The Use of Bioactive Compounds in Hyperglycemia- and Amyloid Fibrils-Induced Toxicity in Type 2 Diabetes and Alzheimer’s Disease

Alpinia oxyphylla Miq. and Its Active Compound P-Coumaric Acid Promote Brain-Derived Neurotrophic Factor Signaling for Inducing Hippocampal Neurogenesis and Improving Post-cerebral Ischemic Spatial Cognitive Functions

(2021) Yacong He et al.   Frontiers in Cell and Developmental Biology

Rosmarinic acid and ursolic acid alleviate deficits in cognition, synaptic regulation and adult hippocampal neurogenesis in an Aβ1-42-induced mouse model of Alzheimer's disease

(2021) Fatima Javed Mirza et al.   PHYTOMEDICINE

A review on ferulic acid and analogs based scaffolds for the management of Alzheimer’s disease

(2021) Yash Pal Singh et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Alpha‐lipoic acid supplementation increases the efficacy of exercise‐ and diet‐induced obesity treatment and induces immunometabolic changes in female mice and women

(2021) Sébastien Le Garf et al.   FASEB JOURNAL

Effects of Folic Acid Combined with DHA Supplementation on Cognitive Function and Amyloid-β-Related Biomarkers in Older Adults with Mild Cognitive Impairment by a Randomized, Double Blind, Placebo-Controlled Trial

(2021) Dong Bai et al.   JOURNAL OF ALZHEIMERS DISEASE

Structural Studies Providing Insights into Production and Conformational Behavior of Amyloid-β Peptide Associated with Alzheimer’s Disease Development

(2021) Anatoly S. Urban et al.   MOLECULES

Inflammation and Insulin Resistance as Risk Factors and Potential Therapeutic Targets for Alzheimer’s Disease

(2021) Angeles Vinuesa et al.   Frontiers in Neuroscience

α-Lipoic Acid Has the Potential to Normalize Copper Metabolism, Which Is Dysregulated in Alzheimer’s Disease

(2021) Kristel Metsla et al.   JOURNAL OF ALZHEIMERS DISEASE

Oleanolic acid alleviates oxidative stress in Alzheimer’s disease by regulating stanniocalcin‐1 and uncoupling protein‐2 signaling

(2020) Qiang Guo et al.   CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY

Catharanthus roseus Combined with Ursolic Acid Attenuates Streptozotocin-Induced Diabetes through Insulin Secretion and Glycogen Storage

(2020) Huda Mohammed Alkreathy et al.   Oxidative Medicine and Cellular Longevity

Protocatechuic acid inhibits inflammatory responses in LPS-activated BV2 microglia via regulating SIRT1/NF-κB pathway contributed to the suppression of microglial activation-induced PC12 cell apoptosis

(2020) Chayanut Kaewmool et al.   JOURNAL OF NEUROIMMUNOLOGY

Beneficial effects of ferulic acid alone and in combination with insulin in streptozotocin induced diabetic neuropathy in Sprague Dawley rats

(2020) Jatinder Dhaliwal et al.   LIFE SCIENCES

Sinapic Acid Promotes Browning of 3T3-L1 Adipocytes via p38 MAPK/CREB Pathway

(2020) In-Seon Bae et al.   Biomed Research International

Neurodegeneration in type 2 diabetes: Alzheimer's as a case study

(2020) Jalaja Madhusudhanan et al.   Brain and Behavior

Is Acetylsalicylic Acid a Safe and Potentially Useful Choice for Adult Patients with COVID-19 ?

(2020) Vanessa Bianconi et al.   DRUGS

Hydroxycinnamic Acid from Corncob and Its Structural Analogues Inhibit Aβ40 Fibrillation and Attenuate Aβ40-Induced Cytotoxicity

(2020) Sijia Hao et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

20(S)-protopanaxadiol and oleanolic acid ameliorate cognitive deficits in APP/PS1 transgenic mice by enhancing hippocampal neurogenesis

(2020) Kaili Lin et al.   Journal of Ginseng Research

Sinapic Acid Ameliorates the Progression of Streptozotocin (STZ)-Induced Diabetic Nephropathy in Rats via NRF2/HO-1 Mediated Pathways

(2020) Ahmed L. Alaofi   Frontiers in Pharmacology

Link between Diabetes and Alzheimer’s Disease Due to the Shared Amyloid Aggregation and Deposition Involving Both Neurodegenerative Changes and Neurovascular Damages

(2020) Gabriela Dumitrita Stanciu et al.   Journal of Clinical Medicine

Association between metformin and neurodegenerative diseases of observational studies: systematic review and meta-analysis

(2020) Fan Ping et al.   BMJ Open Diabetes Research & Care

Novel Perspective on Alzheimer’s Disease Treatment: Rosmarinic Acid Molecular Interplay with Copper(II) and Amyloid β

(2020) Arian Kola et al.   Life-Basel

New Human Islet Amyloid Polypeptide Fragments Susceptible to Aggregation

(2020) Kamil Rozniakowski et al.   CHEMISTRY & BIODIVERSITY

Protective effects of protocatechuic acid against cognitive impairment in an amyloid beta-induced Alzheimer's disease mouse model

