J. Quesenberry et al.   ADVANCED DRUG DELIVERY REVIEWS

Secretion of extracellular hsp90α via exosomes increases cancer cell motility: a role for plasminogen activation

(2010) Jessica McCready et al.   BMC CANCER

Dysregulation of microRNAs in cancer: Playing with fire

(2010) Sonia A. Melo et al.   FEBS LETTERS

Secretory Mechanisms and Intercellular Transfer of MicroRNAs in Living Cells

(2010) Nobuyoshi Kosaka et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Visualizing of the cellular uptake and intracellular trafficking of exosomes by live-cell microscopy

(2010) Tian Tian et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Exosomes account for vesicle-mediated transcellular transport of activatable phospholipases and prostaglandins

(2010) Caroline Subra et al.   JOURNAL OF LIPID RESEARCH

Hypoxic Tumor Cell Modulates Its Microenvironment to Enhance Angiogenic and Metastatic Potential by Secretion of Proteins and Exosomes

(2010) Jung Eun Park et al.   MOLECULAR & CELLULAR PROTEOMICS

Let-7 MicroRNA Family Is Selectively Secreted into the Extracellular Environment via Exosomes in a Metastatic Gastric Cancer Cell Line

(2010) Keiichi Ohshima et al.   PLoS One

Selective Release of MicroRNA Species from Normal and Malignant Mammary Epithelial Cells

(2010) Lucy Pigati et al.   PLoS One

A Novel miRNA Processing Pathway Independent of Dicer Requires Argonaute2 Catalytic Activity

(2010) D. Cifuentes et al.   SCIENCE

Galectin-5 is bound onto the surface of rat reticulocyte exosomes and modulates vesicle uptake by macrophages

(2009) C. Barres et al.   BLOOD

Colorectal cancer cell-derived microvesicles are enriched in cell cycle-related mRNAs that promote proliferation of endothelial cells

(2009) Bok Hong et al.   BMC GENOMICS

Systemic presence and tumor-growth promoting effect of ovarian carcinoma released exosomes

(2009) Sascha Keller et al.   CANCER LETTERS

MicroRNAs: Target Recognition and Regulatory Functions

(2009) David P. Bartel   CELL

Exosomal MicroRNA: A Diagnostic Marker for Lung Cancer

(2009) Guilherme Rabinowits et al.   Clinical Lung Cancer

Characterization of humoral responses of ovarian cancer patients: Antibody subclasses and antigenic components

(2009) Douglas D. Taylor et al.   GYNECOLOGIC ONCOLOGY

Microenvironmental pH Is a Key Factor for Exosome Traffic in Tumor Cells

(2009) Isabella Parolini et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Non-coding RNAs: regulators of disease

(2009) Ryan J Taft et al.   JOURNAL OF PATHOLOGY

The ESCRT machinery in endosomal sorting of ubiquitylated membrane proteins

(2009) Camilla Raiborg et al.   NATURE

Membrane scission by the ESCRT-III complex

(2009) Thomas Wollert et al.   NATURE

Multivesicular bodies associate with components of miRNA effector complexes and modulate miRNA activity

(2009) Derrick J. Gibbings et al.   NATURE CELL BIOLOGY

Rab27a and Rab27b control different steps of the exosome secretion pathway

(2009) Matias Ostrowski et al.   NATURE CELL BIOLOGY

Gene-Expression Signatures in Breast Cancer

(2009) Christos Sotiriou et al.   NEW ENGLAND JOURNAL OF MEDICINE

ExoCarta: A compendium of exosomal proteins and RNA

(2009) Suresh Mathivanan et al.   PROTEOMICS

Distinctive MicroRNA Profiles Relating to Patient Survival in Esophageal Squamous Cell Carcinoma

(2008) Y. Guo et al.   CANCER RESEARCH

Human tumor nanoparticles induce apoptosis of pancreatic cancer cells

(2008) Elodie Ristorcelli et al.   FASEB JOURNAL

MicroRNA signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer

(2008) Douglas D. Taylor et al.   GYNECOLOGIC ONCOLOGY

Induction of myeloid-derived suppressor cells by tumor exosomes

(2008) Xiaoyu Xiang et al.   INTERNATIONAL JOURNAL OF CANCER

Secretion of active membrane type 1 matrix metalloproteinase (MMP-14) into extracellular space in microvesicular exosomes

(2008) Juha Hakulinen et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Discrimination between exosomes and HIV-1: Purification of both vesicles from cell-free supernatants

(2008) Réjean Cantin et al.   JOURNAL OF IMMUNOLOGICAL METHODS

Phase I Clinical Trial of Autologous Ascites-derived Exosomes Combined With GM-CSF for Colorectal Cancer

(2008) Shengming Dai et al.   MOLECULAR THERAPY

Proteomic profiling of exosomes: Current perspectives

(2008) Richard J. Simpson et al.   PROTEOMICS

Ceramide Triggers Budding of Exosome Vesicles into Multivesicular Endosomes

(2008) K. Trajkovic et al.   SCIENCE

Unraveling the microenvironmental influences on the normal mammary gland and breast cancer

(2008) Britta Weigelt et al.   SEMINARS IN CANCER BIOLOGY