Review
Oncology
Kenneth N. Huynh, Sriram Rao, Bradley Roth, Theodore Bryan, Dayantha M. Fernando, Farshid Dayyani, David Imagawa, Nadine Abi-Jaoudeh
Summary: Hypoxia-inducible factor 1 alpha (HIF-1a) is a transcription factor that regulates the cellular response to hypoxia and is upregulated in all types of solid tumor. Hepatocellular carcinoma (HCC) is a highly vascular and hypoxic tumor, and treatments like TACE and TAE can exacerbate hypoxia in HCC. Hypoxia-activated prodrugs (HAPs) have potential as a targeted treatment for hypoxic HCC, but more research is needed to understand their effects in combination with embolization.
Article
Ophthalmology
Bing X. Ross, Lin Jia, Dejuan Kong, Tiantian Wang, Jingyu Yao, Heather M. Hager, Steven F. Abcouwer, David N. Zacks
Summary: The study aimed to determine the necessity of HIF-1a on PR cell survival after RD. The findings suggest that rod-derived HIF-1a plays a key role in promoting PR cell survival.
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2022)
Article
Multidisciplinary Sciences
Marie-Anne Goyette, Islam E. Elkholi, Chloe Apcher, Hellen Kuasne, Carla Rothlin, William J. Muller, Darren E. Richard, Morag Park, Jean-Philippe Gratton, Jean-Francois Cote
Summary: Inhibition of Axl leads to reduction of hypoxia-induced EMT, invasion, and cytokine production, creating a favorable environment for immunotherapy and reducing metastatic burden in HER2(+) breast cancer.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Medicine, Research & Experimental
Tripti Singh, Pallabi Banerjee, Uditi, Sarita Kumari, Anita Chopra, Nagendra Singh, Imteyaz Qamar
Summary: Regucalcin regulates intracellular Ca2+ homeostasis and intracellular signaling pathways. Its expression in hypoxia is upregulated by HIF-1α through direct binding to the HRE binding motifs within the Regucalcin promoter.
Article
Biotechnology & Applied Microbiology
Xin Tang, Cheng Chang, Michelle Hao, Mei Chen, David T. Woodley, Axel H. Schonthal, Wei Li
Summary: HIF-1 and Hsp90 play critical roles in spermatogenesis and tumorigenesis, with Hsp90 alpha affecting the levels of HIF-1 alpha in testis, and Hsp90 beta providing protection for signaling molecules responsible for cellular homeostasis.
CANCER GENE THERAPY
(2021)
Review
Immunology
Qianyan He, Yinzhong Ma, Jie Liu, Dianhui Zhang, Jiaxin Ren, Ruoyu Zhao, JunLei Chang, Zhen-Ni Guo, Yi Yang
Summary: Ischemic stroke, caused by inadequate cerebrovascular blood and oxygen supply, poses a significant global health burden. HIF-1α, a key regulator of oxygen homeostasis, plays a critical role in various aspects of stroke pathophysiology and is an important target for potential therapeutic interventions. Further research into the differential regulation of HIF-1α in different cell types during ischemic stroke is crucial for understanding the disease mechanism and identifying novel treatment strategies.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Fisheries
Zhihai Huang, Weiliang Guan, Xiaobo Wei, Renchi Chen, Xiamin Lyu, Gaohai Zheng, Linchun Mao
Summary: The study found that HIF-1 alpha can protect whiteleg shrimp hemocytes from apoptosis caused by air exposure through upregulating the expression of HSP70 and decreasing intracellular ROS production.
Article
Toxicology
Michael Aschner, Anatoly V. Skalny, Rongzhu Lu, Abel Santamaria, Ji-Chang Zhou, Tao Ke, Mikhail Yu. Karganov, Aristides Tsatsakis, Kirill S. Golokhvast, Aaron B. Bowman, Alexey A. Tinkov
Summary: This review summarizes the existing data on the effects of toxic metals on HIF-1 signaling and its underlying mechanisms, with a special focus on the prooxidant effect of metals. The effect of metals on HIF-1 pathway varies depending on the cell type, ranging from down-regulation to up-regulation. Inhibition of HIF-1 signaling may contribute to hypoxic damage in cells, while metal-induced activation may promote tumor growth and contribute to the carcinogenic effects of heavy metals.