(2020) Jung Ran Choi et al.   FOOD AND CHEMICAL TOXICOLOGY

Dietary Intake of Rosmarinic Acid Increases Serum Inhibitory Activity in Amyloid A Aggregation and Suppresses Deposition in the Organs of Mice

(2020) Xuguang Lin et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Effect of acetylsalicylic acid on inflamed adipose tissue. Insulin resistance and hepatic steatosis in a mouse model of diet-induced obesity

(2020) Claudia Sardi et al.   LIFE SCIENCES

α-Lipoic Acid Maintains Brain Glucose Metabolism via BDNF/TrkB/HIF-1α Signaling Pathway in P301S Mice

(2020) Yan-hui Zhang et al.   Frontiers in Aging Neuroscience

Anti-Neuroinflammatory Potential of Polyphenols by Inhibiting NF-κB to Halt Alzheimer's Disease

(2020) Md. Sahab Uddin et al.   CURRENT PHARMACEUTICAL DESIGN

Ferulic acid delayed amyloid β-induced pathological symptoms by autophagy pathway via a fasting-like effect in Caenorhabditis elegans

(2020) Ningbo Wang et al.   FOOD AND CHEMICAL TOXICOLOGY

Sinapic Acid Alleviates Oxidative Stress and Neuro-Inflammatory Changes in Sporadic Model of Alzheimer’s Disease in Rats

(2020) Vandna Verma et al.   Brain Sciences

Protocatechuic acid improves hepatic insulin resistance and restores vascular oxidative status in type-2 diabetic rats

(2020) Marwa E. Abdelmageed et al.   ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY

Ursolic acid: Pharmacokinetics process in vitro and in vivo , a mini review

(2019) Wen Jinhua   ARCHIV DER PHARMAZIE

Twelve-Week Protocatechuic Acid Administration Improves Insulin-Induced and Insulin-Like Growth Factor-1-Induced Vasorelaxation and Antioxidant Activities in Aging Spontaneously Hypertensive Rats

(2019) Kunanya Masodsai et al.   Nutrients

Protocatechuic acid exerts protective effects via suppression of the P38/JNK- NF-κB signalling pathway in an experimental mouse model of intracerebral haemorrhage

(2019) Zhiyu Xi et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Dietary protocatechuic acid abrogates male reproductive dysfunction in streptozotocin-induced diabetic rats via suppression of oxidative damage, inflammation and caspase-3 activity

(2019) Isaac A. Adedara et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Peptide Conjugates with Small Molecules Designed to Enhance Efficacy and Safety

(2019) Rongjun He et al.   MOLECULES

Inhibitory Activity on Amyloid Aggregation of Rosmarinic Acid and Its Substructures From Isodon japonicus

(2019) Jiayi Sun et al.   Natural Product Communications

Assessment of diets containing curcumin, epigallocatechin-3-gallate, docosahexaenoic acid and α-lipoic acid on amyloid load and inflammation in a male transgenic mouse model of Alzheimer's disease: Are combinations more effective?

(2019) Matthew J. Sharman et al.   NEUROBIOLOGY OF DISEASE

Insulin and Autophagy in Neurodegeneration

(2019) Natália Prudente de Mello et al.   Frontiers in Neuroscience

Abnormal platelet amyloid‐β precursor protein metabolism in SAMP8 mice: Evidence for peripheral marker in Alzheimer's disease

(2019) Lizhi Chen et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Gallic acid: A naturally occurring bifunctional inhibitor of amyloid and metal induced aggregation with possible implication in metal-based therapy

(2019) Asra Nasir Khan et al.   JOURNAL OF MOLECULAR LIQUIDS

The Effects of Folic Acid Administration on Cardiac Oxidative Stress and Cardiovascular Biomarkers in Diabetic Rats

(2019) Slavica Mutavdzin et al.   Oxidative Medicine and Cellular Longevity

Rosmarinic acid suppresses Alzheimer’s disease development by reducing amyloid β aggregation by increasing monoamine secretion

(2019) Tomoki Hase et al.   Scientific Reports

Oleanolic Acid Mitigates 6-Hydroxydopamine Neurotoxicity by Attenuating Intracellular ROS in PC12 Cells and Striatal Microglial Activation in Rat Brains

(2019) Zama N. P. Msibi et al.   Frontiers in Physiology

Therapeutic Potential of Rosmarinic Acid: A Comprehensive Review

(2019) Muhammad Nadeem et al.   Applied Sciences-Basel

Inhibition of Tau amyloid fibril formation by folic acid: In-vitro and theoretical studies

(2019) Samin Ghasemzadeh et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Effect of Ursolic Acid on Insulin Resistance and Hyperinsulinemia in Rats with Diet-Induced Obesity: Role of Adipokines Expression

(2019) Angélica S. González-Garibay et al.   JOURNAL OF MEDICINAL FOOD

Effect of P-Hydroxycinnamic Acid in Mice Model of Cerebral Ischemia-Reperfusion Injury

(2019) Romgase Sakamula et al.   Sains Malaysiana

Oleanolic Acid Exerts a Neuroprotective Effect Against Microglial Cell Activation by Modulating Cytokine Release and Antioxidant Defense Systems

(2019) José M. Castellano et al.   Biomolecules

Protocatechuic acid exhibits hepatoprotective, vasculoprotective, antioxidant and insulin-like effects in dexamethasone-induced insulin-resistant rats

