Article
Biochemistry & Molecular Biology
Yoshiaki Soejima, Nahoko Iwata, Ran Nishioka, Mako Honda, Yasuhiro Nakano, Koichiro Yamamoto, Atsuhito Suyama, Fumio Otsuka
Summary: Orexins play important roles in sleep-wake regulation and food intake in the central nervous system. This study investigated the functions of orexin in adrenal steroidogenesis and its interaction with bone morphogenetic proteins (BMPs). The results suggest that both orexin and BMP-6 accelerate adrenocortical steroidogenesis in human adrenocortical cells, and these pathways mutually inhibit each other.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Hyun Seok, Hee-Youl Kim, Dong-Cheol Kang, Jung-Ho Park, Jong Hoon Park
Summary: The study compared the bone regeneration ability of bone scaffolds using particle and block bones with rhBMP-2, showing that rhBMP-2 with block bones resulted in significantly higher bone volume but also led to the formation of adipose tissue and void spaces.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Multidisciplinary Sciences
Binisha H. Mishra, Pashupati P. Mishra, Emma Raitoharju, Saara Marttila, Nina Mononen, Harri Sievanen, Jorma Viikari, Markus Juonala, Marika Laaksonen, Nina Hutri-Kahonen, Mika Kahonen, Olli T. Raitakari, Terho Lehtimaki
Summary: This study analysed gene co-expression modules shared by early traits of osteoporosis and atherosclerosis, identifying two modules with significant joint association with both diseases. The significant member genes from these modules are involved in biological processes related to bone metabolism or atherosclerosis, potentially providing new joint biomarkers for both diseases.
SCIENTIFIC REPORTS
(2021)
Article
Dentistry, Oral Surgery & Medicine
Maria del Mar Ferra-Canellas, Marta Munar-Bestard, Laura Garcia-Sureda, Beatrice Lejeune, Joana Maria Ramis, Marta Monjo
Summary: The study demonstrates that low-dose BMP4 MI treatment has anti-inflammatory and regenerative properties on gingival fibroblasts, and improves cell viability in 3D gingiva under inflammatory conditions.
JOURNAL OF PERIODONTOLOGY
(2021)
Article
Cell Biology
Ruifan Wu, Shengchun Feng, Fan Li, Gang Shu, Lina Wang, Ping Gao, Xiaotong Zhu, Canjun Zhu, Songbo Wang, Qingyan Jiang
Summary: Obesity is a global health problem associated with metabolic diseases. This study investigates the role of YBX1 in adipogenesis and adipose tissue expansion. The researchers found that YBX1 deficiency inhibited adipocyte differentiation and that YBX1 promotes adipogenesis through ULK1- and ULK2-mediated autophagy. The findings provide insights into the molecular mechanisms and functional importance of YBX1 in regulating autophagy and adipogenesis, highlighting its potential as a therapeutic target for obesity and metabolic diseases.
CELL DEATH & DISEASE
(2023)
Article
Gastroenterology & Hepatology
Martijn A. J. Koppens, Hayley Davis, Gabriel N. Valbuena, Eoghan J. Mulholland, Nadia Nasreddin, Mathilde Colombe, Agne Antanaviciute, Sujata Biswas, Matthias Friedrich, Lennard Lee, Lai Mun Wang, Viktor H. Koelzer, James E. East, Alison Simmons, Douglas J. Winton, Simon J. Leedham
Summary: The study reveals that BMP signaling inhibits dedifferentiation of intestinal epithelial cells, and attenuation of the BMP pathway through stromal upregulation of Grem1 is essential for adaptive reprogramming in intestinal regeneration. However, the functional impact of this intervention is submaximal, suggesting potential therapeutic pathway manipulation in inflammatory bowel disease.
Article
Engineering, Biomedical
Sihan Lin, Shi Yin, Junfeng Shi, Guangzheng Yang, Xutao Wen, Wenjie Zhang, Mingliang Zhou, Xinquan Jiang
Summary: In this study, the dose of bone morphogenetic protein-2 (BMP-2) was reduced and its safety and efficacy were improved through the regulation of magnesium ion (Mg2+). Magnesium ion enhanced cellular bioenergetic levels and the osteoinductivity of BMP-2. A co-delivery system, fabricated using microfluidic and 3D printing technologies, was able to rapidly and robustly induce bone regeneration.