ARCHIVES OF TOXICOLOGY
(2023)
Review
Genetics & Heredity
Mingxiao Luo, Tingting Li, Haiquan Sang
Summary: Chronic liver disease is a prevalent public health problem worldwide, with steatosis driving the progression of the disease to cirrhosis or liver cancer. The hypoxia-inducible factor 1a (HIF-1a) plays a central role in hepatic lipid metabolism by promoting intrahepatic lipid deposition. HIF-1a is also expressed in white adipose tissue, where it contributes to the accumulation of fatty acids in the liver. In contrast, intestinal expression of HIF-1a maintains a healthy microbiota and intestinal barrier, providing protection against hepatic steatosis. This article provides an overview of the role of HIF-1a in hepatic steatosis and highlights the potential for therapeutic interventions targeting the HIF-1a pathway.
JOURNAL OF MOLECULAR MEDICINE-JMM
(2023)
Article
Biochemistry & Molecular Biology
You-Wu Dai, Xin-Jiang Lu, Rui Jiang, Jian-Fei Lu, Guan-Jun Yang, Jiong Chen
Summary: The study revealed that HIF-1 alpha in ayu plays a crucial role in the immune system by regulating cytokine expression, enhancing phagocytic and bactericidal activities, and improving host defenses.
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY B-BIOCHEMISTRY & MOLECULAR BIOLOGY
(2021)
Article
Multidisciplinary Sciences
Jieun Seo, Lei Yan, Tatsuto Kageyama, Ayaka Nanmo, Yang-Sook Chun, Junji Fukuda
Summary: In this study, it was found that hypoxia-inducible factor-1 alpha (HIF-1 alpha) is suppressed in scalp tissues of androgenetic alopecia patients and potentially associated with hair follicle development. Knockdown of HIF-1 alpha in dermal papilla cells (DPCs) resulted in decreased expression of trichogenic genes. Moreover, under a mimicked in vivo environment, HIF-1 alpha-suppressed DPCs showed downregulation of hair induction-related genes. Treatment with a HIF-1 alpha activator increased the expression of trichogenic genes in DPCs. This study suggests that dermal HIF-1 alpha expression plays a crucial role in regulating hair follicle development and offers potential therapeutic strategies for hair loss treatment.
SCIENTIFIC REPORTS
(2023)
Article
Peripheral Vascular Disease
Neeru M. Sharma, Andrea S. Haibara, Kenichi Katsurada, Shyam S. Nandi, Xuefei Liu, Hong Zheng, Kaushik P. Patel
Summary: Central infusion of Ang II leads to neurogenic hypertension, affecting PVN function and increasing sympathetic tone. HIF-1 alpha and N-methyl-D-aspartate receptors play crucial roles in this process.
Article
Cardiac & Cardiovascular Systems
Yiwei Liu, Qipeng Luo, Zhanhao Su, Junyue Xing, Jinlin Wu, Li Xiang, Yuan Huang, Haizhou Pan, Xie Wu, Xiaoling Zhang, Jun Li, Fuxia Yan, Hao Zhang
Summary: Cyanotic congenital heart disease (CCHD) leads to maladaptation of cardiac metabolism during puberty, accompanied by impaired cardiac function. The study identified HIF-1 alpha as the key regulator of cardiac metabolic adaptation in CH animal models, with pubertal insulin resistance potentially suppressing its expression.
Article
Biochemistry & Molecular Biology
Jin-Woo Kim, Hyun-Ju An, HyunJeong Yeo, Yunhui Jeong, HyeonHae Lee, Jusung Lee, Kisik Nam, Jongheon Lee, Dong-Eun Shin, Soonchul Lee
Summary: Activation of the HIF-1α signaling pathway can protect intervertebral discs from degeneration and may serve as a potential therapeutic target in the future.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biotechnology & Applied Microbiology
Lei Zhang, Huili Wu, Yong Zhang, Xingguo Xiao, Feifei Chu, Li Zhang
Summary: This study found that NORAD expression is elevated in CRC tissues and is positively associated with HIF-1 alpha expression. Under hypoxic conditions, enhanced NORAD expression promotes vasculogenic mimicry and resistance to 5-FU in CRC cells. Knockdown of NORAD inhibits hypoxia-induced vasculogenic mimicry and 5-FU resistance, as well as reduces HIF-1 alpha expression and epithelial-mesenchymal transition. NORAD acts as a competitive endogenous RNA of miR-495-3p to regulate HIF-1 alpha. Inhibition of miR-495-3p attenuates the effects of NORAD loss on hypoxia-induced EMT, vasculogenic mimicry, and chemoresistance.