(2019) Yomna A. El-Sonbaty et al.   BIOCHIMIE

P-Coumaric acid alleviates experimental diabetic nephropathy through modulation of Toll like receptor-4 in rats

(2019) Omar M. Zabad et al.   LIFE SCIENCES

Protocatechuic acid attenuates β‑secretase activity and okadaic acid‑induced autophagy via the Akt/GSK‑3β/MEF2D pathway in PC12 cells

(2019) Liping Huang et al.   Molecular Medicine Reports

Ursolic Acid Treatment Alleviates Diabetic Kidney Injury By Regulating The ARAP1/AT1R Signaling Pathway

(2019) Tiankui Ma et al.   Diabetes Metabolic Syndrome and Obesity-Targets and Therapy

Modulation of hyperglycemia and dyslipidemia in experimental type 2 diabetes by gallic acid and p -coumaric acid: The role of adipocytokines and PPARγ

(2018) Adel Abdel-Moneim et al.   BIOMEDICINE & PHARMACOTHERAPY

Ursolic acid improves diabetic nephropathy via suppression of oxidative stress and inflammation in streptozotocin-induced rats

(2018) Hui-lin Xu et al.   BIOMEDICINE & PHARMACOTHERAPY

Protocatechuic acid ameliorates high glucose-induced extracellular matrix accumulation in diabetic nephropathy

(2018) Yali Ma et al.   BIOMEDICINE & PHARMACOTHERAPY

Eicosanoids in platelets and the effect of their modulation by aspirin in the cardiovascular system (and beyond)

(2018) Marilena Crescente et al.   BRITISH JOURNAL OF PHARMACOLOGY

Oleanolic Acid Ameliorates Aβ25-35 Injection-induced Spatial Learning and Memory Deficit in Alzheimer’s Disease Model Rats

(2018) Kai Wang et al.   CNS & Neurological Disorders-Drug Targets

Rosmarinic acid attenuates β-amyloid-induced oxidative stress via Akt/GSK-3β/Fyn-mediated Nrf2 activation in PC12 cells

(2018) Hua Rong et al.   FREE RADICAL BIOLOGY AND MEDICINE

Inhibition of amyloid fibril formation of lysozyme by ascorbic acid and a probable mechanism of action

(2018) Palak Patel et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Inhibitory mechanism of two allosteric inhibitors, oleanolic acid and ursolic acid on α-glucosidase

(2018) Huafang Ding et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Amino group of salicylic acid exhibits enhanced inhibitory potential against insulin amyloid fibrillation with protective aptitude toward amyloid induced cytotoxicity

(2018) Masihuz Zaman et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Aspirin induces Lysosomal biogenesis and attenuates Amyloid plaque pathology in a mouse model of Alzheimer's disease via PPARα

(2018) Sujyoti Chandra et al.   JOURNAL OF NEUROSCIENCE

Folic acid supplementation alters the DNA methylation profile and improves insulin resistance in high-fat-diet-fed mice

(2018) Wei Li et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Mechanistic Studies of the Inhibition of Insulin Fibril Formation by Rosmarinic Acid

(2018) Qiuchen Zheng et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Ursolic acid in health and disease

(2018) Dae Yun Seo et al.   KOREAN JOURNAL OF PHYSIOLOGY & PHARMACOLOGY

Oleanolic acid protects against cognitive decline and neuroinflammation-mediated neurotoxicity by blocking secretory phospholipase A2 IIA-activated calcium signals

(2018) Leguo Zhang et al.   MOLECULAR IMMUNOLOGY

Inhibition of Human Amylin Aggregation and Cellular Toxicity by Lipoic Acid and Ascorbic Acid

(2018) Sarah Kassem Azzam et al.   MOLECULAR PHARMACEUTICS

Brain insulin resistance in type 2 diabetes and Alzheimer disease: concepts and conundrums

(2018) Steven E. Arnold et al.   Nature Reviews Neurology

Protective role of rosmarinic acid on amyloid beta 42-induced echoic memory decline: Implication of oxidative stress and cholinergic impairment

(2018) Deniz Kantar Gok et al.   NEUROCHEMISTRY INTERNATIONAL

Mechanistic perspective and functional activity of insulin in amylin aggregation

(2018) Michal Baram et al.   Chemical Science

Ursolic Acid Attenuates High Glucose-Mediated Mesangial Cell Injury by Inhibiting the Phosphatidylinositol 3-Kinase/Akt/Mammalian Target of Rapamycin (PI3K/Akt/mTOR) Signaling Pathway

(2018) Er-Min Wang et al.   MEDICAL SCIENCE MONITOR

Synergistic action of ursolic acid and metformin in experimental model of insulin resistance and related behavioral alterations

(2018) Ashish Mourya et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Folic Acid Plus α-Tocopherol Mitigates Amyloid-β-Induced Neurotoxicity through Modulation of Mitochondrial Complexes Activity

(2018) Cláudia P. Figueiredo et al.   JOURNAL OF ALZHEIMERS DISEASE

Ferulic Acid Inhibits the Transition of Amyloid-β42 Monomers to Oligomers but Accelerates the Transition from Oligomers to Fibrils