BIOACTIVE MATERIALS
(2022)
Review
Engineering, Biomedical
Marc Bohner, Yassine Maazouz, Maria-Pau Ginebra, Pamela Habibovic, Jonathan G. Schoenecker, Howard Seeherman, Jeroen J. J. P. van den Beucken, Frank Witte
Summary: This study aims to evaluate the hypothesis that sustained local ionic homeostatic imbalance (SLIHI) created by mineral formation during tissue calcification modulates inflammation to trigger heterotopic ossification (HO), and to provide insights for the design of cell-free, drug-free osteoinductive bone graft substitutes.
ACTA BIOMATERIALIA
(2022)
Article
Engineering, Biomedical
Sarah A. Schoonraad, Alan A. Jaimes, Arjun J. X. Singh, Kiera J. Croland, Stephanie J. Bryant
Summary: This study investigates the osteogenic effects of tethered BMP-2 and BMP-9 on human MSCs encapsulated in a hydrogel. The results show that tethered BMP-2 and BMP-9 both effectively enhance osteogenesis of MSCs, leading to a mature osteoblast phenotype.
ACTA BIOMATERIALIA
(2023)
Article
Biochemistry & Molecular Biology
Magdalena Wytrwal, Malgorzata Sekula-Stryjewska, Agata Pomorska, Ewa Oclon, Ewa Zuba-Surma, Szczepan Zapotoczny, Krzysztof Szczubialka
Summary: This study investigated the covalent binding of recombinant human bone morphogenetic protein-2 and -7 in stem cells and its effects on cell adhesion, migration, and osteogenesis. The presence of both proteins enhanced cell adhesion but limited cell motility, while the presence of single proteins promoted cell migration activity. Additionally, the coexistence of the proteins significantly increased early osteogenic marker expression.
Article
Chemistry, Multidisciplinary
Eun Young Jeon, Seung-Hoon Um, Jaeho Park, Youngmee Jung, Cheol-Hong Cheon, Hojeong Jeon, Justin J. Chung
Summary: In this study, a complex coacervate consisting of fucoidan and poly-l-lysine (PLL) was fabricated to encapsulate BMP-2, avoiding denaturation and enhancing therapeutic action. The coacervate showed superior binding ability to BMP-2 and allowed for prolonged release, improving its bioactivity and protection against antagonist and proteolysis. The coated coacervate on collagen sponges demonstrated bioactivity and localized bone regenerating ability in vitro and in vivo evaluations.
Article
Engineering, Biomedical
Yuan-Zhe Jin, Guang-Bin Zheng, Jae Hyup Lee, Shi-Huan Han
Summary: In this study, rat calvaria defect model was used to compare the bone regeneration effect of ErhBMP-2 implanted with DBM or HA as carriers. The group with DBM as the carrier showed significantly higher bone volume and thickness in both weeks, indicating that DBM could be a better carrier for ErhBMP-2 than HA.
BIOMATERIALS RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Fabien Kawecki, Jessica Jann, Michel Fortin, Francois A. Auger, Nathalie Faucheux, Julie Fradette
Summary: The success of dental implant treatment after tooth extraction can be improved by preserving the alveolar ridge using cell-free biomaterials. The use of a bone-like substitute supplemented with bone morphogenetic protein (BMP) can enhance in vitro osteogenic potential and promote alveolar bone healing.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Yoshiaki Soejima, Nahoko Iwata, Nanako Nakayama, Shinichi Hirata, Yasuhiro Nakano, Koichiro Yamamoto, Atsuhito Suyama, Kohei Oguni, Takahiro Nada, Satoshi Fujisawa, Fumio Otsuka
Summary: Orexin plays a key role in regulating sleep, wakefulness and feeding behavior. This study shows that Orexin regulates gonadotropin expression by interacting with GnRH and the pituitary BMP system, and this regulation involves clock gene expression.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Polymer Science
Oana Gherasim, Alexandru Mihai Grumezescu, Valentina Grumezescu, Ecaterina Andronescu, Irina Negut, Alexandra Catalina Birca, Bianca Galateanu, Ariana Hudita
Summary: Osteoconductive and osteoinductive coatings are effective strategies for enhancing the integration of metallic implants with bone. Composite materials based on PLA and HAp benefit bone cell development, while the addition of osteogenic proteins contributes to new bone formation. Laser-processed composites show superior ability to promote osteoprogenitor cell adhesion, viability, and proliferation.
