Regulation of HuR structure and function by dihydrotanshinone-I

The Ribonucleic Complex HuR-MALAT1 Represses CD133 Expression and Suppresses Epithelial-Mesenchymal Transition in Breast Cancer

(2016) E. Latorre et al.   CANCER RESEARCH

Abstract 2449: Targeting an “undruggable” RNA-binding protein: Discovery of small molecule inhibitors of HuR for novel breast cancer therapy

(2015) Xiaoqing Wu et al.   CANCER RESEARCH

Targeting the Multifaceted HuR Protein, Benefits and Caveats

(2015) Chiara Zucal et al.   CURRENT DRUG TARGETS

15,16-Dihydrotanshinone I from the Functional Food Salvia miltiorrhiza Exhibits Anticancer Activity in Human HL-60 Leukemia Cells: in Vitro and in Vivo Studies

(2015) Jun-Jen Liu et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

B Cell–Intrinsic Expression of the HuR RNA-Binding Protein Is Required for the T Cell–Dependent Immune Response In Vivo

(2015) Amy DeMicco et al.   JOURNAL OF IMMUNOLOGY

Posttranscriptional Regulation of the Inflammatory Marker C-Reactive Protein by the RNA-Binding Protein HuR and MicroRNA 637

(2015) Yoonseo Kim et al.   MOLECULAR AND CELLULAR BIOLOGY

The RNA-binding protein HuR is essential for the B cell antibody response

(2015) Manuel D Diaz-Muñoz et al.   NATURE IMMUNOLOGY

Dihydrotanshinone I induced apoptosis and autophagy through caspase dependent pathway in colon cancer

(2015) Lin Wang et al.   PHYTOMEDICINE

Dihydrotanshinone-I interferes with the RNA-binding activity of HuR affecting its post-transcriptional function

(2015) Vito Giuseppe D’Agostino et al.   Scientific Reports

Identification of Small-Molecule Inhibitors of the HuR/RNA Interaction Using a Fluorescence Polarization Screening Assay Followed by NMR Validation

(2015) Zhonghua Wang et al.   PLoS One

The C-terminal RNA binding motif of HuR is a multi-functional domain leading to HuR oligomerization and binding to U-rich RNA targets

(2015) Rafael M Scheiba et al.   RNA Biology

HuR Regulates Alternative Splicing of the TRA2  Gene in Human Colon Cancer Cells under Oxidative Stress

(2014) Y. Akaike et al.   MOLECULAR AND CELLULAR BIOLOGY

A Feedforward Regulatory Loop between HuR and the Long Noncoding RNA linc-MD1 Controls Early Phases of Myogenesis

(2014) Ivano Legnini et al.   MOLECULAR CELL

The Role of HuR in the Post-Transcriptional Regulation of Interleukin-3 in T Cells

(2014) José A. González-Feliciano et al.   PLoS One

The structure of the ARE-binding domains of Hu antigen R (HuR) undergoes conformational changes during RNA binding

(2013) Hong Wang et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Enrichr: interactive and collaborative HTML5 gene list enrichment analysis tool

(2013) Edward Y Chen et al.   BMC BIOINFORMATICS

Examination of Matrix Metalloproteinase-1 in Solution

(2013) Linda Cerofolini et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Novel High Throughput Biochemical Assay to Evaluate the HuR Protein-RNA Complex Formation

(2013) Vito G. D’Agostino et al.   PLoS One

HuR thermal stability is dependent on domain binding and upon phosphorylation

(2012) Rafael Manfred Scheiba et al.   EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS

Magnesium Ion–Water Coordination and Exchange in Biomolecular Simulations

(2012) Olof Allnér et al.   Journal of Chemical Theory and Computation

Downregulation of HuR as a new mechanism of doxorubicin resistance in breast cancer cells

(2012) Elisa Latorre et al.   Molecular Cancer

HuR function in disease

(2011) Subramanya Srikantan   Frontiers in Bioscience-Landmark

Chemokine Transcripts as Targets of the RNA-Binding Protein HuR in Human Airway Epithelium

(2011) J. Fan et al.   JOURNAL OF IMMUNOLOGY

Combination treatment with dihydrotanshinone I and irradiation enhances apoptotic effects in human cervical cancer by HPV E6 down-regulation and caspases activation

(2011) Yintao Ye et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

The mRNA Stability Factor HuR Inhibits MicroRNA-16 Targeting of COX-2

(2011) L. E. Young et al.   MOLECULAR CANCER RESEARCH

Integrative Regulatory Mapping Indicates that the RNA-Binding Protein HuR Couples Pre-mRNA Processing and mRNA Stability

(2011) Neelanjan Mukherjee et al.   MOLECULAR CELL

Transcriptome-wide Analysis of Regulatory Interactions of the RNA-Binding Protein HuR

(2011) Svetlana Lebedeva et al.   MOLECULAR CELL

Different modes of interaction by TIAR and HuR with target RNA and DNA

(2011) Henry S. Kim et al.   NUCLEIC ACIDS RESEARCH

RNA-binding protein HuR autoregulates its expression by promoting alternative polyadenylation site usage

(2011) Weijun Dai et al.   NUCLEIC ACIDS RESEARCH

R.E.D. Server: a web service for deriving RESP and ESP charges and building force field libraries for new molecules and molecular fragments

(2011) Enguerran Vanquelef et al.   NUCLEIC ACIDS RESEARCH

GOSemSim: an R package for measuring semantic similarity among GO terms and gene products

(2010) G. Yu et al.   BIOINFORMATICS

The X-ray Crystal Structure of the First RNA Recognition Motif and Site-Directed Mutagenesis Suggest a Possible HuR Redox Sensing Mechanism

(2010) Roger Marc Benoit et al.   JOURNAL OF MOLECULAR BIOLOGY

The R.E.D. tools: advances in RESP and ESP charge derivation and force field library building

(2010) François-Yves Dupradeau et al.   PHYSICAL CHEMISTRY CHEMICAL PHYSICS

Posttranscriptional regulation of cancer traits by HuR

(2010) Kotb Abdelmohsen et al.   Wiley Interdisciplinary Reviews-RNA

Ubiquitin-mediated proteolysis of HuR by heat shock

(2009) Kotb Abdelmohsen et al.   EMBO JOURNAL

Chemical inhibitors destabilize HuR binding to the AU-rich element of TNF-α mRNA

(2009) Min-Ju Chae et al.   EXPERIMENTAL AND MOLECULAR MEDICINE

Interdomain Flexibility in Full-length Matrix Metalloproteinase-1 (MMP-1)

(2009) Ivano Bertini et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Control of Thymic T Cell Maturation, Deletion and Egress by the RNA-Binding Protein HuR

(2009) O. Papadaki et al.   JOURNAL OF IMMUNOLOGY

Alternative polyadenylation variants of the RNA binding protein, HuR: abundance, role of AU-rich elements and auto-Regulation

(2009) Wijdan Al-Ahmadi et al.   NUCLEIC ACIDS RESEARCH

Hu Antigen R (HuR) Functions as an Alternative Pre-mRNA Splicing Regulator of Fas Apoptosis-promoting Receptor on Exon Definition

(2008) José M. Izquierdo   JOURNAL OF BIOLOGICAL CHEMISTRY

Evidence of Reciprocal Reorientation of the Catalytic and Hemopexin-Like Domains of Full-Length MMP-12

(2008) Ivano Bertini et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Post-transcriptional gene regulation by HuR promotes a more tumorigenic phenotype

(2008) K Mazan-Mamczarz et al.   ONCOGENE