(2018) Lili Cui et al.   JOURNAL OF ALZHEIMERS DISEASE

Ascorbic acid therapy: A potential strategy against comorbid depression-like behavior in streptozotocin-nicotinamide-induced diabetic rats

(2018) Naveen Shivavedi et al.   BIOMEDICINE & PHARMACOTHERAPY

Ascorbic acid supplementation improves postprandial glycaemic control and blood pressure in individuals with type 2 diabetes: Findings of a randomized cross-over trial

(2018) Shaun A. Mason et al.   DIABETES OBESITY & METABOLISM

Sinapic acid and resveratrol alleviate oxidative stress with modulation of gut microbiota in high-fat diet-fed rats

(2018) Chen Yang et al.   FOOD RESEARCH INTERNATIONAL

Ursolic Acid Attenuates Hepatic Steatosis, Fibrosis, and Insulin Resistance by Modulating the Circadian Rhythm Pathway in Diet-Induced Obese Mice

(2018) Eun-Young Kwon et al.   Nutrients

Protocatechuic acid ameliorates neurobehavioral deficits via suppression of oxidative damage, inflammation, caspase-3 and acetylcholinesterase activities in diabetic rats

(2018) Isaac A. Adedara et al.   FOOD AND CHEMICAL TOXICOLOGY

Efficacy of α-lipoic acid against cadmium toxicity on metal ion and oxidative imbalance, and expression of metallothionein and antioxidant genes in rabbit brain

(2017) Hamida M. Saleh et al.   ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH

The α-lipoic acid improves high-fat diet-induced cerebral damage through inhibition of oxidative stress and inflammatory reaction

(2017) Yang Liu et al.   ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY

Gallic acid induced dose dependent inhibition of lysozyme fibrillation

(2017) Mouli Konar et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Low-dose sinapic acid abates the pyroptosis of macrophages via downregulation of lncRNA-MALAT1 in rats with diabetic atherosclerosis

(2017) Yong Han et al.   JOURNAL OF CARDIOVASCULAR PHARMACOLOGY

Rosmarinic Acid Mediates Mitochondrial Biogenesis in Insulin Resistant Skeletal Muscle Through Activation of AMPK

(2017) Govindaraj Jayanthy et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Rosmarinic acid prevents fibrillization and diminishes vibrational modes associated to β sheet in tau protein linked to Alzheimer’s disease

(2017) Alberto Cornejo et al.   JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY

Gallic acid and p-coumaric acid attenuate type 2 diabetes-induced neurodegeneration in rats

(2017) Adel Abdel-Moneim et al.   METABOLIC BRAIN DISEASE

Oleanolic Acid and Its Derivatives: Biological Activities and Therapeutic Potential in Chronic Diseases

(2017) Taiwo Ayeleso et al.   MOLECULES

Oleanolic acid ameliorates cognitive dysfunction caused by cholinergic blockade via TrkB-dependent BDNF signaling

(2017) Se Jin Jeon et al.   NEUROPHARMACOLOGY

Pharmacological effects of protocatechuic acid and its therapeutic potential in neurodegenerative diseases: Review on the basis of in vitro and in vivo studies in rodents and humans

(2017) Kinga Krzysztoforska et al.   NUTRITIONAL NEUROSCIENCE

Ferulic acid attenuates diabetes-induced cognitive impairment in rats via regulation of PTP1B and insulin signaling pathway

(2017) Hao Wang et al.   PHYSIOLOGY & BEHAVIOR

The effect of acetylsalicylic acid on vasopressin, serum insulin levels, insulin resistance, and biochemical parameters in rats induced with experimental diabetes type 2

(2017) Serkan ŞEN et al.   Turkish Journal Of Medical Sciences

Ferulic Acid on Glucose Dysregulation, Dyslipidemia, and Inflammation in Diet-Induced Obese Rats: An Integrated Study

(2017) Norma Salazar-López et al.   Nutrients

Protocatechuic Acid, a Phenolic from Sansevieria roxburghiana Leaves, Suppresses Diabetic Cardiomyopathy via Stimulating Glucose Metabolism, Ameliorating Oxidative Stress, and Inhibiting Inflammation

(2017) Niloy Bhattacharjee et al.   Frontiers in Pharmacology

JNK at the crossroad of obesity, insulin resistance, and cell stress response

(2017) Giovanni Solinas et al.   Molecular Metabolism

Folic Acid Potentiates the Effect of Memantine on Spatial Learning and Neuronal Protection in an Alzheimer's Disease Transgenic Model

(2017) Ta-Fu Chen et al.   JOURNAL OF ALZHEIMERS DISEASE

Compartment-Specific Importance of Ascorbate During Environmental Stress in Plants

(2017) Bernd Zechmann   ANTIOXIDANTS & REDOX SIGNALING

Oleanolic Acid Inhibiting the Differentiation of Neural Stem Cells into Astrocyte by Down-Regulating JAK/STAT Signaling Pathway

(2016) Yu-Lian Zhang et al.   AMERICAN JOURNAL OF CHINESE MEDICINE

Insulin-degrading enzyme: new therapeutic target for diabetes and Alzheimer’s disease?

