The C-terminal RNA binding motif of HuR is a multi-functional domain leading to HuR oligomerization and binding to U-rich RNA targets

The structure of the ARE-binding domains of Hu antigen R (HuR) undergoes conformational changes during RNA binding

(2013) Hong Wang et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Domain-specific phosphomimetic mutation allows dissection of different protein kinase C (PKC) isotype-triggered activities of the RNA binding protein HuR

(2013) Sebastian Schulz et al.   CELLULAR SIGNALLING

RNA Binding of T-cell Intracellular Antigen-1 (TIA-1) C-terminal RNA Recognition Motif Is Modified by pH Conditions

(2013) Isabel Cruz-Gallardo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Apoptotic-induced cleavage shifts HuR from being a promoter of survival to an activator of caspase-mediated apoptosis

(2012) C von Roretz et al.   CELL DEATH AND DIFFERENTIATION

RRM–RNA recognition: NMR or crystallography…and new findings

(2012) Gerrit M Daubner et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Regulation of the mRNA-Binding Protein HuR by Posttranslational Modification: Spotlight on Phosphorylation

(2012) Wolfgang Eberhardt et al.   CURRENT PROTEIN & PEPTIDE SCIENCE

HuR thermal stability is dependent on domain binding and upon phosphorylation

(2012) Rafael Manfred Scheiba et al.   EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS

Sequence requirements for RNA binding by HuR and AUF1

(2012) Andrew Barker et al.   JOURNAL OF BIOCHEMISTRY

High-constitutive HuR phosphorylation at Ser 318 by PKCδ propagates tumor relevant functions in colon carcinoma cells

(2011) Anke Doller et al.   CARCINOGENESIS

HuR function in disease

(2011) Subramanya Srikantan   Frontiers in Bioscience-Landmark

Murine double minute 2 regulates Hu antigen R stability in human liver and colon cancer through NEDDylation

(2011) Nieves Embade et al.   HEPATOLOGY

Modification at HuR(S242) alters HuR localization and proliferative influence

(2010) Hyeon Ho Kim et al.   CELL CYCLE

The X-ray Crystal Structure of the First RNA Recognition Motif and Site-Directed Mutagenesis Suggest a Possible HuR Redox Sensing Mechanism

(2010) Roger Marc Benoit et al.   JOURNAL OF MOLECULAR BIOLOGY

Molecular basis of FIR-mediated c-myc transcriptional control

(2010) Cyprian D Cukier et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Orientation of the central domains of KSRP and its implications for the interaction with the RNA targets

(2010) Irene Díaz-Moreno et al.   NUCLEIC ACIDS RESEARCH

Phosphorylation-mediated unfolding of a KH domain regulates KSRP localization via 14-3-3 binding

(2009) Irene Díaz-Moreno et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Reduced nuclear export of HuR mRNA by HuR is linked to the loss of HuR in replicative senescence

(2009) Jie Yi et al.   NUCLEIC ACIDS RESEARCH

Signalling pathways regulating nucleo-cytoplasmic shuttling of the mRNA-binding protein HuR

(2008) Anke Doller et al.   CELLULAR SIGNALLING

Nuclear HuR accumulation through phosphorylation by Cdk1

(2008) H. H. Kim et al.   GENES & DEVELOPMENT

Dimerization and Protein Binding Specificity of the U2AF Homology Motif of the Splicing Factor Puf60

(2008) Lorenzo Corsini et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Caspase-mediated cleavage of HuR in the cytoplasm contributes to pp32/PHAP-I regulation of apoptosis

(2008) Rachid Mazroui et al.   JOURNAL OF CELL BIOLOGY

Terminal Adenosyl Transferase Activity of Posttranscriptional Regulator HuR Revealed by Confocal On-Bead Screening

(2008) Nicole-Claudia Meisner et al.   JOURNAL OF MOLECULAR BIOLOGY

Posttranslational Modification of the AU-Rich Element Binding Protein HuR by Protein Kinase C  Elicits Angiotensin II-Induced Stabilization and Nuclear Export of Cyclooxygenase 2 mRNA

(2008) A. Doller et al.   MOLECULAR AND CELLULAR BIOLOGY

CS23D: a web server for rapid protein structure generation using NMR chemical shifts and sequence data

(2008) D. S. Wishart et al.   NUCLEIC ACIDS RESEARCH

The third RNA recognition motif of Drosophila ELAV protein has a role in multimerization

(2008) Gakuta Toba et al.   NUCLEIC ACIDS RESEARCH