Article
Cell Biology
Chiung-Yuan Ko, Wen-Ling Wang, Chien-Feng Li, Yung-Ming Jeng, Yu-Yi Chu, Han-Ying Wang, Joseph T. Tseng, Ju-Ming Wang
JOURNAL OF LEUKOCYTE BIOLOGY
(2016)
Article
Oncology
Yu-Chuan Huang, Chung-Ta Lee, Jenq-Chang Lee, Yao-Wen Liu, Ying-Jen Chen, Joseph T. Tseng, Jui-Wen Kang, Bor-Shyang Sheu, Bo-Wen Lin, Liang-Yi Hung
Article
Cell Biology
Yung-Chieh Tsai, Joseph T. Tseng, Chia-Yih Wang, Mei-Tsz Su, Jyun-Yuan Huang, Pao-Lin Kuo
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2017)
Article
Multidisciplinary Sciences
Wei-Sheng Wu, Bor-Wen Tu, Tsung-Te Chen, Shang-Wei Hou, Joseph T. Tseng
Article
Cell Biology
Chien-Hsien Lai, Yu-Chuan Huang, Jenq-Chang Lee, Joseph Ta-Chien Tseng, Kung-Chao Chang, Yen-Ju Chen, Nai-Jhu Ding, Pao-Hsuan Huang, Wen-Chang Chang, Bo-Wen Lin, Ruo-Yu Chen, Yu-Chu Wang, Yi-Chien Lai, Liang-Yi Hung
CELL DEATH & DISEASE
(2017)
Article
Mathematical & Computational Biology
Wei-Sheng Wu, Yu-Xuan Jiang, Jer-Wei Chang, Yu-Han Chu, Yi-Hao Chiu, Yi-Hong Tsao, Torbjorn E. M. Nordling, Yan-Yuan Tseng, Joseph T. Tseng
DATABASE-THE JOURNAL OF BIOLOGICAL DATABASES AND CURATION
(2018)
Article
Multidisciplinary Sciences
Guan-Liang Lin, Huei-Ju Ting, Ta-Chien Tseng, Vivian Juang, Yu-Li Lo
Article
Genetics & Heredity
Yitong Zhang, Joseph Ta-Chien Tseng, I-Chia Lien, Fenglan Li, Wei Wu, Hui Li
Article
Multidisciplinary Sciences
Yu-Hung Lin, Sheng-Jou Hung, Yi-Lin Chen, Cheng-Han Lin, Te-Fang Kung, Yi-Chun Yeh, Joseph T. Tseng, Tsunglin Liu
Article
Oncology
Ya-Ling Chan, Wei-Chung Lai, Jia-Shing Chen, Joseph Ta-Chien Tseng, Pei-Chin Chuang, Jonathan Jou, Chung-Ta Lee, H. Sunny Sun
Article
Biochemistry & Molecular Biology
Wan-Yu Huang, Dar-Ren Chen, Chew-Teng Kor, Ting-Yu Chen, Po-Te Lin, Joseph Ta Chien Tseng, Hung-Ming Wu
Article
Biochemistry & Molecular Biology
Chien-Chung Lin, Chin-You Wu, Joseph Ta-Chien Tseng, Chun-Hua Hung, Shang-Yin Wu, Yu-Ting Huang, Wei-Yuan Chang, Po-Lan Su, Wu-Chou Su
Summary: Intratumoral heterogeneity in EGFR-mutant NSCLC explains mixed responses to EGFR-TKIs. Analyses of EVs revealed that EV miRNAs can impact tumor cells' sensitivity to EGFR-TKIs, offering potential prognostic biomarkers for EGFR-mutant NSCLC.
Article
Biochemistry & Molecular Biology
Tzu-Hsien Yang, Yu-Hsuan Chiang, Sheng-Cian Shiue, Po-Heng Lin, Ya-Chiao Yang, Kai-Chi Tu, Yan-Yuan Tseng, Joseph T. Tseng, Wei-Sheng Wu
Summary: The transcript isoforms regulated by alternative splicing play a significant role in carcinogenesis. The Cancer DEIso database was constructed to facilitate in-depth analysis of gene-level and isoform-level human cancer studies, allowing for searches of differentially expressed genes/isoforms, expression survival analysis, and visualization of gene/isoform stage expression comparisons.
COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL
(2021)
Article
Biochemical Research Methods
Wei-Sheng Wu, Yi-Hong Tsao, Sheng-Cian Shiue, Ting-Yu Chen, Yan-Yuan Tseng, Joseph T. Tseng
Summary: The study developed the RPiso software tool to provide isoform-level ribosome profiling analyses, which is easy to install and execute, and also provides a web-based viewer for interactively visualizing ribosome profiling data on the selected mRNA isoforms.
BMC BIOINFORMATICS
(2021)
Article
Ramya Kumar, Che-Chih Chang, Tze Hann Ng, Jiun-Yan Ding, Ta-Chien Tseng, Chu-Fang Lo, Han-Ching Wang
GENOME ANNOUNCEMENTS
(2018)