Poly(ADP-ribosyl)ation enhances HuR oligomerization and contributes to pro-inflammatory gene mRNA stabilization

Coupling of PARP1-mediated chromatin structural changes to transcriptional RNA polymerase II elongation and cotranscriptional splicing

(2019) Elena A. Matveeva et al.   Epigenetics & Chromatin

An advanced strategy for comprehensive profiling of ADP-ribosylation sites using mass spectrometry-based proteomics

(2019) Ivo A Hendriks et al.   MOLECULAR & CELLULAR PROTEOMICS

Novel insights into PARPs in gene expression: regulation of RNA metabolism

(2019) Yueshuang Ke et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Activation of PARP-1 by snoRNAs Controls Ribosome Biogenesis and Cell Growth via the RNA Helicase DDX21

(2019) Dae-Seok Kim et al.   MOLECULAR CELL

c-Abl–Mediated Tyrosine Phosphorylation of PARP1 Is Crucial for Expression of Proinflammatory Genes

(2019) Ameer Ali Bohio et al.   JOURNAL OF IMMUNOLOGY

The Role of PARPs in Inflammation—and Metabolic—Related Diseases: Molecular Mechanisms and Beyond

(2019) Ke et al.   Cells

PARP Inhibitor Drugs in the Treatment of Breast, Ovarian, Prostate and Pancreatic Cancers: An Update of Clinical Trials

(2018) Dalia Kamel et al.   CURRENT DRUG TARGETS

Inherited disorders of cobalamin metabolism disrupt nucleocytoplasmic transport of mRNA through impaired methylation/phosphorylation of ELAVL1/HuR

(2018) Shyue-Fang Battaglia-Hsu et al.   NUCLEIC ACIDS RESEARCH

HuR biological function involves RRM3-mediated dimerization and RNA binding by all three RRMs

(2018) Marta Pabis et al.   NUCLEIC ACIDS RESEARCH

Hu antigen R (HuR) multimerization contributes to glioma disease progression

(2017) Natalia Filippova et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Erratum: PARP1 promotes gene expression at the post-transcriptional level by modulating the RNA-binding protein HuR

(2017) Yueshuang Ke et al.   Nature Communications

PARP1 expression and its correlation with survival is tumour molecular subtype dependent in glioblastoma

(2017) Balázs Murnyák et al.   Oncotarget

Transcriptome-wide identification of the RNA-binding landscape of the chromatin-associated protein PARP1 reveals functions in RNA biogenesis

(2017) Manana Melikishvili et al.   Cell Discovery

Chemical genetic discovery of PARP targets reveals a role for PARP-1 in transcription elongation

(2016) B. A. Gibson et al.   SCIENCE

Posttranslational control of HuR function

(2016) Ioannis Grammatikakis et al.   Wiley Interdisciplinary Reviews-RNA

Involvement of PARP1 in the regulation of alternative splicing

(2016) Elena Matveeva et al.   Cell Discovery

PARP inhibitors in the management of breast cancer: current data and future prospects

(2015) Luca Livraghi et al.   BMC Medicine

New Facets in the Regulation of Gene Expression by ADP-Ribosylation and Poly(ADP-ribose) Polymerases

(2015) Keun Woo Ryu et al.   CHEMICAL REVIEWS

Dimerization model of the C-terminal RNA Recognition Motif of HuR

(2015) Antonio Díaz-Quintana et al.   FEBS LETTERS

Negative regulation of RNA-binding protein HuR by tumor-suppressor ECRG2

(2015) C Lucchesi et al.   ONCOGENE

The C-terminal RNA binding motif of HuR is a multi-functional domain leading to HuR oligomerization and binding to U-rich RNA targets

(2015) Rafael M Scheiba et al.   RNA Biology

Modulation of TNF-  mRNA stability by human antigen R and miR181s in sepsis-induced immunoparalysis

(2014) C. Dan et al.   EMBO Molecular Medicine

The p38-MK2-HuR pathway potentiates EGFRvIII–IL-1β-driven IL-6 secretion in glioblastoma cells

(2014) F M S Gurgis et al.   ONCOGENE

ELAVL1 regulates alternative splicing of eIF4E transporter to promote postnatal angiogenesis