(2016) Olga Pivovarova et al.   ANNALS OF MEDICINE

Ursolic acid attenuates beta-amyloid-induced memory impairment in mice

(2016) Wenna Liang et al.   ARQUIVOS DE NEURO-PSIQUIATRIA

Antidiabetic and antihyperlipidemic activity of p -coumaric acid in diabetic rats, role of pancreatic GLUT 2: In vivo approach

(2016) Venkatesan Amalan et al.   BIOMEDICINE & PHARMACOTHERAPY

Oral treatment with a zinc complex of acetylsalicylic acid prevents diabetic cardiomyopathy in a rat model of type-2 diabetes: activation of the Akt pathway

(2016) Sevil Korkmaz-Icöz et al.   Cardiovascular Diabetology

Ferulic acid, a natural polyphenol, alleviates insulin resistance and hypertension in fructose fed rats: Effect on endothelial-dependent relaxation

(2016) Hany El-Bassossy et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Ferulic acid improves lipid and glucose homeostasis in high-fat diet-induced obese mice

(2016) Jarinyaporn Naowaboot et al.   CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY

Oleanolic acid derivatives for pharmaceutical use: a patent review

(2016) Chao Lin et al.   EXPERT OPINION ON THERAPEUTIC PATENTS

Free radical scavenging and α-glucosidase inhibition, two potential mechanisms involved in the anti-diabetic activity of oleanolic acid

(2016) J. M. Castellano et al.   GRASAS Y ACEITES

Neuroinflammation pathways: a general review

(2016) Tara Shabab et al.   INTERNATIONAL JOURNAL OF NEUROSCIENCE

Protocatechuic Acid: Inhibition of Fibril Formation, Destabilization of Preformed Fibrils of Amyloid-β and α-Synuclein, and Neuroprotection

(2016) Ruth Hornedo-Ortega et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Folic Acid Supplementation Mitigates Alzheimer’s Disease by Reducing Inflammation: A Randomized Controlled Trial

(2016) Hui Chen et al.   MEDIATORS OF INFLAMMATION

Role of metabolism in neurodegenerative disorders

(2016) Claudio Procaccini et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Relationship Between Obesity, Alzheimer’s Disease, and Parkinson’s Disease: an Astrocentric View

(2016) Cynthia Alexandra Martin-Jiménez et al.   MOLECULAR NEUROBIOLOGY

Multiple mechanisms of age-dependent accumulation of amyloid beta protein in rat brain: Prevention by dietary supplementation with N-acetylcysteine, α-lipoic acid and α-tocopherol

(2016) Maitrayee Sinha et al.   NEUROCHEMISTRY INTERNATIONAL

Perilla frutescensvar.japonicaand rosmarinic acid improve amyloid-β25-35induced impairment of cognition and memory function

(2016) Ah Young Lee et al.   Nutrition Research and Practice

Sinapic Acid and Its Derivatives as Medicine in Oxidative Stress-Induced Diseases and Aging

(2016) Chunye Chen   Oxidative Medicine and Cellular Longevity

Amylin-mediated control of glycemia, energy balance, and cognition

(2016) Elizabeth G. Mietlicki-Baase   PHYSIOLOGY & BEHAVIOR

Cyanidin-3- O -β-glucoside and protocatechuic acid activate AMPK/mTOR/S6K pathway and improve glucose homeostasis in mice

(2016) Veena Talagavadi et al.   Journal of Functional Foods

Rosmarinic acid ameliorates hyperglycemia and insulin sensitivity in diabetic rats, potentially by modulating the expression of PEPCK and GLUT4

(2016) Akio Inui et al.   Drug Design Development and Therapy

Effects of Folic Acid on Secretases Involved in Aβ Deposition in APP/PS1 Mice

(2016) Tian Tian et al.   Nutrients

c-Jun N-terminal Kinase (JNK) Signaling as a Therapeutic Target for Alzheimer’s Disease

(2016) Ramon Yarza et al.   Frontiers in Pharmacology

Ferulic Acid Reverses the Cognitive Dysfunction Caused by Amyloid β Peptide 1-40 Through Anti-Oxidant Activity and Cholinergic Activation in Rats

(2015) Fan-Shiu Tsai et al.   AMERICAN JOURNAL OF CHINESE MEDICINE

Folic acid supplementation during high-fat diet feeding restores AMPK activation via an AMP-LKB1-dependent mechanism

(2015) Victoria Sid et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

Ferulic acid exerts its antidiabetic effect by modulating insulin-signalling molecules in the liver of high-fat diet and fructose-induced type-2 diabetic adult male rat

(2015) Akilavalli Narasimhan et al.   Applied Physiology Nutrition and Metabolism

Early use of oleanolic acid provides protection against 6-hydroxydopamine induced dopamine neurodegeneration

(2015) Musa V. Mabandla et al.   BRAIN RESEARCH

Low brain ascorbic acid increases susceptibility to seizures in mouse models of decreased brain ascorbic acid transport and Alzheimer's disease

(2015) Timothy A. Warner et al.   EPILEPSY RESEARCH

Folic acid attenuates the effects of amyloid β oligomers on DNA methylation in neuronal cells

(2015) Huan Liu et al.   EUROPEAN JOURNAL OF NUTRITION

Folic Acid Inhibits Amyloid β-Peptide Production through Modulating DNA Methyltransferase Activity in N2a-APP Cells

(2015) Wen Li et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Old Things New View: Ascorbic Acid Protects the Brain in Neurodegenerative Disorders