Article
Endocrinology & Metabolism
J. Nam, P. Perera, R. Gordon, Y. H. Jeong, A. D. Blazek, D. G. Kim, B. C. Tee, Z. Sun, T. D. Eubank, Y. Zhao, B. Lablebecioglu, S. Liu, A. Litsky, N. L. Weisleder, B. S. Lee, T. Butterfield, A. L. Schneyer, S. Agarwal
Article
Biochemistry & Molecular Biology
Sandra Kissing, Christina Hermsen, Urska Repnik, Cecilie Kasi Nesset, Kristine von Bargen, Gareth Griffiths, Atsuhiro Ichihara, Beth S. Lee, Michael Schwake, Jef De Brabander, Albert Haas, Paul Saftig
JOURNAL OF BIOLOGICAL CHEMISTRY
(2015)
Article
Orthopedics
A. D. Blazek, J. Namx, R. Gupta, M. Pradhan, P. Perera, N. L. Weisleder, T. E. Hewett, A. M. Chaudhari, B. S. Lee, B. Leblebicioglu, T. A. Butterfield, S. Agarwal
OSTEOARTHRITIS AND CARTILAGE
(2016)
Article
Endocrinology & Metabolism
Brooke K. McMichael, Yong-Hoon Jeong, Justin A. Auerbach, Cheol-Min Han, Ryan Sedlar, Vikram Shettigar, Martin Baehler, Sudha Agarwal, Do-Gyoon Kim, Beth S. Lee
JOURNAL OF BONE AND MINERAL RESEARCH
(2017)
Article
Cell Biology
Anne M. Collaco, Peter Geibel, Beth S. Lee, John P. Geibel, Nadia A. Ameen
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
(2013)
Review
Biochemistry & Molecular Biology
Derrick M. Knapik, Priyangi Perera, Jin Nam, Alisa D. Blazek, Bjoern Rath, Binnaz Leblebicioglu, Hiranmoy Das, Lai Chu Wu, Timothy E. Hewett, Suresh K. Agarwal, Alexander G. Robling, David C. Flanigan, Beth S. Lee, Sudha Agarwal
ANTIOXIDANTS & REDOX SIGNALING
(2014)
Article
Cell Biology
Suman Govindaraju, Beth S. Lee
CELLULAR PHYSIOLOGY AND BIOCHEMISTRY
(2014)
Review
Medicine, Research & Experimental
M. Das, J. Lu, M. Joseph, R. Aggarwal, S. Kanji, B. K. McMichael, B. S. Lee, S. Agarwal, A. Ray-Chaudhury, O. H. Iwenofu, P. Kuppusamy, V. J. Pompili, M. K. Jain, H. Das
CURRENT MOLECULAR MEDICINE
(2012)
Article
Biochemistry & Molecular Biology
Brooke K. McMichael, Stephanie M. Meyer, Beth S. Lee
JOURNAL OF BIOLOGICAL CHEMISTRY
(2010)
Article
Cell Biology
Mamata Singh, Alaina R. Martinez, Suman Govindaraju, Beth S. Lee
JOURNAL OF CELLULAR PHYSIOLOGY
(2013)
Article
Multidisciplinary Sciences
Reeva Aggarwal, Jingwei Lu, Suman Kanji, Matthew Joseph, Manjusri Das, Garrett J. Noble, Brooke K. McMichael, Sudha Agarwal, Richard T. Hart, Zongyang Sun, Beth S. Lee, Thomas J. Rosol, Rebecca Jackson, Hai-Quan Mao, Vincent J. Pompili, Hiranmoy Das
Article
Multidisciplinary Sciences
Brooke K. McMichael, Katharine F. Scherer, Nicole C. Franklin, Beth S. Lee
Article
Multidisciplinary Sciences
Amy Tasca, Kristina Astleford, Ari Lederman, Eric D. Jensen, Beth S. Lee, Rajaram Gopalakrishnan, Kim C. Mansky
SCIENTIFIC REPORTS
(2017)
Review
Biochemistry & Molecular Biology
Beth S. Lee
CURRENT PROTEIN & PEPTIDE SCIENCE
(2012)