(2014) Sung-Hee Chang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The structure of the ARE-binding domains of Hu antigen R (HuR) undergoes conformational changes during RNA binding

(2013) Hong Wang et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Mechanisms coordinating ELAV/Hu mRNA regulons

(2013) Laura E Simone et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

Post-Transcriptional Regulation by Poly(ADP-ribosyl)ation of the RNA-Binding Proteins

(2013) Yingbiao Ji et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

HuR Is Required for IL-17-Induced Act1-Mediated CXCL1 and CXCL5 mRNA Stabilization

(2013) T. Herjan et al.   JOURNAL OF IMMUNOLOGY

Tyrosine phosphorylation of HuR by JAK3 triggers dissociation and degradation of HuR target mRNAs

(2013) J.-H. Yoon et al.   NUCLEIC ACIDS RESEARCH

Poly(ADP-ribose) binding to Chk1 at stalled replication forks is required for S-phase checkpoint activation

(2013) WooKee Min et al.   Nature Communications

Phosphoregulation of the RNA-binding Protein Hu Antigen R (HuR) by Cdk5 Affects Centrosome Function

(2012) Natalia Filippova et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

PARP1 Represses PAP and Inhibits Polyadenylation during Heat Shock

(2012) Dafne Campigli Di Giammartino et al.   MOLECULAR CELL

Regulation of cytoplasmic mRNA decay

(2012) Daniel R. Schoenberg et al.   NATURE REVIEWS GENETICS

HuR protein attenuates miRNA-mediated repression by promoting miRISC dissociation from the target RNA

(2012) Pradipta Kundu et al.   NUCLEIC ACIDS RESEARCH

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

HuR function in disease

(2011) Subramanya Srikantan   Frontiers in Bioscience-Landmark

Integrative Regulatory Mapping Indicates that the RNA-Binding Protein HuR Couples Pre-mRNA Processing and mRNA Stability

(2011) Neelanjan Mukherjee et al.   MOLECULAR CELL

Gene silencing by microRNAs: contributions of translational repression and mRNA decay

(2011) Eric Huntzinger et al.   NATURE REVIEWS GENETICS

Regulation of mRNA Translation and Stability by microRNAs

(2010) Marc Robert Fabian et al.   Annual Review of Biochemistry

Modification at HuR(S242) alters HuR localization and proliferative influence

(2010) Hyeon Ho Kim et al.   CELL CYCLE

The X-ray Crystal Structure of the First RNA Recognition Motif and Site-Directed Mutagenesis Suggest a Possible HuR Redox Sensing Mechanism

(2010) Roger Marc Benoit et al.   JOURNAL OF MOLECULAR BIOLOGY

Ubiquitin-mediated proteolysis of HuR by heat shock

(2009) Kotb Abdelmohsen et al.   EMBO JOURNAL

Coordinated posttranscriptional mRNA population dynamics during T-cell activation

(2009) Neelanjan Mukherjee et al.   Molecular Systems Biology

Alternative polyadenylation variants of the RNA binding protein, HuR: abundance, role of AU-rich elements and auto-Regulation

(2009) Wijdan Al-Ahmadi et al.   NUCLEIC ACIDS RESEARCH

Diverse molecular functions of Hu proteins

(2008) M. N. Hinman et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

RNA recognition motifs: boring? Not quite

(2008) Antoine Cléry et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Nuclear HuR accumulation through phosphorylation by Cdk1

(2008) H. H. Kim et al.   GENES & DEVELOPMENT

Poly(ADP-ribose) Binds to the Splicing Factor ASF/SF2 and Regulates Its Phosphorylation by DNA Topoisomerase I

(2008) Maria Malanga et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Caspase-mediated cleavage of HuR in the cytoplasm contributes to pp32/PHAP-I regulation of apoptosis

(2008) Rachid Mazroui et al.   JOURNAL OF CELL BIOLOGY

Posttranslational Modification of the AU-Rich Element Binding Protein HuR by Protein Kinase C  Elicits Angiotensin II-Induced Stabilization and Nuclear Export of Cyclooxygenase 2 mRNA

(2008) A. Doller et al.   MOLECULAR AND CELLULAR BIOLOGY

The third RNA recognition motif of Drosophila ELAV protein has a role in multimerization

(2008) Gakuta Toba et al.   NUCLEIC ACIDS RESEARCH