(2015) Adriana Covarrubias-Pinto et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Folic acid deficiency enhances abeta accumulation in APP/PS1 mice brain and decreases amyloid-associated miRNAs expression

(2015) Huan Liu et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Folic acid administration inhibits amyloid β-peptide accumulation in APP/PS1 transgenic mice

(2015) Wen Li et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Protective effect of rosmarinic acid against oxidative stress biomarkers in liver and kidney of strepotozotocin-induced diabetic rats

(2015) Nadia Mushtaq et al.   JOURNAL OF PHYSIOLOGY AND BIOCHEMISTRY

Inflammation and Oxidative Stress: The Molecular Connectivity between Insulin Resistance, Obesity, and Alzheimer’s Disease

(2015) Giuseppe Verdile et al.   MEDIATORS OF INFLAMMATION

Rosmarinic acid modulates the antioxidant status and protects pancreatic tissues from glucolipotoxicity mediated oxidative stress in high-fat diet: streptozotocin-induced diabetic rats.

(2015) Jayanthy Govindaraj et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Unknown

(2015) Ciro Coletta et al.   MOLECULAR MEDICINE

Protocatechuic acid activates key components of insulin signaling pathway mimicking insulin activity

(2015) Beatrice Scazzocchio et al.   MOLECULAR NUTRITION & FOOD RESEARCH

An analysis of the attrition of drug candidates from four major pharmaceutical companies

(2015) Michael J. Waring et al.   NATURE REVIEWS DRUG DISCOVERY

Oleanolic acid andN-acetylcysteine ameliorate diabetic nephropathy through reduction of oxidative stress and endoplasmic reticulum stress in a type 2 diabetic rat model

(2015) Eun Soo Lee et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

Protocatechuic Acid Inhibits Inflammatory Responses in LPS-Stimulated BV2 Microglia via NF-κB and MAPKs Signaling Pathways

(2015) Huan-yu Wang et al.   NEUROCHEMICAL RESEARCH

Ameliorative effect of rosmarinic acid on scopolamine-induced memory impairment in rats

(2015) Parisa Hasanein et al.   NEUROSCIENCE LETTERS

Non-selective NSAIDs improve the amyloid-β-mediated suppression of memory and synaptic plasticity

(2015) Jafar Doost Mohammadpour et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

Protocatechuic Acid Restores Vascular Responses in Rats With Chronic Diabetes Induced by Streptozotocin

(2015) Yoswaris Semaming et al.   PHYTOTHERAPY RESEARCH

Ferulic Acid Alleviates Changes in a Rat Model of Metabolic Syndrome Induced by High-Carbohydrate, High-Fat Diet

(2015) Ketmanee Senaphan et al.   Nutrients

Effects of oleanolic acid on the insulin signaling pathway in skeletal muscle of streptozotocin-induced diabetic male Sprague-Dawley rats

(2015) Andrew Mukundwa et al.   Journal of Diabetes

Combination Therapy with Oleanolic Acid and Metformin as a Synergistic Treatment for Diabetes

(2015) Xue Wang et al.   Journal of Diabetes Research

Link between type 2 diabetes and Alzheimer’s disease: from epidemiology to mechanism and treatment

(2015) Xiaohua Li et al.   Clinical Interventions in Aging

Ursolic Acid Attenuates Diabetic Mesangial Cell Injury through the Up-Regulation of Autophagy via miRNA-21/PTEN/Akt/mTOR Suppression

(2015) Xinxing Lu et al.   PLoS One

Inflammation as a link between obesity, metabolic syndrome and type 2 diabetes

(2014) Nathalie Esser et al.   DIABETES RESEARCH AND CLINICAL PRACTICE

Gallic acid, one of the components in many plant tissues, is a potential inhibitor for insulin amyloid fibril formation

(2014) Jayaraman Jayamani et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Effect of ursolic acid and Rosiglitazone combination on hepatic lipid accumulation in high fat diet-fed C57BL/6J mice

(2014) Arjunan Sundaresan et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Protocatechuic acid improves cognitive deficits and attenuates amyloid deposits, inflammatory response in aged AβPP/PS1 double transgenic mice

(2014) Yu Song et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

p-Coumaric Acid and Ursolic Acid from Corni fructus Attenuated β-Amyloid25–35-Induced Toxicity through Regulation of the NF-κB Signaling Pathway in PC12 Cells

(2014) Jeong-Hyun Yoon et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

(R)-(+)-α-Lipoic acid protected NG108-15 cells against H2O2-induced cell death through PI3K-Akt/GSK-3β pathway and suppression of NF-κβ-cytokines

(2014) Abdul Kadir et al.   Drug Design Development and Therapy

Inhibition of insulin amyloid fibril formation by ferulic acid, a natural compound found in many vegetables and fruits

(2014) Jayaraman Jayamani et al.   RSC Advances

Akt/PKB activation and insulin signaling: a novel insulin signaling pathway in the treatment of type 2 diabetes

(2014) Richard Mackenzie et al.   Diabetes Metabolic Syndrome and Obesity-Targets and Therapy

The effects of ferulic acid on β-amyloid fibrillar structures investigated through experimental and computational techniques

(2013) Antonella Sgarbossa et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Gallic acid is the major component of grape seed extract that inhibits amyloid fibril formation

(2013) Yanqin Liu et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Rosmarinic acid prevents lipid peroxidation and increase in acetylcholinesterase activity in brain of streptozotocin-induced diabetic rats

(2013) Nadia Mushtaq et al.   CELL BIOCHEMISTRY AND FUNCTION

Biochemical Basis of the Antidiabetic Activity of Oleanolic Acid and Related Pentacyclic Triterpenes

(2013) J. M. Castellano et al.   DIABETES

Protective effect of gallic acid on alloxan-induced oxidative stress and osmotic fragility in rats

(2013) KM Ramkumar et al.   HUMAN & EXPERIMENTAL TOXICOLOGY

The Protective Effects of α-Lipoic Acid on Kidneys in Type 2 Diabetic Goto-Kakisaki Rats via Reducing Oxidative Stress

(2013) Bo Feng et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Antihyperglycemic Action of Sinapic Acid in Diabetic Rats

(2013) Yih-Giun Cherng et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Ascorbate prevents cell death from prolonged exposure to glutamate in an in vitro model of human dopaminergic neurons

(2013) Santiago Ballaz et al.   JOURNAL OF NEUROSCIENCE RESEARCH

β-Amyloid Amorphous Aggregates Induced by the Small Natural Molecule Ferulic Acid

(2013) Emilia Bramanti et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Oleanolic acid improves hepatic insulin resistance via antioxidant, hypolipidemic and anti-inflammatory effects

(2013) Xin Wang et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Direct and indirect antioxidant properties of α-lipoic acid and therapeutic potential

(2013) Luc Rochette et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Ferulic Acid Is a Nutraceutical β-Secretase Modulator That Improves Behavioral Impairment and Alzheimer-like Pathology in Transgenic Mice

(2013) Takashi Mori et al.   PLoS One

Targeting JNK by a New Curcumin Analog to Inhibit NF-kB-Mediated Expression of Cell Adhesion Molecules Attenuates Renal Macrophage Infiltration and Injury in Diabetic Mice

(2013) Yong Pan et al.   PLoS One

Spectroscopic studies on the antioxidant activity of p-coumaric acid

(2013) Ismail Kiliç et al.   SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY

DNA and Oxidative Damages Decrease After Ingestion of Folic Acid in Patients with Type 2 Diabetes

(2012) Blanca Patricia Lazalde-Ramos et al.   ARCHIVES OF MEDICAL RESEARCH

Protective Effects of Ferulic Acid in Amyloid Precursor Protein Plus Presenilin-1 Transgenic Mouse Model of Alzheimer Disease

(2012) Ji-Jing Yan et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

Brain Insulin Resistance and Deficiency as Therapeutic Targets in Alzheimers Disease

(2012) Suzanne M. de la Monte   Current Alzheimer Research

Anti-inflammatory activities of oleanolic acid on HMGB1 activated HUVECs

(2012) Eun-Ju Yang et al.   FOOD AND CHEMICAL TOXICOLOGY

Immunomodulatory and Anti-inflammatory Effect of p-Coumaric Acid, a Common Dietary Polyphenol on Experimental Inflammation in Rats

(2012) Samuel Joshua Pragasam et al.   INFLAMMATION

Effect of two herbal polyphenol compounds on human amylin amyloid formation and destabilization

(2012) Seyyed Mehdi Mirhashemi   Journal of Medicinal Plants Research

Protective Effects of the Key Compounds Isolated from Corni fructus against β-Amyloid-Induced Neurotoxicity in PC12 Cells

(2012) Seung-Young Hong et al.   MOLECULES

Terpenoids as Potential Anti-Alzheimer’s Disease Therapeutics

(2012) Ki-Yeol Yoo et al.   MOLECULES

Neuroprotective effect of sinapic acid in a mouse model of amyloid β1–42 protein-induced Alzheimer's disease

(2012) Hyung Eun Lee et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

Oleanolic acid

(2012) Jacob Pollier et al.   PHYTOCHEMISTRY

Oleanolic Acid Reduces Hyperglycemia beyond Treatment Period with Akt/FoxO1-Induced Suppression of Hepatic Gluconeogenesis in Type-2 Diabetic Mice

(2012) Xiao-Yi Zeng et al.   PLoS One

Oleanolic Acid: A Novel Cardioprotective Agent That Blunts Hyperglycemia-Induced Contractile Dysfunction

(2012) Rudo F. Mapanga et al.   PLoS One

Staged decline of neuronal function in vivo in an animal model of Alzheimer's disease

(2012) Christine Grienberger et al.   Nature Communications

Protective role of sinapic acid against arsenic – Induced toxicity in rats

(2011) L. Pari et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Low Doses of Acetylsalicylic Acid Increase Risk of Gastrointestinal Bleeding in a Meta-Analysis

(2011) Angel Lanas et al.   Clinical Gastroenterology and Hepatology

Rosmarinic acid and its derivatives: biotechnology and applications

(2011) Victor P. Bulgakov et al.   CRITICAL REVIEWS IN BIOTECHNOLOGY

Cyanidin-3-O- -Glucoside and Protocatechuic Acid Exert Insulin-Like Effects by Upregulating PPAR  Activity in Human Omental Adipocytes

(2011) B. Scazzocchio et al.   DIABETES

Effect of folic acid supplementation on biochemical indices in overweight and obese men with type 2 diabetes

(2011) Bahram Pourghassem Gargari et al.   DIABETES RESEARCH AND CLINICAL PRACTICE

cJUN N-terminal kinase (JNK) activation mediates islet amyloid-induced beta cell apoptosis in cultured human islet amyloid polypeptide transgenic mouse islets

(2011) S. L. Subramanian et al.   DIABETOLOGIA

A High Content Drug Screen Identifies Ursolic Acid as an Inhibitor of Amyloid β Protein Interactions with Its Receptor CD36

(2011) Kim Wilkinson et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Effect of Aspirin on the Expression of Hepatocyte NF-κB and Serum TNF-α in Streptozotocin-Induced Type 2 Diabetic Rats

(2011) Xiaodong Sun et al.   JOURNAL OF KOREAN MEDICAL SCIENCE

α-Lipoic acid (LA) enantiomers protect SH-SY5Y cells against glutathione depletion

(2011) Takashi Yamada et al.   NEUROCHEMISTRY INTERNATIONAL

Amyloid fibril protein nomenclature: 2010 recommendations from the nomenclature committee of the International Society of Amyloidosis

(2010) Jean D. Sipe et al.   AMYLOID-JOURNAL OF PROTEIN FOLDING DISORDERS

Caffeic acid, tyrosol and p-coumaric acid are potent inhibitors of 5-S-cysteinyl-dopamine induced neurotoxicity

(2010) David Vauzour et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Genistein and Folic Acid Prevent Oxidative Injury Induced by β-Amyloid Peptide

(2010) Bingjie Ding et al.   BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY

Oleanolic acid, a natural triterpenoid improves blood glucose tolerance in normal mice and ameliorates visceral obesity in mice fed a high-fat diet

(2010) Célio L. de Melo et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Modulatory effects of vitamin E, acetyl-l-carnitine and α-lipoic acid on new potential biomarkers for Alzheimer's disease in rat model

(2010) Hanaa H. Ahmed   EXPERIMENTAL AND TOXICOLOGIC PATHOLOGY

The combination of exercise training and α-lipoic acid treatment has therapeutic effects on the pathogenic phenotypes of Alzheimer's disease in NSE/APPsw-transgenic mice

(2010) Cho   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

α-Lipoic acid protects diabetic apolipoprotein E-deficient mice from nephropathy

(2010) Xianwen Yi et al.   JOURNAL OF DIABETES AND ITS COMPLICATIONS

Effect of Oryzanol and Ferulic Acid on the Glucose Metabolism of Mice Fed with a High-Fat Diet

(2010) Myoung Jin Son et al.   JOURNAL OF FOOD SCIENCE

Antioxidant and antihyperlipidaemic activity of protocatechuic acid on streptozotocindiabetic rats

(2010) Ranganathan Harini et al.   REDOX REPORT

Synergistic antihyperglycemic effects between plant-derived oleanolic acid and insulin in streptozotocin-induced diabetic rats

(2010) C.T. Musabayane et al.   RENAL FAILURE

Neuroprotection of soyabean isoflavone co-administration with folic acid against β-amyloid 1-40-induced neurotoxicity in rats

(2009) Wei-wei Ma et al.   BRITISH JOURNAL OF NUTRITION

Neuroprotective effects of genistein and folic acid on apoptosis of rat cultured cortical neurons induced by β-amyloid 31-35

(2009) Huan-Ling Yu et al.   BRITISH JOURNAL OF NUTRITION

Improvement of insulin-stimulated glucose-disposal in type 2 diabetes after repeated parenteral administration of thioctic acid

(2009) S. Jacob et al.   EXPERIMENTAL AND CLINICAL ENDOCRINOLOGY & DIABETES

Aralia cordata Protects Against Amyloid β Protein (25–35)–Induced Neurotoxicity in Cultured Neurons and Has Antidementia Activities in Mice

(2009) Soon Ock Cho et al.   JOURNAL OF PHARMACOLOGICAL SCIENCES

Antidiabetic and antioxidant effects of oleanolic acid fromLigustrum lucidumAit in alloxan-induced diabetic rats

(2009) Dawei Gao et al.   PHYTOTHERAPY RESEARCH

NAP and D-SAL: neuroprotection against the β amyloid peptide (1–42)

(2008) Illana Gozes et al.   BMC NEUROSCIENCE

Anti-Inflammatory Effects of Sinapic Acid through the Suppression of Inducible Nitric Oxide Synthase, Cyclooxygase-2, and Proinflammatory Cytokines Expressions via Nuclear Factor-κB Inactivation

(2008) Kyung-Jin Yun et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Antioxidative and Anti-Inflammatory Protection of Oleanolic Acid and Ursolic Acid in PC12 Cells

(2008) Shih-Jei Tsai et al.   JOURNAL OF FOOD SCIENCE

Inhibitory effects of short-term administration of dl-α-lipoic acid on oxidative vulnerability induced by Aβ amyloid fibrils (25–35) in mice

(2008) E. Philip Jesudason et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Rosmarinic acid protects human dopaminergic neuronal cells against hydrogen peroxide-induced apoptosis

(2008) Hyo Jung Lee et al.   TOXICOLOGY